Ru-Lan Hsieh

Shin Kong Wu Ho-Su Memorial Hospital · Department of Physical Medicine and Rehabilitation

Chronic inflammation is the cause of chronic kidney disease (CKD). The nucleotide-binding domain-like receptor protein 3 (NLRP3) inflammasome plays a vital role in the inflammation process and is associated with the regulatory effects of NLRP3 gene polymorphisms. This study evaluated the association between NLRP3 gene polymorphisms and CKD, and fur...

Objective To determine whether intra-articular coinjection with hypertonic dextrose improves the outcome of hyaluronic acid (HA) prolotherapy for knee osteoarthritis Design Prospective, randomized, double-blind trial Setting Medical center in Taiwan Participants In total, 104 participants who fulfilled the American College of Rheumatology clinic...

This study hypothesized that plasma folate and vitamin B12 levels modified the association between blood lead and cadmium and total urinary arsenic levels and bone loss. A total of 447 study subjects who received a physical examination at the Wanfang Hospital Medical Center were recruited. Bone loss was defined as a calcaneus bone mineral density T...

Metal exposure and lifestyle are important risk factors for osteoporosis. Our study aimed to investigate the association between red blood cell lead and cadmium, total urinary arsenic, and plasma selenium levels and bone mineral density (BMD). In addition, we explored whether alcohol and coffee consumption modified the association between BMD and m...

Background : We compared the effects of repeated coinjections of corticosteroids plus hyaluronic acid (HA) with the effects of HA injections alone in patients with knee osteoarthritis. Methods : A double-blind randomized controlled trial was conducted between October 2016 and July 2017 at a medical center. Patients (N = 57) who fulfilled the clini...

The effectiveness of arch-support insoles on children remains controversial. We evaluated the short-term therapeutic effects of arch-support insoles on the physical functional performance, physical function, and psychological well-being of healthy children under the International Classification of Functioning, Disability, and Health (ICF) framework...

Polymorphisms of methylenetetrahydrofolate reductase (MTHFR) and methionine synthase (MTR) are related to cognitive dysfunction and mental disability. These genes, along with folate and vitamin B12 levels, are regulators of one-carbon metabolism, which synthesizes S-adenosylmethionine (SAM) as a methyl donor for arsenic methylation. The aim of this...

Background: Active video games (AVGs) have become popular and have been investigated for their therapeutic purposes. However, the effect of AVGs on patients with knee osteoarthritis (OA) remains uncertain. Objective: We aimed to compare the effects of AVGs with those of traditional therapeutic exercise on patients with knee OA. Method: This was a p...

Developmental delay has been associated with inefficient arsenic methylation capacity in preschool children. Folate and vitamin B12 are important nutrients that produce s-adenosylmethionine during single-carbon metabolism and provide methyl groups for arsenic methylation. The aim of the present study was to explore whether plasma folate and vitamin...

Inefficient arsenic methylation capacity has been associated with developmental delay in preschool children. Selenium has antioxidant and anti-inflammatory properties that protect experimental animals from chemically induced neurotoxicity. The present study was designed to explore whether plasma selenium levels affects arsenic methylation capacity...

This study investigated the effects of a short-term family-centered workshop for children with developmental delays. This study was conducted in a rehabilitation outpatient clinic of a teaching hospital. We recruited 30 children with developmental delays and their parents as the study group and 57 age- and sex-matched children with typical developm...

Background: Limited evidence is available regarding the effects of insoles on pediatric flexible flatfoot because of the heterogeneity and low methodological quality of previous studies. The purpose of this prospective trial is to examine the short-term effects of customized arch support insoles on symptomatic flexible flatfoot in children by usin...

[This corrects the article DOI: 10.1155/2012/583016.].

The aim of this study was to evaluate the association of blood lead, mercury, and cadmium concentrations with developmental delays and to explore the association of these concentrations with the health status of children. This study recruited 89 children with developmental delays and 89 age- and sex-matched children with typical development. Their...

Inefficient arsenic methylation capacity has been associated with developmental delay in children. The present study was designed to explore whether polymorphisms and haplotypes of arsenic methyltransferase (AS3MT), glutathione-S-transferase omegas (GSTOs), and purine nucleoside phosphorylase (PNP) affect arsenic methylation capacity and developmen...

This case–control study identified the association between the arsenic methylation capacity and developmental delays and explored the association of this capacity with the health status of children. We recruited 120 children with developmental delays and 120 age- and sex-matched children without developmental delays. The health status of the childr...

We investigated the clinical efficacy on family functioning and parental satisfaction of a short-term family-centered workshop for children with developmental delays. A total of 32 children with developmental delays and their parents participated in 2-hour weekly group therapy sessions over 6 weeks. The workshop was conducted by rehabilitation prof...

