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Publications (149)
Assisted reproductive technologies (ARTs) involve the laboratory manipulation of gametes and embryos to help couples with fertility problems become pregnant. One of these procedures, controlled ovarian stimulation, uses pharmacological agents to induce ovarian and follicular maturation in vivo. Despite the effectiveness in achieving pregnancy and l...
Purpose
To analyze the copy number variation (CNV) in the X-linked genes BCORL1, POF1B, and USP9X in idiopathic diminished ovarian reserve (DOR).
Methods
This case-control study included 47 women, 26 with DOR and 21 in the control group. Age, weight, height, BMI, and FSH level were evaluated, as well as antral follicle count (AFC), oocyte retrieva...
Objective:
To evaluate the impact of possible maternal and paternal prognostic factors and ovarian stimulation protocols on clinical pregnancy and live birth rates in intrauterine insemination (IUI) cycles.
Methods:
Retrospective observational study of 341 IUI cycles performed from January 2016 to November 2020 at the Assisted Reproduction Servi...
Polycystic ovary syndrome (PCOS) is a multifactorial disorder and obesity occurs in 38% to 88% of these women. Although hyperandrogenism may contribute to telomere lengthening, increased body mass index (BMI) is associated with telomere erosion. We sought to compare leukocyte telomere length (LTL) in PCOS women with normal, overweight, and obese BM...
Objective:
This study aimed to determine the differences in body fat distribution and central obesity indicators using dual-energy X-ray absorptiometry (DXA), adiposity indices, and anthropometric indices between women with and without polycystic ovary syndrome (PCOS).
Materials and methods:
Clinical and laboratory examination history, including...
Background
Moderate-intensity continuous training (MICT) is strongly recommended for polycystic ovarian syndrome (PCOS) treatment. However, recent studies have suggested that high-intensity interval training (HIIT) would promote great benefits for cardiac autonomic control. Therefore, we investigated whether the benefits of HIIT related to cardiova...
Purpose
To evaluate the genetic variants related to polycystic ovary syndrome (PCOS) and its metabolic complications in girls born small for gestational age (SGA).
Design
Retrospective birth cohort study.
Materials and methods
We evaluated 66 women of reproductive age born at term (37–42 weeks of gestational age) according to the birth weight in...
Metabolic and hormonal outcomes of polycystic ovary syndrome (PCOS) have implications on telomere biology and physical activity may prevent telomere erosion. We sought to observe the effects of continuous (CAT) and intermittent (IAT) aerobic training on telomere length, inflammatory biomarkers, and its correlation with metabolic, hormonal, and anth...
Background: Physical activity is an effective non-pharmacological treatment for polycystic ovary syndrome (PCOS) and the reproductive outcomes which may have implications on telomere biology. Objective: To observe the effects of continuous (CAT) and intermittent (IAT) aerobic training on telomere length, inflammatory biomarkers, and its correlation...
Brazil is a large country with rich cultural and ethnic diversity among its different regions. In this ongoing nationwide collaborative study, we are evaluating modifiable lifestyle factors, metabolic and reproductive abnormalities and prevalence of anxiety/depression in a less-well represented population of women with PCOS from Brazil. The design...
Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders, affecting approximately 5–20% of women of reproductive age. PCOS is a multifactorial, complex, and heterogeneous disease, characterized by hyperandrogenism, ovulatory dysfunction, and polycystic ovaries, which may lead to impaired fertility. Besides the reproductive out...
The purpose of this study to assess the effects of different protocols of physical exercise on the domains of the quality of life (QoL), sexual function, anxiety, and depression scores in women with polycystic ovary syndrome (PCOS). Data of 112 women with PCOS were extracted from 2 trials with different protocols of physical exercise: continuous ae...
Objective The present study aimed to investigate the physical performance of handgrip strength (HGS) in women with polycystic ovary syndrome (PCOS).
Methods A case-control study that included 70 women with PCOS and 93 age-matched healthy women aged between 18 and 47 years with body mass index (BMI) between 18 Kg/m2–39.9 Kg/m2. The serum levels of t...
Adolescence is characterized by significant biological and psychological changes. During this time, the increased production of androgens leads to increased sexual behavior, and this may contribute to early initiation of sexual activity. The objectives of the present cross-sectional study of adolescents enrolled in state schools in the city of Ribe...
