Ronaldo Thomatieli-Santos

Universidade Federal de São Paulo | UNIFESP · Departamento de Biociências

Vitiligo is an autoimmune disease characterized by progressive skin depigmentation and the appearance of white patches throughout the body caused by significant apoptosis of epidermal melanocytes. Despite not causing any physical pain, vitiligo can originate several psychosocial disorders, drastically reducing patients' quality of life. Emerging ev...

Abstract: Background: This proposal aims to explain some of the gaps in scientific knowledge on the natural history of coronavirus disease (COVID-19), with a specific focus on immune, inflammatory, and metabolic markers, in parallel with temporal assessment of clinical and mental health in patients with COVID-19. The study will explore the temporal...

Macrophages are one of the top players when considering immune cells involved with tissue homeostasis. Recently, increasing evidence has demonstrated that these macrophages could also present two major subsets during tissue healing; proliferative macrophages (M1-like), which are responsible for increasing myogenic cell proliferation, and restorativ...

Exploring the relationship between exercise inflammation and the peripheral neuroendocrine system is essential for understanding how acute or repetitive bouts of exercise can contribute to skeletal muscle adaption. In severe damage, some evidence demonstrates that peripheral neuroendocrine receptors might contribute to inflammatory resolution, supp...

Factors linked to modern lifestyles, such as physical inactivity, Western diet, and poor sleep quality have been identified as key contributors to the positive energy balance (PEB). PEB rises adipose tissue hypertrophy and dysfunction over the years, affecting cells and tissues that are metabolically critical for energy homeostasis regulation, espe...

The present study aimed to verify the effects of caffeine supplementation on psychobiological parameters and its relationship with inflammatory cytokines in non-athlete subjects. We hypothesized that IL-10 may be responsible for the reduction in fatigue perception in response to caffeine supplementation. It was a randomized, double-blinded, cross-o...

(1) Purpose: Performing strenuous exercises negatively impacts the immune and gastrointestinal systems. These alterations cause transient immunodepression, increasing the risk of minor infections, especially in the upper respiratory tract. Recent studies have shown that supplementation of probiotics confers benefits to athletes. Therefore, the obje...

Objectives: Coronavirus disease 2019 (COVID-19) emerged and rapidly spread worldwide. Several countries have imposed lockdown and isolation in attempt to mitigate viral spread. However, social isolation has a negative effect on psychological aspects, increasing stress, fear, anxiety, anger and emotional disturbance, as well as affecting sleep patt...

The rating of perceived exertion (RPE) indicates the feeling of fatigue. However, hypoxia worsens the condition and can worsen RPE. We evaluated whether carbohydrate and glutamine supplementation alters RPE and physiological markers in running at 70% peak oxygen uptake until exhaustion in a simulated altitude of 4500 m. Nine volunteers underwent th...

Background: Rating of Perceived Exertion (RPE) is a subjective scale to monitor overload and fatigue during exercise. Hypoxia may worsen the perception of fatigue, compromising the self-reported perception of effort and increasing RPE. The objective was to evaluate the effects of carbohydrate (CHO) supplementation on RPE during exercise in hypoxia...

The world is experiencing a severe new pandemic, in which the elderly afflicted with chronic diseases are the most affected. The aging of the immune system (immunosenescence) reduces its efficacy against viral infections and increases its susceptibility to repeated acute infections, such as the flu. The improvement of the immune system functioning...

Abstract Probiotic supplementation arises as playing an immune-stimulatory role. High-intensity and -volume exercise can inhibit immune cell function, which threatens athletic performance and recovery. We hypothesized that 30 days of probiotic supplementation could stabilize the immune system of athletes preventing immune suppression after a marath...

To evaluate the influence of curcumin supplementation on the glycemic profile, inflammatory markers, and oxidative stress in HIV‐infected individuals under antiretroviral therapy. This double‐blind, crossover, randomized clinical trial was composed of 20 subjects arranged initially into experimental group (n = 10) and placebo group (n = 10) groups,...