We compared the short-term efficacy of rigid versus soft lateral wedge arch support (LWAS) insoles for patients with knee osteoarthritis (OA), as assessed using the International Classification of Functioning, Disability and Health (ICF) system, through a prospective, double-blind, randomized controlled trial. Participants who fulfilled the combine...

This prospective, randomized controlled study investigated the effects of short-term interactive video game playing among children with developmental delays participating in traditional rehabilitation treatment at a rehabilitation clinic. One hundred and one boys and 46 girls with a mean age of 5.8 years (range: 3 to 12 years) were enrolled in this...

Clinical trial protocol (main points in English). (DOC)

IRB approval statement. (PDF)

Clinical trial protocol (original language). (DOC)

Consort list. (PDF)

Subject consent form. (DOC)

Clinical trial registration. (PDF)

PurposeTo evaluate the associations between pain and physical functional limitation and health status in patients with knee osteoarthritis (OA).DesignA correlational study.Methods In a convenience sample of 73 patients with knee OA, pain and physical function were assessed using the Western Ontario and McMaster University Osteoarthritis Index. Heal...

Environmental exposure to lead or mercury can cause neurodevelopmental damage. Arsenic is another neurotoxicant that can affect intellectual function in children. This study was designed to explore the difference of arsenic methylation capacity indices between with and without developmental delay in preschool children. We also aimed to identify whe...

Objective: To investigate the immediate and medium-term effects of custom-moulded insoles on patients with knee osteoarthritis. Design: Before-after trial, followed up for 6 months. Subjects: Forty participants, mean age 61 years, who fulfilled the combined radiographic and clinical criteria for knee osteoarthritis, as defined by the American Colle...

Objective: To examine the correlation of function, quality of life (QOL), and parental impact on developmental delayed children. Methods: Sixty parents of children with developmental delays (M:F = 36:24, mean age 4 years and 2 months) and 56 parents of age-sex matched typical development children were included. Pediatric Outcomes Data Collection...

We conducted a double-blind randomized placebo-controlled study to investigate the effects of short-term 890-nm light therapy in patients with chronic low back pain in a rehabilitation clinic. Thirty-eight women and 22 men with chronic low back pain (mean age, 60.3 years; range, 32-80 years) received 40-min sessions of hot-pack therapy combined wit...

We evaluated the correlation of health in preschool Taiwanese children with developmental delays. A total of 70 primary caregivers of 48 male and 22 female preschool Taiwanese children who had been diagnosed with developmental delays were recruited. We administered the Child Health Questionnaire- Parent Form 28 to the parents to evaluate parent-rep...

The effects of active video game play on healthy individuals remain uncertain. A person's functional health status constitutes a dynamic interaction between components identified in the International Classification of Functioning, Disability, and Health (ICF). The aim of this study was to investigate the short-term effects of active video game play...

Objectives To assess the differences in postural stability between patients with knee osteoarthritis and controls without knee osteoarthritis, and to evaluate possible relations between postural stability scores and International Classification of Functioning, Disability and Health (ICF) components.DesignAn age-matched, case-controlled trial with a...

Aims: The study aims to evaluate the quality of life (QOL) and health of children with unclassified developmental delays and the impacts this had on the family. Methods: In total, 60 parents of pre-school children with unclassified developmental delays and 56 parents of age and gender-matched children with typical development were recruited. We...

Objective: To investigate possible correlations between the incidence and severity of Bell's palsy and seasonal variations in Taiwan. Methods: We studied data on the incidence of Bell's palsy over a 3-year period in Taiwan. The electroneurographic quotient was used as an index for the severity of nerve involvement. A higher electroneurographic q...

Objective: To apply Root Cause Analysis to explore the causes of patient falls and determine the implement procedures to prevent them. Design: Root Cause Analysis was conducted retrospectively using comprehensive error review to discover and correct the causes of errors. Setting: Physical medicine and rehabilitation department in a medical center i...

Study design: Randomized, double-blind, placebo-controlled study. Objectives: To examine the short-term therapeutic effects of monochromatic infrared energy (MIRE) on participants with knee osteoarthritis (OA). Patients were assessed according to the International Classification of Functioning, Disability and Health. Background: MIRE is common...

Infrared (IR) therapy is used for pain relief in patients with knee osteoarthritis (OA). However, IR's effects on the cardiovascular system remain uncertain. Therefore, we investigated the local and systemic cardiovascular effects of monochromatic IR therapy on patients with knee OA in a double-blind, randomized, placebo-controlled study. Seventy-o...

