Romain Lan

• Aix-Marseille University

Growth factors are proteins that play an essential part in tissue regeneration and development. They attach surface receptors to mediate their actions on cells. Signaling systems within cells are activated when growth factors bind to their associated receptors. These signaling cascades control the transcription of genes involved in cellular functio...

As the last editorial points out, 1 unequal distribution of services and lack of effective prevention policies in southeast Asia exacerbate health inequities, affecting vulnerable populations such as rural communities and low-income groups. This challenge is exacerbated by limited access to trained professionals, and insufficient oral health educat...

Periodontitis is the inflammation of the supporting structures around the dentition. Several microbial agents, mostly bacteria, have been identified as causative factors for periodontal disease. On the other hand, oral cavity is a rich reservoir for viruses since it contains a wide variety of cell types that can be targeted by viruses. Traditionall...

Background: Treatments for oral squamous cell carcinomas (OSCCs) often result in significant aesthetic and functional issues, impacting patients’ quality of life (QoL). The COVID-19 pandemic’s mask mandates may have provided psychosocial benefits by concealing facial disfigurements, potentially reducing stigma. This study aimed to assess the impact...

Background: Managing noncommunicable diseases effectively requires continuous coordination and monitoring, often facilitated by eHealth technologies like mobile health (mHealth) apps. The end-user version of the Mobile Application Rating Scale is a valuable tool for assessing the quality of mHealth apps from the user perspective. However, the absen...

Background/Objectives: The “One Health” approach underscores the connection between human, animal, and environmental health, promoting solutions to global challenges like climate change and biodiversity loss. The Planetary Health Diet (PHD) promotes a plant-based diet with organically grown plants to reduce the environmental impact of meat producti...

Introduction The increasing interest in teledentistry since the COVID-19 pandemic warrants an evaluation of dentists’ willingness to adopt it. This study aimed to develop a questionnaire to assess dentist’s intention to use teledentistry and the associated factors. Methods A literature search was used to identify items for the questionnaire. The U...

Background In 2022, the World Health Organization highlighted the alarming state of oral health (OH) worldwide and urged action to include OH in initiatives on noncommunicable diseases. The population needs improved OH skills and attitudes and an adequate level of OH literacy (OHL) and general health literacy (HL). The implementation of health prom...

Background: Guided bone regeneration (GBR) is a reliable technique used in vertical and horizontal bone defects. The posterior mandibular region is an area limited by anatomic constraints. The use of resorbable membranes with a cortical component could compensate for the lack of rigidity of resorbable membranes without the complications of non-reso...

BACKGROUND Non-communicable diseases represent a major global health burden, causing 74% of all deaths worldwide. Effective management of these diseases requires ongoing coordination and monitoring, often facilitated by e-health technologies such as mobile health (mHealth) applications. The end-user Mobile Application Rating Scale (uMARS) is a valu...

Background Managing noncommunicable diseases effectively requires continuous coordination and monitoring, often facilitated by eHealth technologies like mobile health (mHealth) apps. The end-user version of the Mobile Application Rating Scale is a valuable tool for assessing the quality of mHealth apps from the user perspective. However, the absenc...

Purpose The rise of stereolithographic surgical guides and digital workflow, combined with a better knowledge of materials and loading principle, has enabled the placement of the temporary prosthesis at the time of implant placement. This scoping review aimed to assess the current knowledge available on stackable guides. Methods The review focused...

Background: Care pathways are useful for optimizing patient or disease management. However, in practice, the implementation of this concept remains below its potential. Probably because it is a complex intervention in complex systems. In such cases, modeling is beneficial. Thus, facilitating the representation of care pathways can go through the fo...

Albumin is the most abundant protein in human serum and a specific amount of albumin also can be found in the saliva. It has several physiological functions such as blood colloidal osmotic pressure, antioxidant activity, binding and transporting of endogenous and exogenous substrates. We conducted an electronic search across several databases such...

A pre-hydrated thermosensitive collagenated biomaterial which sets at body temperature and maintains the space of the missing alveolar bone volume, OsteoBiol GTO® (GTO), has been released as a bone substitute. This study was designed to check its angiogenic and osteogenic potentials compared to OsteoBiol Gen-Os® (Gen-Os) and Geistlich Bio-Oss® (Bio...

Among oral microbiota methanogens, Methanobrevibacter massiliense (M. massiliense) has remained less studied than the well-characterised and cultivated methanogens Methanobrevibacter oralis and Methanobrevibacter smithii. M. massiliense has been associated with different oral pathologies and was co-isolated with the Synergistetes bacterium Pyramido...

Biomimetic dental implants are regarded as one of the recent clinical advancements in implant surface modification. Coatings with varying thicknesses and roughness may affect the dental implant surface’s chemical inertness, cell adhesion, and antibacterial characteristics. Different surface coatings and mechanical surface changes have been studied...

