Robin Kanarek

Tufts University | Tufts

Emotional eating is defined as an increase in eating following negative emotion. Self-reported emotional eating has been associated with physical health concerns. However, experimental and daily diary studies indicate that induced or naturally experienced negative emotions do not reliably lead to increased eating behavior in people without eating d...

Objective: Caffeine and dietary supplement (DS) use by college students is not well-documented. Given reported associations between energy drink consumption and sensation seeking, we used the Sensation Seeking Scale Form V (SSS-V) to assess relationships between sensation-seeking, caffeine, and DS use. Participants: Data from 1,248 college stude...

Acute exercise consistently benefits both emotion and cognition, particularly cognitive control. We evaluated acute endurance exercise influences on emotion, domain-general cognitive control and the cognitive control of emotion, specifically cognitive reappraisal. Thirty-six endurance runners, defined as running at least 30 miles per week with one...

Emotion regulation may influence psychological responses to exercise. We examined whether the emotion regulation strategies, cognitive reappraisal and distraction, influenced psychological state and prefrontal cortex oxygenation during endurance exercise. Twenty-four endurance runners ran for 90 min at 75–85% maximum heart rate in three separate se...

Glucose intake has been found to improve some aspects of cognitive performance; however, results are often inconsistent. This inconsistency may be related to expectations surrounding glucose, which can have strong effects on performance outcomes. The present study evaluated the independent and interactive effects of acute sugar intake, in the form...

Habitual exercise is associated with enhanced domain-general cognitive control, such as inhibitory control, selective attention, and working memory, all of which rely on the frontal cortex. However, whether regular exercise is associated with more specific aspects of cognitive control, such as the cognitive control of emotion, remains relatively un...

Caffeine reliably increases emotional arousal, but it is unclear whether and how it influences other dimensions of emotion such as emotional valence. These experiments documented whether caffeine influences emotion and emotion regulation choice and success. Low to abstinent caffeine consumers (maximum 100 mg/day) completed measures of state anxiety...

Background: Clinical investigations indicate that anorexia nervosa (AN) is associated with impaired cognitive flexibility. Activity-based anorexia (ABA), a rodent behavioral model of AN, is characterized by compulsive wheel running associated with voluntary food restriction and progressive weight loss. The goal of this study was to test whether AB...

Background: Experimental studies suggest that caffeine benefits cognitive function, including cognitive control processes such as response inhibition. However, recent cross-sectional studies purport that caffeine is, alternatively, associated with reduced response inhibition and associated concepts such as increased impulsivity, risk-taking, and ag...

Tea is perceived as more relaxing than coffee, even though both contain caffeine. L-theanine in tea may account for the difference. Consumed together, caffeine and theanine exert similar cognitive effects to that of caffeine alone, but exert opposite effects on arousal, in that caffeine accentuates and theanine mitigates physiological and felt stre...

Habitual caffeine consumption has often been associated with decreasing age-related cognitive decline. However, whether habitual caffeine use preferentially spares different cognitive processes is unclear. Furthermore, whether basing habitual caffeine consumption patterns on current consumption or on a lifetime measure better represents an individu...

Caffeine is the most commonly used behaviorally‐active substance in the world. Caffeine reliably increases arousal, but it is unclear if and how it influences other dimensions of emotion such as positive versus negative feelings, termed affective valence. The present study documented whether caffeine influences emotion and emotion regulation. Parti...

Aging is often accompanied by cognitive changes, the direction of which depends on the specific cognitive domain. Cognitive decline, however, is not an inevitable consequence of aging. Rather, cognitive functioning may be influenced by a number of lifestyle variables including nutrient intake. Nutrition is of particular interest in older adults, as...

Omega-3 fatty acid (n-3 PUFA) intake is associated with improved mood and cognition, but randomized controlled trials addressing the causal nature of such relationships are less clear, especially in healthy, young adults. Stress is one potential mechanism by which n-3 PUFAs may influence mood. Thus the present aim is to evaluate the influence of n-...

Creatine is an antioxidant, neuromodulator and key regulator of energy metabolism shown to improve depressive symptoms in humans and animals, especially in females. To better understand the pharmacological effects of creatine, we examined its influence on depression-related hippocampal gene expression and behaviors in the presence and absence of se...

Background: There is a hypothesis that lack of n-3 polyunsaturated fatty acids (PUFAs) is of aetiological importance in depression. Docosahexaenoic acid, a member of the n-3 PUFA family, is a crucial component of synaptic cell membranes. The aim of this study was to measure RBC membrane fatty acids in a group of depressed patients relative to a wel...

