
Rosa Helena Veras MourãoFederal University of Western Pará · Laboratorio de Bioprospecção e biologia Experimental
Rosa Helena Veras Mourão
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Introduction
Publications
Publications (105)
Psidium acutangulum demonstrated promising results from its extracts for some biological activities, which may favor its use as herbal medicine. However, there is still a lack of research that identifies the chemical components of its essential oil. The present study aimed to evaluate the influence of climatic factors on the yield and the chemical...
Lippia alba (Mill.) N.E.Br. ex Britton & P. Wilson is an aromatic shrub native and not endemic to Brazil, popularly known as lemon balm, and widely used throughout Brazil in folk medicine. This study aimed to evaluate the influence of climatic parameters on the yield, radical-scavenging, and chemical composition of the L. alba essential oil. The sp...
Eugenia patrisii Vahl is a native and non-endemic myrtaceous species of the Brazilian Amazon. Due to few botanical and phytochemical reports of this species, the objective of the present work was to evaluate the seasonal variability of their leaf essential oils, performed by GC and GC-MS and chemometric analysis. The results indicated that the vari...
O fruto de Myrciaria dubia é rico em bioativos, este apresenta alto teor de ácido ascórbico e compostos fenólicos, por este motivo, o fruto vem ganhando destaque pela sua capacidade antioxidante. O objetivo deste estudo foi avaliar se diferentes extratos obtidos de cascas do fruto de M. dubia influencia na atividade antioxidante. Extratos hidroalco...
Differences in snake venom composition occur across all taxonomic levels and it has been argued that this variation represents an adaptation that has evolved to facilitate the capture and digestion of prey and evasion of predators. Bothrops atrox is a terrestrial pitviper that is distributed across the Amazon region, where it occupies different hab...
Riverine communities in the Brazilian Amazon region use a variety of plants to treat snakebites. These plants can be effective against secondary infections, one of the main complications of snakebites. The aim of this study was to determine whether plants traditionally used to treat snakebites in the Brazilian Amazon may also have antimicrobial and...
Pectis elongata is found in the northern and northeastern regions of Brazil. It is considered a lemongrass due to its citric scent. The remarkable citral content and the wide antimicrobial properties and bioactive features of this terpene make this essential oil (EO) eligible for several industrial purposes, especially in cosmetics and phytotherapi...
Aims: Pectis species, belonging to Asteraceae, are aromatic and medicinal herbaceous plants, distributed in the Americas, the West Indies, and the Pacific islands, with lemon, cumin, or oregano aroma, used in infusions to treat several diseases or as spices. Methodology: In this study, the composition of Pectis elongata from the Amazon was correlat...
This work analyzed the chemical compositions and evaluated the antioxidant and cytotoxic activities of essential oils (EO) of Eugenia patrisii (Epat), Eugenia stipitata (Esti), Myrcia splendens (Mspl), Myrcia sylvatica (Msyl), Psidium guajava (Pgua), and Psidium guineense (Pgui-1 and Pgui-2) from the Brazilian Amazon. Sesquiterpenoids were found in...
Aniba rosiodora has been exploited since the end of the nineteenth century for its essential oil, a valuable ingredient in the perfumery industry. This species occurs mainly in Northern South America, and the morphological similarity among different Aniba species often leads to misidentification, which impacts the consistency of products obtained f...
A true sustainable and ecofriendly concept of utilization of natural products must involve not only the obtain-ment of plant material in consonance with biodiversity preservation, but also the potential lower risk to the environment and lower consume of energy in the transformation of the plant into novel products. We therefore describe an elegant...
This study investigated the acute toxicity (LC50-24 hr) effects of the essential oil of
Cymbopogon citratus for adult Argulus sp. and Dolops discoidalis, before and during
oviposition. In vitro acute toxicity (LC50-24 hr) was tested using 20, 40, 60, 80, 100,
120, 140 and 160 μg/L of C. citratus essential oil, and two control groups (one with
culti...
Oil in water nano-emulsions are drug delivery systems constituted by liquid lipophilic nano-droplets dispersed through the external aqueous phase, often reaching the kinetic stability with surfactant as stabilizers. Essential oils can be the oily phase or the source of bioactive compounds. In this study, the essential oil of Aeollanthus suaveolens―...