Our aim was to analyze and compare functional training, interdisciplinary therapy, and interdisciplinary education on cardiorespiratory fitness (CF) and anthropometric characteristics of women with obesity. Forty-four women (age = 39.7 ± 5.9 years, body mass index (BMI) = 35.5 ± 2.8 kg/m2) completed 30 weeks of intervention randomly assigned to 3 g...

Objectives: The aim of this study was to evaluate the combined effects of carbohydrate (CHO) and glutamine (Gln) supplementation on cytokine production by monocytes after exercise until exhaustion performed in hypoxia. Methods: Fifteen physically active men underwent three exercises until exhaustion with an intensity of 70% maximal oxygen intake...

Macrophages are one of the most versatile cells of the immune system, which can express distinct subtypes and functions depending on the physiological challenge. After skeletal muscle damage, inflammatory macrophages subtypes aids muscles to regeneration and are implicate on physical training adaption. Based on this, this study aimed to evaluate tw...

Background: Scientific studies have shown that the potential therapeutic efficacy of curcumin in several diseases is due to its potent antioxidant and anti-inflammatory properties. Consequently, curcumin supplementation seems to be a valuable alternative for HIV-infected individuals. The aim of this study is to evaluate the influence of curcumin s...

Introduction and objective: Moderate exercise performed in normoxia can be immunostimulatory while strenuous exercise can be immunosuppressive. However less is known about the effects of exercise under hypoxia on cytokines. The aim of this study was to evaluate the effects of an acute exercise session performed under hypoxia similar to an altitude...

Obese individuals present adverse changes in the diversity and composition of the gut microbiota, leading to alterations in energy balance, lipid metabolism, endocrine disturbances, and low-grade chronic systemic inflammation increases. Probiotic supplementation appears to change gut microbiota by decrease gut permeability, inflammation, and metabo...

Introduction: Physical exercise at high altitude has become constant. However, the risks associated with this type of exercise represent a major concern, considering the influence of important stressors such as hypoxia and physical exercise on psychobiological and physiological responses. Objective: Analyze the mood state and behavior of physiolog...

Purpose The relationship between inflammatory markers and energetic metabolism has been explored. However, the relationship between exercise intensity and fitness status is unclear, and it is necessary to understand this relationship to apply specific exercise guidance. The purpose of the study was to analyze metabolic and inflammatory responses im...

Obstructive sleep apnoea (OSA) is positively associated with cardiometabolic diseases; however, high levels of physical activity could decrease the incidence of OSA and associated comorbidities. In this study we aimed to examine the incidence of OSA in relation to physical activity, and its role as a protective factor in individuals with OSA on the...

This work evaluated the effects of moderate physical exercise performed under hypoxic conditions on melatonin and sleep. Forty healthy men were randomized into four groups: Normoxia (N) (n = 10); Hypoxia (H) (n = 10); Exercise under Normoxia (EN) (n = 10); and Exercise under Hypoxia (EH) (n = 10). The observation period for all groups was approxima...

The ingestion of branched-chain amino acids (BCAAs) has been pointed as having controversial effects on cardiovascular diseases (CVD) and energy metabolism, is unknow if sprint interval training (SIT) has a synergist effect when associated with BCAA supplementation. The purpose of this study was to evaluate the effects of BCAA supplementation assoc...

Introduction: In general, in obese people a state of hyperleptinemia may impair both energy balance and the inflammatory process. However, it has not been fully investigated whether there is a relationship between hyperleptinemia and cardiorespiratory fitness (CRF) and resting energy expenditure (REE), in obese women. Methods: 83 obese women wer...

Study design: Experimental and cross-sectional study. Objective: To assess the immediate effect of exercise on heart rate (HR), oxygen uptake (VO2), pulmonary ventilation (PV), oxygen pulse (OP), glucose and lipids of wheelchair basketball players with spinal cord injury (SCI). Setting: Center of Studies in Psychobiology and Exercise-São Paulo...

This study analyzed the effects of carbohydrate and glutamine supplementation on salivary immunity after exercise at a simulated altitude of 4500 m. Fifteen volunteers performed exercise of 70% of VO2peak until exhaustion and were divided into three groups: hypoxia placebo, hypoxia 8% maltodextrin (200 mL/20 min), and hypoxia after six days glutami...

