Rpvj Rajapakse

Rpvj Rajapakse
University of Peradeniya | UOP · Department of Veterinary Pathobiology

BVSc, PhD

About

259
Publications
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Publications

Publications (259)
Article
Full-text available
Purpose: Ancylostoma spp. causing canine hookworm infections are distributed worldwide with a high prevalence in the South Asian region. Here, we report the first molecular identification of the canine hookworm infecting the dogs in Sri Lanka. Method: Fresh faecal samples were collected from free-roaming dogs in tea estate communities in Talawak...
Conference Paper
Full-text available
Gastro-intestinal (GI) parasites cause severe illness in dogs and humans, particularly in socioeconomically challenged communities with large stray dog populations. Most of these GI parasites of dogs are zoonoses. Since dogs play a pivotal role in the epidemiology of human infections, investigating the types of GI parasites and prevalence are impor...
Article
Full-text available
Introduction: Otoacariasis, the presence of a tick or mite in the ear canal, has been reported from many parts of the country. Here we report the presence of rickettsial DNA in a tick removed from an otoacariasis patient. Case report: A female tick,Rhipicephales haemaphysaloides, was attached to the ear canal of a male infant aged one and half yea...
Conference Paper
Full-text available
Tick borne parasitic diseases play a major role in reducing the livestock production worldwide. When considering the sheep industry, the common haemoparasites causing losses include Babesia, Anaplasma, Ehrlichia and Theilaria. In the context of Sri Lankan sheep industry, many animals were imported; thus, they may harbour haemoparasitic diseases...
Article
IntroductionThe dog is known as man’s best friend and canine-companionship is associated with positive effects on cardiovascular health.AimWe aim to review the role of cortisol in the association of canine-companionship with human blood pressure, glucose and lipid profile.Methods Electronic databases, and reference lists of the selected articles we...
Article
Full-text available
Seaweeds have been regarded as a reservoir of biologically active molecules that are important in the pharmaceutical industry. The aim of the present study was to explore the wound healing properties and to assess the safety of the seaweed Sargassum ilicifolium and Ulva lactuca. Enhanced cell proliferation and cell migration activities were observe...
Article
Full-text available
Background Momordica charantia or bitter melon is a well-known vegetable with a number of therapeutic actions in Ayurvedic medicine. Alpha-eleostearic acid, a conjugated trienoic fatty acid present in bitter melon is proven to have anticancer properties. Crude seed oil from local bitter melon varieties could be an effective and economical anticance...
Article
Hydroxyapatite (HA) is a widely used biomaterial for coatings on prostheses, which is used to repair, replace and restore the function of traumatized or diseased bone. In the present study, template-assisted electrohydrodynamic atomization (TAEA) was used to pattern Ti surfaces (convex, concave and flat) with different HA nanoparticles, in order to...
Article
Full-text available
PurposeOtoacariasis is a parasitic otopathy reported in many parts of the world. This study presents the seasonal pattern, risk factors, and case notes on human otoacariasis in two climatically different districts: Anuradhapura and Kandy in the Dry and Wet/Intermediate zone of Sri Lanka, respectively.Methods Ticks removed from the ear canal of pati...
Article
Full-text available
Spirocerca lupi, the esophageal nematode of dog , causes a potentially fatal disease in domestic dogs. Immunological techniques can identify the parasite proteins which elicit an immune response. However, the antigenic properties of S. lupi adult worms have not been fully understood. The immuno-reactivity of the naturally infected dog sera with the...
Article
Gastro-intestinal (GI) parasites of primates have a greater potential of becoming zoonotic. This potential may vary in different primates based on multiple factors such as proximity to human settlements and the climate of their habitat. We examined the GI parasites in two subspecies of toque macaque: Macaca sinica sinica (confined to the dry zone)...
Article
Full-text available
The freshwater snail Indoplanorbis exustus play an important role as the sole intermediate host of several medically- and economically-important trematodes, especially zoonotic schistosomes and echinostomes, which can infect and cause diseases in livestock and people. This study aims to explore the mitochondrial cytochrome c oxidase subunit 1 seque...
