Roch Giorgi

Roch Giorgi
Assistance Publique Hôpitaux de Marseille | APHM

MD, PhD

About

305
Publications
24,515
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7,482
Citations
Additional affiliations
May 1999 - present
Aix-Marseille Université
Position
  • Professor (Full)

Publications

Publications (305)
Article
Aims To determine the prognosis of patients treated for infective endocarditis (IE) according to their healthcare pathway. To assess how the ESC guidelines are implemented concerning the performance of transoesophageal echocardiography, the use of antibiotic therapy, and the performance of valve surgery; and to compare the epidemiological profile o...
Article
Full-text available
Background Whether left ventricular non-compaction (LVNC) bears a different prognosis than dilated cardiomyopathy (DCM) is still a matter of debate. Methods From a multicenter French prospective registry, we compared the outcomes of 98 patients with LVNC and 65 with DCM. The primary endpoint combined cardiovascular death, heart transplantation, an...
Article
Full-text available
Background: To analyze worldwide practices regarding the initiation of oral feeding after total laryngectomy (TL). Methods: Online survey. Results: Among the 332 responses received, 278 from 59 countries were analyzed. Our results showed that 45.6% of respondents started water and 45.1% started liquid diet between postoperative days 7 and 10....
Article
Introduction Mortality in infective endocarditis (IE) remains high. Few studies have compared the prognosis and management of patients with IE according to their health-care pathway (HCP) Purpose To determine the prognosis of patients treated for IE according to their HCP. To assess how the ESC guidelines are implemented concerning the performance...
Article
Introduction La survie nette correspond à la survie qui serait observée en l’absence de mortalité due à d’autres causes que la pathologie d’intérêt, ici le cancer. C’est un indicateur qui permet de s’affranchir des différences de mortalité qui seraient imputables à des causes autres que le cancer étudié. Les modèles développés dans le cadre de l’es...
Article
Full-text available
In cancer epidemiology using population-based data, regression models for the excess mortality hazard is a useful method to estimate cancer survival and to describe the association between prognosis factors and excess mortality. This method requires expected mortality rates from general population life tables: each cancer patient is assigned an exp...
Article
Full-text available
In central Senegal, malaria incidence declined in response to scaling-up of control measures from 2000 to 2010 and has since remained stable, making elimination unlikely in the short term. Additional control measures are needed to reduce transmission. We simulated chemoprophylaxis interventions targeting malaria hotspots using a metapopulation math...
Article
Background To describe the characteristics of the largest European study of MEC of salivary glands and to determine the prognostic factors for overall and disease free survival. Patients and methods Patients with MEC were prospectively included in the Réseau d’Expertise Français sur les Cancers ORL Rares (REFCOR, French Network of Rare Head and Ne...
Article
Full-text available
Background Methods for estimating relative survival are widely used in population-based cancer survival studies. These methods are based on splitting the observed (the overall) mortality into excess mortality (due to cancer) and background mortality (due to other causes, as expected in the general population). The latter is derived from life tables...
Preprint
Full-text available
In central Senegal malaria incidences have declined from 2000 to 2010 in response to scaling-up of control measures and then remained stable, making elimination improbable. Additional control measures are needed to reduce transmission. We simulated chemoprophylaxis interventions targeting malaria hotspots, using a meta-population mathematical model...
Article
Introduction Les estimateurs de Kaplan–Meier et de Pohar–Perme sont utilisés pour estimer les distributions de survie dans le cadre de la survie brute et de la survie nette, respectivement. Les courbes de survie sont classiquement comparées par des tests de type log-rank. Ces tests sont optimaux quand les risques sont proportionnels. Des alternativ...
Preprint
Full-text available
Background : Methods for estimating relative survival are widely used in population-based cancer survival studies. These methods are based on splitting the observed (the overall) mortality into excess mortality (due to cancer) and background mortality (due to other causes, as expected in the general population). The latter is derived from life tabl...
Preprint
Full-text available
Background: Methods for estimating relative survival are widely used in population-based cancer survival studies. These methods are based on splitting the observed (the overall) mortality into excess mortality (due to cancer) and background mortality (due to other causes, as expected in the general population). The latter is derived from life table...
Article
Objectives The aim of this study was to identify prognostic factors affecting the survival of the low grade Mucoepidermoid carcinomas (MEC) without clinical‐radiological lymph node involvement (cN0) at the time of the initial work‐up and to determinate the therapeutic strategy for the neck dissection Materials and methods One hundred and fifty two...
Article
Background Pembrolizumab, a humanized immunoglobulin monoclonal antibody directed against the programmed cell death 1 receptor, demonstrated robust efficacy and a manageable safety profile across multiple tumor types in clinical trials. Aim To investigate the efficacy and safety of first-line pembrolizumab for patients with non-small cell lung can...
