Roza Szweda

Roza Szweda
University of Strasbourg | UNISTRA · Institute of Science and Supramolecular Engineering (ISIS)

Doctor of Philosophy

About

26
Publications
3,804
Reads
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522
Citations
Citations since 2017
13 Research Items
408 Citations
20172018201920202021202220230204060
20172018201920202021202220230204060
20172018201920202021202220230204060
20172018201920202021202220230204060
Additional affiliations
September 2009 - present
Polish Academy of Sciences
Position
  • Researcher
September 2009 - present
Centrum Materiałów Polimerowych i Węglowych PAN
Position
  • PostDoc Position

Publications

Publications (26)
Article
With the rapid development of information technology, many aspects of our lives are undergoing a digital transformation. An increasing number of users are going online every year, and constantly improving artificial intelligence is gaining popularity, which leads to the growing production of information. Nowadays, information is usually stored in d...
Article
High-yielding and scalable methods for iterative synthesis of sequence-defined macromolecules are a great challenge in modern polymer chemistry. Sequence-defined macromolecules are fabricated by multi-step iterative processes that involve high reagent and solvent consumption. Moreover, every consecutive step causes yield losses that result in low o...
Chapter
The design of synthetic polymers with controlled monomer sequences is an important emerging trend in polymer science. This new field of research is bio‐inspired by sequence‐defined biopolymers such as proteins and nucleic acids. The chemical synthesis of nonnatural sequence‐controlled polymers (SCPs) has been described in several reviews. However,...
Article
Full-text available
Macromolecules with well-defined structures in terms of molar mass and monomer sequence became interesting building blocks for modern materials. The precision of the macromolecular structure makes fine-tuning of the properties of resulting materials possible. Conjugated macromolecules exhibit excellent optoelectronic properties that make them excep...
Preprint
Macromolecules with well-defined structures in terms of molar mass and monomer sequence became interesting building blocks for modern materials. The precision of the macromolecular structure makes fine-tuning of the properties of resulting materials possible. Conjugated macromolecules exhibit excellent optoelectronic properties that make them excep...
Article
Full-text available
Light-induced alteration of macromolecular information plays a central role in biology and is known to influence health, aging and Darwinian evolution. Here, we report that light can also trigger sequence variations in abiotic information-containing polymers. Sequence-coded poly(phosphodiester)s were synthesized using four phosphoramidite monomers...
Article
A library of 16 digitally‐encoded polyanions was used in a layer‐by‐layer (LbL) polyelectrolyte assembly to nanofabricate thin‐films containing digitally‐coded strata. The polyanions were digital polyphosphodiesters (d‐PPDE) prepared via an automated phosphoramidite process. Each component of the library contained 10 bytes of ASCII‐encoded text (i....
Article
A library of 16 digitally‐encoded polyanions was used in a layer‐by‐layer (LbL) polyelectrolyte assembly to nanofabricate thin‐films containing digitally‐coded strata. The polyanions were digital polyphosphodiesters (d‐PPDE) prepared via an automated phosphoramidite process. Each component of the library contained 10 bytes of ASCII‐encoded text (i....
Article
Aggregation of thermoresponsive chains to form mesoglobules is a promising way to make nanoaggregates useful as drug carriers. Here, we present for the first time, a route for the formulation of mesoglobules that may be used as polymer carriers for doxorubicin (DOX). For this purpose, a thermoresponsive terpolymer composed of diethylene glycol meth...
Article
Kissorphin (KSO) is a new peptide derived from kisspeptin-10. This peptide possesses neuropeptide FF (NPFF)-like biological activity in vitro; NPFF, in many cases, inhibits opioid and ethanol effects in rodents. Therefore, the current study explored the influence of KSO on acute ethanol- and morphine-induced hyperactivity, and on the development an...
Article
Due to their strong tendency to self-aggregate, unfunctionalized oligoarylacetylenes are difficult to synthesize. Here, tailored polystyrene soluble supports, prepared by atom transfer radical polymerization and post-polymerization modification, were tested for preparing sequence-defined oligoarylacetylenes. Controlled aromatic sequences were obtai...
Article
Polymer-peptide/protein conjugates immobilized on surface have gained considerable attention, mostly due to their broad scope of applications in biomedical fields. To optimize their properties, the combined knowledge of polymer chemistry and biochemistry has to be applied. The main methods to obtain such surfaces involve “grafting to” or “grafting...
Article
Full-text available