Article
Full-text available
We present a rare case of a 31-year-old pregnant mother in 37 weeks of gestation who presented with a 3-day history of vomiting, epigastric pain, and icterus, subsequently diagnosed as a rickettsial disease in pregnancy (with positive IgG titer for SFG) complicated with hepatitis, coagulopathy, pulmonary hemorrhage, and post-partum hemorrhage, who...
Conference Paper
Gastrointestinal (GI) parasites in non-human primates have a greater potential to become zoonotic as well as anthroponotic. This study examined the GI parasites in two subspecies of toque macaque: Macaca sinica sinica in the dry zone and Macaca sinica aurifrons in the wet zone of Sri Lanka. Fresh faecal samples were collected from Polonnaruwa Archa...
Conference Paper
Full-text available
Gastrointestinal (GI) parasites in non-human primates have a greater potential to become zoonotic as well as anthroponotic. This study examined the GI parasites in two subspecies of toque macaque: Macaca sinica sinica in the dry zone and Macaca sinica aurifrons in the wet zone of Sri Lanka. Fresh faecal samples were collected from Polonnaruwa Archa...
Article
Full-text available
Background Seaweeds are an important source of bioactive compounds which are applied in various aspects of medicinal investigations. The present study was conducted to investigate cytoxicity (in-vitro and in-vivo) and wound healing activity of different seaweed species in Sri Lanka. Methods Twenty-three seaweed samples, belonging to Phaeophyta (Br...
Article
PurposeThe aim of the present study was to carry out a detailed study of morphological features and to determine the phylogenetic position of Parabronema smithii (Cobbold, 1882) found in wild elephants in Sri Lanka.Methods Adult worms were collected from stomach ulcers at postmortem examination of wild elephants in the Udawalawe National Park, Sri...
Article
Full-text available
We report Armillifer moniliformis species infecting the endemic Sri Lankan brown palm civet (Paradoxurus montanus) from the Knuckles Range Forest Conservation Area, Sri Lanka. Larval stages of A. moniliformis were found during the postmortem of three civet cats found dead. Morphological studies were done by a light microscope and a scanning electro...
Article
Full-text available
Fascioloides jacksoni (syn. Fasciola jacksoni, Cobbold, 1869) (Platyhelminthes: Echinostomatoidea), is a liver fluke that causes severe morbidity and mortality of Asian elephants (Elephas maximus maximus). Understandings on molecular diagnosis, epidemiology, genetics and evolution of this flatworm are limited. In this study, we present the complete...
Article
Full-text available
The complete mitochondrial sequence of 17,030 bp was obtained from Echinostoma revolutum and characterized with those of previously reported members of the superfamily Echinostomatoidea, i.e. six echinostomatids, one echinochasmid, five fasciolids, one himasthlid, and two cyclocoelids. Relationship within suborders and between superfamilies, such a...
Article
Full-text available
Hydroxyapatite (HA) is a widely used biomaterial for coatings on prostheses which are used to repair, replace and restore the function of traumatised or diseased bone. In the present study, template-assisted electrohydrodynamic atomisation (TAEA) was used to pattern Ti surfaces (convex, concave and flat) with different HA nano particles in order to...
Article
Full-text available
Seaweed is an enormous resource comprised with natural bioactive compounds with several therapeutic effects including anticancer activity. In this context, the biochemical composition of seaweed plays a major role. Many biochemical compounds isolated from seaweed, fractions of seaweed and crude extracts has revealed ability of seaweed to fight agai...
Article
Full-text available
Fasciola jacksoni is a significant contributor to the health and mortality of Asian elephants, particularly those in Sri Lanka. Despite the impact of fascioliasis on elephant populations it is a neglected veterinary disease with limited taxonomic understanding. Molecular characterization and phylogenetic analysis of F. jacksoni was carried out to e...
Article
Full-text available
Coprological examination of gastrointestinal (GI) parasites and their life stages in humans and dogs and in soil was carried out in a low income tea estate community in the Central Province. This community has limited access to public health facilities and veterinary services and lives in close contact with free roaming dogs. Parasites in faeces we...
