Roberto Cighetti

Istituto di Istruzione Superiore A. Cesaris

📢 Last Chance Alert! 📢 Due to unforeseen circumstances, two spots have opened up for our upcoming field school! If you've been eager to join us for an unforgettable learning experience, now's your chance! Field School Details: Location: Crkveno Brdo (medieval period), Senta, Serbia Dates: from 22nd of July till 10th of August Activities: Excav...

An increasing number of pathologies have been linked to Toll-like Receptor 4 (TLR4) activation and signaling. New hit and lead compounds that target the TLR4 activation process are urgently needed. We report on the synthesis and biological properties of protonatable glycolipids based on glucose and trehalose scaffolds. Some of these compounds poten...

A growing body of data suggests that therapies based on Toll-like receptors (TLR) targeting, in particular TLR4, holds promise in curing autoimmune and inflammatory pathologies still lacking specific treatment, included several rare diseases. While TLR4 activators (agonists) have already found successful clinical application as vaccine adjuvants, t...

Monosaccharide lipid A mimetics based on a glucosamine core linked to two fatty acid chains and bearing one or two phosphate groups have been synthesized. Compounds 1 and 2, each with one phosphate group, were practically inactive in inhibiting LPS-induced TLR4 signaling and cytokine production in HEK-blue cells and murine macrophages, but compound...

The sincerest form of flattery! A novel, symmetric lipid A mimetic (D1) formed by two glucose units linked through a 6-6' succinic diamide linker is active in modulating the activity of human TLR4. D1 inhibits endotoxin-stimulated TLR4 activation by inhibiting interaction of endotoxin with both receptors CD14 and MD-2 (associated to TLR4). D1 also...

Toll-like receptor 4 (TLR4), the receptor of bacterial endotoxins in mammalians, plays a pivotal role in the induction of innate immunity and inflammation. TLR4 activation by bacterial lipopolysaccharide (LPS) is achieved by the coordinate and sequential action of three other proteins, the lipopolysaccharide binding protein (LBP), the cluster diffe...

The identification of the bacterial endotoxin receptors for innate immunity, most notably the Toll-like receptor 4 (TLR4), has sparked great interest in therapeutic manipulation of innate immune system. In this chapter, several natural and synthetic molecules that modulate the TLR4-mediated LPS signalling in animals and humans are presented, and th...

The identification of the bacterial endotoxin receptors for innate immunity, most notably TLR4 (Toll-like receptor 4), has sparked great interest in therapeutic manipulation of the innate immune system. In the present mini-review, several natural and synthetic molecules that modulate the TLR4-mediated LPS (lipopolysaccharide) signalling in animals...