Roxana Uri Miranda

• PhD in Biotechnology
• Metropolitan Autonomous University

Aim: Fructose is a highly lipogenic compound related to the onset of steatosis, its progression to steatohepatitis, and the eventual initiation of hepatocellular carcinoma (HCC). One of the cancer hallmarks is the metabolic adaptation to the environmental sources; however, this characteristic could be exploited to manipulate the HCC tumor’s respons...

The development of an HIV-1 cure remains a huge scientific challenge due to its high genetic/antigenic variability that favors the evasion of the host’s immune system and formation of the viral reservoir. We developed a molecular model to detect exclusively HIV-1 infected cells by regulating the expression of an epitope of rabies virus glycoprotein...

Lovastatin has great medical and economic importance, and its production in Aspergillus terreus is positively regulated at transcriptional level, by reactive oxygen species (ROS) generated during idiophase. To investigate the role of the transcription factor Yap1 in the regulation of lovastatin biosynthesis by ROS, an orthologue of yap1 was identif...

The growth differentiation factor 11 (GDF11), a member of the superfamily of the transforming growth factor β, has gained relevance in the last few years due to its remarkable effects in cellular biology, particularly in the nervous system, skeletal muscle, the heart, and many epithelial tissues. Some controversies have been raised about this growt...

Background and aim: Hepatocellular carcinoma (HCC) is the fourth cause of cancer-related death and its incidence has been increasing in both men and women. One of the main concerns has been the consumption of hypercaloric diets mainly rich in carbohydrates such as fructose. High fructose diet is related to the development of Non-Alcoholic Fatty Liv...

Cholestasis is a clinical syndrome common to a large number of hepatopathies, in which either bile production or its transit through the biliary tract is impaired due to functional or obstructive causes; the consequent intracellular retention of toxic biliary constituents generates parenchyma damage, largely via oxidative stress-mediated mechanisms...

Growth Differentiation Factor 11 (GDF11), a member of the super family of the Transforming Growth Factor β, has gained more attention in the last few years due to numerous reports regarding its functions in other systems, which are different to those related to differentiation and embryonic development, such as age-related muscle dysfunction, skin...

Tuberculosis (TB) is one of the deadliest infectious diseases in humankind history. Although, drug sensible TB is slowly decreasing, at the present the raise of TB cases produced by multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains are a big challenge. Thus, looking for new therapeutic options against these MDR strains is manda...

Metabolic factors are the major risk of non-alcoholic fatty liver disease, although other factors may contribute steatosis. Cadmium exposure produces histopathological and molecular changes in liver, which are consistent with steatosis. In the present study, we describe the effect of low cadmium acute treatment on hepatocytes obtained from mice fed...

Little is known of how the stress response varies when animals confront seasonal life-history processes. Antioxidant defenses and damage caused by oxidative stress and their link with immunocompetence are powerful biomarkers to assess animal´s physiological stress response. The aim of this study was A) to determine redox state and variation in basa...

Nowadays, reactive oxygen species-mediated cellular signaling is a growing field. The evidence of the requirement of these species in cellular processes such as proliferation, differentiation, apoptosis and even, survival, is leaving clear that reactive oxygen species are not just noxious entities, not anymore. As it happens in many biological syst...

Abstract Osteoarthritis (OA) is a degenerative disorder that is characterized by articular cartilage breakdown , osteophytes formation, and subchondral bone sclerosis; its development and progression are mediated by proinflammatory mediators, as well as by reactive oxidative species (ROS). Recently there has been identified a mitochondrial protein...

The increment in the prevalence of obesity incidence in Mexico is leading to the increase in many chronic maladies, including liver diseases. It is well known that lipid-induced liver sensitization is related to the kind of lipid rather than the amount of them in the organ. Cholesterol overload in the liver aggravates the toxic effects of canonical...

Alcohol is undoubtedly, the main toxic agent that people consume by recreation and the abuse is associated with liver damage, mainly by the overproduction of reactive oxygen species and the toxic effects of its first metabolite acetaldehyde. It is known that acetaldehyde targets mitochondria inducing redox imbalance and oxidative stress. Mitochondr...