Rolf Becker

Rolf Becker
Freie Universität Berlin | FUB

Prof. Dr. med.

About

101
Publications
10,445
Reads
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1,125
Citations
Citations since 2016
3 Research Items
338 Citations
2016201720182019202020212022020406080
2016201720182019202020212022020406080
2016201720182019202020212022020406080
2016201720182019202020212022020406080

Publications

Publications (101)
Article
OBJECTIVE Aim of the present study was to assess the risk of major anomalies in the offspring of consanguineous couples, including data of the prenatal situation.METHODS Over 20 years (1993-2012), 35,391 fetuses were examined by prenatal sonography. In 675 cases (1.9%) parents were consanguineous, with 307 couples (45.5%) related as first cousins,...
Article
Introduction: The efficacy of a therapy with certoparin; also in combination with aspirin and prednisolone; in high-risk pregnancies has been examined prospectively. Method: Data of 616 pregnancies have been analyzed. 238 patients injected Mono Embolex 3000; 239 patients Mono Embolex 8000 only. 62 patients injected Mono Embolex 8000 and took aspiri...
Article
Full-text available
Objective: To identify patients at very high risk for adverse pregnancy outcome (APO) at the 20- to 23-week scan and to assess the effectiveness of Aspirin (ASS) and low molecular weight heparin (LMWH) starting after this examination. Patients and methods: By applying an algorithm based on multivariate logistic regression analysis using the para...
Article
Unlabelled: Recurrent abortions are a common problem. A therapy with low-molecular- weight heparin is usual in deep vein thrombosis with thrombophilia, in woman with recurrent abortions or other risks, like EPH-gestosis or HELLP-Syndrom. Patients, method: The efficacy of a mono-therapy with LMWH (3000-16000 daily) in women with risk pregnancies...
Article
To assess the prevalence and detection rate of major anomalies (MAs) by applying first trimester anomaly scan (FTAS) including first trimester fetal echocardiography (FTFE) to all fetuses and discuss ethical implications. The study group included 6879 consecutive fetuses with known outcome of pregnancy (follow-up: 98%), 6565 with 'normal' nuchal tr...
Article
Here we describe the successful application of massively parallel sequencing for noninvasive prenatal detection of trisomy 21. In addition, for the detection of a broader spectrum of fetal aneuploidies, a target enrichment approach was successfully tested. The circulating cell-free DNA was prepared from 53 maternal blood samples and analysed using...
Article
Recurrent abortions are a common problem and after each miscarriage the risk of another abortion increases. It has been discussed if a therapy with low- molecular- weight heparin (LMWH) would help to bear a child successfully. In women with recurrent abortions a systemic inflammatory immune-response as well as augmented vascular thrombosis of the p...
Article
Recurrent abortions are a common problem. A therapy with low-molecular-weight heparin is usual in deep vein thrombosis with thrombophilia, in woman with recurrent abortions or other risks, like EPH-gestosis or HELLP-Syndrom. Patients, method: The efficacy of a mono-therapy with LMWH (3000–16 000 daily) in women with risk pregnancies has been examin...
Article
Zusammenfassung Rezidivierende Aborte sind leider häufig. Möglicherweise hilft eine Therapie mit niedermolekularem Heparin (NMH), eine weitere Schwangerschaft erfolgreich auszutragen. Bei Frauen mit rezidivierenden Aborten werden eine systemische, inflammatorische Immunantwort und vermehrt vaskuläre Thrombosen in der Plazenta nachgewiesen. Weil Hep...
Article
To establish and test a multivariate approach for identification of patients with high risk for adverse pregnancy outcome (APO) by a combination of sonographic (20+0-23+6 weeks) and biometrical data in a test group and to prove its effectiveness in a validation group. In order to develop a multivariate approach for identifying patients at high risk...
Article
To evaluate the acceptance of noninvasive screening for trisomy 13, 18, 21 and the impact on invasive testing rates in women at an age≥35 years. In a retrospective analysis from 2003-2006 including 13 268 women≥35 years old with singleton pregnancies and 3133 invasive procedures, we evaluated the prenatal detection rate of aneuploidies in two cohor...
Article
Our purpose was to assess the relation between the depth of notch in the uterine arteries at 20-23 weeks and the incidence and severity of subsequent pregnancy complications. The Notch Index (NI) was defined as (C - D)/C, with C = postsystolic zenith and D = postsystolic nadir. For evaluation, the mean NI of the two uterine arteries was determined....