Previous research from our laboratory has determined that in the absence of a gustatory response or taste hedonics, intraperitoneal (i.p.) glucose administration enhanced morphine-mediated analgesia in rats and had antinociceptive actions on its own. Two experiments examined the potential of a central mechanism for glucose’s actions on morphine-med...

Extensive experimental psychology research has attempted to parse the complex relationship between psychosocial stress, mood, cognitive performance, and physiological changes. To do so, it is necessary to have effective, validated methods to experimentally induce psychosocial stress. The Trier Social Stress Test (TSST) is the most commonly used met...

Both acute and chronic exercise is consistently associated with a number of benefits to physical and mental health, including cardiovascular function, body weight, mood, and cognition. Near-infrared spectroscopy is an ideal method to measure changes in oxygenated and deoxygenated hemoglobin (O2Hb and dHb) levels in the prefrontal cortex (PFC) durin...

The effects of intraperitoneal (ip) d-glucose administration on antinociception were studied in male Long-Evans rats. Rats were assessed for antinociception using the hot-water tail-withdrawal procedure (54±0.2° C) to determine if peripheral administration of d-glucose (300, 560, or 720mg/kg) would enhance morphine-mediated antinociception (MMA) (1...

Depression is one of the most prevalent disorders in the United States, and rates of depression are higher for women than men. Despite their widespread use, drugs used in the treatment of depression are only moderately more effective than placebo in treating the disorder. Effective treatment of perinatal depression is of particular concern as treat...

Information processing is generally biased toward global cues, often at the expense of local information. Equivocal extant data suggests that arousal states may accentuate either a local or global processing bias, at least partially dependent on the nature of the manipulation, task, and stimuli. To further differentiate the conditions responsible f...

We examined the potential effectiveness of four brief interventions, three behavioral and one nutritional, for helping high math-anxious college students regulate negative emotions immediately prior to a time-pressured arithmetic test. Participants with low versus high math anxiety performed a timed arithmetic task after practicing one of three sho...

The development of a conditioned taste aversion to a novel food was examined in the Mongolian gerbil. Ingestion of an orange-flavored sucrose solution was followed by intraperitoneal injections of 3 ml/100 g body weight.15 M LiCl, 4 ml/100 g body weight.15 M LiCl, or 3 ml/100 g body weight physiological saline. Two-bottle preference tests between t...

Appetitive motivational states are fundamental neural and behavioral mechanisms underlying healthy and abnormal eating behavior, though their dynamic influence on food-related behavior is unknown. The present study examined whether personal food-related preferences would activate approach and avoidance systems, modulating spontaneous postural sway...

Although body image is often considered a trait characteristic which is relatively constant over time, it also has a state component which is susceptible to fluctuations across time. Both dietary habits and exercise can impact attitudes towards and perceptions of the body in both a trait and state-dependent manner. Considering the ability of high-c...

Energy drinks containing caffeine, taurine, and glucose may improve mood and cognitive performance. However, there are no studies assessing the individual and interactive effects of these ingredients. We evaluated the effects of caffeine, taurine, and glucose alone and in combination on cognitive performance and mood in 24-hour caffeine-abstained h...

Obesity is a major public health concern in the United States. Over the last several decades, the prevalence of obesity among both adults and children has grown at an alarming rate and is now reaching epidemic proportions. The increase in obesity has been associated with rises in a host of other chronic conditions including cardiovascular disease,...

Dietary creatine has been promoted for its positive health effects, and is best known for its use by athletes to boost physical performance. Creatine also has protective effects on the brain in models of neuronal damage, and improves cognitive performance on stressful tasks. However, there is little research examining how soon behavioral effects ar...

The potential role of metabolic impairments in the pathophysiology of depression is motivating researchers to evaluate the treatment efficacy of creatine, a naturally occurring energetic and neuroprotective compound found in brain and muscle tissues. Growing evidence is demonstrating the benefit of oral creatine supplements for reducing depressive...

Exercise is endorsed for its physiological and psychological benefits, and has been proposed to have positive effects on impression formation. To test this proposal, 62 female and 44 male college students read one of three brief descriptions of either a fictitious male or female "target" student. The descriptions varied only in exercise level: no e...

Attention deficit hyperactivity disorder (ADHD) is one of the most common behavioral disorders in children. Symptoms of ADHD include hyperactivity, low frustration tolerance, impulsivity, and inattention. While the biological pathways leading to ADHD are not clearly delineated, a number of genetic and environmental risk factors for the disorder are...

