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April 1990 - present
Publications
Publications (149)
Resumo: O Sistema Nacional de Gerenciamento de Produtos Controlados (SNGPC) armazena dados de dispensação de medicamentos industrializados, manipulados e insumos farmacêuticos sob controle especial e antimicrobianos, a partir dos registros de farmácias e drogarias privadas. Este trabalho explorou a qualidade dos dados inseridos no SNGPC, a partir d...
Many studies investigating right to health litigation involving medicines mention “high-cost medicines”. However, detailed data on the characteristics of legal claims for these drugs and their share in terms of volume and spending in right to health litigation involving medicines is scarce. This paper presents a protocol for a scoping review that s...
O objetivo do presente estudo foi avaliar a judicialização de procedimentos cirúrgicos ortopédicos no âmbito do sistema de saúde brasileiro, a partir das demandas apostas ao Instituto Nacional de Traumatologia e Ortopedia (INTO), entre janeiro/2014 e dezembro/2017. Trata-se de estudo de abordagem exploratória, descritiva e retrospectiva, de naturez...
Accelerated population aging has led to a progressive increase in dementia, particularly Alzheimer’s Disease (AD). The study’s objective was to perform a cost-utility analysis on the use of memantine in the severe stage of AD in Brazil compared to no specific pharmacological treatment from the perspective of the Brazilian Unified Health System (SUS...
Issue and problem
In Brazil, 47% of people are insufficiently physically active (Guthold et al, 2018). According to the Global Physical Activity Observatory, 13.2% of deaths in Brazil are caused by inactivity. Besides, Ding et al (2016) estimated the direct health cost attributable to physical inactivity in this country at 1.6 billion US dollars. R...
Background
Yellow fever is an arbovirus with variable severity, including severe forms with high mortality. The vaccination is the most effective measure to protect against the disease. Nonserious and serious adverse events have been described in immunocompromised individuals, but previous studies have failed to demonstrate this association. This s...
Objective:
To elaborate a Theoretical Model of Sexual and Reproductive Health care offered in Primary Health Care.
Method:
Documentary research, with a qualitative approach. Government documents and evaluative studies constituted the data sources, collected between August 2018 and June 2019, and analyzed based on the health evaluation literature...
Objective
To elaborate a Theoretical Model of Sexual and Reproductive Health care offered in Primary Health Care.
Method
Documentary research, with a qualitative approach. Government documents and evaluative studies constituted the data sources, collected between August 2018 and June 2019, and analyzed based on the health evaluation literature.
R...
We conducted a systematic review and a meta-analysis to assess the risk of serious adverse events in the elderly after yellow fever vaccination compared to the non-elderly population. We searched multiple databases and grey literature, and we selected research without language and publication date restrictions. Studies were analyzed in a descriptiv...
We conducted a systematic review and meta-analysis to assess the risk of serious adverse events in the elderly after yellow fever vaccination compared to the non-elderly population. We searched multiple databases and grey literature and selected research without language and publication date restriction. Studies were analysed in a descriptive way,...
The health crisis triggered by the COVID-19 pandemic has challenged public management in several countries to ensure the timely and efficient procurement of the various health technologies necessary to cope with it, such as medicines, diagnostic tests, personal protective equipment (PPE) and medical materials/equipment, among others. This article i...
ABSTRACT Objective: To elaborate a Theoretical Model of Sexual and Reproductive Health care offered in Primary Health Care. Method: Documentary research, with a qualitative approach. Government documents and evaluative studies constituted the data sources, collected between August 2018 and June 2019, and analyzed based on the health evaluation lite...
Background
Nanocrystalline silver dressings can reduce the number of changes, facilitating burn wound management. However, the evidence regarding their efficacy and cost-consequences compared to well-established treatments, such as 1% silver sulfadiazine, is still scarce.
Objective
To determine the efficacy, safety, and costs of nanocrystalline si...
Telehealth has the potential to solve several problems in health care and management, increasing the quality, accessibility, utilization, effectiveness and efficiency of services and reducing costs. This article presents a scoping review protocol that aims to characterize the conceptual models and frameworks related to the implementation and evalua...
Background
This study examines the dynamics of the eculizumab patenting, orphan designation, and marketing authorization process in different countries and regulatory systems and analyzes drug revenues since its first marketing authorization.
Methods
A retrospective case study was conducted. Multiple information sources were used to: determine the...