Article
Full-text available
Background: Seaweeds contain biologically active molecules which are important in the pharmaceutical industry. The present study was aimed to investigate the effects of aqueous extract of seaweeds: Sargassum illicifolium (S.i) on the stimulation of mouse fibroblast cell proliferation and migration. Materials and methods: Sargassum illicifolium-SW1...
Article
Full-text available
Background Dengue is a global problem mainly in the tropics. Meticulous clinical management of cases has reduced the death rate significantly, but large numbers of people still succumb to severe complications of the infection. Presence of myocarditis is often overlooked leading to a poor outcome. Clinical management guidelines of dengue do not stre...
Article
Full-text available
Spinose ear tick, Otobius megnini (Family Argasidae) is a one-host soft tick that parasitizes domesticated animals and occasionally humans. It causes otoacariasis or parasitic otitis in humans and animals and also known to carry infectious agents. Intra aural infestations of O. megnini is a serious health problem in the well-groomed race horses in...
Article
The aim of the present study was to characterizing the somatic antigens of adult-Spirocerca lupi against the serum of naturally infected dogs and hyperimmune serum raised in rabbit.
Article
Full-text available
Several countries residing envenomation due to Naja naja had revealed a disparity in the venom composition according to their geographic location and Sri Lankan cobra still lacks the evidence to support this. Therefore, the current study was focused on addressing relationship between the histopathological changes according to geographic variation o...
Conference Paper
Full-text available
Marine sponges are playing a vital role in drug discovery due to large number of bioactive compounds having medicinal properties. These compounds can be artificially synthesized and protect marine natural resources. Anticancer and cytotoxic activity of eleven selected Sri Lankan marine sponges were determined using MTT, 3-(4, 5-dimethylthiazol-2-yl...
Conference Paper
Infectious bronchitis virus (IBV) is one of the most important emerging viral diseases affecting poultry industry in Sri Lanka. The present study was aimed to detect the IBV in commercial layers, broilers and village chicken in two districts of Sri Lanka; Kurunegala and Jaffna. IBV suspected poultry farms were investigated between August 2016 to Ju...
Article
Full-text available
Aim The objective of this study was to describe and characterize the postmortem and histopathological findings of putative esophageal chondrosarcoma associated with Spirocerca lupi. Materials and Methods Spirocerca-associated esophageal nodules were collected from 54 dogs at postmortem examination and were stained with hematoxylin and eosin. Of th...
Article
Full-text available
Background: Over the last two decades intra-aural tick infestation (otoacariasis) has been a common occurrence in the hilly central region in Sri Lanka. Very occasional detection of isolated unilateral facial nerve palsy associated with otoacariasis attributed to toxin damage of the nerve prompted us to study the clinico-epidemiology and aetio-pat...
Article
Mesoporous hydroxyapatite (MPHA) particles have recently gained a great deal of interest in a broad range of fields including biomedical fields, wastewater treatment and catalysis. In this paper, we describe a novel and convenient route to synthesise MPHA particles using calcium carbonate nanoparticle templates for the formation of mesopores in HA....
Article
Full-text available
Parasites can influence the fitness of individuals particularly of small populations of endangered species. An island-wide, cross sectional, coprological survey was carried out from 03 January to 30 October 2015, to determine the gastrointestinal (GI) parasites of the Sri Lankan Elephant Elephas maximus maximus. Fresh fecal samples from wild, capti...
Article
There are 3 species of hump-nosed pit vipers in Sri Lanka: Hypnale hypnale, Hypnale zara, and Hypnale nepa. The latter 2 are endemic to the country. Microangiopathic hemolytic anemia (MAHA) is a known complication of hump-nosed pit viper bites. It was previously documented as a complication of general viper bites and not species specific. We report...
Poster
Full-text available
Parasites can influence the fitness of individuals particularly of small populations of endangered species. Only few studies have examined the gastrointestinal (GI) parasites of Asian and African elephants and there is no published literature available on the GI parasites of elephants in Sri Lanka. A cross sectional, coprological survey of the Sri...
