Roberta M. Sabino

Roberta M. Sabino
Massachusetts Institute of Technology | MIT

Doctor of Philosophy

About

20
Publications
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277
Citations

Publications

Publications (20)
Article
Biomaterial-associated thrombosis is still a major concern for blood-contacting implants. After the medical device is implanted and comes in contact with blood, several complex reactions occur, which may lead to thrombus formation and failure of the device. Therefore, it is essential to evaluate the biomaterial interaction with the whole blood. Sev...
Article
Blood compatibility of cardiovascular implants is still a major concern. Rapid endothelialization of these implant surfaces has emerged as a promising strategy to enhance hemocompatibility and prevent complications such as thrombus formation and restenosis. The successful endothelialization of implant surfaces mostly depends on the migration of end...
Article
SARS-CoV-2 is a pandemic coronavirus that causes severe respiratory disease (COVID-19) in humans and is responsible for millions of deaths around the world since early 2020. The virus affects the human respiratory cells through its spike (S) proteins located at the outer shell. To monitor the rapid spreading of SARS-CoV-2 and to reduce the deaths f...
Article
Full-text available
In the midst of a huge demand for high-precision miniaturized medical implants made up of potential biomaterials, the biomedical Ti-6Al-4V alloy meets the uncompromising standards for longevity, biocompatibility, and sterilizability required to interact with living cells in medical settings. This research tailored the existing capabilities of a tra...
Article
In the midst of a huge demand for high-precision miniaturized medical implants made up of potential biomaterials, the biomedical Ti-6Al-4V alloy meets the uncompromising standards for longevity, biocompatibility, and sterilizability required to interact with living cells in medical settings. This research tailored the existing capabilities of a tra...
Article
Full-text available
Global demographic trends have signaled a growing need for biomedical implants such as artificial hips, dental implants, spine screws, coronary stents, and heart pacemakers. The reliability of a manufactured implant can be primarily ensured in terms of its surface integrity, dimensional accuracy, and biocompatibility. In the case of subtractive man...
Article
Full-text available
Titanium and its alloys are widely used in different biomaterial applications due to their remarkable mechanical properties and bio-inertness. However, titanium-based materials still face some challenges, with an emphasis on hemocompatibility. Blood-contacting devices such as stents, heart valves, and circulatory devices are prone to thrombus forma...
Article
Titanium and its alloys are the most used biomaterials for orthopedic and dental applications. However, up to 10% of these medical devices still fail, mostly due to implant loosening and suboptimal integration at the implant site. The biomaterial surface plays a critical role in promoting osseointegration, which can reduce the risk of device failur...
Article
The surface modification via subtractive manufacturing intends to localize the desired properties on the produced surface during the machining. In the case of miniaturized components, the powder mixed-micro-electric discharge machining (PM-µ-EDM), a potential variant of EDM, can achieve superior microfeatures such as dimensional accuracy and surfac...
Article
Studies investigate the electrospinnability of poly(ε-caprolactone)/protein blends to produce fibers for tissue engineering applications. However, no reports show that zein can improve the scaffolding capacity toward stem cells and promote antiadhesive and bactericidal properties to the poly(ε-caprolactone)/zein fibers. We create fibers with averag...
Article
In this work free-standing gels formed from gellan gum (GG) by solvent evaporation are coated with polysaccharide-based polyelectrolyte multilayers, using the layer-by-layer approach. We show that PEMs composed of iota-carrageenan (CAR) and three different natural polycationic polymers have composition-dependent antimicrobial properties, and suppor...
Article
In this study, a surface modification strategy using natural biopolymers on titanium is proposed to improve bone healing and promote rapid and successful osseointegration of orthopedic implants. Titania nanotubes were fabricated via an anodization process and the surfaces were further modified with polyelectrolyte multilayers (PEMs) based on Tanflo...
Article
To develop hemocompatible surfaces, a cationic tannin derivate (TN) was used to prepare polyelectrolyte multilayers (PEMs) with the glycosaminoglycans heparin (HEP) and chondroitin sulfate (CS). The surface chemistry of the PEMs was characterized using X-ray photoelectron spectroscopy and water contact angle measurements. PEMs assembled with chitos...
Article
Chemical modification of polysaccharides is an important route to enhance, develop or change polysaccharide properties. In this study, carboxymethylation of kappa-carrageenan (KC) with monochloroacetic acid was performed to achieve different degrees of substitution (DS) of carboxymethyl-kappa-carrageenan (CMKC). The degree of substitution ranged fr...
Article
Biomaterial‐associated thrombus formation and bacterial infection remain major challenges for blood‐contacting devices. For decades, titanium‐based implants have been largely used for different medical applications. However, titanium can neither suppress blood coagulation, nor prevent bacterial infections. To address these challenges, tanfloc/hepar...
Article
Studies report the production of gold nanoparticles (AuNPs) and polysaccharides-based composites. However, there are few reports about AuNPs synthesis in-situ followed by the formation of hydrogel composites. Here, we show AuNPs synthesis in-situ into the pectin solutions to yield cytocompatible pectin-capped AuNPs/chitosan hydrogel composites. Vis...
Article
Physical kappa-carrageenan-based hydrogels are often prepared from dilute aqueous kappa-carrageenan (κ-carrageenan) solutions at the presence of metallic ions or by mixing these solutions with proteins and other polysaccharides. The κ-carrageenan hydrogels have been used for technological purposes; however, there are no reports about the properties...
Article
Here, we have demonstrated the production and characterization of hydrogel scaffolds based on chitosan/gellan gum (CS/GG) assemblies, without any covalent and metallic crosslinking agents, conventionally used to yield non-soluble polysaccharide-based materials. The polyelectrolyte complexes (physical hydrogels called as PECs) are characterized by F...
Article
The need to improve blood biocompatibility of medical devices is urgent. As soon as blood encounters a biomaterial implant, proteins adsorb on its surfaces, often leading to several complications such as thrombosis and failure of the device. Therefore, controlling protein adsorption plays a major role in developing hemocompatible materials. In this...
Article
Curcumin (CUR) is a hydrophobic drug which has been loaded into polymeric carrier matrices by using experimental strategies with many steps, as well as by using conventional and volatile organic solvents. For the first time, this study reports the use of an ionic liquid ([Hmim][HSO4⁻]) to solubilize polycation-polyanion polymer pairs and hydrophobi...

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Project (1)
Project
Obtaining a biocompatible material antimicrobial properties using polycaprolactone (PCL), protein (Zein) and chitosan. Compare the effects of the molecules on material properties such as fiber diameter, biocompatibility and antimicrobial activity.