Body image can be influenced by day-to-day events, including food intake. The present study investigated the effects of foods typically perceived as "healthy" or "unhealthy" on state body image and mood. College-aged women were told the experiment was designed to assess the effects of food on cognition. Using a between-subjects design, participants...

Supplemental creatine has been promoted for its positive health effects and is best known for its use by athletes to increase muscle mass. In addition to its role in physical performance, creatine supplementation has protective effects on the brain in models of neuronal damage and also alters mood state and cognitive performance. Creatine is found...

Impairments in bioenergetic function, cellular resiliency, and structural plasticity are associated with the pathogenesis of mood disorders. Preliminary evidence suggests that creatine, an ergogenic compound known to promote cell survival and influence the production and usage of energy in the brain, can improve mood in treatment-resistant patients...

Exercise improves cardiovascular health, strengthens muscles and bones, stimulates neuroplasticity, and promotes feelings of well-being. However, when taken to extremes, exercise can develop into an addictive-like behavior. To assess the addictive potential of exercise, withdrawal symptoms following injections of 1.0 mg/kg naloxone were compared in...

The role of meals in mood and cognitive performance is discussed. An overview is given of the nature of mood and cognition in psychological research followed by a description of how individual macro- and micronutrients affect brain functioning. The chapter concludes with a discussion of individual meals and how mental function is affected by meals,...

In addition to its metabolic consequences, obesity may lead to impairments in learning and memory. To test this possibility, male Long-Evans rats were fed ground chow, or chow and either a 32% sucrose solution or hydrogenated vegetable fat (Crisco®) for eight weeks. Cognitive behavior was then assessed using a novel object recognition task. To dete...

To examine how a low-carbohydrate diet affects cognitive performance, women participated in one of two weight-loss diet regimens. Participants self-selected a low-carbohydrate (n=9) or a reduced-calorie balanced diet similar to that recommended by the American Dietetic Association (ADA diet) (n=10). Seventy-two hours before beginning their diets an...

Recent work suggests that obesity may adversely affect cognitive behavior. To examine this suggestion, the effects of feeding a standard chow diet, and either supplemental sugar or fat on the development of obesity and performance on a test of spatial learning, the Morris Water Maze (MWM), were assessed in young male Long-Evans rats. Rats given acc...

Following the administration of the diabetogenic drug streptozotocin, rats selecting their diet from separate sources of macronutrients (e.g., proteins, fats, and carbohydrates) demonstrated less severe symptoms of diabetes than did rats fed ground Purina chow or a composite diet containing the same nutrient sources as found in the self-selection d...

Restricting food intake (FI) to 1 h/day for rats housed in running wheels can serve as a model for the excessive exercise often observed in individuals with anorexia nervosa. When maintained on this schedule for several days, rats decrease food intake, increase running and can die of starvation. Studies have shown that freely fed rats allowed to ru...

Two experiments examined how an afternoon confectionery snack affects a variety of cognitive processes critical to learning. For Experiment 1, thirty-eight male undergraduates completed a dual learning task where the primary task involved learning either a map or stories and the secondary task required monitoring a radio broadcast for a specific wo...

Exercise decreases the antinociceptive effects of opiate drugs. It has been hypothesized that the exercise-induced attenuation of opiate drug action is the result of the development of cross-tolerance between endogenous opioids released during exercise and exogenous opiates. The present study was designed to evaluate the role of exercise on non-opi...

Chronic ingestion of a sweet-tasting sucrose solution enhances the pain relieving actions of opioid agonists. These results, taken in conjunction with research demonstrating that sucrose stimulates the production and release of endogenous opioid peptides, have led to the hypothesis that the effects of palatable foods and fluids on pain sensitivity...

Chronic exercise in a running wheel increases baseline pain sensitivity while attenuating the antinociceptive effects of peripherally administered opiate agonists in laboratory rodents. To determine if these effects are due to exercise-induced changes in the central nervous system (CNS) or an artifact of exercise-induced alterations in peripheral p...

This book illustrates how food and the act of eating touches the everyday lives of individuals, including nearly every aspect of human behaviour and development. It assists in recognizing the associations that current scientific evidence concerning nutrition and behaviour suggests are likely true, given the current understanding of work that bridge...

This book illustrates how food and the act of eating touches the everyday lives of individuals, including nearly every aspect of human behaviour and development. It assists in recognizing the associations that current scientific evidence concerning nutrition and behaviour suggests are likely true, given the current understanding of work that bridge...

This book illustrates how food and the act of eating touches the everyday lives of individuals, including nearly every aspect of human behaviour and development. It assists in recognizing the associations that current scientific evidence concerning nutrition and behaviour suggests are likely true, given the current understanding of work that bridge...