Os autores revisam os artigos publicados cujo objetivo principal fosse avaliar a influência da anticoncepção hormonal (AH) na sexualidade feminina. Há uma variabilidade muito grande na resposta das mulheres aos AH e ainda não há como se prever quais mulheres irão apresentar efeitos colaterais sexuais. Estes efeitos, entretanto, podem ser causa de a...
Objective
To study the global DNA methylation pattern in spermatozoa of patients with varicocele as well as investigate their semen quality.
Design
Prospective observational case-control study.
Setting
University-affiliated hospital.
Patient(s)
A total of 26 men with varicocele and 26 fertile men without the disorder.
Interventions
Analysis of...
Rev Bras Ginecol Obstet 2020;42(6):305-309.
Objective
To assess the utility of bioimpedance (BIA) and skinfolds thickness (SF) in body fat percentage measuring (%BF) compared to the reference method dual-energy x-ray absorptiometry (DXA) in Brazilian reproductive age women, as well as to estimate of inter- and intra-observer precision for SF.
Subjects and methods
170 women aged 18-37 years...
Background: Idiopathic central precocious puberty (iCPP) presents a disproportionate advancement of bone age and maturation, as well as metabolic and endocrinological changes that may be related to effects on telomere biology.
Objective: To investigate the telomere length in iCPP girls treated with GnRHa.
Study design: Observational case-control st...
O mundo vive uma pandemia sem precedentes recentes causada pelo novo coro-navírus, SARS-CoV-2. As projeções matemáticas para o Brasil apontam que a curva da epidemia se encontra em um platô, com mais de 190 mil novas infecções diárias previstas até a segunda quinzena de junho de 2020. Embora distante de ser uma es-tratégia com a eficácia desejada,...
Objective
To evaluate the effects of continuous (CA) and intermittent (IA) aerobic training on hormonal and metabolic parameters and body composition of women with polycystic ovary syndrome (PCOS).
Design
Prospective, interventional, randomized study.
Methods
RCT (Randomized Controlled Training) with sample allocation and stratification into thre...
Metaphase II oocytes (MII) from polycystic ovary syndrome (PCOS) frequently have impaired oocyte competence. Since telomere maintenance is important for folliculogenesis, oocyte maturation, and early embryonic development, we sought to verify the implications of PCOS on telomere length and telomerase activity in immature oocytes and cumulus cells....
Background
Conventional cryopreservation methods induce chemical and mechanical damage to the sperm membranes. The cryoprotectant potential of phospholipids of vegetal origin as soybean lecithin has been investigated as a substitute for egg yolk in diluents used for the cryopreservation of human spermatozoa. Therefore, the objective of this study w...
Background:
Both physical and mental health care for women with polycystic ovary syndrome (PCOS) require a multidisciplinary approach. We evaluated the effects of continuous (CAT) and intermittent (IAT) aerobic training in different protocols that measure body image, anxiety, depression and sexual dysfunction in women with PCOS.
Methods:
In this...
Introduction
Brazil is a large country, with a population of mixed ethnic background and broad variation in dietary and physical activity traits across its five main regions. Because data on Brazilian women with polycystic ovary syndrome (PCOS) are still scarce, a nation-wide collaborative study was designed to determine the prevalence of metabolic...
Polycystic ovary syndrome predisposes alterations which contribute to the reduction of quality of life. This randomized controlled clinical trial study was to evaluate the effect of two protocols of aerobic exercise on quality of life in women with polycystic ovary syndrome. Women were allocated to three groups: continuous aerobic training ( n = 28...
Varicocele is the main identifiable cause of male infertility. Despite the impairment of spermatogenesis and its associated infertility, not all men with varicocele are infertile or have alterations in semen parameters. Furthermore, varicocele can be corrected surgically, which may improve semen parameters. Given all of their adverse effects on mal...
Background:
Physical activity is prescribed as a component of primary management for polycystic ovary syndrome (PCOS). This nonrandomized, therapeutic, open, single-arm study investigated the effects of progressive resistance training (PRT) on obesity indices in women with PCOS, and the relationship between obesity indices and telomere content.
M...
Background:
Polycystic ovary syndrome (PCOS) is associated with lower levels of satisfaction with body image, which can affect sexuality and social well-being. Thus, we evaluated body image in women with PCOS and its association with body dis(satisfaction), anthropometric indices, sexual function, anxiety, and depression.
