Rozana Nazaryan

Protective function of oral fluid is evident in maintaining constant saliva volume, moisturizing mucous membranes of the oral cavity, teeth enamel, preventing the defeat of soft and hard tissues of the oral cavity by pathogenic microorganisms. A number of factors, called "barriers of colonization", specifically and nonspecifically manage the proces...

Abstract. Understanding the harmful effects of using tobacco products (cigarettes, electronic cigarettes (e-cigarette) or vape, IQOS, hookah, etc.) by various segments of the population is one of the important ways to improve the condition of the tissues of the oral cavity, since smoking is an important risk factor for the occurrence of chronic des...

Cherubism, as one of the forms of fibrous jaw dysplasia, is a congenital malformation of bone tissue and is hereditary. Although cherubism is better known as a problem of maxillofacial surgery and orthodontics, these patients need to consult an ophthalmologist. The aim of our study was to share with ophthalmologists the experience of diagnosis and...

The involvement of commensals and opportunistic pathogens and the role of protective mechanisms in the development of dental diseases in children with cystic fibrosis require more detailed study. Aim: The aim of the study was to determine the ecological characteristics of the oral microbiota and some antimicrobial factors of saliva in children wi...

Smoking is one of the most common bad habits which could realize in pathological process in different organs and systems. At the same time, smoking in childhood and adolescence especially contributes to the deterioration of somatic condition, increases the risk and causes the severity of respiratory diseases, which in the future affects the develop...

Objective. The tobacco usage is a risk factor of the variety oral diseases. To date, the effect of this risk factor on the composition of the oral microbial community has been considered by single studies with unclear pathogenic links. One of the possible factors that could be critical is a severe disturbance microbiota of oral cavity under influen...

Lesions of the oral mucosa may be a sign of systemic human diseases. Most of manifested in the oral cavity diseases are benign, but it is necessary to differentiate them from more serious diseases. Dentists should know the manifestations and recent advances in the diagnosis and treatment of oral diseases, among which are viral infections, especiall...

Background. There are many questions regarding the peculiarities of the course of odontogenic maxillary sinusitis, the likelihood of complications and the correct dosage of load during dental implantation. Purpose – to identify changes in minimal bone density in chronic odontogenic maxillary sinusitis and to compare it with chronic rhinogenic catar...

Background: An important aspect in the treatment of patients with intestinal yersiniosis is the administration of effective antibiotic therapy. Performed research aimed to determine the spectrum and level of antimicrobial activity of 2H-pyrano[2,3- c]pyridine derivatives on the museum and clinical strains of gram-negative microorganisms Yersinia en...

Background and aims Vascular endothelial growth factor (VEGF) is regarded as a potent stimulating factor for angiogenesis and vascular permeability and probably is connected with an inflammatory reaction. Our study aimed to determine the effect of VEGF in the inflammatory process in the oral mucosa of experimental animals in the modulation of atopi...

The clinical manifestations of herpes infection depend on the pathogenic properties of the pathogen and on the state of immunity of the infected organism. Herpesviruses type 1-3 are predominantly neurotropic and cause diseases of the nervous system. The reproduction of the virus is carried out in the neurons of the nerve ganglia and epithelial cell...

Background. The interrelation of disorders in periodontal tissues with metabolic changes caused, in particular, by a violation of microcirculation, observed namely in smoking but the fact that the effect of smoking on the condition of periodontal tissues at a young age has been studied less than other risk factors deserves special attention. The ai...

One of the urgent problems of modern medicine is the high incidence of herpesvirus infections. The high prevalence of herpesviruses in the human population of the world allow us to consider herpes a common systemic disease of the whole organism. Doctors of any specialty are faced with the clinical manifestations of herpes infection in patients, and...

It is known that every day 2,500 children under the age of 18 try their first cigarette, and more than 400 of them become new, regular smokers, and half of them will die from this addiction in the future. Aim: The aim of the study is to determine changes in the indices of dental status in adolescents with tobacco smoking. Materials and methods:...

Aim: The aim of the study was to identify the consequences of the use of fixed otrhodontic appliances (FOAs) on the morphological state of the tissues of the lower wall of the maxillary sinus, depending on the duration of their use. Materials and methods: The study involved 115 male and female patients aged 18 to 25 years. All patients were divi...

Plenty variants of the teeth endodontic structure requires a thorough study of the root canal anatomy and morphology peculiarities, which will make it possible to estimate the volume and complexity of future endodontic intervention, make a prediction of the treatment result, and forecast possible complications. For an objective assessment of the to...