Article
Net survival is used in epidemiological studies to assess excess mortality due to a given disease when causes of death are unreliable. By correcting for the general population mortality, it allows comparisons between regions or periods and thus evaluation of health policies. The Pohar-Perme non-parametric estimator of net survival has been recently...
Article
Full-text available
Background: In the context of environmentally influenced communicable diseases, proximity to environmental sources results in spatial heterogeneity of risk, which is sometimes difficult to measure in the field. Most prevention trials use randomization to achieve comparability between groups, thus failing to account for heterogeneity. This study ai...
Article
In cancer epidemiology using population-based data, regression models for the excess mortality hazard is a useful method to estimate cancer survival and to describe the association between prognosis factors and excess mortality. This method requires expected mortality rates from general population life tables: each cancer patient is assigned an exp...
Article
Full-text available
Background Net survival, a measure of the survival where the patients would only die from the cancer under study, may be compared between treatment groups using either “cause-specific methods”, when the causes of death are known and accurate, or “population-based methods”, when the causes are missing or inaccurate. The latter methods rely on the as...
Article
Introduction La survie nette est la survie qui serait observée si la seule cause possible de décès était la pathologie d’intérêt, ici le cancer. Cet indicateur permet de s’affranchir des différences de mortalité qui seraient imputables à des causes autres que le cancer. Dans l’estimation de la survie nette, les modèles proposés considèrent la morta...
Article
Introduction La survie nette correspond à la survie que l’on observerait dans un monde hypothétique où le cancer étudié serait la seule cause possible de décès. Il s’agit d’un indicateur pertinent, notamment dans le cadre des essais multicentriques à long terme avec des patients qui survivent plus longtemps et qui sont plus âgés, car elle s’affranc...
Preprint
Full-text available
In cancer epidemiology using population-based data, regression models for the excess mortality hazard is a useful method to estimate cancer survival and to describe the association between prognosis factors and excess mortality. This method requires expected mortality rates from general population life tables: each cancer patient is assigned an exp...
Article
Full-text available
Background: Evidence is growing regarding the ability of platelet-rich plasma (PRP) injections to enhance functional capacity and alleviate pain in knee osteoarthritis (OA). However, heterogeneity in common practice regarding PRP preparation and biological content makes the initiation of this activity in a hospital complex. The aim of this study wa...
Preprint
Full-text available
The aim of the present study was to develop a method for multiscale analysis of non-stationary and non-periodic epidemic time series. Indeed, the epidemiologists may need to know the features, at different resolutions, of short duration outbreaks that did not exhibit periodic cycles. Among of the large number of wavelets, we have developed a contin...
Article
Relative survival methods used to estimate the excess mortality of cancer patients rely on the background (or expected) mortality derived from general population life tables. These methods are based on splitting the observed mortality into the excess mortality and the background mortality. By assuming a regression model for the excess mortality, us...
Article
Nivolumab, a fully human immunoglobulin monoclonal antibody inhibiting the programmed cell death protein‐1 receptor, demonstrated robust efficacy and a manageable safety profile across multiple tumor types in clinical trials. The aim of the present study was to investigate the efficacy and safety of nivolumab for pretreated patients with non-small...
Preprint
Full-text available
Background: In central Senegal malaria incidences have declined in recent years in response to scaling-up of control measures, but now remains stable, making elimination improbable. Additional control measures are needed to reduce transmission. Methods: By using a meta-population mathematical model, we evaluated chemotherapy interventions targeting...
Article
Introduction L’étude du pronostic de patients atteints d’un cancer, sur données populationnelles issues de registres, est affinée par l’estimation de la survie nette. On prend ainsi en compte la mortalité due au cancer étudié en s’affranchissant de la part due aux autres causes affectant la population générale. Un estimateur non paramétrique de la...
Article
Introduction Dans l’analyse de données massives en santé, il est préférable de ne considérer que les variables les plus importantes pour un modèle donné afin de réduire les temps de calcul. Par exemple, pour qualifier l’état physiologique d’un patient à partir de descripteurs de nature médicale, seules les variables les plus pertinentes devraient ê...
Article
Background: Raised plasma levels of endogenous adenosine after cardiac surgery using cardiopulmonary bypass (CPB) have been related to the incidence of postoperative atrial fibrillation (POAF). Objective: We wished to assess if caffeine, an adenosine receptor antagonist could have a beneficial effect on the incidence of POAF. Design: A randomi...
Article
Purpose: To evaluate efficacy and safety of superior rectal artery embolization of hemorrhoidal disease as a first-line invasive treatment. Materials and methods: This prospective study was conducted between 2014 and 2015 on 25 consecutive patients (16 men and 9 women with a mean age of 53 y [range, 30-76 y]) with grade II-III hemorrhoids refrac...
