Romain Bourboulou

Romain Bourboulou
Institut de neurobiologie de la méditerranée INMED | INMED

Master of Science

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8
Publications
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50
Citations

Publications

Publications (8)
Article
Full-text available
Intracellular amyloid beta oligomer (iAβo) accumulation and neuronal hyperexcitability are two crucial events at early stages of Alzheimer's disease (AD). However, to date, no mechanism linking iAβo with an increase in neuronal excitability has been reported. Here, the effects of human AD brain-derived (h-iAβo) and synthetic (iAβo) peptides on syna...
Preprint
Full-text available
Background Intracellular amyloid-beta oligomers (iAβo) accumulation and neuronal hyperexcitability are two crucial events at early stages of Alzheimer’s disease (AD). However, to date, no mechanism linking them has been reported. Methods Here, the effects of human AD brain-derived (h-iAβo) and synthetic (iAβo) peptides on synaptic currents and act...
Preprint
Full-text available
Background: Intracellular amyloid-beta oligomers (iAβo) accumulation and neuronal hyperexcitability are two crucial events at early stages of Alzheimer’s disease (AD). However, to date, no mechanism linking them has been reported. Methods: Here, the effects of human AD brain-derived (h-iAβo) and synthetic (iAβo) peptides on synaptic currents and ac...
Article
Full-text available
In area CA1 of the hippocampus, the selection of place cells to represent a new environment is biased towards neurons with higher excitability. However, different environments are represented by orthogonal cell ensembles, suggesting that regulatory mechanisms exist. Activity-dependent plasticity of intrinsic excitability, as observed in vitro, is a...
Article
Full-text available
The ability to flexibly navigate an environment relies on a hippocampal-dependent cognitive map. External space can be internally mapped at different spatial resolutions. However, whether hippocampal spatial coding resolution can rapidly adapt to local features of an environment remains unclear. To explore this possibility, we recorded the firing o...
Preprint
The ability to flexibly navigate an environment relies on a hippocampal-dependent internal cognitive map. Explored space can be internally mapped at different spatial resolutions. However, whether hippocampal spatial coding resolution can be dynamically controlled within and between environments is unknown. In this work we recorded the firing of hi...
Article
Full-text available
The accumulation of amyloid peptides 40 and 42 in senile plaques is one of the hallmark lesions of Alzheimer Disease (AD). Great efforts are currently made to design molecules able to target these lesions in brain, both for diagnostic and therapeutic aims. Recent studies showed that curcumin has high affinity for the amyloid deposits. Curcumin is a...
Article
Full-text available
The accumulation of amyloid peptides 40 and 42 in senile plaques is one of the hallmark lesions of Alzheimer Disease (AD). Great efforts are currently made to design molecules able to target these lesions in brain, both for diagnostic and therapeutic aims. Recent studies showed that curcumin has high affinity for the amyloid deposits. Curcumin is a...

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