Rodrigo Angerami

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Verified

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• MD, PhD, Infectious Diseases
• Medical Doctor at State University of Campinas (UNICAMP)

Human migration is a dynamic, multifaceted and complex phenomenon shaped by economic, political, social, climatic and environmental factors [1], [2], [3], [4]. Migration refers to the relocation of individuals from their habitual residence to a new location, while travel involves journeying between destinations for various purposes [5]. In recent y...

Yellow fever (YF) is an acute, potentially fatal, viral illness and remains a global threat, especially in endemic regions such as Africa and South America. Two types of outbreaks and scenarios are well-defined: YF in Africa and YF in the Americas. In Africa, where YF originated, the vectors and most simian species have more resistance to YF infect...

RMSF, a tickborne infection caused by Rickettsia rickettsii , produces severe and fatal disease in humans and dogs. Since the beginning of the 21st century, cases have risen dramatically, most notably in Mexico and Brazil, where outbreaks occur in urban centers including cities with populations of > 1,000,000 persons. Reported case fatality rates c...

In South America, cutaneous leishmaniasis is caused by several species of the parasite of the genus Leishmania. Here, we describe an imported case of cutaneous leishmaniasis acquired in Peru by a Brazilian patient during her travel to Iquitos. Infection by Leishmania parasites was confirmed by histopathologic examination, and the patient was treate...

Lyme borreliosis or Lyme disease is the most frequently reported tick-borne disease in the Northern Hemisphere. In countries of the Southern Hemisphere, such as Brazil, since the early 1990s, some researchers have argued for the existence of an autochthonous Lyme-like borreliosis, known locally as the Baggio–Yoshinari syndrome (BYS), an alleged “Br...

https://www.sciencedirect.com/science/article/pii/S141386702400415X

https://www.sciencedirect.com/science/article/pii/S1413867024005282

https://www.sciencedirect.com/science/article/pii/S1413867024004227

Background We evaluated the predictive factors for case confirmation and death from Brazilian spotted fever in an endemic area of Southeastern Brazil. Methods A cross-sectional study was conducted. All suspected cases reported between 2007 and 2021 were analyzed using two logistic regression models. Results 60 cases were confirmed. Male sex, age...

A febre maculosa (FM) é uma designação utilizada no Brasil para descrever um conjunto de zoonoses causadas por bactérias do gênero Rickettsia transmitidas por carrapatos infectados. Trata-se de doenças infecciosas febris agudas, com gravidade variável, que podem apresentar desde formas leves e atípicas até formas graves com elevada taxa de letalida...

The year 2024 marked a pivotal moment in the history of public health in the Americas as the region grappled with an unprecedented surge in dengue cases1,2. Dengue, primarily transmitted by Aedes aegypti and A. albopictus, now also has the risk of transmission by A. vitattus3, detected in Caribbean countries such as the Dominican Republic and Puert...

We detected Mayaro virus (MAYV) in 3.4% (28/822) of febrile patients tested during 2018–2021 from Roraima State, Brazil. We also isolated MAYV strains and confirmed that these cases were caused by genotype D. Improved surveillance is needed to better determine the burden of MAYV in the Amazon Region.

Introdução: As febres recorrentes (FR) transmitidas por piolho e por carrapato e a Doença de Lyme (DL) são enfermidades ocasionadas por microrganismos do gênero Borrelia e despertam preocupação nos seres humanos. No Brasil, as informações epidemiológicas acerca dessas borrelioses são escassas, o que dificulta o diagnóstico clínico, laboratorial e o...

Introdução Malária é uma doença infecciosa, febril e aguda causada por protozoários do gênero Plasmodium transmitidos por mosquitos Anopheles. No Brasil, a maioria dos casos ocorre na região Amazônica e cerca de 90% são associados ao Plasmodium vivax. Há, entretanto, uma preocupação crescente com a malária que atinge viajantes não imunes e a ocorrê...

Introdução A pandemia de COVID-19 impactou no diagnóstico e tratamento da tuberculose (TB), principalmente em relação a descoberta precoce dos casos de tuberculose e supervisão do tratamento diretamente observado. Além disto, a coinfecção TB e COVID-19 deve ser estudada no sentido de compreender a interação destes dois patógenos e o impacto na apre...

