Roshni Sivasevan

• DNB
• Professor (Full) at Regional Cancer Centre

Aim and Objectives: is study was done to assess the outcomes in Periampullary Carcinoma patients who received Adju-vant Chemoradiation a er surgical resection. e primary objectives were to assess the overall survival and disease free survival. e secondary objectives were to assess the patterns of relapse and also to evaluate the prognostic factors...

Longitudinal time-to-event analysis is a statistical method to analyze data where covariates are measured repeatedly. In survival studies, the risk for an event is estimated using Cox-proportional hazard model or extended Cox-model for exogenous time-dependent covariates. However, these models are inappropriate for endogenous time-dependent covaria...

Introduction Small cell lung cancer (SCLC) represents about 15% of all lung cancers. Extensive stage (ES) SCLC represents around 60% of diagnosed SCLC cancers. The median survival in untreated ES SCLC is 2 to 4 months and that of treated cases is 8 to 13 months. Aim and Objectives This retrospective analysis aims to find out the clinical outcome of...

Background Radical chemoradiation is the standard of treatment for locally advanced squamous cell carcinoma of esophagus and for patients with operable disease, but who are medically unfit or unwilling for surgery. As the esophagus is a central organ, the planning target volume (PTV) is central, lies close to the spinal cord and heart, and is surro...

Ductal adenocarcinoma of the pancreas is one of the commonly diagnosed cancers and is a leading cause of cancer mortality in the population. The prognosis of patients even after undergoing a complete resection is generally poor, with a median survival of 13–20 months and a 3-year survival of 30%. Therefore, adjuvant therapies including adjuvant che...

Purpose: This retrospective analysis is aimed to report the single institution experience from an Asian country utilizing Intensity Modulated Radiotherapy (IMRT) based Chemo radiation in Anal Canal Squamous Cell Carcinoma (ASCC) with an emphasis on efcacy, toxicity and disease and treatment-related variables associated with outcomes. Study was con...

Atypical features of Posterior reversible encephalopathy syndrome (PRES) (diffusion restriction, involvement of corpus callosum & white matter tracts along posterior limbs of internal capsule) were seen in a patient after oxaliplatin administration (FOLFOX- 4 regimen). Findings were most obvious on diffusion weighted images, similar to acute methot...

Purpose: Lower socioeconomic status is associated with inferior cancer survival in high-income countries, but whether this applies to low- and middle-income countries is not well described. Here, we use a population-based cancer registry to explore the association between educational level and stage of cancer at diagnosis in South India. Methods:...

A case report about a rare tumor. Intraabdominal desmoplastic small round cell tumor

Isolated skeletal muscle metastasis in a case of adenocarcinoma lung

Malignant germ cell tumour (GCT) in the mediastinum is a rare entity in routine clinical practice. Aim of the study was to assess long-term survival of primary mediastinal GCTs and the factors influencing the outcome of patients treated at Regional Cancer Centre (RCC), Trivandrum. Materials and methods :Patients registered at RCC, Trivandrum, durin...

The study aims to assess pathologic complete response (pCR) and clinical significance in patients treated with pre-operative chemo-radiotherapy for locally advanced rectal carcinoma in the Regional Cancer Centre, Trivandrum, during 2008-2012 (n= 114), followed-up till 2014. Pre-operative radiation was given using external beam radiation (50.4Gy in...

The thought of subjecting an elderly patient with rectal cancer to protocol-based neoadjuvant chemoradiation (NACTRT), surgery and adjuvant chemotherapy is sought with fear due to their multiple comorbidities and impaired functional status associated with the process of ageing. Hence, many a times the treatment is compromised and it is a fact that...

'Primary adenoid cystic carcinoma of lung: a case report

Background: The European Society for Medical Oncology (ESMO) recently released a magnitude of clinical benefit scale (ESMO-MCBS) for systemic therapies for solid cancers. Here, we evaluate contemporary randomized controlled trials (RCTs) against the proposed ESMO thresholds for meaningful clinical benefit. Methods: RCTs evaluating systemic thera...

Background To compare the dosimetric outcomes of volumetric arc radiotherapy (RapidArc), intensity-modulated radiotherapy (IMRT), and 3D conformal radiotherapy (3DCRT) plans for primary liver tumours. Methods 7 patients with localised unresectable hepatocellular carcinoma were included in this study. CT simulation was done with voluntary deep insp...

Carcinoma rectum often presents as painless bleeding per rectum, altered bowel habits, abdominal discomfort, and rarely as intestinal obstruction or bowel perforation. Here is a case of a patient with long standing fistula in ano who presented to Regional Cancer Centre, Thiruvananthapuram with a gluteal mass and was later diagnosed to be adeno carc...

Metastasis of gastric adenocarcinoma to the prostate gland is extremely rare. Herein, we report a case of gastric adenocarcinoma in a 56-year-old man with prostatic metastasis diagnosed through the analysis of biopsy specimens from representative lesions in the stomach and prostate gland. Immunohistochemistry of the prostatic tissue showed positive...