Methods:
In this cross-...
Background:
Polycystic ovarian syndrome (PCOS) women have a high prevalence of obesity and alterations in cardiovascular autonomic control, mainly modifications in heart rate variability (HRV) autonomic modulation. However, there are few studies about other autonomic control parameters, such as blood pressure variability (BPV) and baroreflex sensi...
Varicocele pathophysiology is related to increased oxidative stress, which might result in loss sperm DNA integrity as well as in genomic instability. Sperm telomere shortening and loss of global DNA methylation are the main features of genomic instability, leading to cell senescence and death, whereas sperm DNA fragmentation (SDF) characterizes th...
Infertility in a couple can lead to emotional instability in both partners, and to problems in their interpersonal relationship that could cause decreased sexual interest and marital instability. Our purpose is to determine the impacts of infertility on the sexuality of couples, and the challenges this presents for providing sexual healthcare to th...
Background:
Even before the onset of age-related diseases, obesity might be a contributing factor to the cumulative burden of oxidative stress and chronic inflammation throughout the life course. Obesity may therefore contribute to accelerated shortening of telomeres. Consequently, obese persons are more likely to have shorter telomeres, but the a...
Objective:
To analyze whether telomere length, X-chromosome inactivation (XCI), and androgen receptor (AR) GAG polymorphism are related to idiopathic premature ovarian insufficiency (POI).
Design:
Case-control study.
Setting:
University hospital.
Patient(s):
A total of 121 women, including 46 nonsyndromic POI and 75 controls.
Intervention(s...
Kogure, GS, Silva, RC, Miranda-Furtado, CL, Ribeiro, VB, Pedroso, DCC, Melo, AS, Ferriani, RA, and Reis, RMd. Hyperandrogenism enhances muscle strength after progressive resistance training, independent of body composition, in women with polycystic ovary syndrome. J Strength Cond Res XX(X): 000-000, 2018-The effects of resistance exercise on muscle...
Objective:
This study aimed to evaluate the clinical pregnancy rate of intrauterine insemination cycles in relation to patient age, cause of infertility, ovulation induction method, number of mature follicles and sperm with progressive motility.
Methods:
This retrospective observational study included 237 intrauterine insemination cycles perform...
Objective To evaluate the effects of nutritional counseling on the dietary habits and anthropometric parameters of overweight and obese adolescents with polycystic ovary syndrome (PCOS). Methods This was a prospective, longitudinal and auto-controlled study. Thirty adolescents aged 13-19 years-old, diagnosed with PCOS received nutritional counselin...
Varicocele is found in approximately 20% of adults and adolescents and in 19-41% of men seeking treatment for infertility. It is associated with a decrease in sperm count as well as sperm motility and morphology. The currently accepted description of the pathophysiology of varicocele does not explain all its clinical manifestations; therefore, othe...
Varicocele has a negative impact on seminal parameters and deleterious effects on the sperm DNA. We aim to verify the effect of varicocele on seminal quality, sperm DNA fragmentation, global DNA methylation and telomere content. Were evaluated 20 men with varicocele and 20 men without the disease. The seminal quality was evaluated by spermogram and...
Anderson Sanches de Melo, Rosana Maria dos Reis, Rui Alberto Ferriani, Carolina Sales Vieira Department of Gynecology and Obstetrics, Ribeirão Preto School of Medicine, University of São Paulo, Ribeirão Preto, São Paulo, Brazil Abstract: Polycystic ovary syndrome (PCOS) is an endocrine disorder among women of reproductive age characterized by chron...
Background:
Physiologically, a reduction in telomere length (LTL) occurs with aging, but epigenetic changes may accelerate telomere shortening and also facilitate the onset of oxidative/inflammatory stress and the development of clinical/metabolic comorbidities in life spam. Although individuals born small for gestational age (SGA) may be related...
O estudo buscou avaliar o comprimento telomérico e a fragmentação do DNA espermático, bem como os parâmetros relacionados a qualidade seminal em homens com varicocele. Foi realizado um estudo caso-controle com 28 voluntários, sendo 13 homens com varicocele e 15 homens sem a doença, em que foram coletados amostras de sêmen de 2014 a 2016. Foi realiz...