Since the first recorded case of COVID-19 on February 26, 2020, Brazil has seen an exponential growth in the number of cases and deaths. The national testing approach has been insufficient to correctly use this tool in the support of containing the epidemic in the country. In this communication, we discuss efforts and challenges to scale-up COVID-1...
Objetivo: Identificar as iniciativas de teleducação e informações em saúde direcionadas ao enfrentamento da pandemia da COVID-19 oferecidas pelos Núcleos Estaduais de Telessaúde vinculados ao Programa Telessaúde Brasil Redes. Método: Estudo exploratório, transversal, de abordagem quali-quantitativa, na forma de casos múltiplos, usando informações d...
RESUMO A Avaliação de Tecnologias em Saúde (ATS) respalda políticas públicas na gestão de tecnologias em diversos países. No Brasil, a institucionalização da ATS se iniciou em 2000, no Ministério da Saúde, e contou com a participação da Agência Nacional de Saúde Suplementar (ANS). Contudo, o sistema público e a saúde suplementar trilharam diferente...
RESUMO A Avaliação de Tecnologias em Saúde (ATS) respalda políticas públicas na gestão de tecnologias em diversos países. No Brasil, a institucionalização da ATS se iniciou em 2000, no Ministério da Saúde, e contou com a participação da Agência Nacional de Saúde Suplementar (ANS). Contudo, o sistema público e a saúde suplementar trilharam diferente...
This study characterized the evolution of Brazilian public telemedicine policy in the Brazilian Unified Health System for 30 years from 1988 to 2019 by analyzing its legal framework. We identified 79 telemedicine-related legislations from the federal government (laws, decrees, and ordinances) and 31 regulations of federal councils of health profess...
Background:
The treatment of choice for advanced non-small cell lung cancer is selected according to the presence of specific alterations. Patients should undergo molecular testing for relevant modifications and the mutational status of EGFR and translocation of ALK and ROS1 are commonly tested to offer the best intervention. In addition, the test...
Objectives:
Severe consequences of mother-to-child transmission of syphilis and high increasing incidence of congenital syphilis remains an important public health problem in Brazil. Our objective was to assess the cost-effectiveness of a rapid point-of-care test (RT) and treatment of positive mothers immediately compared with a laboratory-based st...
COVID-19 has created enormous challenges for health systems worldwide, with the rapidly growing number of deaths and critical patients with pneumonia requiring ventilatory support. Alternative methods to control the spread of the disease such as social isolation, extreme quarantine measures, and contact tracing have been used around the world. Howe...
Background:
In 2018, there were 70.8 million refugees, asylum seekers and persons displaced by wars and conflicts worldwide. Many of these individuals face a high risk for tuberculosis in their country of origin, which may be accentuated by adverse conditions endured during their journey. We summarised the prevalence of active and latent tuberculo...
RESUMO A COVID-19 tem representado um desa o global aos sistemas de saúde, expandindo em velocidade crescente de óbitos, de pacientes críticos com pneumonia e necessidade de suporte respiratório. Métodos alternativos para controlar a propagação da doença, como o isolamento social, medidas extremas de quarentena e o rastreio dos contactantes dos cas...
Introdução: O enfrentamento da pandemia COVID-19 desafia o Brasil sobre as medidas a tomar com a crise sanitária instalada e quais intervenções são mais eficientes e efetivas frente aos problemas decorrentes da nova doença. Esse quadro de incertezas tem levado a ações de financiamento de pesquisa em saúde, que visam o aprimoramento científico e tec...
Background: In 2018, there were 70.8 million refugees, asylum seekers and persons displaced by wars and conflicts worldwide. Many of these individuals face a high risk for tuberculosis in their country of origin, which may be accentuated by adverse conditions endured during their journey.
Objective: We summarised the prevalence of active and latent...
OBJECTIVES: This study examined the purchases of eculizumab, a high-cost monoclonal antibody used in the treatment of rare diseases by Brazilian federal agencies, in terms of purchased quantities, expenditures, and prices. METHODS: Eculizumab purchases made between March 2007 and December 2018 were analyzed, using secondary data extracted from the...
This study evaluated purchases of the eculizumab made by Brazilian federal government agencies from January / 2007 to December / 2018, in terms of the quantities purchased, expenses and prices.
