Robijaona Baholy

• University of Antananarivo

This study comprehensively investigated three Moringa species in Madagascar Moringa drouhardii, M. hildebrandtii and M. oleifera. Recognizing the significant nutritional and medicinal potential of M. oleifera, this research aimed to expand our understanding of the endemic Malagasy species. A multi-faceted approach was employed, encompassing phytoch...

Abstract Background: Cancer is a significant public health problem worldwide and constitutes the second leading cause of death after cardiovascular disease. This study was thus designed to identify new natural compounds from Malagasy medicinal plants traditionally used to treat cancer. Methods: In silico analyses by molecular docking to model ligan...

La Drépanocytose peut être décrite du point de vue biochimique comme la conséquence d'un dysfonctionnement du shunt de pentoses phosphate, la principale voie métabolique impliquée dans la protection des érythrocytes contre les radicaux libres. A cet effet, après la lyse érythrocytaire, l'oxyhémoglobine peut s'auto-oxyder en méthémoglobine en libéra...

La Drépanocytose peut être décrite du point de vue biochimique comme la conséquence d'un dysfonctionnement du shunt de pentoses phosphate, la principale voie métabolique impliquée dans la protection des érythrocytes contre les radicaux libres. A cet effet, après la lyse érythrocytaire, l'oxyhémoglobine peut s'auto-oxyder en méthémoglobine en libéra...

Aim: To assess the population's knowledge of COVID-19 in order to guide future scientific research on the alternative management of this pandemic by Traditional Pharmacopoeia. Place and Duration of Study: The study was undertaken in Lisala city (province of Mongala, Democratic Republic of the Congo), from 26 July to 10 August 2020. Methodology: The...

Curcuma longa is mostly distributed in Asia and is the most common traditional drug of Indian and Chinese medicines used as anti-inflammatory, wound healing, antibacterial, anticancer and antioxidant agents. The present study was designed to characterize Curcuma longa L. from Madagascar by the determination of heavy metals and mineral elements of 3...

The aim of the present study was to evaluate the chemical composition and antioxidant activity of Melicope madagascariensis essential oil from Madagascar East Coast Rainforest. Essential oil from the leaves of this plant species was extracted by hydro-distillation and analyzed by TLC and GC-FID. The extraction revealed a yield is of 0.4% for a mass...

In Madagascar, the household food insecurity is linked to poverty and bad life condition, which affects the entire population including pregnant women and several nutrients are absent from their daily ration and lead to malnutrition. The aim of this work was to develop a food complement for pregnant women with lower income in Madagascar. This resea...

Laterite is one of the most widespread raw materials, especially in Madagascar. Its valorization as a building material would help to solve many socioeconomic problems in Madagascar as well as in Africa. The use of this type of material fits well within the framework of high environmental quality, since the process uses an abundant material that do...

Cement is an essential material for construction, which is one of the world's leading industries and one of the largest employers. Of vital importance for housing and basic infrastructure, the cement industry plays a key role in economic development and poverty reduction in emerging and developing countries. Cement production remains fundamentally...

The pregnant woman feeding is very important for the optimal embryonic development of the zygote. The present study suggests a formulation of food supplement in soup form. We were able to make a soup which is composed of vegetables and animal products. This product like food supplement can cover the pregnancy nutrients needs. In fact, the nutrients...

Une enquête a été réalisée auprès de 500 élèves (254 filles et 246 garçons) dans le but d’évaluer les conditions d’hygiène dans les écoles de la sous-division de Madimba (Province de Kongo-Centrale, RD Congo). Il ressort de cette étude que 21 écoles (soit 65.6%) ont chacune un point d’eau fonctionnel. Dans 91% des cas, le matériel de nettoyage anal...

Profil épidémiologique et clinique du Paludisme et de la drépanocytose à l'hôpital général de référence de gbado-lite (Nord-Ubangi) en république démocratique du Congo Abstract Le paludisme et la drépanocytose sont deux maladies qui constituent un problème majeur de Santé Publique en République démocratique du Congo. Leur prise en charge demeure un...

Objective: To validate scientifically the traditional use of Salacia leptoclada Tul. (Celastraceae) (S. leptoclada) and to isolate and elucidate the structure of the biologically active compound. Methods: Bioassay-guided fractionation of the acetonic extract of the stem barks of S. leptoclada was carried out by a combination of chromatography techn...

The artemisin based-therapeutic combinations (ATC) are an approach developed to solve the malaria parasite chemo-resistance problem in endemic area. The aim of this study is to evaluate the factors associated to the weak proportion of children under the age of 5 years treated with the ATC against malaria. The data collected on a sampling of 9177 tr...

