Rodolfo Pinto-Almazán

Rodolfo Pinto-Almazán
Instituto Politécnico Nacional | IPN · Escuela Superior de Medicina

Doctor of Philosophy
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About

51
Publications
14,603
Reads
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622
Citations
Additional affiliations
October 2016 - October 2017
University of Southern California
Position
  • PostDoc Position
September 2015 - September 2021
Hospital Regional de Alta Especialidad de Ixtapaluca
Position
  • Professor
September 2013 - August 2015
Hospital Regional de Alta Especialidad de Ixtapaluca
Position
  • Professor
Education
February 2010 - September 2014
Universidad Nacional Autónoma de México
Field of study
  • Biomedical Sciences
February 2008 - January 2010
Instituto Politécnico Nacional
Field of study
  • Pharmacology
August 2001 - February 2007
Universidad La Salle México
Field of study
  • Pharmaceutical and Biological Chemistry

Publications

Publications (51)
Article
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Metabolic syndrome (MetS) contributes to the spread of cardiovascular diseases, diabetes mellitus type 2, and neurodegenerative diseases. Evaluation of sex- and hormone-dependent changes in body weight, blood pressure, blood lipids, oxidative stress markers, and alterations in different types of memory in Sprague–Dawley rats fed with a high fat and...
Article
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Metabolic syndrome is a set of risk factors that consist of abdominal obesity, arterial hypertension, alterations in the lipid profile, and hyperglycemia. The current therapeutic strategy includes polypharmacy, using three or more drugs to control each syndrome component. However, this approach has drawbacks that could lead to therapeutic failure....
Article
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Consensus has been reached that symptoms of depression can begin as early as preschool. Nevertheless, only few studies have associated environmental (malnutrition) and social factors (poverty condition, access to health systems, etc.) to the onset of depression in preschoolers. The aim of this study was to explore possible associations between maln...
Article
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Background and Objectives: The development of severe COVID-19 is related to the preexistence of comorbidities and an inadequate nutritional status. The latter is a critical factor for the development of infection and the progression of the disease. Notably, optimal nutrition impacts immune system function, as malnutrition is related to high cytokin...
Article
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Background Nakaseomyces glabratus (N. glabratus) formerly known as Candida glabrata (C. glabrata), is an endogenous opportunistic pathogen, which is generally located in the gastrointestinal tract but can spread in immunocompromised patients. N. glabratus is the second most common pathogen that causes candidemia in several countries. N. glabratus v...
Article
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Background: Traumatic brain injury (TBI) is a major cause of death and disability, with a rising incidence in recent years. Factors such as age, sex, hypotension, low score on the Glasgow Coma Scale, use of invasive mechanical ventilation and vasopressors, etc., have been associated with mortality caused by TBI. The aim of this study was to identif...
Article
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Gonadal steroids exert different effects on the central nervous system (CNS), such as preserving neuronal function and promoting neuronal survival. Estradiol, progesterone, and testosterone reduce neuronal loss in the CNS in animal models of neurodegeneration. However, hormone replacement therapy has been associated with higher rates of endometrial...
Article
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The primary mechanism of traumatic spinal cord injury (SCI) comprises the initial mechanical trauma due to the transmission of energy to the spinal cord, subsequent deformity, and persistent compression. The secondary mechanism of injury, which involves structures that remained undamaged after the initial trauma, triggers alterations in microvascul...
Article
The present study analyses the clinical characteristics of patients diagnosed with cutaneous fusarium through a systematic review of cases reported in literature. A total of 39 cases were included, of which 53% were men, 30% were women, and in 17% the sex was not specified. The age ranged from 5 to 85 years. Most cases were reported in Brazil, foll...
Article
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Fungal melanonychia is an uncommon condition, most typically caused by opportunistic melanin-producing pigmented filamentous fungi in the nail plate. In the present study, the clinical characteristics of patients diagnosed with fungal melanonychia were analyzed through a systematic review of cases reported in the literature. The MESH terms used for...