Eculizumab is a monoclonal antibody used to treat complications in two rare diseases, Paroxysmal Night Hemoglobinuria and Atypical Hemolytic Uremic Syndrome...
Objective: To characterize researches that evaluate actions implemented with a focus on sexual and reproductive health; to describe factors that favor or hinder its application in Primary Health Care. Method: Scope review performed from the databases LILACS, MEDLINE, SCOPUS, Web of Science, CINAHL and POPLINE, and in the Brazilian Electronic Theses...
Objective: To synthesize the available evidence and state of the art of economic evaluations which evaluate the use of memantine, whether alone or combined with donepezil, for moderate to severe Alzheimer’s disease (AD), focusing on the analytical decision models built. Method: The electronic databases MEDLINE, EMBASE, NHS EED, CEA Registry and LIL...
Objectives
The goal of this study was to perform a cost-effectiveness analysis from the public health system perspective, comparing five strategies for Latent Tuberculosis Infection (LTBI) diagnosis in primary health care workers in Brazil.
Design
Analytical model for decision making, characterized by cost-effectiveness analysis.
Setting
Primary...
Background: In 2018, there were 70.8 million refugees, asylum seekers and persons displaced by wars and conflicts worldwide. Many of these individuals face a high risk for tuberculosis in their country of origin, which may be accentuated by adverse conditions endured during their journey. We summarised the prevalence of active and latent tuberculos...
Background: In 2017, there were 68.5 million refugees, asylum seekers and persons displaced by wars and conflicts worldwide. Tuberculosis prevalence in the country of origin and adverse conditions endured during their journey may increase their risk for tuberculosis.
Objective: We summarized the prevalence of active and latent tuberculosis infectio...
Objective: To synthesize the available evidence and state of the art of economic evaluations
which evaluate the use of memantine, whether alone or combined with donepezil, for
moderate to severe Alzheimer’s disease (AD), focusing on elaborate analytical decision
models. Method: The electronic databases MEDLINE, EMBASE, NHS EED, CEA
Registry and LIL...
markets, suggesting there is variability in the decision-drivers or local comparators used by different agencies. Pairwise comparison of markets suggests that categories aligned most frequently between Brazil and Germany (55%), followed by Brazil and France (45%) and France and Germany (41%). Potential differences in decision-drivers were also iden...
Intimate partner violence (IPV) is a worldwide public health problem. Many proposals aiming to eliminate its occurrence include the empowerment of women through their socio-economic development. In this context, some studies suggested that microcredit programs (MP) and cash transfer programs (CTP) are initiatives that can also reduce the risk of IP...
Introdução: O mesotelioma pleural maligno é um câncer raro, agressivo e que apresenta expectativa de aumento na incidência até 2030. As melhores formas de tratar essa neoplasia continuam em debate. Objetivo: Sintetizar as evidências de eficácia e segurança dos esquemas quimioterápicos de primeira linha disponíveis para o tratamento do mesotelioma p...
The objective of this study was to know the profile of the users of Primary Health Care who seek for Reproductive Planning and to evaluate their perceptions about the educational activities offered at this health care level. This is a descriptive study with a qualitative approach, performed in four Primary Health Care Units, located in the city of...
Resumo: Em abril de 2019, foi assinada a portaria de incorporação do medicamento nusinersena no Sistema Único de Saúde (SUS). É o medicamento mais caro já incorporado ao SUS, para uso no tratamento de atrofia muscular espinhal 5q tipo I. A incorporação é referida como um marco na tomada de decisão sobre novas tecnologias no SUS, a ser viabilizada p...
The aim of this study is to synthesize the evidence, through a systematic review, on efficacy and safety of the percutaneously implanted structural cardiac device called PARACHUTE® (PercutAneous Ventricular RestorAtion in Chronic Heart FailUre due to Ischemic HearT DiseasE) in patients with chronic heart failure (HCF).
RESUMO
Introdução: O registro sanitário de medicamentos é instrumento essencial na avaliação da qualidade, segurança e eficácia. O marco regulatório vigente veda a incorporação de novas tecnologias sem registro no Sistema Único de Saúde (SUS), cabendo à Comissão Nacional de Incorporação de Tecnologias (Conitec) assessorar o Ministério da Saúde ness...
