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Publications (34)
Dear colleagues.
It is our pleasure to inform you that our Special Issue of Life on photobiomodulation therapy in knee osteoarthritis is now open for submission! The purpose of the issue is to disseminate research and catalyze debate on all matters on the topic. We will consider articles on mechanisms of action, efficacy, effectiveness, factors in...
This narrative review analyses the Australian Guideline (2018) for the treatment of knee osteoarthritis (KOA) developed using Grading of Recommendations Assessment, Development, and Evaluation (GRADE) methodology. The Guideline recommended against the use low-level laser therapy (LLLT). Why this conclusion was reached is discussed in this review in...
Background and aims:
The Visual Analogue Scale (VAS) is a popular tool for the measurement of pain. A variety of statistical methods are employed for its analysis as an outcome measure, not all of them optimal or appropriate. An issue which has attracted much discussion in the literature is whether VAS is at a ratio or ordinal level of measurement...
Objective:
This review examines the evidence of neural inhibition as a mechanism underlying pain relief and anesthetic effect of photobiomodulation (PBM).
Background:
PBM for pain relief has also been used for more than 30 years; however, the mechanism of its effectiveness has not been well understood.
Methods:
We review electrophysiological s...
Postoperative cognitive dysfunction (POCD) is a decline in memory following anaesthesia and surgery in elderly patients. While often reversible, it consumes medical resources, compromises patient well-being, and possibly accelerates progression into Alzheimer's disease. Anesthetics have been implicated in POCD, as has neuroinflammation, as indicate...
This chapter discusses the analgesic effects of low level laser therapy (LLLT). There are a number of dental situations and conditions where the analgesic effects of LLLT are used to good effect. Understanding the mechanism of analgesia enables more effective treatment and in each of these conditions laser-induced neural inhibition provides a plaus...
The purpose of this study was to evaluate effects of transcutaneous 650 and 808 nm laser irradiation (LI) to a single point overlying rat sciatic nerve; a comparison to four point LI and relevance to the clinical application of low-level laser therapy (LLLT) and laser acupuncture (LA).
Transcutaneous LI inhibits somatosensory and motor conduction w...
Low-level laser therapy (LLLT) has been shown in clinical trials to relieve chronic pain and the World Health Organization has added LLLT to their guidelines for treatment of chronic neck pain. The mechanisms for the pain-relieving effects of LLLT are however poorly understood. We therefore assessed the effects of laser irradiation (LI) on somatose...
The objective of this review was to systematically identify experimental studies of non-ablative laser irradiation (LI) on peripheral nerve morphology, physiology, and function. The findings were then evaluated with special reference to the neurophysiology of pain and implications for the analgesic effects of low-level laser therapy (LLLT).
LLLT is...
We evaluated the effectiveness of 300 mW, 830 nm laser in the management of patients with chronic neck pain, in general practice, between May 1998 and June 1999. Data was obtained from 78 patients who rated self-assessed improvement of symptoms on a visual analog scale. An average improvement of 67.5 percent was found in 48 patients who reported a...
Objective: This pilot study was undertaken to test techniques of application of laser therapy, appropriate outcome measures and to determine effect sizes in order to facilitate the performance of a larger, clinical trial of laser therapy in chronic neck pain. Methods: We conducted a randomized double-blind, placebo-controlled study of low level las...
Neck pain is a common and costly condition for which pharmacological management has limited evidence of efficacy and side-effects. Low-level laser therapy (LLLT) is a relatively uncommon, non-invasive treatment for neck pain, in which non-thermal laser irradiation is applied to sites of pain. We did a systematic review and meta-analysis of randomis...
The effect of 300 mW, 830 nm laser on chronic neck pain : a double-blind, randomised placebo-controlled study. Pain 2006;124:201-10.
Préparé par Julia Hush, Rédacteur CAP.
Question
: La thérapie par laser à faible dose (830 nm, 300 mW) permet-elle une amélioration de la douleur, de l’incapacité et de la qualité de vie chez les personnes souffrant...
Dr. Çhow looks at the mechanism of pain and asks the question regarding the effects on nerves.
KeywordsLLLT–inhibition–nerves–inflammation
Low-level laser therapy has evidence accumulating about its effectiveness in a variety of medical conditions. We reviewed 51 double blind randomized controlled trials (RCTs) of laser treatment. Analysis revealed 58% of trials showed benefit of laser over placebo. However, less than 5% of the trials had addressed beam disguise or allocation concealm...
We report the formation of 830 nm (cw) laser‐induced, reversible axonal varicosities, using immunostaining with β‐tubulin, in small and medium diameter, TRPV‐1 positive, cultured rat DRG neurons. Laser also induced a progressive and statistically significant decrease (p < 0.005) in MMP in mitochondria in and between static axonal varicosities. In c...
Treatment efficacy of physical agents in osteoarthritis of the knee (OAK) pain has been largely unknown, and this systematic review was aimed at assessing their short-term efficacies for pain relief.
Systematic review with meta-analysis of efficacy within 1-4 weeks and at follow up at 1-12 weeks after the end of treatment.
36 randomised placebo-con...
A randomized, double-blind, placebo-controlled study of low-level laser therapy (LLLT) in 90 subjects with chronic neck pain was conducted with the aim of determining the efficacy of 300 mW, 830 nm laser in the management of chronic neck pain. Subjects were randomized to receive a course of 14 treatments over 7 weeks with either active or sham lase...
Low-level laser therapy (LLLT) is widely used in the treatment of musculoskeletal pain. However, there is controversy over its true efficacy. We aimed to determine the efficacy of LLLT in the treatment of neck pain through systematically reviewing the literature.
A search of computerized bibliographic databases covering medicine, physiotherapy, all...
We investigated if low level laser therapy (LLLT) of the joint capsule can reduce pain in chronic joint disorders. A literature search identified 88 randomised controlled trials, of which 20 trials included patients with chronic joint disorders. Six trials were excluded for not irradiating the joint capsule. Three trials used doses lower than a dos...
Low Level Laser Therapy (LLLT) is controversial because of conflicting outcomes in peer reviewed literature. The possible combination and permutation of laser parameters is almost infinite. Defining what is an appropriate dose of laser energy for anyone condition remains anecdotal. A number of factors have contributed to the heterogenity of the lit...
Title A systematic review of the literature of the effects of laser irradiation on peripheral mammalian nerves: implications for the analgesic effects of low-level laser therapy. Introduction Early studies of the effects of laser irradiation (LI) on peripheral nerves used an injury model to study stimulation of repair processes. The focus on stimul...