Article
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Microsporum canis is a widely distributed dermatophyte, which is among the main etiological agents of dermatophytosis in humans and domestic animals. This fungus invades, colonizes and nourishes itself on the keratinized tissues of the host through various virulence factors. This review will bring together the known information about the mechanisms...
Article
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Metabolic syndrome (MetS) is a complex disease that includes metabolic and physiological alterations in various organs such as the heart, pancreas, liver, and brain. Reports indicate that blackberry consumption, such as maqui berry, has a beneficial effect on chronic diseases such as cardiovascular disease, obesity, and diabetes. In the present stu...
Chapter
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Resumen Los índices de calidad resultan de algoritmos destinados a evaluar la dieta habitual y categorizar a los individuos en función de si su patrón de alimentación es saludable o no. Debido a que la malnutrición sigue siendo un enorme obstáculo para el desarrollo sostenible y además constituye una de las barreras a las que se enfrenta el Segundo...
Article
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Background: Trichophyton rubrum (T. rubrum) is the most common etiological agent of human dermatophytosis worldwide. T. rubrum has various phenotypic virulence factors that allow the infection to establish and evolve. Several enzymes, including keratinase, protease, lipase, deoxyribonuclease, elastase, and collagenase, are some of these virulence f...
Article
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Background: Sporotrichosis is a fungal infection that can affect both humans and animals, caused by a species of thermo-dimorphic fungi of the genus Sporothrix. This pathology can be acquired by subcutaneous traumatic inoculation through contact with contaminated plants, soil or decomposing organic matter, and/or by inhalation of conidia. The infe...
Article
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During the pandemic, some mortality-related factors were age, sex, comorbidities (obesity, diabetes mellitus, and hypertension), recovery time, hospitalizations, and biochemical markers. The present work aimed to identify the mortality and survival factors in adults with moderate and severe pneumonia due to COVID-19 during the first and second wave...
Research Proposal
Full-text available
Special Issue Information Dear Colleagues, Metabolic disorders (MetDis) are a group of pathologies (central obesity, insulin resistance, dyslipidemia, hypertension, etc.) that cause alterations in normal metabolic processes. They are currently highly prevalent in the world. Scientific evidence has demonstrated sexual differences in the epidemiolog...
Article
Background: Alzheimer's disease (AD) affects women more than men and consequently has been associated with menopause. Tibolone (TIB) has been used as a hormone replacement therapy to alleviate climacteric symptoms. Neuroprotective effects of TIB have also been reported in some animal models. Objective: This study aimed to assess the effect of TI...
Article
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Malnutrition is a public health problem in developing countries, affecting the child population, which favors the appearance of infections such as oral candidiasis. In Mexico, information on the presence of oral colonization by Candida spp. in asymptomatic children is scarce. The present study aimed to determine the presence of Candida spp. in the...
Article
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Background: Sporotrichosis is a fungal infection caused by species of the Sporothrix genus. Presently, the prevalence of sporotrichosis in the Americas is unknown, so this study aims to analyze the cases reported in the past 10 years. Methods: An advanced search was conducted from 2012 to 2022 in English and Spanish in PUBMED, SciELO, and Cochra...
Article
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Metabolic syndrome (MS) is a cluster of metabolic signs that increases the risk of developing type 2 two diabetes mellitus and cardiovascular diseases. MS leads to pancreatic beta cell exhaustion and decreased insulin secretion through unknown mechanisms in a time-dependent manner. ATP-sensitive potassium channels (KATP channels), common targets of...
Article
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During pregnancy, there is a state of immune tolerance that predisposes them to viral infection, causing maternal-fetal vulnerability to the adverse effects of COVID-19. Bacterial coinfections significantly increase the mortality rate for COVID-19. However, it is known that all drugs, including antibiotics, will enter the fetal circulation in a var...
Article
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The potential of polyphenols for treating chronic-degenerative diseases (particularly neurodegenerative diseases) is attractive. However, the selection of the best polyphenol for each treatment, the mechanisms by which they act, and their efficacy are frequently discussed. In this review, the basics and the advances in the field, as well as suggest...