Introdução O relatório global da Organização Mundial de Saúde mostrou que o número de casos novos notificados de tuberculose (TB) caiu de 7,1 para 5,8 milhões entre os anos de 2019 e 2020. Revelou também que houve aumento do número de óbitos por tuberculose, fato ocorrido pela primeira vez na última década. Objetivo Comparar a apresentação, diagnó...

Introdução A pandemia de Covid-19 expôs o sistema de saúde à necessidade de manejo de uma nova doença associada a um colapso do sistema hospitalar. Entretanto, durante esses 26 meses, ocorreram mudanças relacionadas ao manejo clínico, à organização dos serviços, às medidas de isolamento social, às variantes virais e, principalmente, à vacinação, qu...

Background: Zika virus (ZIKV) is an emerging arbovirus associated with foetal malformations and neurological complications. The infection is usually associated with mild symptoms. The comparison between the allelic frequency of polymorphic genes in symptomatic infected individuals in the population can clarify the pathogenic mechanisms of ZIKV. Du...

Endocardite Infecciosa (EI) é uma condição clínica que requer rápido diagnóstico e abordagem terapêutica precoce, oportuna e apropriada, sendo que o diagnóstico microbiológico frequentemente se fundamenta nas técnicas de hemoculturas. No entanto, nas EI com hemoculturas negativas, outras estratégias para o diagnóstico laboratorial devem ser conside...

A difteria é doença infecciosa causada pelo bacilo Gram positivo Corynebacterium diphtheriae. Em geral, a infecção se expressa clinicamente pelo acometimento de trato respiratório ou cutâneo, sendo rara a infecção de corrente sanguínea. Infecções assintomáticas podem ocorrer e são mais frequentes quando associadas a cepas não toxigênicas. Epidemiol...

A SARS-CoV-2 B.1.1.7 variant of concern (VOC) has been associated with increased transmissibility, hospitalization, and mortality. This study aimed to explore the factors associated with B.1.1.7 VOC infection in the context of vaccination. On March 2021, we detected SARS-CoV-2 RNA in nasopharyngeal samples from 14 of 22 individuals vaccinated with...

Background Hantavirus is known to be transmitted from rodents to humans. However, some reports from Argentina and Chile have claimed that the hantavirus strain – Andes virus (ANDV) – can cause human-to-human transmission of the disease. The aim of this systematic review was to assess the evidence for human-to-human transmission of hantavirus. Meth...

Background. Hantavirus is known to be transmitted from rodents to humans. However, some reports from Argentina and Chile have claimed that the hantavirus strain Andes virus (ANDV) can cause human-to-human transmission of the disease. The aim of this systematic review was to assess the evidence for human-to-human transmission of hantavirus. Methods....

Resumo Introdução A leptospirose figura na lista de doenças de notificação compulsória no Brasil. Objetivo Avaliar o sistema de vigilância epidemiológica da leptospirose no município de Campinas, São Paulo, no período de 2007-2014. Método Foi realizado um estudo de prevalência dos casos de leptospirose no sistema de vigilância epidemiológica. Foram...

Zika virus (ZIKV) has the ability to cross placental and brain barriers, causing congenital malformations in neonates and neurological disorders in adults. However, the pathogenic mechanisms of ZIKV-induced neurological complications in adults and congenital malformations are still not fully understood. Gas6 is a soluble TAM receptor ligand able to...

Background: Some studies have determined that the SARS-CoV-2 B.1.1.7 variant of concern (VOC) has been associated with increased transmissibility, hospitalization, and mortality. This study aimed to explore the factors associated with B.1.1.7 VOC infection in the context of vaccination with adenovirus-vectored and inactivated vaccines. Methods: We...

Background: Mutations accrued by SARS-CoV-2 lineage P.1—first detected in Brazil in early January, 2021—include amino acid changes in the receptor-binding domain of the viral spike protein that also are reported in other variants of concern, including B.1.1.7 and B.1.351. We aimed to investigate whether isolates of wild-type P.1 lineage SARS-CoV-2...

We documented 4 cases of severe acute respiratory syndrome coronavirus 2 reinfection by non-variant of concern strains among healthcare workers in Campinas, Brazil. We isolated infectious particles from nasopharyngeal secretions during both infection episodes. Improved and continued protection measures are necessary to mitigate the risk for reinfec...

