Robyn Shuttleworth

Robyn Shuttleworth
University of Saskatchewan | U of S · Department of Biology

Doctor of Philosophy (Mathematics)

About

10
Publications
676
Reads
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70
Citations
Citations since 2016
10 Research Items
70 Citations
2016201720182019202020212022051015202530
2016201720182019202020212022051015202530
2016201720182019202020212022051015202530
2016201720182019202020212022051015202530
Introduction
Currently working on the application of a cell-dense triphasic model for cryoprotectant equilibration.

Publications

Publications (10)
Article
Successful cryopreservation requires the addition of cryoprotective agents (CPAs). The addition of permeating CPAs, such as glycerol, is associated with some risk to the cells and tissues. These risks are both related to the CPA themselves (CPA toxicity) and to the volume response of the cell (osmotic damage). To minimize the potential for damage d...
Article
Successful cryopreservation of complex specimens, such as tissues and organs, would greatly benefit both the medical and scientific research fields. Vitrification is one of the most promising techniques for complex specimen cryopreservation, but toxicity remains a major challenge due to the high concentration of cryoprotectants (CPAs) needed to vit...
Article
Full-text available
Local cancer invasion of tissue is a complex, multiscale process which plays an essential role in tumour progression. During the complex interaction between cancer cell population and the extracellular matrix (ECM), of key importance is the role played by both bulk two-scale dynamics of ECM fibres within collective movement of the tumour cells and...
Article
Local cancer cell invasion is a complex process involving many cellular and tissue interactions and is an important prerequisite for metastatic spread, the main cause of cancer related deaths. As a tumour increases in malignancy, the cancer cells adopt the ability to mutate into secondary cell subpopulations giving rise to a heterogeneous tumour. T...
Preprint
Local cancer invasion of tissue is a complex, multiscale process which plays an essential role in tumour progression. Occurring over many different temporal and spatial scales, the first stage of invasion is the secretion of matrix degrading enzymes (MDEs) by the cancer cells that consequently degrade the surrounding extracellular matrix (ECM). Thi...
Preprint
Local cancer cell invasion is a complex process involving many cellular and tissue interactions and is an important prerequisite for metastatic spread, the main cause of cancer related deaths. Occurring over many different temporal and spatial scales, the first stage of local invasion is the secretion of matrix-degrading enzymes (MDEs) and the resu...
Article
Full-text available
Recognised as one of the hallmarks of cancer, local cancer cell invasion is a complex multiscale process that combines the secretion of matrix-degrading enzymes with a series of altered key cell processes (such as abnormal cell proliferation and changes in cell–cell and cell–matrix adhesion leading to enhanced migration) to degrade important compon...
Preprint
Cancer cell invasion is recognised as one of the hallmarks of cancer and involves several inner-related multiscale processes that ultimately contribute to its spread into the surrounding tissue. In order to gain a deeper understanding of the tumour invasion process, we pay special attention to the interacting dynamics between the cancer cell popula...
Chapter
Cancer cell invasion, recognised as one of the hallmarks of cancer, is a complex process involving the secretion of matrix-degrading enzymes that have the ability to degrade the surrounding extracellular matrix (ECM). Combined with cell proliferation and migration, and changes in cell-cell and cell-matrix adhesion, the tumour is able to spread into...

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