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Introduction
Additional affiliations
June 2012 - present
March 2012 - present
ELSA-Brasil Musculoskeletal
Position
- Principal Research
January 2012 - present
Publications
Publications (80)
Objectives
This analysis describes the protocol of a study with a case-cohort to design to prospectively evaluate the incidence of subclinical atherosclerosis and Cardiovascular Disease (CVD) in Chronic Inflammatory Disease (CID) participants compared to non-diseased ones.
Methods
A high-risk group for CID was defined based on data collected in al...
Objective
To investigate the effect of cosmetic camouflage in health-related quality of life (HRQoL) in women with systemic lupus erythematosus (SLE) and permanent facial skin damage.
Methods
This is a randomized controlled clinical trial (Universal Trial Number: U1111-1210-2554e) with SLE women from outpatients using ACR/1997 and/or SLICC/2012 cr...
Background/objective:
Chronic knee pain (CKP) is a common pain complaint in older adults that is often associated with disability. This study investigated the relationship between 2 components of subjective well-being (depressive symptoms and life satisfaction) and CKP phenotypes based on the presence of knee disability.
Methods:
A cross-section...
The objective of this study is to investigate the association of clinical markers of obesity and weight trajectories with chronic musculoskeletal pain (CMP). This is a cross-sectional study using baseline data from ELSA-Brasil MSK cohort. CMP was evaluated at nine body sites (neck, shoulders, upper back, elbows, lower back, wrists/hands, hips/thigh...
Information on measurement properties of translated versions of the Western Ontario and McMaster Universities (WOMAC) osteoarthritis index is still limited. This study investigated the internal consistency, test–retest reliability/agreement, construct validity, and floor and ceiling effects of Portuguese–Brazil WOMAC applied to civil servants at ba...
Introduction:
In Brazil, the prevalence and costs of pain will increase substantially with population ageing. Understanding of pain epidemiology is needed for the development of health care policies that can minimize this projected burden.
Objective:
To investigate the prevalence of pain and associated factors at baseline of the Brazilian Longit...
Objective
To investigate the association between the intake of selected food groups and beverages and serum uric acid (UA).
Design
Cross-sectional study using the baseline data (2008–2010) from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). Food intake was assessed by food frequency questionnaire with 114 items. Linear and logisti...
Background
Health-related quality of life (HRQoL) can be negatively impacted by visible skin lesions.¹
Objectives
To investigate the effect of cosmetic camouflage on health-related quality of life of systemic lupus erythematosus (SLE) women presenting sequelae of cutaneous manifestations on the face.
Methods
This is a randomized controlled clinic...
Objective
To compare the performance of different knee osteoarthritis (OA) classification criteria in a subsample of subjects of ELSA-Brasil Musculoskeletal cohort (ELSA-Brasil MSK) in comparison with the clinical-radiographic evaluation of an experienced rheumatologist.
Method
A cross-sectional study of the diagnostic accuracy of different knee O...
Background: Hyperuricemia is a necessary causal component for the development of gout and it is determined by the balance between uric acid’s (UA) production and its excretion. UA is the final product of purine metabolism and it is known that endogenous synthesis accounts for approximately two thirds and dietary intake for one third of purine load....
https://doi.org/10.1186/s42358-018-0019-7
Objectives
To evaluate the incidence and variability of traditional coronary artery disease (CAD) risk factors in a cohort of lupus patients and to investigate if prednisone use predicts an increase in the number of risk factors.
Methods
A total of 151 women, 37.8 ± 11.1 (mean ± SD) years old at baseline, were reevaluated after a median period of...
Absolute cardiovascular risk of an individual with rheumatoid arthritis (RA) is greater when compared to the general population, and several factors have proven to be important for the development of coronary artery disease (CAD) in these patients, including factors related to the underlying disease, such as the systemic inflammatory response, drug...