Article
Full-text available
A case of Okihiro syndrome (OS) detected by 2- and confirmed by 3-dimensional ultrasound at 13+2 gestational weeks is reported. While the pregnant woman affected by the OS presented with limb anomalies, the fetus showed severe thoracoabdominal and skeletal anomalies. Termination of pregnancy was performed at 14+1 gestational weeks and confirmed the...
Article
Pränataldiagnostik (PND) und Pränatale Therapie gehören zur „Pränatalen Medizin“, welche die Erkennung, Behandlung und auch Vorbeugung von Erkrankungen des Menschen vor seiner Geburt zum Ziel hat. Es handelt sich um eine vergleichsweise junge Wissenschaft. Die erste Publikation, die sich mit dem Einsatz von Ultraschall als bildgebendem Verfahren in...
Article
In 1:50 000 to 1:100 000 births, conjoined twins occur, caused by incomplete division of the embryonic disc more than 13 days after fertilisation. We present a case of cephalothoracopagus janiceps, a very rare form of conjoined twins, which was diagnosed at 13 weeks of gestation. Three-dimensional and colour Doppler ultrasound enabled precise prena...
Article
To assess the diagnostic efficacy of the first-trimester anomaly scan including first-trimester fetal echocardiography as a screening procedure in a 'medium-risk' population. In a prospective study, we evaluated 3094 consecutive fetuses with a crown-rump length (CRL) of 45-84 mm and gestational age between 11 + 0 and 13 + 6 weeks, using transabdomi...
Article
Problemstellung: Esophageal atresia (ET) is a malformation, which is difficult to diagnose at prenatal screening, especially in the 2nd trimester of pregnancy. Indicators of ET are an empty or almost empty fetal stomach and polyhydramnios. Visualization of the esophageal fluid filled pouch at the level of ET has been described in recent years, but...
Article
Problemstellung: Softmarkers as indicators of chromosomal abnormalities of the fetus are described for more than 15 years now. The main problems of softmarkers are, that they are usually published as sonographic phenomenon in high risk pregnancies prior to amniocentesis. So the positive predictive value is usually overestimated when applied to a sc...
Article
Full-text available
Premature obstruction of the foramen ovale is a rare but serious clinical entity. Obstruction can be associated with right ventricular failure, fetal hydrops, tricuspid regurgitation, left heart obstructive defects and supraventricular tachycardia. In most cases, the diagnosis is made at the postmortem examination. The etiology is unknown. We discu...
Article
The first case of a fetal trisomy 6 mosaicism proven at 25 weeks of gestation by analysis of fetal urine cells is described. Chromosomal analysis was indicated by an ultrasonographically diagnosed heart defect at 21 weeks of gestation. The chromosomal aberration was detected in amniotic fluid cells while fetal blood cells showed a normal chromosome...
Article
We report on a case of a fetal epignathus combined with two fetus-like structures resembling acardius acranius. The anomaly was detected at 23 weeks of gestation and led to termination of pregnancy at 24 weeks. This is the first description of epignathus with parasitic fetuses detected prenatally. It shows that the boundary between fetal teratoma a...
Article
Full-text available
On the ''4 optimal chamber view'', we propose to check 4 key points: pulmonary inferior veins attaching the heart to lungs, in a strict axial plane; 4 chambers, mobile, balanced and concordant with a normal offset of the AV valves on the crux of the heart. We also describe the difficulties and the possible traps of the 4 chamber view. We justify ea...
Article
We report on three pregnancies complicated by Adams-Oliver syndrome in a consanguineous Turkish couple. Two cases were correctly diagnosed prenatally at 22+3 and 13+0 weeks gestation following the first case of Adams-Oliver syndrome in which severe anomalies of the extremities were observed at 26+5 weeks' gestation. In this first case, the diagnosi...
Article
Both invasive and non-invasive prenatal medicinal procedures are well accepted in Germany. The health care system offers each pregnant woman a total of three sonographic examinations. Most of these examinations turn up normal findings, leading to the pregnancy being continued without fear. In the case of anomalies being detected, the findings may b...
Article
Prenatal and postnatal findings in three fetuses with a ring chromosome 6 are presented, and the literature of this rare cytogenetic disorder is reviewed. The described fetuses illustrate the broad spectrum of the clinical manifestation of ring chromosome 6. In one fetus, the disorder was diagnosed incidentally by a routine amniocentesis due to adv...
Article
To assess the diagnostic value of Doppler sonography of the uterine arteries (DSUA) at 20-23 gestational weeks as screening procedure in a low risk population. The study group consisted of 7508 singleton low-risk pregnancies. Doppler sonography of both uterine arteries was performed as routine part of anomaly scan. Impedance of both uterine arterie...
