Ron Summers

Ron Summers
Collegium Basilea

Information Engineering

About

105
Publications
6,758
Reads
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567
Citations
Additional affiliations
August 2008 - present
Loughborough University
April 1998 - July 2008
Loughborough University
September 1988 - March 1998
City, University of London
Position
  • Professor (Associate)
Education
October 1984 - March 1992
City, University of London
Field of study
  • Information Engineering in Biology and Medicine

Publications

Publications (105)
Article
Full-text available
Due to the complexity of the end of life care industry, around 92,000 patients are not given adequate palliative care due to shortage of specialist trained staff and funding. There is a need to use socio-economic and demographic characteristics of population areas to improve delivery of training and staffing to care providers. The research aims to...
Article
Full-text available
Descriptions of systems and their power for explanation and interpretation are limited when the framework in which they operate is restricted to one level of scale. In fact, the majority of work in all disciplines is afflicted by this restriction. Using methods, tools and computing power now available, multiscale systems descriptions have become po...
Article
Full-text available
Many papers have been published that concern technological change and its application to health service delivery. However, this is just one of the innovations required to establish a holistic solution for a purposeful intervention. A further two are considered in this paper: education provision to support all stakeholders involved in the health del...
Article
Full-text available
Multi-scale biomedical systems are those that represent interactions in materials, sensors, and systems from a holistic perspective. It is possible to view such multi-scale activity using measurement of spatial scale or time scale, though in this paper only the former is considered. The biomedical application paradigm comprises interactions that ra...
Article
The aim of this paper is to investigate the technological feasibility of integrating e-health solutions as an aid to the health monitoring of patients in their own homes. The approach taken to this task is based on system engineering from which models are produced to indicate how home-based health care may be envisaged. The model outputs indicate t...
Article
Full-text available
Non-contact imaging photoplethysmography (PPG) is a recent development in the field of physiological data acquisition, currently undergoing a large amount of research to characterize and define the range of its capabilities. Contact-based PPG techniques have been broadly used in clinical scenarios for a number of years to obtain direct information...
Chapter
This paper presents simulations of in vitro Epithelial to Mesenchymal Transition (EMT). The conditions of 2D migration on the surface, and 3D invasion into a collagen gel are represented as a cellular Potts model. The model demonstrates that a loss of endocardial adhesion is a sufficient condition for 2D migration behaviour, while a simultaneous lo...
Article
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Congenital heart defects are characterized by abnormal positioning of some anatomical structures relative to a normal heart. Classically the classification of the disease or the stage of the disease is based on the measurement of the relative position of these structures by the cardiac morphologist. We propose a method in which the heart volume is...
Article
Accurate knowledge of normal cardiac development is essential for properly understanding the morphogenesis of congenital cardiac malformations that represent the most common congenital anomaly in newborns. The heart is the first organ to function during embryonic development and is fully formed at 8weeks of gestation. Recent studies stemming from m...
Article
Full-text available
Lateral inhibition is described as an emergent property of the Delta-Notch signalling network. Two separate model representations of lateral inhibition are proposed for different purposes. One provides information about bioenergetics while the other has the capability to produce a physical representation. It is proposed that both can be used in fur...
Article
The accurate analysis of congenital heart defect (CHD) specimens is often difficult and up to now required the opening of the heart. The objective of this study is to define a non-destructive method that allows for the precise analysis of each specimen and its different cardiac components in order to improve classification of the defect and thus pr...
Article
Epithelial to mesenchymal transition (EMT) is a fundamental process during development and disease, including development of the heart valves and tumour metastases. An extended cellular Potts model was implemented to represent the behaviour emerging from autonomous cell morphology, labile adhesion, junctional coupling and cell motility. Computer si...
Article
Executable biology at various levels of spatial scale is becoming increasingly important in order to understand the complexity exhibited in living systems. This paper describes how a multiscale systems approach can be used to integrate these models of behaviour to provide an insight into the development of cardiac valves. In particular, simulations...