This study aimed to evaluate the sedative and anesthetic potential of the essential oil (PHEO) and hydrolate (PHH) from the fruit of Protium heptaphyllum and the isolated compounds (IC) of PHEO in tambaqui (Colossoma macropomum) juveniles. Fish were placed in aquaria with different concentrations of PHEO, PHH or IC (sabinene, terpinen-04-ol, γ-terp...
The objective of this work was to evaluate the use of Myrcia sylvatica Hydrolate (MSH) as a sedative under conditions of simulated transport of Colossoma macropomum juveniles. Simulated a 17 h transport of the load densities 30, 60, and 90 fish/L, with 2.5%, 5%, and 7.5% MSH and water-only control (W.C.). There was no significant difference in surv...
Ethnopharmacological relevance
In the region of Western Pará, Amazonia, Brazil, Philodendron megalophyllum is widely used for the treatment of envenomations caused by bites from venomous snakes. The traditional use of plants is usually done through oral administration of an infusion (decoction) soon after the bite occurs. The efficiency of aqueous...
Psidium guineense (Myrtaceae) tem grande potencial econômico e medicinal. Este trabalho avaliou a composição química, atividade antioxidante e citotóxica do óleo essencial de um espécime de Psidium guineense coletado em Curuçá-PA. O óleo essencial foi obtido por hidrodestilação (3h) e sua composição química analisada por CG-EM. A atividade antioxid...
The objective of this study was to evaluate the efficacy of the citral chemotype of Lippia alba essential oil (EOLA) as an additive in a simulated transport with different loading densities of tambaqui (Colossoma macropomum) juveniles. Simulated transport of tambaqui juveniles at three loading densities (30, 60 and 90 fish/L) was carried out either...
Passiflora nitida Kunth. (maracujá-do-mato) é uma espécie nativa do Brasil com ocorrência nas regiões norte, nordeste e centro-oeste. O seu fruto é consumido principalmente in natura, sendo pouco explorado quanto as suas propriedades funcionais. O objetivo deste estudo, foi extrair substâncias pécticas do mesocarpo de Passiflora nitida Kunth. O mes...
The essential oil of Eugenia uniflora has been attributed anti-depressive, antinociceptive, antileishmanial, larvicidal, antioxidant, antibacterial, and antifungal activities. It is known that the cultivation of this plant can be affected by seasonality, promoting alteration in the oil composition and its biological activities. This study aims to p...
Essential oils of Psidium species were obtained by hydrodistillation, the
composition of the oils was analyzed by GC and GC-MS and the antioxidant activity
evaluated by the DPPH method. The P. acutangulum (PA-01 and PA-02), P. guineense
(PG-01 to PG-06) and P. guajava (PGU-01 to PGU-06) were collected from different
locations at Pará state. In the...
Essential oils of Psidium species were obtained by hydrodistillation, the
composition of the oils was analyzed by GC and GC-MS and the antioxidant activity
evaluated by the DPPH method. The P. acutangulum (PA-01 and PA-02), P. guineense
(PG-01 to PG-06) and P. guajava (PGU-01 to PGU-06) were collected from different
locations at Pará state. In the...
Lippia alba (Mill.) N.E.Br. ex Britton & P. Wilson, Verbenaceae, is considered a great source of a bioactive volatile oil. Due to the wide range of known chemotypes, its chemical analysis is very important. Among the several activities of this volatile oil, a potential larvicidal action against Culicidae species is highlighted. However, the low wat...
The aim of this study was to investigate the anesthetic effect of the essential oils (EOs) of Lippia alba (citral and linalool chemotypes, EOLA-C and EOLA-L respectively) and Lippia origanoides (chemotype carvacrol, EOLO-Ca) on tambaqui (Colossoma macropomum) juveniles. The tested concentrations of the L. alba and L. origanoides EOs were: 25, 50, 1...
Variability in snake venom composition has been frequently reported and correlated to the adaptability of snakes to environmental conditions. Previous studies report plasticity for the venom phenotype. However, these observations are not conclusive, as the results were based on pooled venoms, which present high individual variability. Here we teste...