Growing interest for polymers containing oligoethylene side groups was observed within last years. Amongst these polymers the poly[oligo(ethylene glycol) methacrylate]s (POEGMAs) became most important. These polymers are biocompatible. Many of these polymers are thermoresponsive, when dissolved in water or physiological media, exhibit a narrow phas...
Article
This review is focused on recent achievements in the covalent attachment of biological entities, such as oligopeptides, proteins and enzymes, to thermoresponsive synthetic polymers and the influence of conjugation on the properties of macromolecules. Bioconjugation, including polymers, has been intensively studied in the last years. Initially polym...
Article
In order to improve their MS/MS sequencing, structure of sequence-controlled synthetic polymers can be optimized based on considerations regarding their fragmentation behavior in collision-induced dissociation conditions, as demonstrated here for two digitally encoded polymer families. In poly(triazole amide)s, the main dissociation route proceeded...
Article
This review is focused on recent achievements in the covalent attachment of biological entities, such as oligopeptides, proteins and enzymes, to thermoresponsive synthetic polymers and the influence of conjugation on the properties of macromolecules. Bioconjugation, including polymers, has been intensively studied in the last years. Initially polym...
Article
This study describes a novel approach to polymeric nanocarriers of the therapeutic peptide met-enkephalin based on the aggregation of thermoresponsive polymers. Thermoresponsive bioconjugate poly((di(ethylene glycol) monomethyl ether methacrylate)-ran-(oligo(ethylene glycol) monomethyl ether methacrylate) is synthesized by AGET ATRP using modified...
Article
This report demonstrates the feasibility of radiation grafting for the preparation of polymer layers functionalised with short peptide ligands which promote cell adhesion. Thermoresponsive poly [tri(ethylene glycol) monoethyl ether methacrylate] (PTEGMA) layers were synthesised on a polypropylene substrate by post-irradiation grafting. A cell adhes...
Article
Full-text available
This study describes a novel approach to the preparation of crosslinked polymeric nanoparticles of controlled sizes that can be degraded under basic conditions. For this purpose thermoresponsive copolymers containing azide and alkyne functions were obtained by ATRP of di(ethylene glycol) monomethyl ether methacrylate (D) and 2-aminoethyl methacryla...
Article
Full-text available
Peptide and protein arrays have gained increasing attention due to their potential application in many areas of research, clinical diagnosis, and pharmacy. Atypical array consists of a support containing immobilized peptides or proteins positioned in an addressable format. The greatest advantage of the arrays is the possibility for miniaturization,...
Article
Poly(ethylene glycol)s (PEGs) with different lengths were used as linkers during preparation of peptide surfaces for protease detection. In the first approach the PEG monolayers were prepared using a "grafting to" method on 3-aminopropyltrietoxysilane (APTES)-modified silicon wafers. Protected peptides with fluorescent marker were synthesized by Fm...
Article
The progress in synthetic polymer chemistry has allowed the precise design of hybrid and multifunctional colloidal particles, which differ in type, size and shape, thus enhancing their possible applications as target-oriented carriers of low and high molar mass active species. This survey discusses the basic principles and factors, associated with...
Article
Full-text available
Peptide surfaces were obtained by the covalent immobilisation of fluorescently labelled pentapeptides carboxyfluorescein–glycine–arginine–methionine–leucine–glycine, either directly or through a poly(ethylene glycol) (PEG) linker on modified silicon wafers. Each step during the preparation of the peptide surfaces was confirmed by several surface ch...
Article
This paper describes the synthesis of enzymatically cleavable hybrid biomaterial – poly(N-isopropylacrylamide)-pentapeptide conjugate through atom transfer radical polymerization of N-isopropylacrylamide from a resin-loaded peptide macroinitiator. A pentapeptide labeled with a dansyl group (Gly-Arg-Lys-Phe-Gly-dansyl) was synthesized using solid-ph...
Article
This study describes the synthesis and aggregation behavior of thermosensitive poly(di(ethylene glycol) monomethyl ether methacrylate) (P(DEGMA-ME)) conjugated with the fluorescently labeled pentapeptide glycine-arginine-lysine-phenylalanine-glycine-dansyl (GRKFG-Dns). The GRKFG-Dns was obtained using Fmoc solid-phase peptide synthesis and was modi...
Article
The photodegradation of polyglycidol in aqueous solution with UV wavelength of 254 nm was investigated. The experiments were carried out in air at a constant temperature and the photodegradation of polyglycidol (PGl) was compared to that of poly(ethylene oxide) (PEO), the most widely studied polyether. Size exclusion chromatography with multiangle...

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Project
The long-term scientific goal of CReaNet is to develop biocompatible Chemical Reaction Networks for signal amplification and novel (bio)materials. See our website http://h2020crea.net!