Ronald Bual

Ronald Bual
Mindanao State University - Iligan Institute of Technology | MSUIIT · Department of Chemical Engineering and Technology

Doctor of Engineering

About

8
Publications
1,236
Reads
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80
Citations
Citations since 2016
8 Research Items
80 Citations
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20162017201820192020202120220510152025
20162017201820192020202120220510152025
20162017201820192020202120220510152025

Publications

Publications (8)
Article
Full-text available
Milkfish (Chanos chanos) is an abundant fish commodity in the Philippines that generates a large number of wastes such as skin, scales, viscera, and bones, which, upon disposal, cause environmental pollution. The abundance of these wastes, such as fish skin, rich in bioactive natural products such as collagen, elicits interest in their conversion i...
Article
Full-text available
The extracellular matrix (ECM) in a liver-specific extracellular matrix (L-ECM) scaffold facilitates hepa-tocyte viability and maintains hepatocyte functions in vitro. However, whether an intact composition of ECM is required for an efficient ECM-based substrate design remains to be clarified. In this study, two L-ECM hydrogels, namely L-ECM I and...
Article
In recent years, studies on liver graft construction using the decellularized liver as a template for transplantation therapy have attracted much attention. However, the therapeutic effect of constructed liver grafts in hepatic failure has not been evaluated. Therefore, we aimed to develop a novel evaluation system demonstrating the curative effect...
Article
Full-text available
Accurate determination of the amount of glycosaminoglycans (GAGs) in a complex mixture of extracellular matrix (ECM) is important for tissue morphogenesis and homeostasis. The aim of the present study was to investigate an accurate, simple and sensitive alcian blue (AB) method for quantifying heparin in biological samples. A method for analyzing he...
Article
A solubilized liver-specific extracellular matrix (L-ECM) substratum was obtained by decellularization of porcine liver using Triton X-100 and pepsin treatments. The L-ECM was able to immobilize hepatocyte growth factor at a high efficiency of 87%. L-ECM gelled spontaneously in a physiologically neutral environment. Primary hepatocytes embedded in...
Article
Fabrication of functional scaffolds is one of the main goals of tissue engineering, particularly scaffolds mimicking the native extracellular matrix (ECM) and stimulating a microenvironment that supports cell growth and function. In this study, a scaffold was developed using liver-derived ECM (L-ECM), gelatin, and polycaprolactone (PCL) by conventi...
Poster
Full-text available
Electrospinning has gained a lot of attention because of its ease of producing fibrous scaffolds, cost- effectiveness, and tunability. The fabricated scaffold obtained highly interconnected nonwoven fabrics which are very similar to the fibrillar structure of the extracellular matrix. Bicomponent gelatin and polycaprolactone (PCL) nanofibers have l...
Article
Full-text available
The decellularization of organs has attracted attention as a new functional methodology for regenerative medicine based on tissue engineering. In previous work we developed an L-ECM (Extracellular Matrix) as a substrate-solubilized decellularized liver and demonstrated its effectiveness as a substrate for culturing and transplantation. Importantly,...

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