Pineapple is a fruit consumed in Togo. Two varieties: Brazza and Smooth Cayenne are grown in the south of the country in the Plateaux and Maritime regions; the fruits are exported to the big cities of which Lome the capital. The finding is that crowns are rejected when there is a shortage of planting material. This study has as a general objective...

This study seeks to determine the best way to extract oil from Bemolanga tar sands. The study was carried out using an experimental design. Solid-liquid extraction method using Soxhlet were performed in order to optimize the extraction of asphalt content in Bemolangatar sands and reduce its environmental impact. Two solvents were used: Chloroform a...

Ethno-botanical surveys were conducted in the South of Madagascar (according to the convention on the biological diversity) and plant species were selected based on informant consensus factor among traditional healers. The bioassay-guided fractionation of plant extracts was carried out by the combination of chromatography techniques (TLC and column...

An ethno-botanical survey was conducted among traditional healers and medicinal plant vendors in Kinshasa city (DR Congo) in order to identify plant species used in traditional medicine to treat common diseases, with the aim of documenting, preserving, and sustaining this valuable traditional knowledge. Surveys were conducted from February to April...

The aim of the present study was to evaluate the chemical composition and antimicrobial activity of essential oils from Croton greveanus, Croton borarium and Croton geayi. An ethno-botanical survey was conducted in the south of Madagascar from January to February 2010. Essential oils were extracted from the leaves of selected plants species by hydr...

The price of the crude is continuing to scaling down, but one wonders what would be the consequence of that crude price drop off on the bitumen produced at the refineries. Madagascar would have a solution to use either the Bemolanga tar sands naturally (as it is) or to use extracted bitumen to replace the imported bitumen for tarring its roads. In...

Madagascar has not come up to petroleum discovery till now, nevertheless many petroleum companies have acquired licenses for petroleum exploration in the western sedimentary basin of Madagascar, since the new promotional petroleum exploration undertaken on 1980. The existence of the two non conventional fossil deposits discovered since longtime ago...

Malaria is one of the three deadly dangerous infectious diseases and is successfully treated with medicinal plants in endemic regions. This work was carried out with the aim to investigate the phytochemical screening and antiplasmodial activities of Mundulea antanossarum seeds extract using two standardized parasites strains (Plasmodium falciparum...

From the root bark of Eliea articulata Cambess (Hypericaceae), a medicinal plant species endemic to Madagascar, two new compounds typical of Xanthone and flavonone named Elieaxanthone and Elieaflavonone containing two membered rings in its side chain were isolated by repeated silica gel column chromatography. Their structures were determined by 1D...

Objective: To isolate and characterize the cytotoxic compounds from Diospyros quercina (Baill.) G.E. Schatz & Lowry (Ebenaceae). Methods: An ethno-botanical survey was conducted in the south of Madagascar from July to August 2010. Bio-guided fractionation assay was carried out on the root bark of Diospyros quercina, using cytotoxicity bioassay o...

To validate scientifically the traditional use of Salacia leptoclada Tul. (Celastraceae) (S. leptoclada) and to isolate and elucidate the structure of the biologically active compound. Bioassay-guided fractionation of the acetonic extract of the stem barks of S. leptoclada was carried out by a combination of chromatography technique and biological...

An ethno-botanical survey was conducted among traditional healers in the district of “Bas-Fleuve”, Democratic Republic of Congo in order to identify plant species used in folk medicine for health care. Twenty-five traditional healers from five territories of Bas-Fleuve district were interviewed about plants species used in traditional medicine to t...

One hundred and ninety plants, of which 51 are used to treat malaria in traditional medicine, were collected in five different ecosystems of Madagascar for a screening programme devoted to the search of naturally-occurring antimalarial compounds. Thirty-nine plants, of which 12 are used as herbal antimalarials, were found to display in vitro activi...

Three new isoquinoline alkaloid dimers with pavine and benzyl-tetrahydroisoquinoline moieties have been isolated, by bioassay-guided fractionation, from an alkaloid extract of Hernandia (= Hazomalania) voyronii Jumelle. All had inherent antiplasmodial activity in vitro and two enhanced chloroquine effectiveness in vitro in a dose-dependent manner....

Hernandia voyronii is traditionally used as adjuvant to chloroquine in Madagascar. Neutral and basic alkaloidal extracts of this plant were evaluated for their intrinsic in vitro antimalarial activity, cytotoxicity and chloroquine potentiating action against the chloroquine resistant Plasmodium falciparum strain FCM29. Bioassay directed fractionati...