Article
A published model of Notch-mediated lateral induction is re-implemented as a multiscale model using Compucell3D. The implications of the model for regulatory processes during the growth of the endocardial cushions are investigated. During embryonic heart development, Notch signaling operates by lateral induction to demarcate the endocardial cells c...
Article
Cell behaviour during epithelial to mesenchymal transition (EMT) was simulated using the cellular Potts formalism in Compucell3D. A recent in vitro study revealed that the mechanism of endocardial scattering can be induced independently of invasion into the extracellular matrix (ECM). This suggests that loss of endocardial cohesion alone is not suf...
Article
A 3D simulation of in vitro epithelial to mesenchymal transition (EMT) is presented. The simulation uses Compucell3D to realize a cellular Potts model of this process. The purpose of the model is to test the hypothesis that EMT can be achieved through a combination of a) the loss of endocardial cohesion; and b) a gain of endocardial to extracellula...
Article
Cell behavior during endocardial to mesenchymal transition (EMT) was simulated using the cellular Potts formalism in Compucell 3D. The processes of loss of endocardial cohesion and invasion into the extracellular matrix (ECM) were stimulated by changing surface energy parameters. The simulations match in vitro results which suggest that endocardial...
Article
This paper describes progress made in combining multiple ontologies in a post- coordinated approach. This is applied to the annotation of phenotvpes relevant to heart development and congenital heart diseases. The aim is to provide coordination for multiscale modeling and simulation that is presently being conducting in this field. Cardiac developm...
Article
Full-text available
Biomedical engineers and clinical scientists tend to focus their research on one level of scale, be it in the domain of biochemistry, cell biology or anatomy. However, there is increasing interest in a multiscale systems approach which attempts to integrate models of behaviour between different levels of scale to gain understanding of emergent effe...
Article
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The paper demonstrates the progress made in biomedical photonics engineering at Loughborough University since 1998. Research, development of concepts and innovation of products for principal use in healthcare can be traced back to the initial clinical request for a device to measure oxygen saturation in the peripheral tissues. Since then a directed...
Article
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A model of the lysis-lysogeny decision cycle of the Phage-γ virus has been re-implemented using standard engineering tools.The model is based on previous systems biology-based work and is constructed using the biological knowledge of the protein signalling networks within the virus. It explores how the emergent effects from the protein interactions...
Article
Full-text available
Multiscale systems engineering provides a way to integrate models of real-world phenomena that allows a holistic understanding of component interactions at different levels of scale simultaneously. The discipline draws upon information engineering to provide ontological representations that are derived from digital libraries of terms, themselves fo...
Conference Paper
Clinicians at Nottingham University Hospitals NHS Trust have developed a clinical information model that enables detailed patient data to be gathered in clinics, stored in a patient record, linked with samples in a Biobank and then used to identify and select patient cohorts for research studies. The objective has been to enable the assembly of coh...
Article
Full-text available
This paper provides a first description of a multiscale systems modeling approach applied to the congenital birth defect known as the tetralogy of Fallot. The multiscale approach adopted owes a lot to the effort of the world-wide physiome consortium and the work of research groups within the European Union on the Virtual Physiological Human. Both a...
Article
Full-text available
Science is made feasible by the adoption of common systems of units. As research has become more data intensive, especially in the biomedical domain, it requires the adoption of a common system of information models, to make explicit the relationship between one set of data and another, regardless of format. This is being realised through the OBO F...
Article
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The growing trend for implementation of healthcare information systems at enterprise and national levels requires the integration of multiple component standards as well as mechanisms for supporting diverse multidisciplinary needs and approaches to care delivery. Most of these large-scale programmes are being undertaken against the context of exist...