Article
Full-text available
Background: Mathematical models of human mobility have demonstrated a great potential for infectious disease epidemiology in contexts of data scarcity. While the commonly used gravity model involves parameter tuning and is thus difficult to implement without reference data, the more recent radiation model based on population densities is parameter...
Article
What is known and objective: There are various reasons why antiepileptic treatment can fail. One is drug-resistant epilepsies, but non-adherence, or poor adherence, to treatment may make some patients' treatment ineffective. The consequences of poor adherence include treatment failure or introduction of more complex treatments involving greater to...
Article
Objectives: We aimed to determine primarily the oral health status of patients with upper aerodigestive tract cancer before radiotherapy, and secondarily the prevalence of risk factors for poor oral status. Methods: A cross-sectional study was conducted in Marseille University hospital. Assessment criteria were the Decay, Missing and Filled (DMF...
Article
Aims Leadless cardiac pacing has recently been proposed as alternative to conventional right ventricular (RV) pacing. With this approach, devices are directly screwed or fixed with tines in the RV wall, but the possible consequences on RV and tricuspid valve (TV) structure and function remain unknown. We thus conducted a study to evaluate this pote...
Article
Full-text available
Introduction Little is known about the long-term outcome of growth in early treated infants in resources limited countries. Here, we compared growth parameters over the first 5 years of life of early treated HIV-infected and uninfected children and identified factors associated with growth retardation, taking into account informative censorship. M...
Article
Objective: To describe the characteristics of infective endocarditis (IE) in octogenarians and assess their prognosis. Methods: Patients with definite IE hospitalised at a referral centre between July 2008 and July 2013 were prospectively included. A total of 454 patients were divided into three groups: 230 patients under 65 years old, 173 patie...
Article
Objectives: To evaluate the prevalence of obstructive sleep apnea syndrome (OSAS) in a population of patients treated for an advanced cancer of the oropharynx (AJCC Stage III or IV), depending on treatment strategy and to evaluate its impact on quality of life. Design: Prospective cohort study. Setting: University Teaching Hospital of La Conce...
Article
Full-text available
Purpose: The risk factors of pneumothorax after lung radiofrequency (RF) ablation are long known. The objective was to demonstrate that the visualisation of an aeric RF path after the needle withdrawal was predictive of pneumothorax occurrence and chest tube placement. Materials and methods: A total of 70 patients were retrospectively included in t...
Article
Full-text available
Aims: When compared with the former Sapien XT (XT-THV), the Sapien 3 trans-catheter heart valve (S3-THV) embeds an outer annular sealing cuff to prevent para-valvular regurgitation (PVR). The consequences of this new feature on valve haemodynamics have never been evaluated. We aimed to compare both types of prostheses regarding patient-prosthesis...
Article
Background: Hand hygiene is a major means for preventing healthcare-associated infections. One critical point in understanding poor compliance is the lack of relevant markers used to monitor practices systematically. Methods: This study analysed hand hygiene compliance and associated factors with a radio-frequency-identification-based real-time...
Article
Breast cancer affects mostly older women but there are no guidelines especially devoted to adjuvant chemotherapy for this population. In this context, this study was carried out in a population-based cohort of French elderly women with breast cancer, to check adherence to the existing national guidelines according to the women's age, taking into ac...
Article
Full-text available
Background: Health care-associated infections are a major worldwide public health issue. Hand hygiene is a major component in the prevention of pathogen transmission in hospitals, and hand hygiene adherence by health care workers is low in many studies. We report an intervention using text messages as reminders and feedback to improve hand hygiene...
Article
Résumé But Rapporter les résultats oncologiques d’une cohorte de patients atteints d’un cancer de la prostate et placés en surveillance active (SA) selon les critères SURACAP. Matériels et méthodes Il s’agit d’une étude multicentrique reprenant les patients inclus dans le protocole SURACAP et évaluant de façon rétrospective la durée de surveillan...
Article
Background and objectives: The relative bleeding risk of aspirin versus vitamin K antagonists (VKA) is unclear. Most of previous meta-analyses included trials with target INR for VKA therapy far beyond usually recommended range (2-3). The aim of this study was to compare the bleeding risk of aspirin and VKA, as indicated by the aggregate body of c...
Article
Recently goodness-of-fit tests have been proposed for checking the proportional subdistribution hazards assumptions in the Fine and Gray regression model. Zhou, Fine, and Laird proposed weighted Schoenfeld-type residuals tests derived under an assumed model with specific form of time-varying regression coefficients. Li, Sheike, and Zhang proposed a...
Article
Full-text available
Background: The reliability of spatial statistics is often put into question because real spatial variations may not be found, especially in heterogeneous areas. Our objective was to compare empirically different cluster detection methods. We assessed their ability to find spatial clusters of cancer cases and evaluated the impact of the socioecono...