Article
La enfermedad del coronavirus 2019, abreviada COVID-19, es un padecimiento que afecta princi-palmente al sistema respiratorio, pero que puede tener efectos sobre otros sistemas del orga-nismo. En el 80 a 85% de los casos la enfermedad cursa asintomática o con sintomatología leve a moderada, pero en algunos pacientes la enfermedad puede evolucionar...
Article
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In recent years, a progressive increase in the incidence of invasive fungal infections (IFIs) caused by Candida glabrata has been observed. The objective of this literature review was to study the epidemiology, drug resistance, and virulence factors associated with the C. glabrata complex. For this purpose, a systematic review (January 2001–Februar...
Article
Full-text available
Metabolic syndrome (MetS) is a complex disease that affects almost a quarter of the world's adult population. In MetS, diabetes, obesity, hyperglycemia, high cholesterol, and high blood pressure are the most common disorders. Polypharmacy is the most used strategy for managing conditions related to MetS, but it has drawbacks such as low medication...
Article
The metabolic syndrome (MetS) includes numerous interrelated clinical, anthropometric, biochemical, and metabolic components and has become a public health problem due to its impact on morbimortality. Inflammation is a central mechanism underlying the etiology and clinical manifestations of MetS, contributing to its related pathological outcomes. D...
Article
Background: Child malnutrition represents a major public health problem with physiological, psychological, and social short- and long-term implications. Objective: To compare the influence of nutritional status on oxidative stress (OS) markers in children aged 3-6 years. Methods: Children were categorized into four groups: underweight, normal weigh...
Article
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The physiopathologic characteristics of COVID-19 (high levels of inflammatory cytokines and T-cell reduction) promote fungal colonization and infection, which can go unnoticed because the symptoms in both diseases are very similar. The objective of this work was to study the current epidemiology of systemic mycosis in COVID-19 times. A literature s...
Article
Background: Alzheimer's disease (AD) causes memory deficit and alterations in other cognitive functions, mainly in adults over 60 years of age. As the diagnosis confirmation is performed by a postmortem neuropathological examination of the brain, this disease can be confused with other types of dementia at early stages. About 860,000 Mexicans are...
Article
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SARS-CoV-2 infects host cells by interacting its spike protein with surface angioten-sin-converting enzyme 2 (ACE2) receptors, expressed in lung and other cell types. Although several risk factors could explain why some countries have lower incidence and fatality rates than others, environmental factors such as diet should be considered. It has bee...
Article
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Background: The increase or reduction of the medial longitudinal arch (MLA) can affect essential functions in the foot biomechanics with long-term health consequences. The aim of the present study was to determine the height of the MLA in children from 3 to 6 years of age through five methods of footprint analysis for the diagnosis of flat foot....
Article
Dermatophyte infections are the most common fungal infections in humans; among them, tinea capitis (TC)-the most contagious fungal infection-is caused by anthropophilic, zoophilic, and geophilic dermatophytes.. The purpose of this systematic review was to determine the different aetiological variants involved in TC and the overall epidemiology of t...
Article
The metabolic syndrome includes changes in blood glucose levels, arterial hypertension, triglycerides, dyslipidemia and central obesity. Countless reports have described the correlation between the metabolic syndrome and cognitive impairment. However, only a few reports have assessed cognitive impairment associated with the metabolic syndrome in an...
Article
Full-text available
Introduction: Prolonged ozone exposure can produce a state of oxidative stress, which in turn causes alterations in the dynamics of the brain and affects memory and learning. Moreover, different investigations have shown that high flavonoid content berries show a great antioxidant activity. The relationship between the protective effect of the maqu...
Article
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Antecedentes: las farmacodermias son polimorfas y suelen afectar sin distinción a todas las razas y grupos etarios. Existe escasa información de su prevalencia en la población pediátrica mexicana. Objetivos: determinar la prevalencia de lesiones cutáneas asociadas a medicamentos e identificar los principales fármacos relacionados en pacientes pediá...
Article
Albeit cholinergic depletion remains the key event in Alzheimer’s Disease (AD), recent information describes stronger links between monoamines (trace amines, catecholamines, histamine, serotonin, and melatonin) and AD than those known in the past century. Therefore, new drug design strategies focus efforts to translate the scope on these topics and...