Varicocelectomy may improve the seminal parameters and the quality of genetic material in men with varicocele. We sought to verify the effect of varicocelectomy on semen quality, hormonal parameters, sperm DNA fragmentation (SDF) and global DNA methylation (SGDM) in patients with varicocele. This is a randomized clinical trial study, comprising 19...
Background:
Physical activity is known to relieve the metabolic complications of polycystic ovary syndrome (PCOS), and exercise is also associated with telomere biology. We investigated the changes induced by progressive resistance training (PRT) in telomere content and metabolic disorder in women with PCOS and controls.
Participants and methods:...
Purpose:
This study investigated the effects of progressive resistance training (PRT) on lean muscle mass (LMM) in women with or without polycystic ovary syndrome (PCOS), and its effects on metabolic factors and concentrations of related steroid hormones.
Design:
This was a nonrandomized, therapeutic, open, single-arm study.
Participants:
In a...
Purpose Aerobic exercises may improve quality of life (QoL) in women with polycystic ovary syndrome (PCOS). However, there is no data on the effect of resistance exercise training (RET) programs on the QoL of women with PCOS. Thus, this study aimed to assess the effect of a 16-week RET program on QoL in PCOS women. Methods This 16-week case-control...
Introduction: Varicocele is one of the major and most frequent causes of poor quality sperm, leading to infertility. This disease is related to high scrotal temperature and consequently an increase in oxidative stress, with a negative impact on the seminal parameters and sperm DNA fragmentation. Retrospective and nonrandomized studies have shown th...
Introduction
There is a need for specific measures to address overall care in women with polycystic ovary syndrome (PCOS). Physical resistance training (PRT) has been shown to improve certain body parameters. However, the effect of PRT on the sexual function of PCOS women has not been evaluated.
Aim
The study aimed to assess sexual function and em...
Varicocele is a disease characterized by abnormal dilatation of the testicular veins within the pampiniform plexus due to difficult blood return in this region. The prevalence of varicocele is 30 to 40% in infertile men, who frequently show seminal changes and a high rate of sperm DNA Fragmentation Index (DFI), one of the conditions responsible for...
Background
Uterine leiomyoma is the most common gynecological tumor in the reproductive years. However, it is extremely rare in adolescence (<1%), with few reports found in the literature. The biological behavior of such tumors in this age group is unknown, as well as the best possible treatment for this population. We aimed to analyze all availabl...
Abstract The aim of this study was to compare metabolic parameters, body composition (BC) and muscle strength of women with and without polycystic ovary syndrome (PCOS). This was a case-control study that evaluated 40 women with PCOS and 40 controls. Androgens and insulin resistance were measured. BC was based on dual-energy X-ray absorptiometry. I...
To analyze whether leukocyte telomere length (LTL) is impaired in women with polycystic ovary syndrome (PCOS).
Case-control study.
Hospital.
A total of 274 women, including 150 patients with PCOS and 124 controls.
None.
Body mass index (BMI), waist circumference, systemic arterial pressure, lipid profile, E2, LH, T, androstenedione, PRL, TSH, sex h...
Background: Varicocele is one of the major and most frequent causes of poor quality sperm leading many men to infertility.
Among the patients with this anatomic anomaly, have been observed a high sperm DNA fragmentation. The varicocelectomy
has been suggested as a possible tool used for infertility treatments.
Aim: To evaluate sperm DNA fragmentati...
Background: The egg yolk-based extenders contributed significantly to advances in human sperm cryopreservation. The use
of soybean lecithin, that formulation contains 10% of phospholipid present in egg yolk, has recently been investigated. In a
preliminary test conducted in our laboratory, purified soybean phosphatidylcholine lipids (soy PC) added...
Infertility is directly related to chromosomal abnormalities in germ cells. Among them, the aneuploidies are the most frequent chromosomal abnormalities and responsible for embryo implantation failures, miscarriages, fetal losses and newborns with congenital malformations, mental disability and neuropsychomotor developmental delay. Male patients wi...
To compare the frequency of metabolic syndrome (MetS) and the risk factors associated with this syndrome in women from the Brazilian Southeast with polycystic ovary syndrome (POS) evaluated during adolescence and adult age.
This was a cross-sectional study conducted on 147 patients with a diagnosis of POS who were divided into two groups: Adolescen...
To compare the metabolic parameters, body composition and muscle strength of women with Polycystic Ovary Syndrome (PCOS) to those of women with ovulatory menstrual cycles.