In Brazil, the infusion from leaves of Lippia alba (Verbenaceae), popularly known as Erva-cidreira, is used for the treatment of infections, digestive disorders, cough, asthma, colds and anxiolytic, among others. It has been used in phytotherapy practices of communities of Santarém, Pará State, Brazil, cultivated in a public program of medicinal pl...
The use of natural products, such as essential oils (EOs), is a potential novel approach to treat fish bacterial infections with a lower risk of developing resistance. There has been a number of studies reporting the activity of EOs as those obtained from the species Achyrocline satureioides, Aniba parviflora, Aniba rosaeodora, Anthemis nobilis, Co...
Ethnopharmacological relevance
Oils and extracts of Eugenia uniflora have been reported as antimicrobial, antifungal, antinociceptive, antiprotozoal, antioxidant and cytotoxic.
Aim of the study
The oils of five specimens (E1 to E5) that occur in the Brazilian Amazon were extracted, analyzed for their chemical composition, and submitted to antioxid...
Anesthetics are effective to reduce or minimize stress in handling operations related to fish cultures. Aiming to avoid residual effects of synthetic drugs, several natural agents, such as essential oils (EOs), have been tested. The aim of this study was to determine the optimal concentration of the EO of Ocimum micranthum for induction of anesthes...
In teleost fish, stress initiates a hormone cascade along the hypothalamus-pituitary-interrenal (HPI) axis to provoke several physiological reactions in order to maintain homeostasis. In aquaculture, a number of factors induce stress in fish, such as handling and transport, and in order to reduce the consequences of this, the use of anesthetics has...
The extracts of Plathymenia reticulata and Connarus favosus are widely used in the folk medicine. The potential protective effects of these extracts have been evaluated against cadmium in the yeast Saccharomyces cerevisiae, and against mercurial contamination in zebrafish Danio rerio. In yeast, both extracts efficiently protected the Δycf1 mutant s...
The study aimed to establish the lethal concentration at 96 h (LC50-96h) of hydrolate of Lippia alba (citral chemotype) (LAH) in juvenile tambaqui (Colossoma macropomum), as well as to identify the anaesthetic induction and recovery times. The acute toxicity test LC50-96h was performed in five animals per replicate (three replicates per treatment)....
Introduction: Ethnobotanical studies report that Myrcia guianensis (Myrtaceae), belonging to a group of plants known as pedrá-ume-caá or insulin plant, is used as a tea to treat various diseases, including diabetes, a metabolic disorder that leads to the constant production of free radicals. The objective of this work was to determine the antioxida...
This study investigated the efficacy of essential oils of Lippia alba (EOLA) citral chemotype and Lippia origanoides (EOLO) and their effects on ventilatory frequency (VF) of silver catfish, Rhamdia quelen. Fish were exposed to 50-300 µL L−1 of EOLA and 25-300 µL L−1 of EOLO to determine induction times to sedation, anesthesia, and recovery. Moreov...
Lippia alba is a flowering shrub in the verbena family and its essential oil (EO) is known for its sedative, antidepressant and analgesic properties. In the Amazon region of Brazil, it is used in aquaculture to anesthetize fish during transport. Many of the specialized metabolites found in EOs presumably evolved to protect plants from herbivores, e...
Background: Psidium guineense, known as Araçá, is a Brazilian botanical resource with commercial application
perspectives, based on the functional elements of its fruits and due to the use of its leaves as an anti-inflammatory
and antibacterial agent. The essential oils of leaves of twelve specimens of Araçá were analyzed by GC and GC-MS to
identif...
Myrcia sylvatica (G. Mey.) DC., Myrtaceae, is an aromatic species that occurs in savanna areas of the Lower Amazon River, Brazil. Its essential oil showed an excellent yield, presenting a moss green coloration and a woody and spicy scent. The seasonal and circadian study of the leaf oils and the analysis of oil composition of the fruits were perfor...
The effects of pre-transport handling and addition of essential oil of Myrcia sylvatica (EOMS) during transport on stress pathways activation in Rhamdia quelen were investigated. Fish (n = 400, 25.2 ± 2.9 g) were captured in production ponds and transferred to 100-L tank (density 100 g L− 1). After 24 h, 10 fish were sampled (before transport group...