Early diagnosis of dental caries in children is difficult. This fact is applied to children with Down syndrome. In order to identify predictors of dental diseases, a crystallographic method is widely used for studying oral fluid. The aim of the work is to evaluate the mineralizing potential of oral fluid in children with Down syndrome before and a...

Cystic fibrosis (CF) promotes the development of gingivitis in children. The high prevalence and early manifestation of gingivitis is due to a combination of many factors. The pathogenic mechanisms of cystic fibrosis lead to disruption of normal physiological processes in the oral cavity, in particular, to a decrease in the level of salivation, to...

Investigation of the properties of the oral liquid and polymorphism of the MUC5B gene in children with cystic fibrosis Nazaryan R., Tkachenko M.,Volkova N. The article presents the study of biophysical and biochemical properties of saliva and polymorphism of the MUC5B protein gene in children with cystic fibrosis. It has been determined that the de...

The aim of the work was to establish the relationship between the genotype of the cystic fibrosis transmembrane conductance regulator (CFTR), the level of local immune reactivity and the degree of chronic gingivitis in children with cystic fibrosis. The study has shown significant differences in the local immunity indices of the oral mucosa and the...

Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease characterized by synovial hyperplasia and the destruction of cartilage and bone with unclear morphogenesis of pathological changes in oral cavity. Simultaneously microcirculatory disturbance is important link of pathogenesis in many pathological conditions in oral cavity with in...

The most important disorders during menopause related to hormonal disbalance: increased levels of gonadotropic hormones of the pituitary gland and a decreased level of estrogens, that affects on target organs, such as bone tissue. The aim of our work was to determine effects of body weight index on the bone density of the maxillary sinus’s walls i...

Medical specialists face a number of difficulties with processing of data obtained during spiral computed tomography (SCT). One of them is the objective selection of points for calculating the morphological characteristics of bone tissue.The goal of our study was to optimize interpretation of the data of radiological methods used for assessment of...

Spiral computed tomography (SCT) is the most accessible and informative imaging method. Medical specialists face a number of difficulties with searching of CT-images. The goal of our study was to optimize interpretation of the data of radiological methods used for assessment of the paranasal sinuses (PNSs) with estimation of measurement uncertainty...

Objective. Determining the anatomical variability of the upper maxillary sinus and ostiomeatal complex components as well as on the basis of the obtained data the selection of the optimal access to the zones of the maxillary sinus to choose sinusitis treatment method, which allows minimizing intra- and postoperative complications. Methods. The resu...

Study is devoted for rs1801270 polymorphism of CDKN1A gene due to the level of intensity of caries development in children with Down syndrome. The full development of oral cavity organs is ensured through a complex of genes whose protein products control different stages of this difficult process. Changes in gene structure, as well as disturbance o...

Protective function of oral fluid is evident in maintaining constant saliva volume, moisturizing mucous membranes of the oral cavity, teeth enamel, preventing the defeat of soft and hard tissues of the oral cavity by pathogenic microorganisms. A number of factors, called "barriers of colonization", specifically and nonspecifically manage the proces...

Background and aims: Prevalence of atopic diseases is progressively increasing in children with unclear clinical picture in oral cavity. This study aimed to find correlation between the total antioxidant and periodontal status in the saliva of periodontally compromised with atopy. Materials and methods: The groups consisted of patients of atopic...

Nazaryan R, Kryvenko L, Gargin V. The role of nitric oxide synthase in the modulation of the immune response in atopic disease. The New Armenian Medical Journal. 2017 Vol.11;No 2, p. 52-57

Chronic recurrent aphthous stomatitis (CRAS) belongs to the group of chronic, inflammatory, ulcerative diseases of the oral mucosa. The aim of this study was to determine the effects of ozone on the morphofunctional peculiarities of the soft tissues in modeling chronic recurrent aphthous stomatitis. We performed experimental investigation for study...

Background. Today there is a necessity for significant clinical and experimental studies considering the pathogenesis of atopic diseases development in view of their increasing frequency, including children. Objective. The aim of this study was to identify the activity of endothelial and inducible nitric oxide synthase (eNOs and iNOs) in soft tissu...

We investigated periodontium of newborn rats with experimental model of IUGR. Light microscopy showed that microcirculatory response was characterized by a pronounced decrease in vascular density (20,9±18,2 %); presence both contractility and dilatation of the capillary bed. Endotheliocytes of microcirculatory bed are flattened; there are signs of...