Background: A new SARS-CoV-2 lineage, named P.1 (20J/501Y.V3), has recently been detected in Brazil. Mutations accrued by the P.1 lineage include amino acid changes in the receptor-binding domain of the spike protein that also are reported in variants of concern in the United Kingdom (B.1.1.7) and South Africa (B.1.325). Methods: We isolated two P...

Brazilian spotted fever (BSF) is a highly lethal disease in southeastern Brazil. BSF is caused by the bacterium Rickettsia rickettsii and is transmitted by the bites of the tick of the genus Amblyomma. The spatial distribution of BSF risk areas is not well known in the country given the complexity of the transmission cycle. This study used the ecol...

Background: Rickettsia parkeri strain Atlantic rainforest has emerged in Brazil during the last 10 years, with three laboratory-confirmed human cases. While these cases were epidemiologically associated with the tick Amblyomma ovale, in none of them the tick specimens that bit the patients could be identified. Results: We report a clinical case of...

Background: Rickettsia parkeri strain Atlantic rainforest has emerged in Brazil during the last 10 years, with three laboratory-confirmed human cases. While these cases were epidemiologically associated with the tick Amblyomma ovale, in none of them the tick specimens that bit the patients could be identified. Results: We report a clinical case...

This study involves a 49-year-old male, who for three years suffered with a myelodysplastic syndrome and who needed frequent blood transfusions. One day following a transfusion, he presented fever and abdominal pain. The fever became persistent and only improved temporarily with two cycles of intravenous ciprofloxacin. Nearly 120 days after beginni...

We report a fatal case of Bartonella henselae bacteremic patient. He had negative serology and PCRs from whole blood and liquid culture; only ftsZ nested PCR was positive from the blood liquid culture. The isolate had positive PCRs. When considered, bartonellosis diagnosis can be still challenging because of technical limitations.

We report a clinical case of African tick-bite fever in a Brazilian traveler right after his return from South Africa. Definitive diagnosis was supported by seroconversion between acute-phase and convalescent-phase serum samples, detection of rickettsial DNA in skin lesions, and in vitro culture of Rickettsia africae from the patient’s skin. Most o...

Spotted fever caused by rickettsial species, the most important tick-borne disease. In Brazil, is nationwide communicable compulsory disease to the Ministry of Health. Since 2007, all suspected cases of spotted fever have been integrated into the Notifiable Diseases Information System (SINAN). In this descriptive study we evaluate the timeliness (e...

Recent Zika outbreaks in South America, accompanied by unexpectedly severe clinical complications have brought much interest in fast and reliable screening methods for ZIKV (Zika virus) identification. Reverse-transcriptase polymerase chain reaction (RT-PCR) is currently the method of choice to detect ZIKV in biological samples. This approach, none...

Two recent researches described the spread of East/Central/South African (ECSA) lineage of chikungunya virus (CHIKV) in the Northeastern and Southeastern Brazil (Charlys da Costa et al. 2017, Cunha et al. 2017) . Initial studies in Northern Brazil, as observed in Caribbean, identified the Asian as the circulating lineage of the chikungunya. However...

Two recent researches described the spread of East/Central/South African (ECSA) lineage of chikungunya virus (CHIKV) in the Northeastern and Southeastern Brazil (Charlys da Costa et al. 2017, Cunha et al. 2017) . Initial studies in Northern Brazil, as observed in Caribbean, identified the Asian as the circulating lineage of the chikungunya. However...

Infection with Zika virus (ZIKV), a mosquito-borne flavivirus has been casually linked with increased congenital microcephaly in Brazil from 2015 through 2016. Sensitive and specific diagnosis of patients with Zika fever (ZIKF) remains critical for patient management. We developed a ZIKV NS5 qRT-PCR assay by combining primers described by Balm et a...

Abstract Background. Zika virus (ZIKV) infections have been linked to different levels of clinical outcomes ranging from mild rash and fever to severe neurological complications and congenital malformations. Methods. We investigated the clinical and immunological response, focusing on the immune mediators profile in 95 acute ZIKV-infected adult pat...