A case-control study was conducted on 27 women with PCOS and 28 control women with ovulatory cycles, aged 18 to 27 years with a body mass index of 18 to 39.9 kg/m², who did not p...
OBJETIVOS: Comparar os parâmetros metabólicos, a composição corporal e a força muscular de mulheres com Síndrome dos Ovários Policísticos (SOP) em relação a mulheres com ciclos menstruais ovulatórios. MÉTODOS: Estudo caso-controle com 27 mulheres com SOP e 28 mulheres controles com ciclos ovulatórios, com idade entre 18 e 37 anos, índice de massa c...
This study aimed to evaluate the results of neovaginoplasty by a modified McIndoe-Bannister technique and by the non-surgical Frank technique.
This retrospective study was conducted on a convenience sample of 25 women with vaginal agenesis undergoing surgical or conservative treatment at an Infant-Pubertal Gynecology Outpatient Clinic. Data were ob...
Purpose
The aim of this study was to quantify aromatase gene expression in mural lutein-granulosa cells of women with endometriosis undergoing assisted reproduction techniques (ART, IVF or ICSI). Methods: a case-control study was performed on 11 women with endometriosis (all stages, ASRM criteria) and 11 women with male or tubal causes of infertili...
Objectives: Compare clinical and metabolic parameters, as well as predictors of metabolic syndrome (MS), in adolescent and adult women with polycystic ovary syndrome (PCOS). Methods: A Cross-sectional study was conduced in Faculty of Medicine of Ribeirão Preto, University of São Paulo. A total of 147 women with PCOS were divided into 2 groups: 42 a...
To correlate ovarian reserve (OR) markers with response in assisted reproduction techniques (ART) and determine their ability to predict poor response among patients with endometriosis (EDT).
We evaluated ART cycles of 27 women with EDT and 50 with exclusive male factor. Basal follicle stimulating hormone (FSH) and anti-müllerian hormone (AMH) leve...
OBJETIVO: avaliar a concentração dos hormônios esteroides no fluido folicular (FF) de folículos pequenos (10-14 mm) e grandes (> 18 mm) de mulheres com síndrome dos ovários policísticos (SOP) submetidas à hiperestimulação ovariana controlada (HOC) e ciclos de fertilização in vitro (FIV). MÉTODOS: estudo caso-controle foi conduzido em 13 mulheres in...
To determine whether basal levels of follicle-stimulating hormone (FSH) and anti-müllerian hormone (AMH), antral follicle count (AFC), and the numbers of dominant follicles, oocytes, and mature oocytes retrieved after ovarian stimulation differed between infertile women with endometriosis and healthy women undergoing assisted reproduction technique...
Purpose:
to evaluate the concentration of steroid hormones in follicular fluid (FF) of small (10-14 mm) and large (> 18 mm) follicles of women with polycystic ovary syndrome (PCOS) submitted to controlled ovarian hyperstimulation (COH) and in vitro fertilization (IVF) cycles.
Methods:
a case-control study was conducted on 13 infertile women with...
Patients with dyskeratosis congenita (DC), a disorder of telomere maintenance, suffer degeneration of multiple tissues. Patient-specific induced pluripotent stem (iPS) cells represent invaluable in vitro models for human degenerative disorders like DC. A cardinal feature of iPS cells is acquisition of indefinite self-renewal capacity, which is acco...
497
Patients with dyskeratosis congenita (DC), a disorder of telomere maintenance, suffer premature degeneration of multiple tissues. Bone marrow failure is the principal cause of mortality, and allogeneic stem cell transplantation is limited by increased treatment-related mortality. Somatic cells can be reprogrammed using defined genetic and chemi...
Background Polycystic ovary syndrome (PCOS) is associated with adverse metabolic effects. Some cardiovascular disease (CVD) risk markers are increased in women with PCOS. However, early markers of atherosclerosis are also associated with obesity and insulin resistance, which are related to PCOS. These markers may result either directly from PCOS or...
Objective: The aim of this retrospective study was to compare the pregnancy rates and characteristics of ovar- ian stimulation between rFSH filled by mass or filled by bioassay for intrauterine insemination in couples with unexplained and male subfertility.
Methods: We assessed 51 cycles of patients that had used rFSH bioassay and 51 cycles of pati...