Rosalie Maltby- Master of Science
- Researcher at University of Oklahoma
Rosalie Maltby
- Master of Science
- Researcher at University of Oklahoma
About
7
Publications
1,302
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Introduction
I am a researcher and manager for the Markham lab in the Biology Department at OU. I am interested in the molecular mechanisms that drive the energetically challenging electrical signals of weakly electric fish, especially Eigenmannia virescens. I am particularly interested in how the genetic and cellular mechanisms affect the ionic currents and what role they play in maintaining a delicate energy balance in a cell where ionic currents can exceed 10 microamps. My primary focus is the IKir, produced by the KATP channel complex. Along with laboratory management, I am also focused in undergraduate research operations and in the implementation of broader impact initiatives, including overseeing a public outreach program
Current institution
Additional affiliations
September 2019 - present
August 2008 - April 2012
April 2012 - present
Education
August 2008 - May 2012
August 2003 - August 2008
Publications
Publications (7)
Weakly electric freshwater fish use self-generated electric fields to image their worlds and communicate in the darkness of night and turbid waters. This active sensory/communication modality evolved independently in the freshwaters of South America and Africa, where hundreds of electric fish species are broadly and abundantly distributed. The adap...
Escherichia coli is a single species consisting of many biotypes, some of which are commensal colonizers of mammals and others that cause disease. Humans are colonized on average with five commensal biotypes, and it is widely thought that the commensals serve as a barrier to infection by pathogens. Previous studies showed that a combination of thre...
High-frequency action potentials (APs) allow rapid information acquisition and processing in neural systems, but create biophysical and metabolic challenges for excitable cells. The electric fish Eigenmannia virescens images its world and communicates with high-frequency (200-600 Hz) electric organ discharges (EODs) produced by synchronized APs gen...
Weakly electric fish navigate and communicate with electric organ discharges (EODs) produced by the coordinated action potentials of muscle-derived electric organ cells (electrocytes). EOD production incurs significant metabolic costs in the electric fish Eigenmannia virescens which reduces signal amplitude during food restriction. This effect is m...
The intestine is inhabited by a large microbial community consisting primarily of anaerobes and, to a lesser extent, facultative anaerobes, such as Escherichia coli, which we have shown requires aerobic respiration to compete successfully in the mouse intestine (S. A. Jones et al., Infect. Immun. 75:4891-4899, 2007). If facultative anaerobes effici...
Systemic lupus erythematosus (SLE) is a multifactorial disorder characterized by the presence of autoantibodies. We and others have implicated free radical mediated peroxidative damage in the pathogenesis of SLE. Since harmful free radical products are formed during this oxidative process, including 4-hydroxy 2-nonenol (4-HNE) and malondialdehyde (...
Mutant screens and transcriptome studies led us to consider whether the metabolism of glucose polymers, i.e., maltose, maltodextrin,
and glycogen, is important for Escherichia coli colonization of the intestine. By using the streptomycin-treated mouse model, we found that catabolism of the disaccharide
maltose provides a competitive advantage in vi...