Acute and chronic pain management is a highly pressing clinical issue. There is considerable evidence that environmental factors associated with nutritional status are of particular significance in determining pain sensitivity and responsiveness to opiate analgesics. The short-term intake of palatable (particularly sweet-tasting) foods and fluids h...

The relationship between breakfast composition and cognitive performance was examined in elementary school children. Two experiments compared the effects of two common U.S. breakfast foods and no breakfast on children's cognition. Using a within-participant design, once a week for 3 weeks, children consumed one of two breakfasts or no breakfast and...

To address the question of how animals choose diets from an array of nutritionally different foods, researchers have designed experiments in which animals are provided with separate sources of the three macronutrients, protein, fat and carbohydrate. These experiments are useful for investigating the neuroanatomical and neurochemical mechanisms invo...

Both nicotine and sucrose can enhance performance on cognitive tasks. However, little is known about whether nicotine and sucrose could act jointly to augment mental performance. To investigate if there is an interaction between nicotine and sucrose on cognitive behavior, performance on a continuous performance task (CPT) and a spatial memory task...

Nicotine has analgesic actions in experimental animals and humans. Moreover, the analgesic properties of nicotine in experimental animals are increased by intake of sweet-tasting nutritive fluids. It is important to determine if the effects of diet on nicotine-induced analgesia are limited to experimental animals, or if these effects can be transla...

Rats given long-term access to a palatable sucrose solution are more sensitive to (1) the analgesic potency of morphine and (2) the anorectic actions of naltrexone. In the present experiment, the ability of naltrexone to antagonize the antinociceptive properties of morphine was examined in sucrose- and chow-fed rats. Twenty adult male Long-Evans ra...

Consumption of palatable food and fluids alters the behavioral consequences of psychoactive drugs. To further investigate the effects of intake of palatable nutrients on the rewarding properties of these drugs, the effects of chronic intake of a sweet sucrose solution on the development of conditioned place preferences (CPP) to a mu-opioid agonist,...

The relationship between consumption of a confectionery snack after an overnight fast and cognitive function was examined using a variety of cognitive tasks, including spatial memory, verbal memory, attention, visual perception and short-term memory, in a sample of 21 boys, ages 9-12 years. Performance on the vigilance attention task was significan...

Chronic intake of a palatable sucrose solution enhances the antinociceptive potency of systemically administered mu, and kappa opioid receptor agonists. To investigate whether the effects of sucrose on the actions of opioid drugs are mediated within the central nervous system (CNS), antinociception was examined following the administration of mu an...

Recent work has shown that chronic exercise is associated with a reduction in the pain-relieving actions of opioid drugs in experimental animals. To determine whether this reduction represents an interaction between exogenously administered opioids and the endogenous opioid system, or is the result of altered drug pharmacokinetics, the antinocicept...

To address the question of how animals choose diets from an array of nutritionally different foods, researchers have designed experiments in which animals are provided with separate sources of the three macronutrients, protein, fat and carbohydrate. These experiments are useful for investigating the neuroanatomical and neurochemical mechanisms invo...

Previous work has demonstrated that intake of palatable foods can alter the behavioral actions of opioid drugs. To investigate whether intake of palatable fare only affects opioid-induced behaviors or more generally influences drug-induced responses, this study examined the effects of chronic intake of a palatable sucrose solution on nicotine-induc...

The analgesic potency of opioid drugs varies as a function of gender, and can be modified by the intake of palatable sweet-tasting solutions. To determine if gender interacts with diet-induced changes in antinociceptive responses, male and female Long-Evans rats were fed laboratory chow and water alone, or chow, water and either a 32% w/v sucrose s...

Previous research has demonstrated that voluntary exercise is associated with a reduction in mu-opioid-induced antinociception. To determine if the effects of voluntary exercise on opioid-induced antinociception were limited to drugs that affect the mu opioid receptor or were more general, the analgesic effects of the kappa opioid agonist U50,488H...

Previous research has shown that rats consuming a sucrose solution and chow are more sensitive to the analgesic actions of morphine, a selective mu opioid agonist, and the anorectic actions of opioid antagonists, than rats eating only chow. However, from these data, it cannot be determined if sucrose intake only modifies the behavioral consequences...

The effects of diet and lighting conditions on the actions of the kappa opioid receptor agonist, U50,488H, on food and water intakes were examined in male Long-Evans rats. Animals were fed chow and water, or chow, water and either a 32% sucrose solution or a 0.15% saccharin solution. In the first part of the study, sucrose and saccharin solutions w...