After severe skeletal muscle damage, communication between inflammatory macrophages, myogenic cells, and modulatory secretion factors is essential to induce re-establishment of skeletal muscle structure. To analyze when characteristic gene expression of macrophages, myogenic cells, and SLPI are modulated after an exercise-induced muscle damage (EIM...

Background Hypoxia and high altitudes affect various organs, which impairs important physiological functions, such as a disruption of the intestinal barrier mediated by increased translocation of bacteria and increased circulating endotoxin levels. Physical exercise can alter endotoxin concentration in normoxia. The aim of this study is to evaluate...

Qi Gōng is a type of exercise that involves meditation and is used for health. With a background from the martial arts, it is known also as an auto healing exercise with three main elements according to Traditional Chinese Medicine (TCM): body focus (posture and movement), breathing and mind focus (meditative elements). Heart rate variability is a...

Purpose: We sought explore the effects of doxorubicin on sleep patterns and locomotor activity. To investigate these effects, two groups were formed: a control group and a Doxorubicin (DOXO) group. Methods: Sixteen rats were randomly assigned to either the control or DOXO groups. The sleep patterns were examined by polysomnographic recording and lo...

Introduction: Exercise performed at the hypoxia equivalent of an altitude of 4200 m is associated with elevated inflammatory mediators and changes in the Th1/Th2 response. By contrast, supplementation with carbohydrates has an anti-inflammatory effect when exercise is performed under normoxic conditions. The objective of this study was to evaluate...

Exposure to hypoxia causes damage in several physiological systems, whose tissues are dependent on the O2 supply. Recently, there has been growing attention on the immunosuppressive and inflammatory potential of the hypoxia, including stimulation, nuclear factor kappa B pathway in macrophages and Th2 response from lymphocytes. These changes may res...

Background: The Dark chocolate (DC) is abundant in flavanols that exert benefits to cardiovascular system is well known to anti degenerative and antithrombotic actions. Complementarily the physical exercise has been shown to mobilization substrates with positive influence in lipid profile and decrease the cardiometabolic risk in prehypertension sub...

Background: Exercise under hypoxic conditions represents an additional stress in relation to exercise in normoxia. Hypoxia induces oxidative stress and inflammation as mediated through tumour necrosis factor (TNF)-α release that might be exacerbated through exercise. In addition, vitamin E supplementation might attenuate oxidative stress and infla...

White adipose tissue (WAT) plays a fundamental role in maintaining energy balance and important endocrine functions. The loss of WAT modifies adipokine secretion and disrupts homeostasis, potentially leading to severe metabolic effects and a reduced quality of life. Doxorubicin is a chemotherapeutic agent used clinically because of its good effecti...

CT mean of constitutive. Gene expression of ribosomal protein L19 (Rpl19) at 24 hours, 96 hours and 12 days after induction of cell differentiation in 3T3L1 cells treated with 1uM of doxorubicin. The gene expression was evaluated by real time PCR. Data are mean ± standard deviation of 4 to 6 experiments. Two way ANOVA followed by Bonferroni post te...

RNA analysis by agarose gel electrophoresis. mRNA analysis by 2% agarose gel electrophoresis visualized by ethidium bromide staining of 3T3L1 cells treated with 1uM of doxorubicin at 24 hours, after induction of cell differentiation. Figure represents 4 experiments per group. (TIFF)

The aim of this study was to identify the possible association between biochemical markers of exercise addiction and affective parameters in a sample of athletes during 2 weeks of withdrawal exercise. Eighteen male runners were distributed into a control group (n = 10) composed of runners without exercise addiction symptoms and an exercise addictio...

Macrophages are cells of the innate immune response which trigger inflammation resolution. The phenotype of “classically activated macrophages” (M1), has anti-tumoricidal, anti-bactericidal activity. On the other hand, “alternatively activated macrophages” (M2) are involved in tissue remodelling and immunomodulatory functions. The change in the pol...