Article
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Introducción: La hipotermia terapéutica (HT) está indicada para la protección cerebral en casos de riesgo de lesión; sin embargo, por sus efectos electrolíticos su uso es controversial. Objetivo: Determinar las variaciones electrolíticas y metabólicas de la HT en sus distintas fases, las complicaciones que generan y su relación con la mortalidad en...
Article
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Oxidative stress (OS) is a key process in the development of many neurodegenerative diseases, memory disorders, and other pathological processes related to aging. Tibolone (TIB), a synthetic hormone used as a treatment for menopausal symptoms, decreases lipoperoxidation levels, prevents memory impairment and learning disability caused by ozone (O3)...
Article
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Estrogen receptor modulators are compounds of interest because of their estrogenic agonistic/antagonistic effects and tissue specificity. These compounds have many clinical applications, particularly for breast cancer treatment and osteoporosis in postmenopausal women, as well as for the treatment of climacteric symptoms. Similar to estrogens, neur...
Article
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Hormone replacement therapy (HRT) increases the risk of endometrial and breast cancer. A strategy to reduce this incidence is the use of tibolone (TIB). The aim of this paper was to address the effects of TIB on the central nervous system (CNS). For the present review, MEDLINE (via PubMed), LILACS (via BIREME), Ovid Global Health, SCOPUS, Scielo an...
Article
Oxidative stress is related to the development of central nervous system diseases involving memory processes. Cholinergic system and memory processes are disrupted by ozone exposure. In rats, ozone induces motor disturbances and memory deficits as well as biochemical changes in brain regions related to memory processes. In this work, we analyzed th...
Article
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This work describes the effect of two series of isoindolines 1(a–g) and 2(a–g) on histone deacetylase 8 (HDAC8) activity by theoretical study (docking method) and experimental assays using a commercial kit, as well as the effect of isoindolines on HDAC8 expression on HeLa cells. The theoretical study show interactions of the isoindolines with two H...
Article
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Introduction: Oxidative stress increases brain lipid peroxidation, memory and motor deficits and progressive neurodegeneration. Tibolone, a treatment for menopausal symptoms, decreases lipid peroxidation levels and improves memory and learning. Aim: To study the effect of chronic administration of tibolone on lipid peroxidation, memory and motor...
Article
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RESUMEN Introducción: La diabetes mellitus es una enfermedad crónica que aparece cuando las células del páncreas no producen insulina sufi ciente o cuando el organismo no uƟ liza efi cazmente la insulina que produce. Existen tres Ɵ pos de diabetes me-llitus: la diabetes mellitus Ɵ po 1, la diabetes mellitus Ɵ po 2 y la diabetes gestacional. ObjeƟ v...
Article
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ABSTRACT Aging and neurodegenerative diseases share oxidative stress cell damage and depletion of endogenous antioxidants as mechanisms of injury, phenomenons that occurring at different rate in each process. Nevertheless, as the central nervous system (CNS) consists largely of lipids and has a poor activity of catalase, a low amount of superoxide...
Article
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Gonadal hormones regulate expression and activation of protein tau. Tibolone is a drug used as first- choice comprehensive treatment for the relief of menopausal symptoms, because it and its various metabolites have estrogenic properties and progestogenic/androgenic effects; however, the effect on the activation of tau protein and its signaling cas...
Article
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Several growth factors, such as vascular endothelial growth factor, brain-derived neurotrophic factor, and insulin-like growth factor-I are involved in the actions of progesterone in the central nervous system. Previous studies in neuronal and glial cultures have shown that progesterone may regulate growth factor signaling, increasing the phosphory...
Article
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A high performance liquid chromatography (HPLC) method for the estimation of pravastatin in human serum samples has been developed to monitor dyslipidemic patients. The method was fully validated and validation parameters were in the linearity range 10–200 ng/mL, correlation coefficient 0.99, mean recovery >0.73, quantification limit 10 ng/mL, and...

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