Article
Aims We sought to compare outcomes and costs of a stepwise approach to transvenous lead extraction (TLE) involving laser-assisted sheaths or mechanical polypropylene sheaths, with/without crossover. Methods and results We prospectively included patients who underwent TLE (between August 2013 and December 2014) as part of a stepwise approach involv...
Article
Background: Net survival, the survival probability that would be observed, in a hypothetical world, where the cancer of interest would be the only possible cause of death, is a key indicator in population-based cancer studies. Accounting for mortality due to other causes, it allows cross-country comparisons or trends analysis and provides a useful...
Article
Full-text available
Background: Carotid artery stenting (CAS) has been advocated as an alternative to redo surgery for the treatment of post-carotid endarterectomy (CEA) stenosis. This study analyzed the efficacy of CAS for post-CEA restenosis, focusing on an analysis of technical and anatomical predictive factors for in-stent restenosis. Methods: We performed a re...
Data
CAS for post CEA restenosis-xls. Statistical data. (XLS)
Article
Introduction Afin d’anticiper la propagation d’une epidemie, la mobilite humaine peut etre estimee par les modeles de gravite et de radiation. De facon generale un modele de gravite stipule que le flux de mobilite entre deux sites geographiques s’accroit proportionnellement aux tailles de populations et decroit en fonction de la distance entre les...
Article
Full-text available
Aim: Evaluation of the aortic "elastic reserve" might be a relevant marker to assess the risk of aortic event. Our aim was to compare regional aortic elasticity at rest and during supine bicycle exercise at 1.5 T MRI in healthy individuals. Methods: Fifteen volunteers (8 men), with a mean age of 29 (23-41) years, completed the entire protocol. I...
Article
Introduction L’expertise par les pairs est actuellement le mode d’évaluation des projets de recherche soumis à des appels à projets institutionnels. L’objectif de ce travail est de décrire le processus d’expertise des projets de recherche institutionnels et de dégager des propositions de recommandations afin d’améliorer le processus d’expertise aca...
Conference Paper
Introduction La survie est un des indicateurs fréquemment utilisés pour évaluer le pronostic d’une maladie, aussi bien dans les essais cliniques que dans les études populationnelles. Un autre critère d’intérêt est la survie nette, qui permet de distinguer la mortalité liée à la pathologie étudiée (en excès) de la mortalité liée aux autres causes. L...
Article
Since 2001, the World Health Organization classification of tumours of haematopoietic and lymphoid tissues and the International Classification of Diseases for Oncology (third edition) have improved data collection for lymphoma subtypes in most European cancer registries and allowed reporting on the major non-Hodgkin lymphoma subtypes. Treatment of...
Article
Introduction L’hépatectomie majeure (HM) sur foie de cirrhose reste une contre-indication pour de nombreuses équipes. Le but de ce travail est d’étudier la morbi-mortalité après hépatectomie majeure sur cirrhose et d’identifier les facteurs de risque (FDR). Méthodes L’ensemble des HM pour CHC sur cirrhose, entre 2000 et 2014, ont été analysées à p...
Article
To compare the cost effectiveness of adding a pancreatitis-associated protein (PAP) assay to common immunoreactive trypsinogen (IRT) and DNA cystic fibrosis (CF) newborn screening strategies. Using data collected on 553,167 newborns, PAP cut-offs were calculated based on non-inferiority of the detection rates of classical forms of CF. Cost effectiv...
Article
Full-text available
To assess the value of cardiac magnetic resonance (CMR) using phase-contrast velocity mapping for paravalvular aortic regurgitation (PAR) quantification. All patients undergoing transcatheter aortic valve implantation (TAVI) in our centre between November 2012 and August 2013, without CMR-contraindication were included. PAR severity was assessed 5...
Article
In population-based cancer studies, it is often of interest to compare cancer survival between differentpopulations. However, in such studies the exact causes of death are often unavailable or unreliable. Net survivalmethods were developed to overcome this difficulty. Net survival is the survival that would be observed, in ahypothetical world, if t...
Article
Introduction Choisir le modèle statistique approprié aux besoins de l’étude est déterminé par le type et la nature des données. Cependant, la structure hiérarchique des données reste encore peu évaluée pour définir le modèle statistique adapté. Dans de nombreux domaines, la population que l’on souhaite étudier s’intègre au sein de groupes plus vast...
Article
Introduction Plusieurs méthodes statistiques permettent d’évaluer l’impact d’un facteur sur la répartition spatiale d’une maladie donnée. Cependant, leur fiabilité est souvent remise en question et des variations spatiales réelles peuvent être confondues à celles issues d’un bruit statistique, surtout lorsque les indicateurs sanitaires sont disponi...