Resumo Recentemente, inúmeras campanhas nacionais promovidas por hospitais, sociedades médicas e outras organizações têm estimulado o rastreamento do câncer de próstata, em consonância com iniciativas mundiais conhecidas como Novembro Azul. Essas campanhas aconselham a utilização do toque retal acompanhado da dosagem sérica do antígeno prostático e...
In 2004, the federal government has announced a new mechanism to improve the access of the Brazilian population to medicines, called “Programa Farmácia Popular do Brasil". The model named “Aqui Tem Farmácia Popular" (ATFP), started in 2006 with the participation of the private retail pharmacies, has been the main responsible for the expansion of th...
Segundo a última Conta-Satélite de Saúde, as despesas com o consumo final de bens e serviços de saúde em 2015 corresponderam a 9,1%% do Produto Interno Bruto nacional (R$ 546 bilhões). Desse total, o consumo de serviços respondeu por 79,2% e o de medicamentos a 19,0%, mas houve queda da participação destes últimos entre 2010 (22,4%) e 2015 (IBGE, 2...
OBJECTIVE
To estimate the cost of diagnosis and treatment of asthma.
METHODS
We used the perspective of society. We sequentially included for 12 months, in 2011-2012, 117 individuals over five years of age who were treated for asthma in the Pneumology and Allergy-Immunology Services of the Piquet Carneiro Polyclinic, Universidade do Estado do Rio...
Resumo A Comissão Nacional de Incorporação de Tecnologias em Saúde (Conitec), instituída em 2011, assessora o Ministério da Saúde nas decisões relacionadas à incorporação, exclusão ou alteração de novos medicamentos, produtos e procedimentos no Sistema Único de Saúde. O estudo investigou o processo de recomendação pela Conitec e o perfil das demand...
The National Commission for incorporation of Health Technologies (CONITEC), established in 2011, advises the Ministry of Health in decisions related to the incorporation, exclusion or change of medicines, products and procedures in the Unified Health System (SUS).The study investigated the decision-making process, profile of demands and incorporati...
9068
Background: Success of a target therapy is directly correlated with the accuracy of its companion diagnostic test. Without a corresponding biomarker, target therapy may yield shorter survival, waste time, increase burdens and costs. As important as conducting cost-effectiveness studies for therapies, it is also valuable to compare different mo...
Background:
There are safety concerns with using unlicensed medicines across countries including Brazil. Consequently this needs to be evaluated and concerns address if pertinent.
Aim:
Investigate such purchases by the Brazilian Federal Government from 2004 to 2013.
Methods:
Procurement data from a public-access databank that contains procurem...
OBJETIVOS: O estudo comparou os valores pagos pelo Programa Aqui Tem Farmácia Popular (ATFP) com os custos integrais relativos à provisão pela Secretaria Municipal de Saúde do Rio de Janeiro (SMS-RJ), de um rol de medicamentos comuns, tomando por base o ano de 2012.
MÉTODOS: A comparação envolveu o rol comum de medicamentos da assistência farmacêut...
OBJECTIVE
To analyze the costs of public pharmaceutical services compared to Farmácia Popular Program (Popular Pharmacy Program).
METHODS
Comparison between prices paid by Aqui Tem Farmácia Popular Program (Farmácia Popular is available here) with the full costs of medicine provision by the Municipal Health Department of Rio de Janeiro. The compar...
Objetivo:
Analisar o perfil das compras realizadas por órgãos federais brasileiros dos antineoplásicos mesilato de imatinibe, trastuzumabe e L-asparaginase, entre janeiro/2004 e dezembro/2013.
Métodos:
Dados de compras foram extraídos do Sistema Integrado de Administração de Serviços Gerais-SIASG. Foram analisados: quantidade, preço unitário, data...
Há exatos 40 anos, a Lei n° 6.360 estabelecia o registro como pilar que antecede a utilização e comercialização de medicamentos no país, trazendo ao âmbito sanitário a necessidade de comprovações científicas de segurança, eficácia e qualidade dos produtos candidatos ao ingresso no mercado farmacêutico (BrasiL, 1976). O cenário regulatório atual, nã...
Avaliou-se a custo-efetividade da adição da tomografia de emissão de pósitrons (18FDG-PET-TC) aos métodos convencionais na detecção de recorrência de cânceres diferenciados de tireoide. O modelo analítico de decisão representou coorte hipotética de pacientes adultos, de alto risco pela estratificação inicial, submetidos a tireoidectomia total e abl...