Article
To examine the characteristics of computerized decision support systems (CDSS) currently available to nurses working in the National Health Service (NHS) in England. A questionnaire survey sent to a stratified random sample of 50% of all NHS care providers (Trusts) in England, asking respondents to provide information on CDSS currently used by nurs...
Conference Paper
Full-text available
This paper describes a research and innovation platform for the development of ideas relating to the investigation of blood perfusion in peripheral tissue. The Loughborough Innovation Platform for Health Technologies (LIPHT) can be used to demonstrate the use of the research and innovation pipe-line in more than one dimension. For this paper the fi...
Article
Full-text available
This paper describes a research and innovation platform for the development of ideas relating to the investigation of blood perfusion in peripheral tissue. The Loughborough Innovation Platform for Health Technologies (LIPHT) can be used to demonstrate the use of the research and innovation pipe-line in more than one dimension. For this paper the fi...
Conference Paper
Full-text available
This paper discusses the architecture and implementation of SSS2, a high-performance real-time signal processing system developed with a hybrid ESL/RTL methodology and targeted to biomedical image processing. Traditional methodologies, as well as new tools, such as Cebatech's C2R untimed-C synthesizer have been employed in the design of the system....
Conference Paper
Full-text available
Contact and spot measurement have limited the application of photoplethysmography (PPG), thus an imaging PPG system comprising a digital CMOS camera and three wavelength light-emitting diodes (LEDs) is developed to detect the blood perfusion in tissue. With the means of the imaging PPG system, the ideally contactless monitoring with larger field of...
Article
Full-text available
This paper presents a camera-based imaging photoplethysmographic (PPG) system in the remote detection of PPG signals, which can contribute to construct a 3-D blood pulsation mapping for the assessment of skin blood microcirculation at various vascular depths. Spot measurement and contact sensor have been currently addressed as the primary limitatio...
Article
This paper will investigate innovations in information management for use in clinical trials. The application typifies a complex, adaptive, distributed and information-rich environment for which continuous innovation is necessary. Organisational innovation is highlighted as well as the technical innovations in workflow processes and their represent...
Article
Full-text available
This invited session is intended to address the needs of current and budding entrepreneurial bioengineers. It will draw on the personal experiences of the panelists, relaying their attempts to meet the demands and delights of their customers, while still managing to act responsibly for their shareholders. The audience will be asked to participate,...
Article
A report prepared in December, 2006, suggested some of the recommendations that need to be adopted by the Cast Business School at City University, to emerge as a modern institute. Three of the major recommendations involved achieving the status of the Preferred UK Body for Measurement and Control Technology, extending its membership outside the cou...
Article
Full-text available
The aim of our research project, described in this paper, was to develop a purpose-built clinical trials support system [CTSS], which would be sufficiently comprehensive, integrated and flexible, so as to support the vast majority of research studies that were to be managed and conducted by one UK-based health authority. Whilst at the start of this...
Chapter
Issues and complexities that arise from the adoption of clinical knowledge management are explored within the context of delivering drugs to the lungs. The move towards electronic data capture and information retrieval is documented together with cross-organisational working and sharing of clinical records. Key drivers for change are identified and...
Article
The aim of our research project, described in this paper, was to develop a purpose-built clinical trials support system [CTSS], which would be sufficiently comprehensive, integrated and flexible, so as to support the vast majority of research studies that were to be managed and conducted by one UK-based health authority. Whilst at the start of this...
Chapter
Issues and complexities that arise from the adoption of clinical knowledge management are explored within the context of delivering drugs to the lungs. The move towards electronic data capture and information retrieval is documented together with cross-organisational working and sharing of clinical records. Key drivers for change are identified and...
Chapter
Non-AI decision making can be defined as those methods and tools used to increase information content in the context of some specific clinical situation without having cause to refer to knowledge embodied in a computer program. Theoretical advances in the 1950s added rigor to this domain when Meehl argued that many clinical decisions could be made...