Systemic lupus erythematosus (SLE) patients have a high risk for cardiovascular events, but few studies have evaluated the recognition and none have evaluated the control of cardiovascular risk factors (RF) in SLE patients. The study aims to describe the recognition and control frequencies of systemic arterial hypertension (SAH), dyslipidemia, and...
Introdução: Gota é causada pela formação de cristais de monourato de sódio (MUS) intrarticular, ocorrendo classicamente quando nível sérico de ácido úrico (AU) permanece persistentemente acima de 6,8 mg/dL. Descreve‐se aqui paciente com gota e uricemia normal, caracterizando desafio diagnóstico e terapêutico.
Descrição do caso: Na primeira consult...
Objective:
To describe the performance of a non-fluoroscopic fixed-flexion PA radiographic protocol with a new positioning device, developed for the assessment of knee osteoarthritis (OA) in Brazilian Longitudinal Study of Adult Health Musculoskeletal Study (ELSA-Brasil MSK).
Material and methods:
A test–retest design including 19 adults (38 knee...
A radiografia do joelho em flexão fixa utilizando um novo posicionador produziu medidas da largura do espaço articular com alta repetibilidade: estudo ELSA-Brasil Musculoesquelético (ELSA-Brasil ME) informações sobre o artigo Histórico do artigo: Recebido em 18 de novembro de 2015 Aceito em 21 de outubro de 2016 On-line em 26 de novembro de 2016 Pa...
Objective: To describe the performance of a non-fluoroscopic fixed-flexion PA radiographic protocol with a new positioning device, developed for the assessment of knee osteoarthritis (OA) in ELSA-Brasil MSK.
Material and methods: A test–retest design including 19 adults (38 knee images) was con- ducted. Feasibility of the radiographic protocol was...
Background
Studies have shown that omega-3 fatty acids reduce the concentrations of eicosanoids, cytokines, chemokines, C-reactive protein (CRP) and other inflammatory mediators.
Objective
To investigate the effects of omega-3 fatty acids on circulating levels of inflammatory mediators and biochemical markers in women with systemic lupus erythemat...
Background
Health-related control and self-efficacy beliefs can be assessed in the general population using Multidimensional Health Locus of Control-A subscales (MHLC-A) and the General Self-Efficacy Scale (GSES), respectively.
Objective
To test construct validity, internal consistency, reliability (test-retest) and ceiling and floor effects of Po...
Background:
Studies have shown that omega-3 fatty acids reduce the concentrations of eicosanoids, cytokines, chemokines, C-reactive protein (CRP) and other inflammatory mediators.
Objective:
To investigate the effects of omega-3 fatty acids on circulating levels of inflammatory mediators and biochemical markers in women with systemic lupus eryth...
Objectives:
To analyze the association of adipokines and tumor necrosis factor α (TNFα) and its receptors with characteristics of systemic lupus erythematosus (SLE) and to investigate the correlation between adipokines and the TNF system.
Methods:
One hundred and thirty-six SLE women, aged ≥18 years old, were assessed. TNFα, soluble TNFα recepto...
Background
High frequency of obesity among SLE patients has been described, however, it is unknown whether obesity can modify the inflammatory status of those individuals.
Objectives
To analyze the profile of cytokines and evaluate whether obesity interferes with the inflammatory status of SLE patients.
Methods
Cross-sectional study included 189...
Purpose: To evaluate the medial tibial plateau (MTP) alignment, repeatability of MTP alignment and joint space width (JSW) measurements, and their correlations, in the radiographic protocol selected for the investigation of knee osteoarthritis in the ELSA-Brasil Musculoskeletal Study (ELSA-Brasil MSK).
Methods: A test-retest study of 38 knees (19 a...
Purpose: To characterize participants of the ELSA-Brasil Musculoskeletal Study (ELSA-Brasil MSK) in terms of function scores from the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC-f), and to identify associated factors.
Methods: ELSA-Brasil MSK is an ancillary study of the Brazilian Longitudinal Study of Adult Health (ELSA-B...