Conference Paper
Full-text available
Shrimp farming in Sri Lanka has been identified as an economically important industry which earns about 70% of total aquaculture exports of the country. However, the occurrence of White spot syndrome virus (WSSV) has hampered the development of the shrimp industry in Sri Lanka. The Variable Number of Tandem Repeats (VNTRs) in three Open Reading Fra...
Article
Full-text available
Background This study revisits the clinico-epidemiology and serological patterns of rickettsioses in the central region of Sri Lanka and highlights the need of advanced diagnostics for precise identification of species responsible for rickettsioses. Methods The patients treated for rickettsioses between November 2009 and October 2011 were recruite...
Poster
Full-text available
Previous studies have proven that Seaweeds contain bioactive molecules with therapeutic values. However, seaweed properties in cutaneous wound healing have not explained yet. Therefore, a study was conducted to explore the potential wound healing properties of a seaweed (Sargassum ilicifolium) extracts using a an experimental rabbit model. In this...
Article
Full-text available
Hydroxyapatite (HA) nanoparticles are heavily used materials in biomedical applications. Therefore, identification of cheap and readily available raw-materials for the synthesis of HA nanoparticles is very important to fulfill the current demand. Herein, for the first time, we have developed a novel method to convert readily available, extensively...
Article
Full-text available
Toxocara pteropodis, an intestinal nematode, occurs in several captive and free-ranging pteropid bat species. We report infection in free-ranging Indian flying foxes (Pteropus medius) in Sri Lanka and contribute to our understanding of parasites in free-ranging P. medius .
Article
Full-text available
Sri Lanka is home to four species of wildcats: Leopard, Fishing Cat, Rusty-spotted Cat and Jungle Cat. All four, except the Jungle Cat, are listed threatened. A coprological survey was carried out in 2014 to determine the gastrointestinal (GI) parasites of wild and captive cats in Sri Lanka. Parasite eggs and cysts were isolated and morphologically...
Article
Full-text available
Horses are not native to Sri Lanka. They are imported from neighbouring countries to be used for police work, sporting or riding and esthetic purposes. An isolated population of about 500 feral horses lives in the Delft Island in northern Sri Lanka. These feral horses served hundred years for western conquests and when they left Sri Lanka, horses w...
Presentation
Full-text available
seaweeds have biological molecules which are important in pharmaceutical industry. But, in Sri Lanka the biomedical potentials of seaweeds have not yet received much attention. The present study was conducted to explore the potential wound healing properties and investigate the safety assessment. For this study seaweed samples were collected from t...
Conference Paper
Spinose ear tick, Otobius megnini is a one-host soft tick (Family Argasidae) that parasitizes domestic animals and occasionally humans. From its centre of origin SouthWestern North America, it has been distributed over a vast geographic region. In Sri Lanka, it has been reported from horses in Nuwara Eliya racecourses and their jockeys as an intra-...
Conference Paper
Full-text available
Spinose ear tick, Otobius megnini is a one-host soft tick (Family Argasidae) that parasitizes domestic animals and occasionally humans. From its centre of origin SouthWestern North America, it has been distributed over a vast geographic region. In Sri Lanka, it has been reported from horses in Nuwara Eliya racecourses and their jockeys as an intra-...
Conference Paper
Full-text available
Introduction: Hantaviruses are RNA viruses belonging to the family Bunyaviridae and genus of Hantaviruses; transmit to humans directly by rodents considered as the natural reservoir of the disease. Humans develop two important clinical syndromes: hemorrhagic fever with renal syndrome (HFRS) in Europe and Asia, and Hantavirus cardiopulmonary syndrom...
Conference Paper
Full-text available
Seaweeds have been shown to be the sources of biologically active natural compounds with pharmacological potentialities. But, in Sri Lanka the biomedical potentials of seaweeds have not yet received much attention. The present study was conducted to explore the potential wound healing properties of selected seaweeds using a mice model. For this stu...