Article
Mobile healthcare provision in the home environment presents many challenges. Patients are becoming more informed about the management of chronic conditions and the use of technology to support the process is rising. Issues such as system interoperability, cost, security and training all have to be addressed to ensure effective use of mobile device...
Article
Purpose – This paper aims to supply an introduction to the bioinformatics discipline for information professionals, outlining how current information management issues are hampering the effective integration and interoperability of resources. Design/methodology/approach – The approach taken is to outline some of the more challenging issues to illu...
Article
Effective information management of the pharmacogenomics discipline presents many unique challenges. Genetic and genomic data generated via high-throughput methods need to be integrated with phenotypic data which are defined at multiscale levels, ranging from the molecular to the clinical level. Repositories storing these data are distributed and v...
Article
Databases of medical devices were identified via complex search strategies to discover breadth and depth of coverage. The databases could be categorised into three types: Product, Business and Regulation. Evaluation of the databases uncovered several issues including: lack of continuity relating to the level of information provided; and little or n...
Article
Issues and complexities that arise from the adoption of clinical knowledge management are explored within the context of delivering drugs to the lungs. The move towards electronic data capture and information retrieval is documented together with cross-organisational working and sharing of clinical records. Key drivers for change are identified and...
Chapter
Issues and complexities that arise from the adoption of clinical knowledge management are explored within the context of delivering drugs to the lungs. The move towards electronic data capture and information retrieval is documented together with cross-organisational working and sharing of clinical records. Key drivers for change are identified and...
Article
During September 2003, interviews took place to collect data to develop a technology roadmap for rehabilitation engineering. The emerging themes were used to create the roadmap. Criteria were developed to endorse the data prior to the representation process. Added value was by the collection and representation of supporting evidence. Roadmapping 'b...
Conference Paper
Patient centred care is the key driver in the development of electronic patient record in the UK. Research has focused on the investigation of the elements to be utilised for data capture and dissemination of clinical information. A set of typical Use Cases has been developed, describing patient and clinical aspects, the device to systems interface...
Conference Paper
The aim of this study is to investigate the acceptability and usability of information technology as one means of psycho-social rehabilitation of paraplegic and quadriplegic patients with spinal cord injury. From a group of 66 selected individuals, 17 (25.7%) prioritised a course in information technology as a form of rehabilitation. Out of the 16...
Conference Paper
The relationship between mobile communication devices and clinical knowledge management is explored. The issues and drivers required for successful implementation are discussed. The role of all stakeholders in the healthcare process is described as crucial to the successful adoption of mobile devices in healthcare.
Article
This paper discusses issues relating to the development and evaluation of the next generation of computerised control systems in healthcare delivery. It will be argued that further increases in the cost-effectiveness of healthcare delivery and the successful implementation of organisational learning models of healthcare can best be achieved if comp...
Conference Paper
Full-text available
In this paper we present our experience of using Web services to support interoperability of data sources at the Food and Agriculture Organization of the United Nations (FAO). We describe an information bus architecture based on Web Services to assist with multilingual access of data stored in various data sources and automatic document generation....
Conference Paper
Full-text available
During the autumn of 2000, 80 clinicians took part in a study to test a set of Clinical Headings developed to facilitate clinical communication. Realworld patient scenarios were used to develop a simulator to test current and re-structured clinical documentation. The relationship between perceived use and actual results was explored. The project ra...
Article
In a progressive care system, patients are transferred between different healthcare units within a healthcare facility, depending on the different stages in the patients’ care. Although a progressive care system allows for improved delivery of treatment and monitoring through the division and specialization of labour and other resources, it is also...
Article
The purpose of this paper is to discuss issues relating to the further computerisation of healthcare delivery. It is argued that the adoption of various patient management paradigms and the fulfillment of productivity targets can only be realistically achieved through the development of clinical information systems whose computerised functionality...
Article
In fMRI both model-led and exploratory data-driven methods are used to identify groups of voxels according to their correlation either with an external reference or with some similarity measure. Here we present a technique to assess intragroup homogeneity using Kendall's coefficient of concordance W once groups have been identified. We show that th...