Malgré les progrès des traitements chirurgicaux et oncologiques, les taux d’incidence et de survie à 5 ans (~50 %) liés aux cancers oraux (CO) ne se sont pas améliorés au cours des dernières décennies et demeurent un problème majeur de santé publique. 70 % sont encore diagnostiqués à un stade tardif (T3 ou T4), avec un délai de diagnostic moyen de...

Background and Aims: Previous observational studies found inconsistent associations between serum vitamin D levels and dental caries risk. A dose-response meta-analysis of cross-sectional studies was performed to investigate the association. Methods: To April 2023, the ISI Web of Science, PubMed, Scopus, and Google Scholar databases were searched f...

Background: This paper aimed to study the association of serum Vitamin D level and Body Mass Index (BMI) as representatives of malnutrition at micro and macro levels, respectively, on dental caries. Method and Participants: A total of 333 randomly selected children aged 6–12 years in Sulaimani, Kurdistan, Iraq were examined for three variables of t...

There are many dental age estimation methods, but all the methods do not correspond, especially for aging methods for adults and mature individuals, to the reality of the forensic field, which favors simple, effective, and easy-to-use methods. Ruquet (2015) developed a method based on alveolar bone loss that predicts age for individuals between 25...

The absence of teeth in children due to congenital agenesis, syndromic or not, can lead to oral dysfunctions with general repercussions and socio-psychological problems. The challenge is to provide functional and aesthetically pleasing results in terms of temporary rehabilitation during growth and long-term rehabilitation in adulthood. The case pre...

Introduction: The distinction between giant cell tumors and giant cell granulomas is challenging, as both entities have overlapping diagnostic criteria, especially in oral locations. The two entities have similar clinical and radiological presentations, but they differ in their prognoses. Objective: The main objective of this study was to list t...

Introduction : Oral mucositis (OM) is a common side effect of radiotherapy (RT) or radio-chemotherapy (RT/CT) for head and neck cancers. It causes lesions leading to impairment of the quality of life, dysphagia, pain, and in up to 20% of cases, a dosimetry concession, decreasing local tumor control, thereby impacting the survival rate. Positive res...

Mobile health apps can contribute to increased quality of individual oral hygiene behaviors. This study provides an overview and an evaluation of quality of oral-hygiene-related mobile apps currently available in Google Play Store and the French Apple App. A shortlist of nine apps was assessed by 10 oral health professionals using the Mobile App Ra...

Background Tobacco and alcohol are the main risk factors for oral squamous cell carcinoma, the low survival rate of which is a public health problem. European-wide health policies (a prevention campaign, tobacco packaging) have been put in place to inform the population of the risks associated with consumption. Due to the increase in smoking among...

Introduction Le lichen oral est une pathologie inflammatoire chronique, dont la prise en charge implique différents praticiens : dermatologues, chirurgiens oraux, stomatologues, chirurgiens maxillo-faciaux, chirurgiens-dentistes, anatomopathologistes. Notre objectif était de réaliser des recommandations multidisciplinaires afin d’homogénéiser les p...

Introduction Oral lichen is a chronic inflammatory disease for which diagnostic management and follow-up are heterogeneous given the absence of specific guidelines in France. Our objective was to develop French multidisciplinary guidelines for the management of oral lichen. Materials and methods Working groups from the Groupe d’Etude de la Muqueus...

Background: Tobacco and alcohol are the main risk factors for oral squamous cell carcinoma, the low survival rate of which is a public health problem. European-wide health policies (prevention campaign, tobacco packaging) have been put in place to inform the population of the risks associated with their consumption. Due to the increase in smoking a...

Statement of problem Whether recommendations for the use of occlusal devices are made uniformly in terms of indications, designs, and wearing time is unclear. Different recommendations may lead to different clinical outcomes. Purpose The purpose of this survey was to assess the professional practice of dental surgeons in France regarding the use o...

Introduction: The paracetamol is the most widely used painkiller to dental pain. Patients self-medicating with paracetamol for dental pain had 12.8 more times lead to overdose than patients with other pains. The aim of this work was to propose a standardized management in case of paracetamol overdose from a clinical case report. Observation: A 56-y...

Purpose: The objective of this study was to develop a deep convolutional neural network (CNN) that would identify the brand and model of a dental implant from a radiograph. Materials and methods: A data augmentation procedure provided a total of 1,206 dental implant radiographic images of three different brands for six models (Nobel Biocare Nobe...

BACKGROUND Background: Tobacco and alcohol are the main risk factors for oral cancers, whose low survival rate is a public health problem. Health policies on a European scale (prevention campaign, modification of tobacco packaging) have therefore been launched to prevent and dissuade the population from the consequences of their consumption. Due to...

Introduction : Certaines pathologies présentent des tendances saisonnières dans leur incidence et leur prévalence. Ces tendances s’expriment par l’intérêt affiché dans le nombre de recherches sur Internet pour ces pathologies selon les mois de l’année. Matériel et Méthodes : Les données des requêtes de Google Trends© ont été extraites de décembre 2...