Purpose: To describe the measures and procedures used for the investigation of osteoarthritis (OA) in the ELSA-Brasil Musculoskeletal Study (ELSA-Brasil MSK) and to report preliminary findings on the quality of radiographic readings for tibiofemoral OA. Methods: Civil servants pertaining to a subcohort of the Brazilian Longitudinal Study of Adult H...
PURPOSE: To compare different knee osteoarthritis classification criteria for sensitivity and specificity for use in epidemiological studies.
METHODS: Cross-sectional study of a subsample of the participants in the ELSA-Brasil Musculoskeletal Study (ELSA - Brasil MSK) evaluated between February 2014 and June 2015. Postero-anterior and lateral knee...
Cardiovascular disease (CVD) has emerged as a major cause of morbidity and mortality in patients with inflammatory rheumatic diseases, notably systemic lupus erythematosus and rheumatoid arthritis. The pathophysiology of premature and accelerated atherosclerosis in those patients is multifactorial, involving traditional cardiovascular risk factors,...
Introdução: O Estudo Logitudinal de Saúde do Adulto (ELSA-Brasil) é o maior estudo epidemiológico da América Latina sobre fatores de risco para o desenvolvimento e a progressão das principais doenças crônicas não transmissíveis (DCNT). Em 2012, a investigação de doenças/sintomas musculoesqueléticos foi incorporada por meio do estudo ancilar ELSA-Br...
Introdução: Síndromes dolorosas são frequentemente acompanhadas por declínio na função, sendo a incapacidade funcional um dos mais importantes preditores de morbidade e mortalidade. Objetivo: Caracterizar participantes da linha de base do ELSA-Brasil Musculoesquelético quanto à incapacidade funcional de joelhos e identificar seus fatores associados...
Introdução: A distância intermarginal (DIM) do platô tibial em radiografias do joelho pode influenciar a medida do espaço articular (EA) tibiofemoral, podendo interferir na investigação da incidência e progressão da osteoartrite. Objetivo: Investigar a correlação entre DIM e EA tibiofemoral. Métodos: Foi realizado estudo teste-reteste (intervalo de...
Introdução: Marcadores de obesidade são fatores de risco reconhecidos para dor crônica; entretanto, evidência sobre relação entre índice de massa corporal (IMC) e dor em múltiplos locais é conflitante. Obesidade abdominal parece estar envolvida em mecanismos sistêmicos associados ao aparecimento de dor em múltiplos locais. Objetivos: Investigar a r...
The present invention patent relates to a positioner for the acquisition and quality control of
radiographic images of knees in the fixed flexion position. The design of the device allows adjusting its height quickly and easily, for convenient use with adults of any height,
without requiring any kind of accessory. The positioner is provided with sp...
Background Adipokines, tumor necrosis factor α(TNFα)and its receptors, participate in the regulation of the immune system and inflammation in immune disease (1). The role and interactions between those cytokines and systemic lupus erythematosus (SLE) characteristics and treatment is poorly studied and understood.
Objectives To analyze the associati...
Various studies have demonstrated the impact of omega‐3 fatty acids on the concentration of C reactive protein (CRP), pro‐inflammatory eicosanoids, cytokines, chemokines and other inflammatory mediators. Therefore, the supplementation of these types of lipids may represent additional option treatment for chronic systemic diseases, such as Systemic...
Various studies have demonstrated the impact of omega-3 fatty acids on the concentration of C reactive protein (CRP), pro-inflammatory eicosanoids, cytokines, chemokines and other inflammatory mediators. Therefore, the supplementation of these types of lipids may represent additional option treatment for chronic systemic diseases, such as Systemic...
The progression of carotid atherosclerosis in lupus patients is frequently encountered, and it is determined by both traditional and nontraditional risk factors. Of the 181 patients initially included in the study, 157 patients were reevaluated after 39(37-42) months. The progression of atherosclerosis was defined as the increase in the intima-medi...