Article
We present a case of a 27 year old I. gravida, I. para. Despite of regular ultrasonographic examination the diagnosis of skeletal malformation at the fetus was not before 33. weeks of gestation. It was the rare type of a bothside femur-fibula-ulna (FFU) complex. The FFU-complex is a no lethal malformation with typical unilateral combination from de...
Article
CHARGE association has been diagnosed postnatally in increasing numbers since the first description in 1979. The acronym CHARGE includes the abnormalities ocular Colobomas (iris, retina or nervus opticus), Heart disease, Atresia of choanae, Retarded growth and development and/or central nervous system anomalies, Genital hypoplasia, Ear anomalies an...
Article
To determine the correlation between placental position at 20-23 weeks and incidence of birth complications caused by placental position. In an ongoing prospective study, placental position was determined by transabdominal sonography as part of anomaly scanning at 20-23 gestational weeks, followed by transvaginal sonography in uncertain or suspicio...
Article
Full-text available
We report on a case of absent pulmonary valve syndrome in a woman with a history of one healthy child and one child with tetralogy of Fallot with absent pulmonary valve. The diagnosis was missed at the first ultrasound examination performed at 13 + 5 weeks of gestation and correctly diagnosed at 21 + 5 weeks. Re-evaluation of the ultrasound examina...
Article
Following the introduction of transvaginal sonography, several first trimester diagnoses of the exencephaly anencephaly sequence have been reported, with the earliest being described at 10 weeks of gestation. We report a case with a high index of suspicion for exencephaly at 9 weeks and 3 days because of three sonographic features: the cranial pole...
Article
We report on a case of embryonic anomaly detected at 9 + 5 gestational weeks. The lower part of the embryo was located in the coelomic cavity. Lower extremities could not be depicted. The abdominal wall showed the appearance of omphalocoele. After termination of pregnancy at 10 weeks, autopsy confirmed the anomaly of the lower embryonic parts consi...
Article
We report on a case of embryonic anomaly detected at 9 + 5 gestational weeks. The lower part of the embryo was located in the coelomic cavity. Lower extremities could not be depicted. The abdominal wall showed the appearance of omphalocoele. After termination of pregnancy at 10 weeks, autopsy confirmed the anomaly of the lower embryonic parts...
Article
Larsen syndrome shows a broad spectrum of clinical manifestation ranging from a lethal form of the disorder to a mild clinical expression with absence of major diagnostic features. Here we show that even intrafamilial manifestation may vary extremely to the point that Larsen syndrome in a father has been diagnosed only by typical sonographic featur...
Article
Wir beschreiben die Beobachtung eines Feten mit einer vollständigen Aplasie der Schädelkalotte mit Herniation von mit Leptomeninx bedecktem Hirngewebe in die Fruchthöhle, bei der es bis zur 20. SSW nicht zu einer Degeneration von Hirnsubstanz gekommen war. Unser Fall zeigt, daß die Aplasie der Schädelkalotte eine zwar notwendige, nicht aber hinreic...
Article
Elevation of alphafetoprotein in pregnancy warrants a thorough diagnostic workup. In most cases, no pathologic result in the fetus will be obtained. A case report is presented on a hepatocellular carcinoma (HCC) during pregnancy, in which a massive increase of alpha-fetoprotein (AFP) was found during a routine screening for neural tube defects in t...
Article
Advances in ultrasound technology and sonographer’s experience lead to the description of many rare syndromes and malformations through prenatal diagnosis. Diaphragmatic hernia is a rather common malformation but can be an indicator of different syndromes. We report the prenatal diagnosis of lethal multiple pterygium syndrome type II which has been...
Article
Advances in ultrasound technology and sonographer's experience lead to the description of many rare syndromes and malformations through prenatal diagnosis. Diaphragmatic hernia is a rather common malformation but can be an indicator of different syndromes. We report the prenatal diagnosis of lethal multiple pterygium syndrome type II which has been...
Article
Primary cardiac tumors are rare findings in adults and children. A case is presented in which ultrasound examination revealed an incredibly large tumor in the heart of a fetus at 24 weeks. Tumor filled the whole left ventricle. Histology and immunohistochemistry were indicative of rhabdomyoma, i.e., a hamartoma that is often associated with tuberou...
Article
We report a case of feto-feto-fetal-transfusion-syndrome (FFFTS) in a spontaneous monochorionic triamniotic triplet pregnancy primarily diagnosed at 17 weeks of gestation. During the course of pregnancy, sequentially two triplets appeared as donor. Symptoms of a recipient (polyhydramnios, tricuspid valve insufficiency, and ascites) were present in...