To investigate the effects of short-term light therapy with 890-nm radiation on pain, physical activity, and postural stability in patients with knee osteoarthritis (OA). A double-blind, randomized, placebo-controlled study. Rehabilitation clinic. Women (n=62) and men (n=10) with a mean age of 61.2 years (range, 40-88y). All patients fulfilled the...

Objective: To examine the relationship between the Pediatric Outcomes Data Collection Instrument (PODCI) and functional impairment in Chinese children with developmental delays and between PODCI and their parents’ health Methods: This was a cross-sectional study. A total of 49 parents of 35 male and 14 female Chinese children with developmental del...

The objective of this study was to describe a serious complication of acupuncture treatment in a high-risk patient with aplastic anemia. A 44-year-old woman with aplastic anemia experienced right calf pain after running. After poor results with physical therapy, she received needle acupuncture for pain relief. However, aggravated pain with swelling...

To study the long-term changes in physical functional performance and quality of life in hemodialysis patients living in the community in Taiwan. This prospective study monitored 27 ambulatory hemodialysis patients for 16 months living in the community in Taiwan. Physical capacity (6-minute walk test, grip strength, pinch strength and chair-rising...

Objectives: To describe the number of people with spinal cord injury who returned to work (RTW) 1 yr after discharge from inpatient rehabilitation and to investigate whether RTW can be predicted from wheelchair capacity at discharge from inpatient rehabilitation, after correction for confounders. Design: Prospective cohort study in which 1 18 subje...

This study aimed to evaluate the still unknown factors correlating with the degree of nerve involvement in early Bell's palsy. This retrospective chart review study of newly diagnosed cases of Bell's palsy was conducted over a three-year period. Information on age, sex, day of onset, comorbidities, corticosteroid use, and electroneurographic test r...

To study the quality of life, health satisfaction and family impact on caregivers of children with developmental delays in Taiwan. Cross-sectional study. The caregivers of children with diagnoses of developmental delays recruited from a teaching hospital in northern Taiwan. The main caregivers of 48 male and 22 female children with developmental de...

Methicillin-resistant Staphylococcus aureus (MRSA) cervical spinal subdural empyema as a result of a retropharyngeal abscess has not been reported previously. We present a 65-year-old male intravenous drug user who developed spinal subdural empyema after an operation for a retropharyngeal abscess. Although imaging diagnosis and follow-up surgery we...

Zusammenfassung Diese Studie überprüft die zusätzlichen therapeutischen Effekte der Elektroakupunktur für Patienten mit erstmaligem ischämischem Schlaganfall. Design Randomisierte kontrollierte Studie Studienteilnehmer Insgesamt 63 Patienten mit erstmaligem ischämischem Schlaganfall. Methode Die Studiengruppe und die Kontrollgruppe nahmen an ein...

In hemodialysis patients, quality of life (QOL) may vary across a range of individual conditions and social environments. In this study, we focused on ambulatory hemodialysis patients, examining their QOL compared with that of age-matched controls. Correlates of QOL in ambulatory hemodialysis patients were also examined. QOL was evaluated by WHOQOL...

This study examined the additional therapeutic effects of electroacupuncture for patients with first-ever ischaemic stroke. Randomized controlled study. A total of 63 patients with first-ever ischaemic stroke. The study and control groups underwent a conventional rehabilitation program, with the former receiving an additional 8 courses of electroac...

Studies focusing on maximal cardiovascular fitness in ambulatory hemodialysis patients are lacking. The main purpose of this study is to look at maximal cardiovascular fitness in ambulatory hemodialysis patients, and the secondary purpose is to look at correlates with such fitness. We studied maximal cardiovascular fitness in ambulatory hemodialysi...

To investigate the therapeutic effects of one shot of low-frequency percutaneous electrical nerve stimulation one shot of transcutaneous electrical nerve stimulation in patients with low back pain. In total, 133 low back pain patients were recruited for this randomized, control study. Group 1 patients received medication only. Group 2 patients rece...

Hsieh RL, Lee WC: One-shot percutaneous electrical nerve stimulation vs. transcutaneous electrical nerve stimulation for low back pain: Comparison of therapeutic effects. Am J Phys Med Rehabil 2002;81:838–843. Objective: To investigate the therapeutic effects of one shot of low-frequency percutaneous electrical nerve stimulation vs. one shot of tra...

Life expectation is a valuable summary index in public health and actuarial science. The life expectancies published in the vital statistics, however, are derived from the "current" rather than from the "cohort" life table. The former is based on a strong assumption of constant mortality in the population, whereas the latter calls for a recording o...

A cross-sectional study on the correlates of elderly disability was conducted in Taiwan. A total of 400 subjects was randomly selected according to Barthel Index scores from among 2600 subjects, which was a sample of a previous community-based health survey of elderly aged 65 or over. After comprehensive interviews and examinations of the subjects,...