A large retrospective study using the GeoSentinel database observed the most frequent clinical syndromes among ill travelers returning from countries of South America as follows: dermatological disorders (264/1000 patients), acute diarrhea (219/1000 patients), systemic febrile illness (143/1000 patients), respiratory disorders (50/1000 patients). I...

In Brazil, two pathogenic Rickettsia species have been identified causing tick-borne spotted fever (SF). The aetiological agent Rickettsia rickettsii causes serious illness, particularly in the south-eastern region of the country. Moreover, the Rickettsia sp. strain Atlantic Rainforest cause milder clinical manifestations in south-eastern, south an...

A large retrospective study using the GeoSentinel database observed the most frequent clinical syndromes among ill travelers returning from countries of South America as follows: dermatological disorders (264/1000 patients), acute diarrhea (219/1000 patients), systemic febrile illness (143/1000 patients), respiratory disorders (50/1000 patients). I...

Recurrent hepatitis C after orthotopic liver transplantation (OLT) is universal and can lead to graft failure and, consequently, reduced survival. Hepatitis C treatment can be used to prevent these detrimental outcomes. The aim of this study was to describe rates of hepatitis C recurrence and sustained virological response (SVR) to interferon-based...

A vigilância de influenza baseada na detecção de casos de Síndrome Respiratória Aguda Grave (SRAG) em serviços de saúde é uma das estratégias a serem executadas por todos os hospitais em âmbito nacional, e tem como um dos objetivos avaliar o perfil de morbimortalidade associado aos vírus respiratórios. Dentre as ações realizadas incluem-se a busca...

Brazilian spotted fever (BSF) is caused by the bacterium Rickettsia rickettsii. Because of its high case-fatality rate and apparent increase in areas of transmission, it is considered to be the rickettsial illness of primary public health interest. Cases of this disease have historically occurred in Southeastern Brazil. This article reports the fir...

INTRODUCTION Brazilian spotted fever is an infectious disease with a high mortality rate if not treated early. Differential diagnosis is difficult, as the first clinical signs are non-specific and can be confused with other diseases. The aim of the study was to investigate evidence of infection with Rickettsia rickettsii and Rickettsia parkeri in n...

A panel of national experts was convened by the Brazilian Infectious Diseases Society in order to organize the national recommendations for the management of zika virus infection. The focus of this document is the diagnosis, both clinical and laboratorial, and appropriate treatment of the diverse manifestations of this infection, ranging from acute...

Background: Zika virus (ZIKV) is an emerging arthropod-borne flavivirus transmitted by Aedes mosquitoes. Recent commentaries regarding ZIKV routes of transmission describe a potential transmission by transfusion. Herein, we report a probable case of transfusion-transmitted ZIKV infection through a platelet transfusion that was detected from postdo...

Santa Catarina State in southern Brazil is the state with the second highest number of laboratory-confirmed cases of spotted fever illness in Brazil. However, all these cases were confirmed solely by serological analysis (seroconversion to spotted fever group rickettsiae), which has not allowed identification of the rickettsial agent. Here, a clini...

We report here the genome sequence of Zika virus, strain ZikaSPH2015, containing all structural and nonstructural proteins flanked by the 5′ and 3′ untranslated region. It was isolated in São Paulo state, Brazil, in 2015, from a patient who received a blood transfusion from an asymptomatic donor at the time of donation.

In 2010, introduction of the meningococcal C conjugate vaccine in Brazil for children < 2 years providing an immediate reduction in the incidence rates of disease among the age groups targeted for the vaccine, but no impact was observed in unvaccinated age groups. Knowledge about meningococcal carriage is crucial for improving our understanding of...

Fifteen bacterial isolates from spotted fever group rickettsiosis in Brazil were genetically identified as Rickettsia rickettsii. In a phylogenetic analysis with other R. rickettsii isolates from GenBank, the Central/South American isolates showed low polymorphism and formed a clade distinct from two North American clades, with the North American c...

Background Although malaria in Brazil almost exclusively occurs within the boundaries of the Amazon Region, some concerns are raised regarding imported malaria to non-endemic areas of the country, notably increased incidence of complications due to delayed diagnoses. However, although imported malaria in Brazil represents a major health problem, on...