Roger Bjugn

• University of Oslo

In order to succeed in realising general health-policy goals for cancer care, they must be formulated as specific and realistic objectives. An administrative organ must be provided with the authority and funding needed to establish the technical solutions required. Reporting to national registries must take place automatically in electronic form, o...

Retrospective review of diagnostic histopathology samples in secondary research projects may generate cases with discordance in diagnosis between the pathologist originally signing out the sample and the reviewer. In this article the authors discuss ethical and legal issues involved in secondary review and propose how diagnostic discrepancies in re...

To improve quality, pathology organizations have published guidelines with key parameters for histopathology reporting on cancer resections. Checklists or structured templates improve upon the presence of key parameters in histopathology reports, but data are lacking on long-term sustainability of such reporting. From 2003 to 2006, the Cancer Regis...

Stakeholders are individuals, groups, or organizations that are affected by or can affect a particular action undertaken by others. Biobanks relate to a number of donors, researchers, research institutions, regulatory bodies, funders, and others. These stakeholders can potentially have a strong influence upon the organization and operation of a bio...

Complete and accurate histopathology reports are fundamental in providing quality cancer care. The Cancer Registry of Norway and the Norwegian Society of Pathology have previously developed a national electronic template for histopathology reporting on colorectal carcinoma resection specimens. The present study was undertaken to investigate (1) whe...

Both individual patient treatment and cancer registries depend on adequate histopathology reports. To ensure the quality of these reports, professional organizations have published guidelines on minimum data sets for various cancer types. Norway has a population of 4.6 million, and all individuals have a unique identification number. As required by...

Whisker trimming deprives the cortical barrel field from the patterned sensory input that derives from active touch but leaves passive tactile signals unaltered. We have studied in the rat barrel field, by stereological procedures, the effects of a sustained period of unilateral deprivation by whisker clipping during adolescence and early adulthood...

We have evaluated quantitatively the whisker barrel field (posteromedial barrel subfield, PMBSF) size in rats raised in standard cages and in rats chronically exposed to an enriched sensory environment. Some animals were subjected to either chronic trimming of the right whiskers, or permanent transection of the right infraorbital nerve. Coronal bra...

The aim of the present study was to investigate the quality of fetal, perinatal and infant (< 12 months of age) autopsy reports. One hundred and thirty-six reports were scored for seven major categories (History, External description, Internal examination, Histology report, Other investigations, Placenta, Conclusions/Commentary) derived from "Guide...

Colorectal cancer is the second most common cancer among both men and women in Norway. The quality of the information given in the histopathological report is crucial for staging and treatment, and standardised reports are recommended. Such standardised schemes for histopathological reporting and surgical specimen handling were introduced from 1 Ju...

Anterograde transneuronal degeneration is caused by the loss of afferent input to the nerve cells and may occur in a number of neuronal systems. Transection of the adult spinal cord, causing anterograde transneuronal degeneration in ventral horn neurons, distal to the lesion, has been reported by some authors, while others contend that no such chan...

Of 238 patients admitted to Haugesund hospital, 159 completed a questionnaire evaluating the primary health care system and describing events before admission to hospital. Half of the patients had contacted the health care system within one hour after onset of symptoms. Two thirds of the 159 patients had consulted a general practitioner, while 33 p...

159 patients admitted to a local hospital completed a questionnaire during the autumn of 1992 in order to evaluate the service rendered to the patients during their stay in the admission/emergency unit. The patients were generally satisfied with the service rendered in the admission/emergency unit. However, some patients were dissatisfied with the...

Male, adult Wistar rats were exposed to 500 micrograms/m3 mercury vapor 6 h per day, 5 days a week for 4 wk. They were subsequently killed by transcardial perfusion. The molars were extracted, demineralized, and embedded in resin before sectioning. Autometallographic development was performed according to the method of Danscher & Möller-Madsen. Mer...

By means of stereological techniques such as the optical disector, the total number of cells in the spinal cords of five albino mice were estimated. The mean number of cells in the gray and the white matter was 9.0 and 4.1 million, respectively. Of the cells in the gray matter, 4.0 million were classified as neurons, 2.8 million as glial and 1.7 mi...

The total numbers of neurons and glial and endothelial cells in five rat spinal cords were estimated by stereological techniques. Each spinal cord was divided into 12 slabs of equal length. One transverse and one oblique slice was cut from each slab. The volumes of gray and white matter of each cord were then estimated by point-counting techniques...

A questionnaire survey was conducted among 33 medical students (22 men and 11 women) working as part or full-time research trainees at the University of Bergen in 1990, in order to examine various aspects of their working conditions. Most trainees (81%) experienced a well-organized initial research project, and 85% were quite content with their per...

A questionnaire survey on scientific interest among 324 medical students at the University of Bergen in 1990 showed that 14% of the students had already participated in medical research programmes (10% still research trainees). In addition, 45% had considered starting working as a research trainee while a student. Many were discouraged, however, by...

In an investigation in spring 1989 on research training at the Medical Faculty, University of Bergen, 111 questionnaires were returned of a total of 180 distributed. 35% of the trainees were satisfied with the training, 31% not, while 30% did not know as yet. Trainees who had been full-time research fellows for two years or more (n = 33), were spli...

A research training programme should have a clearly defined aim and a framework for accomplishment and contents. In Norway no such programme exists for the medical PhD. Present research training depends to a large extent on the individual student. The aim of this paper is to contribute to a discussion on the goals for a research programme and to re...

Applying different stereological techniques, the total ependymal volume in the spinal cord of mice was estimated to be 83 x 10(6) microns cubed, the number of cells to be 163,000 and the mean ependymal cell volume to be 510 microns cubed. Compared to choroid plexus cells in the third ventricle, the ependymal cells in the spinal cord contained a sma...

In order to investigate an effect of descending nerve fibres on mouse spinal cord ependymal ultrastructure, pharmacological manipulation with the serotonergic system or transection of the spinal cord was done. Biochemical analysis showed an 83% reduction of serotonin content in spinal cord tissue after p-chlorophenylalanine injections and a 93% red...

This study was done in order to investigate the normal ultrastructure of well-preserved mouse spinal canal ependyma using light, scanning and transmission electron microscopy. The ependymal lining was found to consist of a simple, cuboidal epithelium essentially similar to the unspecialized cuboidal ependyma of the brain ventricles. Apart from grea...

Seventy-two mice were used to find out which of 13 vascular perfusion procedures gave best structural preservation of the spinal cord ependyma and central canal lumen. Best results were obtained by 3% glutaraldehyde in Tyrodes solution with 50% of normal NaCl amount, 0.06 M sucrose and 2% dextran T-40 (556 mOsmol, pH 7.2, 0-4 degrees C). This was p...

In the present study on rat kidney tubules an intraluminal, electron-dense granular substance was found in animals perfusion-fixed with dextran-containing fluids. Most findings were made in thick ascending limbs of Henle and distal convoluted tubules. The incidence decreased from 50% to zero when intravascular rinsing time was increased from zero t...

Dialyzed and dehydrated human urine and purified Tamm-Horsfall's glycoprotein revealed similar morphology by scanning electron microscopy. Single filaments, with diameters between 15-45 nm, splitting off and merging with thicker fibers at irregular intervals made up a three-dimensional meshwork with submicrometer pores. The resulting "fishing net"...