La durée des traitements orthodontiques est une des plaintes principales des patients en pratique orthodontique, en particulier chez les patients adultes. Le traitement orthodontique chez l’adulte doit s’adapter à des particularités comme l’absence de croissance et l’augmentation des atteintes parodontales. La corticotomie alvéolaire se définit com...

L’objectif de ce travail est de faire le point sur les manifestations buccales de la sclérose tubéreuse de Bourneville (STB) à travers le cas d’un jeune patient. Un jeune homme de 15 ans était adressée pour la mise en place de minivis orthodontique afin de fermer des espaces d’agénésies de 35 et 45. L’interrogatoire retrouvait une STB dont les mani...

Introduction : Les implants zygomatiques semblent être une bonne alternative dans les cas de patients opérés de maxillectomies mais aussi pour les patients présentant une atrophie osseuse maxillaire sévère avec demande de réhabilitation prothétique sans avoir recours à des étapes de chirurgies pré-implantaires lourdes et chronophages. L’objectif pr...

Introduction : Récemment, de nombreuses techniques d’aide au diagnostic des lésions potentiellement malignes ou malignes de la cavité orale ont vu le jour (autofluorescence, spectroscopie, analyse cytologique microscopique, Narrow Band Imaging ...) sans jamais apporter la preuve scientifique de leurs intérêts, en complément ou en remplacement de l’...

La granulomatoses oro-faciale (GOF) est une entité rare regroupant toutes les pathologies caractérisées par une inflammation granulomateuse non caséeuse de la région oro-faciale. Le diagnostic est histologique. L’étiologie n’est pas connue. L’oedème labial d’abord intermittent, pouvant s’installer de manière permanente, est un symptôme classique de...

Parotitis is a frequent disease in general pediatrics. Pneumoparotitis is a rare affection that belongs to differential diagnoses of parotitis, along with infections, lymphadenitis, autoimmune disorders, inflammatory conditions, vascular malformations or neoplasms. It is usually described in musicians using wind instruments or in other situations i...

Introduction: The parotid duct (PD) is often involved in parotid gland diseases. A skin landmark could help the surgeon to locate its position. The parotid duct line (PDL) joins the tragus-antitragus point to the middle of the half upper lip. The aim of this study was to assess and scientifically validate this landmark. Methods: A monocentric pr...

The aim of this study was to perform a critical review of published data on the epidemiological, aetiological, clinical, histological, biological, and therapeutic characteristics of patients with angina bullosa haemorrhagica (ABH). A literature search was conducted in the PubMed, Science Direct, Web of Science, and Cochrane Library databases. All p...

Background: This study examines the epidemiological and clinical characteristics and therapeutic outcomes in patients with denosumab related-osteonecrosis of the jaw (DRONJ). Material and methods: The patients included are all being monitored by three oral and maxillofacial surgery departments for an osteonecrosis of the jaw (ONJ) linked to deno...

Objective This study examines the epidemiological and clinical characteristics and therapeutic outcomes in patients with denosumab related-osteonecrosis of the jaw (DRONJ). Study design: The patients included are all being monitored by three oral and maxillofacial surgery departments for an osteonecrosis of the jaw (ONJ) linked to denosumab alone f...

Introduction: Metastatic carcinoma of the colon is frequently encountered. In the literature, metastasis of malignant tumors in the buccal cavity are rare. They represent less than 1% of oral malignant lesions. Observation: We present a case of oral metastasis of colon adenocarcinoma in the mandible of a 62-year-old patient. The physical examina...

Introduction: Canalicular adenoma (CA) is a benign tumor that develops in the accessory salivary glands. Observation: We reported a case of CA of the upper lip in a 61-year-old man. Discussion: The clinical diagnosis of CA is difficult, and a lot of possible differential diagnoses exist, including benign or malignant salivary tumors. Thus, the diag...

Résumé Introduction Le fibro-odontome améloblastique (FOA) est une tumeur bénigne rare représentant 1 à 3 % des tumeurs odontogènes. Le FOA touche le patient jeune, avant 20 ans. L’exérèse chirurgicale permet habituellement la guérison. Les récidives et les transformations malignes sont possibles. Observation Une patiente de 3 ans, sans antécéden...

Le denosumab est un traitement inhibiteur de la résorption osseuse qui vise à augmenter la masse osseuse chez des patients présentant une ostéopénie secondaire à des thérapies antihormonales, après un cancer du sein ou de la prostate. Cette molécule initialement indiquée dans le traitement de l’ostéoporose post-ménopausique est désormais aussi util...

This article presents the analysis of dental remains and waste from the dental office of a German rest camp of the First World War in order to study the living conditions of the soldiers, the care policy and the prosthetic rehabilitation techniques used in this context. The study included both dental and prosthetic remains, revealed during the exca...