Article
This article presents issues relating to the future direction of the information science discipline. A 10-year time horizon is chosen so that predictions will not be influenced unduly by change in the information environment. To know where the discipline is going relies on knowledge of where it has been; this trajectory is investigated in terms of...
Conference Paper
The discharge communications between the John Radcliffe Hospital, Oxford, and its referring General Practitioner's (GPs) in the community are investigated. These documents are known by a variety of names. To prevent confusion two descriptors are introduced: the immediate discharge document (IDD), and full discharge document (FDD). From a survey of...
Article
This paper presents a methodological framework for modelling that has found wide application in the complex domains of physiology and medicine. The processes of model validation are centrally embedded within this framework. The parallelism between modelling per se and the development of model-based decision support systems is then considered, showi...
Article
The clinical process, as it arises in the context of the critical care environment, can be seen in terms of a generic feedback model. This model, in expanded form, provides a basis for understanding the increasingly important roles performed by information management and decision support. Progress in both these areas has been seen in the achievemen...
Chapter
This paper describes an investigation into using artificial neural networks (ANNs) to model the non-linearities in a complex system, a nuclear reactor. A simple one compartment finite difference model of the plant is developed and an exact ANN equivalent formed directly without training. Conventional training using standard transfer functions avail...
Conference Paper
Modeling patient flows is an important modeling issue, providing healthcare managers with information regarding the resourcing requirements during the planning phase of new healthcare facilities, as well as the performance evaluation of existing facilities. This paper develops a generic model of patient flows in a progressive patient-care system ba...
Article
Full-text available
Demonstrates how the cause of the ventricular contraction (VC), reflected by its electrophysiological precursors (ECG), and its related effect on the haemodynamic system [characterized by the systemic arterial pressure (SAP), sometimes called the mean systolic arterial pressure (MSAP)] can be fused together for a ventricular rhythm (VR) tracking pu...
Article
The rapid accurate diagnosis of critical disorders is an essential component of intensive care. Traditional diagnostic techniques have relied on physician experience, which is based on a data set chosen from his or her personal preferences, rather than from scientific merit. In this article, we show that there are alternative methods of selecting c...
Article
SUMMARY The interaction of computers with the pharmacist will outline the role of computing in the pharmaceutical profession and will indicate present practice as well as providing an idea of how this role can be enhanced. It is clear that computer-based systems can transform some, but not all, procedures at different levels of integration. For exa...
Conference Paper
The use of Artificial Neural Network technology offers an objective way for determining the significance of primary medical evidence. Of interest in this paper is an application in an intensive care setting, an environment which is well known for its problems in dealing with data information explosion. To tame this complexity and provide assistance...
Conference Paper
The World Wide Web (Web) offers a very simple and cost effective way of exchanging multimedia information over wide area networks (WAN). In its usual form the Web allows users to download files from a remote server and view them locally as hypertext documents. These documents can contain multimedia data, for example, text, images, and audio clips....
Article
This paper describes a general model of acid-base chemistry of the blood which can be used to simulate physiological perturbation of acid-base chemistry on addition or removal of any buffer acid or base. In particular, it is shown how this model can be used to estimate the concentrations of buffer acids and bases when blood is equilibrated to a new...
Conference Paper
This paper describes an investigation into using a genetic algorithm to evolve the optimum set of inputs for a neural network. The network is to be used in a novel way for the prediction of nuclear reactor parameters under fault conditions. The development of transients is calculated in a recursive manner. The previous work and the next stage of re...
Conference Paper
The human decision-making process is simultaneously (and sometimes contradictory) logical, associative, fuzzy and probabilistic. To model this process faithfully, computer-aided medical diagnostic systems should possess all of these features. Therein lies one of the problems which hinders successful development of computer-based diagnostic aids: no...