Significance:
Analysis of individual transcripts and venom protein isoforms produced by specimens of a venomous snake (Bothrops atrox), from the Brazilian Amazon rainforest, revealed that transcriptional and translational mechanisms contribute to venom phenotypic variation. Our finding of evidence for high expression of toxin proteins with conserv...
The effects of diet supplemented with Myrcia sylvatica essential oil (EOMS) on growth and stress tolerance to different stocking densities were assessed in Sparus aurata. Initially, three experimental groups were established: i) control, ii) 1.0 and iii) 2.0 mL EOMS kg dry feed-1. After 90 days, nine fish per group were anesthetized, weighed and sa...
The viability using Lippia alba essential oil as an anesthetic for fish was studied, particularly with respect to physiological effects during recovery. Anesthesia of silver catfish (Rhamdia quelen) using 100 and 300 μL L⁻¹ of two different chemotypes of L. alba essential oil (citral EO-C and linalool EO-L) prevented the increase of plasma cortisol...
The goal of this study was to investigate the sedative and anesthetic properties of essential oils (EOs) in map treefrog tadpoles (Hypsiboas geographicus) and to determine the sedation and deep anesthesia induction times as well as the recovery time. The tadpoles were exposed to one of the EOs from three plant species: Aniba rosaeodora (EOAR - 25,...
Ethnopharmacological relevance:
Extracts of leaves and bark of Aniba fragrans are used as tea (decoction) to treat snakebites in communities in the Brazilian Amazon. The aqueous extract of the leaves of A. fragrans has been proven to be effective against Bothrops venom, but only when pre-incubated with the venom. This study sought to assess the po...
Copaifera multijuga Hayne, Fabaceae, is a tree species Amazonian known as “mari mari” or “copaíba roxa”. Its oil-resins are popularly used for various medicinal purposes, especially as anti-inflammatory. The aims of this study were: determine the viscosity of the oil-resins and analyze the chemical composition of the essential oils from oils-resins...
Lippia alba hydrolate (LAH) is produced as a secondary product in essential oil extraction. The objective of this study was to evaluate the use of LAH in a simulation of the transport of tambaqui (Colossoma macropomum) juveniles. A series of 17 hr simulations were performed using load densities of 30, 60 and 90 juveniles per L and four LAH concentr...
We present an extensive study of the optical properties of Myrcia sylvatica essential oil with the goal of investigating the suitability of its material system for uses in organic photovoltaics. The methods of extraction, experimental analysis, and theoretical modeling are described in detail. The precise composition of the oil in our samples is de...
Bothrops atrox snakes are the leading cause of snake bites in Northern Brazil. The venom of this snake is not included in the antigen pool used to obtain the Bothrops antivenom. There are discrepancies in reports on the effectiveness of this antivenom to treat victims bitten by B. atrox snakes. However, these studies were performed using a pre-incu...
Biological significance:
In this report, we compared isoforms present in venoms from snakes collected at different Amazonian habitats. By means of a species venom gland transcriptome and the in silico functional prediction of each isoform, we were able to predict the principal venom activities in vitro and in animal models. We also showed remarkab...
Ethnopharmacological importance:
The hemiparasitic species Psittacanthus plagiophyllus Eichl. (Loranthaceae), also known as erva de passarinho, is used in folk medicine in the Santarém region in the state of Pará, Brazil, to treat gastritis and a variety of inflammatory disorders. In view of the lack of pharmacological studies on this species in t...
The aim of this study was to evaluate if Lippia alba has different chemotypes according to the chemical composition of the essential oil (EO) considering collection site, and if the EO may have different effects on blood and plasma parameters in silver catfish, Rhamdia quelen, during and immediately after anesthesia. The citral (EO-C) and linalool...
Essential oils (EO) from leaves and branches of Nectandra puberula Schott (Nees) and from leaves of N. cuspidata Nees & Mart. were obtained by hydrodistillation and their chemical compositions determined by gas chromatography - mass spectrometry (GC-MS). The main compounds identified from N. puberula EO were apiole (22.2%), β-caryophyllene (15.1%),...
