Roni A Setton

Harvard University | Harvard

The default network is widely implicated as a common neural substrate for self-generated thought, such as remembering one's past (autobiographical memory) and imagining the thoughts and feelings of others (theory of mind). Findings that the default network comprises subnetworks of regions - some commonly and some distinctly involved across processe...

Resting-state functional magnetic resonance imaging (fMRI) investigations have provided a view of the default network (DN) as composed of a specific set of frontal, parietal, and temporal cortical regions. This spatial topography is typically defined with reference to an influential network parcellation scheme that designated the DN as one of seven...

Aging comes with declines in episodic memory. Memory decline is accompanied by structural and functional alterations within key brain regions, including the hippocampus and lateral prefrontal cortex, as well as their affiliated default and frontoparietal control networks. Most studies have examined how structural or functional differences relate to...

Several studies have shown that older adults generate autobiographical memories with fewer specific details than younger adults, a pattern typically attributed to age-relate declines in episodic memory. A relatively unexplored question is how aging affects the content used to represent and recall these memories. We recently proposed that older adul...

The neuroscience of creativity seeks to disentangle the complex brain processes that underpin the generation of novel ideas. Neuroimaging studies of functional connectivity, particularly functional magnetic resonance imaging (fMRI), have revealed individual differences in brain network organization associated with creative ability; however, much of...

Autobiographical memory (AM) involves a rich phenomenological re-experiencing of a spatio-temporal event from the past, which is challenging to objectively quantify. The Autobiographical Interview (AI; Levine et al. Psychology and Aging, 17(4), 677-689, 2002) is a manualized performance-based assessment designed to quantify episodic (internal) and...

Global signal fluctuations are a dominant source of variance in spontaneous BOLD activity. These brain-wide signals co-occur with respiratory and other physiological changes. An often overlooked possibility is that these physiological associations with global BOLD fluctuations are components of a unified physiological process. Here we combine analy...

Loneliness is associated with differences in resting-state functional connectivity (RSFC) within and between large-scale networks in early- and middle-aged adult cohorts. However, age-related changes in associations between sociality and brain function into late adulthood are not well understood. Here, we examined age differences in the association...

Recollection of one’s personal past, or autobiographical memory (AM), varies across individuals and across the life span. This manifests in the amount of episodic content recalled during AM, which may reflect differences in associated functional brain networks. We take an individual differences approach to examine resting-state functional connectiv...

Central to understanding human behavior is a comprehensive mapping of brain-behavior relations within the context of lifespan development. Reproducible discoveries depend upon well-powered samples of reliable data. We provide to the scientific community two, 10-minute, multi-echo functional MRI (ME-fMRI) runs, and structural MRI (T1-MPRAGE), from 1...

The intrinsic functional organization of the brain changes into older adulthood. Age differences are observed at multiple spatial scales, from global reductions in modularity and segregation of distributed brain systems, to network-specific patterns of dedifferentiation. Whether dedifferentiation reflects an inevitable, global shift in brain functi...

Recollection of personal past events differs across the lifespan. Older individuals recall fewer episodic details and convey more semantic information than young. Here we examine how gray matter volumes in temporal lobe regions integral to episodic and semantic memory (hippocampus and temporal poles, respectively) are related to age differences in...

White matter hyperintensities (WMH) are among the most prominent structural changes observed in older adulthood. These changes coincide with functional changes to the intrinsic network organization of the aging brain. Yet little is known about how WMH are associated with changes to the whole-brain functional connectome in normal aging. We used a le...

Autobiographical memory (AM) involves a rich phenomenological re-experiencing of a spatio-temporal event from the past, which is challenging to objectively quantify. The Autobiographical Interview (AI; Levine et al., 2002, Psychology & Aging) is a manualized performance-based assessment designed to quantify episodic (internal) and semantic (externa...

Positions of power involving moral decision-making are often held by older adults (OAs). However, little is known about age differences in moral decision-making and the intrinsic organization of the aging brain. In this study, younger adults (YAs; n = 117, Mage = 22.11) and OAs (n = 82, Mage = 67.54) made decisions in hypothetical moral dilemmas an...

The Survey of Autobiographical Memory (SAM) was designed as an easy-to-administer measure of self-perceived autobiographical memory (AM) recollection capacity. We provide a comprehensive psychometric evaluation of the SAM in younger and older adults. First, we evaluated the reliability of the SAM as a measure of self-perceived recollective capacity...

Neuronal variability patterns promote the formation and organization of neural circuits. Macroscale similarities in regional variability patterns may therefore be linked to the strength and topography of inter-regional functional connections. To assess this relationship, we used multi-echo resting-state fMRI and investigated macroscale connectivity...

The intrinsic network architecture of the brain is continuously shaped by biological and behavioral factors from younger to older adulthood. Differences in functional networks can reveal how a lifetime of learning and lived experience can alter large-scale neurophysiological dynamics, offering a powerful lens into brain and cognitive aging. Quantif...

Poor estimation of one's future actions has been associated with the influence of reward over executive control processes during prospection. However, the neural mechanisms underlying this reward-control trade-off remain poorly understood. In the present study, we take advantage of projection bias, underestimating how motivations will change in the...

As we age, the architecture of cognition undergoes a fundamental transition. Fluid intellectual abilities decline while crystalized abilities remain stable or increase. This shift has a profound impact across myriad cognitive and functional domains, yet the neural mechanisms remain under-specified. We have proposed that greater connectivity between...

Background: Age-related brain changes leading to altered socioemotional functioning may increase vulnerability to financial exploitation. If confirmed, this would suggest a novel mechanism leading to heightened financial exploitation risk in older adults. Development of predictive neural markers could facilitate increased vigilance and prevention....

We present the basic tenets of fuzzy trace theory, a comprehensive theory of memory, judgment, and decision making that is grounded in research on how information is stored as knowledge, mentally represented, retrieved from storage, and processed. In doing so, we highlight how it is distinguished from traditional models of decision making in that g...

The Clinic for Special Children (CSC) has integrated biochemical and molecular methods into a rural pediatric practice serving Old Order Amish and Mennonite (Plain) children. Among the Plain people, we have used single nucleotide polymorphism (SNP) microarrays to genetically map recessive disorders to large autozygous haplotype blocks (mean = 4.4 M...