Article
ADNEXPERT is a knowledge-based system for the computer-assisted ultrasound diagnosis of adnexal tumors. In a case-based approach, ADNEXPERT used histopathologic and sonographic data from 2,290 adnexal tumors. After an ultrasound examination, the gynecologist interacts with the system. A maximum of 15 questions are posed; all but one question (age)...
Article
To determine the quality of prenatal sonographic weight estimation, comparing breech and vertex presentations. In 147 breech presentations (BP) and 149 vertex presentations (VP), the biparietal head diameter (BPD), the fronto-occipital head diameter (FOD) and the transverse abdominal diameter (ATD) were measured. From these data, the weight was est...
Article
Prenatal diagnosis (PND) in Germany is well established. A wide spectrum of sonographic, cytogenetic, molecular and biochemical investigations can be chosen by pregnant women. While sonographic examinations are offered to all pregnant women, the methods requiring invasive procedures are performed predominantly when there is a higher risk than in th...
Article
Studienziel: Ziel der Untersuchung ist es, die Qualität der präpartalen sonographischen Gewichtsschätzung bei Beckenendlagen (BEL) zu überprüfen und mit einem Kollektiv von Schädellagen zu vergleichen. Methode: Bei 147 Beckenendlagen (BEL) und 149 Schädellagen (SL) wurden präpartal der biparietale Kopfdurchmesser (BPD), der fronto-okzi-pitale Kopfd...
Article
A case report is presented on a hepatocellular carcinoma (HCC) during pregnancy, in which a massive increase in alpha-fetoprotein (AFP) was found during a routine screening for neural tube defects in the 17th week of pregnancy. The amniocentesis revealed a normal AFP level in the amniotic fluid. Liver sonography in the 21st week of pregnancy showed...
Article
A cytogenetic discrepancy in chorionic villi with implications for prenatal diagnosis is described. Chromosome analysis revealed a normal karyotype in banded metaphases from short-term culture and a chromosome count of 46 in cells of the long-term culture. After the birth of a malformed infant, a structurally aberrant chromosome 6 was found in lymp...
Article
We report on two laparoscopically sterilised patients who presented with increasing lower abdominal pain and sonographically proven adnexal masses. The first patient, who had been sterilised two years ago, underwent primary laparotomy. The mass was found to correspond to the cystically altered distal part of the right sterilised tube being torquate...
Article
The authors report on a case where the Klippel-Trenaunay symptom complex was combined with a Sturge-Weber-Krabbe syndrome, which, however, was only noticeable during pregnancy by fetal macrosomy and hydramnios. The child was delivered on term by Caesarean section and presented no paediatric problems; however, during the first few years of its life...
Article
Wir berichten ubcr einen Fall einer Kombination des Klippel-Trenaunay-Symptomenkomplexcs mit eincm Sturge-Weber-Krabbe-Syndrom, welcher in der Schwanger-schaft lediglich durch fetale Makrosomie und Hydramnion auffiel. Das Kind wurde durch Sectio am Termin geboren, konnte padiatrisch problemlos versorgt werden, entwickelte jedoch innerhalb der erste...
Article
We report on prenatal diagnosis in a case of Klippel-Trenaunay syndrome with excessive tumour manifestations concerning thorax and upper extremities. The child was delivered at 37 weeks' gestation by cesarean section and, after several operations, is developing normally up to now.
Article
Postterm pregnancies of more than 290 completed gestational days (n = 110) were simultaneously supervised after admission by pulsed Doppler ultrasound of the common carotid and the umbilical arteries, nonstress and contraction stress tests (NST/CST) and vibroacoustic stimulation tests (VAST). The results of these tests were blinded for the clinicia...
Article
We report on a case of unilateral primary fetal hydrothorax leading to nonimmunological fetal hydrops (NIHF). The NIHF was treated successfully by inserting two consecutive intrauterine catheters at 23 weeks gestation. The first catheter was dislocated through the uterine wall to the maternal peritoneal cavity. At 36 weeks gestation, the mother had...
Article
One hundred and three intrauterine growth retardation (IUGR) pregnancies were scheduled for pulsed Doppler ultrasound of the common carotid and the umbilical artery, nonstress and contraction stress tests (NST/CST) as well as vibroacoustic stimulation tests (VAST). The last examinations < 3 days before birth were compared by receiver-operator chara...
Article
Migration disorders of foetal neurons are rare conditions which are normally diagnosed after birth and may be followed by severe alterations of neurological development. We describe a case of foetal hemilateral polymicrogyria in combination with hemihypoplasia of the brain, the symptoms of which were diagnosed in the 23rd week of pregnancy, leading...