Fluoxetine hydrochloride, a selective serotonin reuptake inhibitor, leads to reductions in food intake and body weight and is under investigation as a possible treatment for obesity. Additionally, it has been suggested that fluoxetine administration could lead to a selective suppression in carbohydrate consumption. Because women more often than men...

Previous research has demonstrated that chronic intake of nutritive sweet solutions, but not nonnutritive sweet solutions, enhances morphine's analgesic potency. To separate out the effects of sweet taste from other changes in dietary intake, which result when rats consume a sucrose solution, the effects of altering dietary levels of protein, or vi...

Food intake and body weight are determined by a complex interaction of regulatory pathways. To elucidate the contribution of the endogenous peptide cholecystokinin, mice lacking functional cholecystokinin-A receptors were generated by targeted gene disruption. To explore the role of the cholecystokinin-A receptor in mediating satiety, food intake o...

The effects of exercise on morphine-induced analgesia were examined in male and female Long-Evans rats. In Experiment 1, 10 male rats were housed in standard laboratory cages, and 10 in activity wheels for 20 days prior to nociceptive testing. Pain thresholds were assessed using a tail-flick (TF) procedure. Morphine sulfate was administered using a...

Administration of fluoxetine, a selective serotonin reuptake inhibitor, results in decreases in food intake and body weight. The present study investigated whether the anorectic actions of fluoxetine were due to a general decrease in caloric intake or macronutrient specific. Male Long-Evans rats were maintained on a dietary self-selection regime wi...

Research has demonstrated that intake of palatable carbohydrates and fats enhanced morphine-induced analgesia (MIA) in Sprague-Dawley rats. To determine if the effects of palatable foods on nociceptive responses would generalize to other strains of animals and other opioid agonists, the present experiments investigated whether intake of palatable f...

Previous research has suggested that chronic intake of palatable foods and fluids enhances the activity of the endogenous opioid system. To examine this suggestion, the effect of naltrexone on food intake was examined in male Long-Evans rats with or without prior exposure to palatable solutions. In Experiment 1, rats were fed laboratory chow alone...

Over the past two decades, substantial research has been conducted to investigate the idea that alterations in short-term nutritional intake play a role in influencing cognitive behaviour and mood. A portion of this research has examined specifically the effect of meal intake on the performance of mental tasks and subjective feelings of mood. Resul...

The effects of saccharin, sucrose, or Polycose intake on morphine-induced analgesia (MIA) were examined in 40 adult male Long-Evans rats. Rats were tested for MIA on a tail-flick apparatus following acute (5-h) and chronic (3-wk) intake of a 0.15% saccharin solution, a 32% sucrose solution, a 33.68% Polycose solution, or water. During the chronic p...

The effects of duration of sucrose consumption on morphine-induced analgesia (MIA) were examined in 20 adult male Long-Evans rats. Ten rats were tested for MIA on a tail-flick apparatus following acute (5 h), chronic (3 weeks) intake, and subsequent removal of a 32% sucrose solution. Ten rats that never received the sucrose solution served as contr...

The effects of intake of a palatable food source on oral amphetamine intake were assessed in adult male Long-Evans rats. In Experiment 1, six rats were given an amphetamine sulfate solution (0.1 mg/ml) and four rats were given water as their sole source of fluid. Rats were given a choice of chow and granulated sucrose for a week, alternated with we...

The hypothalamus plays a central role in the integrated regulation of energy homeostasis and body weight, and a number of hypothalamic neuropeptides, such as neuropeptide Y (ref. 1), galanin, CRH (ref. 3) and GLP-1 (ref. 4), have been implicated in the mediation of these effects. To discover new hypothalmic peptides involved in the regulation of bo...

The effects of wheel running on oral intake of amphetamine were examined in six male Sprague-Dawley rats given a 0.075-mg/ml amphetamine sulfate solution as their sole source of liquid, six rats given a 0.15-mg/ml amphetamine solution, and four rats given water as their sole source of liquid. All animals were housed in Wahmann running wheels and ad...

This study investigated the effect of reported eating behavior on person perception. Subjects (87% white, 4% African-American, 9% Asian; 60% female) were presented with brief descriptions of a fictitious male or female target subject that included a food diary describing either a small, medium, or large breakfast and lunch. One-half the food diarie...

The effects of dietary mineral levels on caloric intake, nutrient choice, body weight, adipose tissue weight, interscapular brown adipose tissue (IBAT) weight, and thermogenic capacity, an