A current trend in materials processing is the synthesis of high-reactivity powders with a particle size averaged at the nanoscopic scale. This is normally achieved by considering chemical routes that allow processing of the materials at temperatures markedly lower than those required in the conventional method. Here we introduce a simple but novel...

If there is an incompatibility in the training load planned by the coach with that perceived by the athlete, the chances of development of the overtraining syndrome increase. This study investigated the correspondence the perceived internal training load of wheelchair basketball players with training load planned by the coach, over a period of five...

Sarcopenia is a geriatric condition that comprises declined skeletal muscle mass, strength and function, leading to the risk of multiple adverse outcomes, including death. Its pathophysiology involves neuroendocrine and inflammatory factors, unfavorable nutritional habits and low physical activity. Sleep may play a role in muscle protein metabolism...

During hypoxia conditions, psychological states can be worsened. However, little information is available regarding the effect of physical exercise performed in hypoxia conditions on mood state and anxiety symptoms. The aim of the present study was to elucidate the acute effect of moderate physical exercise performed at hypoxia on mood states and a...

Objective This study evaluated the effect of carbohydrate and/or glutamine supplementation on the immune system and inflammatory parameters after exercise in hypoxic conditions at 4,500m. Methods Nine male underwent three sessions of exercise at 70% VO2peak until exhaustion as follows: (1)hypoxia with a placebo, (2)hypoxia with 8% maltodextrin (20...

O rápido crescimento do basquetebol em cadeira de rodas no cenário Paralímpico tem despertado atenção para a melhora nos níveis de desempenho esportivo. A utilização de ferramentas avaliativas relacionadas ao desempenho esportivo, que auxiliem no acompanhamento dos atletas e no planejamento do treinamento, se torna de grande importância. Entre tant...

Macrophages are one of the most heterogenic immune cells involved in skeletal muscle regeneration. After skeletal muscle damage, M1 phenotypes exhibit pro-inflammatory reaction. In a later stage, they are converted to M2 phenotypes with anti-inflammatory properties. To study when gene expressions of macrophage polarization are changed after damage...

The aim of this study was to evaluate the effects of moderate aerobic exercise training on sleep, depression, cortisol, and markers of immune function in patients with chronic primary insomnia. Twenty-one sedentary participants (16 women aged 44.7 ± 9 years) with chronic primary insomnia completed a 4-month intervention of moderate aerobic exercise...

Background & Aim Dyslipidemia is involved with in development of cardiovascular diseases and obesity, exercise is recommended as a successful intervention. Dietary L-arginine (L-arg) supplementation may improve in lipid metabolism. However, these combined strategies on lipid profile were not tested yet. This study examines the effects of short term...

Apresentação de dados em congresso paralímpico, mostrando que o aumento de capacidade aeróbia não está necessariamente relacionado com melhora na composição corporal de atletas de basquetebol em cadeira de rodas.

The present study reports the results of thick films (20-130 µm) produced through electrophoretic deposition of BaTi0.85Zr0.15O3 (BTZ) nanometric powders synthesized by the Pechini's method. The BTZ powderscalcined at 600°C/2h presented a single crystalline phase with an average particle size of ~20nm. To thick films deposition, a stable suspension...

The number of persons who relocate to regions of high altitude for work, pleasure, sport, or residence increases every year. It is known that the reduced supply of oxygen (O 2 ) induced by acute or chronic increases in altitude stimulates the body to adapt to new metabolic challenges imposed by hypoxia. Sleep can suffer partial fragmentation becaus...

The purpose of the present study was to assess the dietary fat intake, glucose, insulin, Homeostasis model assessment for insulin resistance HOMA-IR, and endotoxin levels and correlate them with adipokine serum concentrations in obese adolescents who had been admitted to long-term interdisciplinary weight-loss therapy. The present study was a longi...

Aging causes several physiological alterations, including alterations in sleep. It is possible that difficulty sleeping can be exacerbated by increased inflammation in older individuals. Moderate exercise training may be a modality of non-pharmacological treatment for sleep disorders and inflammation. We aimed to assess the effects of moderate exer...