Objective:
To investigate the effects of rapid anesthesia and long-term sedation with the essential oils (EOs) of Myrcia sylvatica (EOMS) and Curcuma longa (EOCL) on biochemical and oxidative parameters in matrinxã.
Study design:
Prospective, randomized, laboratory experiment.
Animals:
A total of 72 matrinxã (Brycon amazonicus) adults weighing...
Ethnopharmacological importance:
The effectiveness of aqueous extract of Bellucia dichotoma Cogn. (Melastomataceae) specimems collected in Santarém, PA, against some biological activities of Bothrops atrox venom (BaV) has been scientifically proven. Here, we analyzed the components and assessed the anti-snakebite potential of aqueous extracts of b...
Parasitic diseases have an enormous health and economic impact and are a particular problem in tropical regions of the world. Disease caused by protozoa, such as trypanosomiasis, are the cause of most parasite related morbidity and mortality. Thus, the aim of this study was to verify the trypanocidal effectiveness of Lippia alba and Lippia origanoi...
Anaesthetic substances are necessary to reduce fish stress during aquaculture activities. The objectives of this study were: (i) to determine the efficacy of essential oils (EOs) of Myrcia sylvatica (EOMS) and Curcuma longa (EOCL) as anaesthetics for Colossoma macropomum and (ii) to evaluate the effects of rapid anaesthesia and long-term sedation (...
Background:
Myrcia amazonica. DC is a species predominantly found in northern Brazil, and belongs to the Myrtaceae family, which possess various species used in folk medicine to treat gastrointestinal disorders, infectious diseases, and hemorrhagic conditions and are known for their essential oil contents.
Materials and methods:
This study aimed...
Psittacanthus plagiophyllus (Loranthaceae) e uma das especies utilizadas no distrito de Alter do Chao, Santarem - PA, para o tratamento de gastrite. Levando em consideracao o uso popular desta especie, aliado a ausencia de estudos farmacologicos e a sua grande disponibilidade nas savanas de Alter do Chao, o objetivo deste trabalho foi investigar o...
Curcuma longa L. produces rhizomes traditionally sold on the international market as "Turmeric". It is a shrub from Asia, extensively cultivated in India, China, Japan and Indonesia. In Brazil, it is known as "Curcuma" or "Acafrao" and mainly used for food. The aim of this study was to evaluate the plant growth, depending on the incidence of light...
Mikania laevigata (Asteraceae) is popularly used in the treatment of respiratory diseases, including asthma, bronchitis, and cough. In Brazil, guaco extracts are used as medicinal products authorized by the National Health Surveillance Agency (ANVISA). In the study, it was evaluated the adaptation and the influence of the seasonal variation of guac...
The plants of the genus Salacia are commonly used in the treatment of diabetes tipe-2, in several countries of the world. The phytochemical study of the stem of Salacia impressifolia led to the isolation and identification of seven compounds. The compounds include the steroids sitosterol and 3-O-β-D-glucopyranosyl sitosterol, of the coumarin isosco...
Lippia origanoides Kunth from Northeast Brazil is a plant of pleasant odor used by local people as a food seasoning in substitution the oregano where its carvacrol-rich oil has showed significant antimicrobial activity against human pathogens.
GC and GC-MS analyzed the plant oil composition and its antibacterial activity was evaluated by disk diffu...
Rosewood has two plant sources: Aniba rosaeodora Ducke and Aniba parviflora (Meiss.) Mez. It is distributed in all Amazon regions, including Brazil, Guyana, Suriname, Peru, Colombia, and Venezuela. Rosewood oil has a characteristic aroma and is a long-established ingredient used in fragrances and food products. This colorless to pale-yellow oil pre...
Aquaculture activities promote stress situations that decrease fish welfare. In this sense, the objective of this study was to evaluate the effects of adding essential oil of Myrcia sylvatica (EOMS), a substance that has been used to mitigate activation of stress system in other teleost, in the diet of gilthead sea bream (Sparus aurata). Juveniles...
Aquaculture practices include several procedures as capture, handling and transport, which cause stress in fish. Anesthetics or sedative substances have been used to reduce this stress. The aim of this study was to evaluate the effects of essential oil of Myrcia sylvatica (EOMS) in the water on stress system activation in the silver catfish Rhamdia...