Systemic inflammation, therapy with corticosteroids, and reduced physical activity may increase the predisposition to accumulate body fat in patients with systemic lupus erythematosus (SLE). The aim of this study was to assess the nutritional status and food intake of patients with SLE.
One hundred seventy women with SLE were evaluated consecutivel...
The objective of this study is to determine the socio-demographic, clinical and laboratory characteristics of outpatients with SLE who present with excess weight as well as to assess the immunosuppressive therapy used. One hundred and seventy women with SLE were evaluated consecutively in a transversal study. The relationship between excess weight...
The objective of this study is to determine the causes and predictors of death in systemic lupus erythematosus (SLE) patients. Causes of death were defined based on death certificates, medical records, and information collected from doctors and relatives. Possible variables predicting mortality were assessed by Kaplan-Meier and Cox regression metho...
Multiple symmetric lipomatosis (MSL) is a relatively uncommon entity of unknown etiology characterized by symmetrically subcutaneous accumulation of nonencapsulated adipose tissue. Approximately 200 to 300 cases have been published.
The aims of this article are to report the case of a 58-year-old Brazilian patient with MSL and provide a comprehensi...
INTRODUÇÃO: Pacientes com lúpus eritematoso sistêmico (LES) podem apresentar alterações nutricionais desencadeadas pela doença ou pelo tratamento, e essas condições podem interferir no prognóstico. OBJETIVOS: Avaliar o estado nutricional, a atividade física e os aspectos associados em pacientes com LES. MÉTODOS: As características nutricionais, clí...
Patients with systemic lupus erythematosus (SLE) may present nutritional changes triggered by disease or treatment, and these conditions may interfere with prognosis.
Assess the nutritional status, physical activity and associated factors in patients with SLE under treatment at the Service of Rheumatology of Hospital das Clínicas/Universidade Feder...
The objective of the study was to quantify plasma myeloperoxidase (MPO) levels in systemic lupus erythematosus (SLE) patients
and to evaluate a correlation between MPO levels and disease activity. 71 female SLE patients and 70 controls were studied.
Patients were divided into two groups: Group I (n=48) with SLEDAI-2K score 0–5 and Group II (n=23) w...
The progression of carotid atherosclerosis in lupus patients is frequently encountered, and it is determined by both traditional and nontraditional risk factors. Of the 181 patients initially included in the study, 157 patients were reevaluated after 39(37-42) months. The progression of atherosclerosis was defined as the increase in the intima-medi...
To determine the frequency of carotid plaque and intima-media thickness (IMT) in patients with systemic lupus erythematosus (SLE) and their association with risk factors in a Brazilian university setting. Carotid plaque and IMT were identified and measured by ultrasonography. Traditional risk factors and lupus-related factors were analysed. One hun...
Patients with systemic lupus erythematosus (SLE) have recognized reduction in endothelium-dependent vasodilation. Evidence demonstrates that statins are able to improve endothelial function independently on their hypolipemic action.
To evaluate the efficacy of atorvastatin in improving vasodilation in SLE patients with and without conventional risk...
INTRODUÇÃO: a patogênese da doença arterial coronariana no lúpus eritematoso sistêmico não está completamente estabelecida, porém fatores relacionados ao lúpus e ao seu tratamento parecem se associar à presença de fatores de risco tradicionais. Esses fatores de risco estão presentes em indivíduos com lúpus em uma freqüência maior em relação à popul...
INTRODUCTION: the pathogenesis of coronary disease in systemic lupus erythematosus patients is not completely understood. Risk factors associated with lupus or its treatment may be associated with traditional risk factors for coronary disease. Such risk factors are more common in patients with lupus. OBJECTIVE: to determine the frequency of cardiov...
The objective of this study is to determine the causes and predictors of death in systemic lupus erythematosus (SLE) patients. Causes of death were defined based on death certificates, medical records, and information collected from doctors and relatives. Possible variables predicting mortality were assessed by Kaplan-Meier and Cox regression metho...
