Robert Van der Leest

• MD PhD
• Dermatologist at Erasmus MC

Background: Skin cancer patients are primarily at increased risk of developing subsequent skin cancers of the same type. Shared risk factors might also increase the occurrence of a different type of subsequent skin cancer. Objective: To investigate risks of different skin tumor combinations after a first melanoma, squamous cell carcinoma (SCC) a...

Objective: In the Netherlands the incidence of melanomas in situ and thin invasive melanomas is rising more quickly than that of thicker melanomas. Our aim was to gain insight into this increase and to test the hypothesis that it is attributable to over-diagnosis. Method: We analysed data taken from the Netherlands Cancer Registry on all primary...

In the Netherlands the incidence of melanoma has been increasing whilst melanoma survival has improved significantly in the last 20 years(1) . As a result, there is an increasing number of melanoma survivors, who are at increased risk of developing new melanomas(2) . There is limited and conflicting literature concerning the survival of patients wi...

A previous keratinocyte carcinoma is probably the strongest predictor of developing new keratinocyte carcinomas, which makes these patients an interesting population for prevention interventions. Investing in large cohort studies and consortia might increase the validity of observational findings and should stimulate scientists to investigate the u...

Melanoma patients are known to be at risk of developing multiple cutaneous (pre-) malignancies, however, the exact dimensions of these risks are unknown. In this meta-analysis, risks of developing a melanoma, basal cell carcinoma (BCC) or squamous cell carcinoma (SCC) after a melanoma were investigated. An extensive systematic literature search was...

Doel De overleving bepalen van patiënten met een melanoom, naarmate zij langer leven na de diagnose. Opzet Retrospectief onderzoek. Methoden Alle patiënten die in de periode 1994-2008 de diagnose ‘invasief melanoom’ kregen, werden geïncludeerd. De prognose van melanoompatiënten werd berekend voor elk extra overleefd jaar na de diagnose, in de...

There is evidence from cohort studies for an inverse association between atopic dermatitis and asthma and cutaneous melanoma. However, these studies have been too heterogeneous and did not show statistically significant results. Also, this association has not been compared to traditional melanoma risk factors. To test for associations between histo...

Limited data is available on the prevalence and risk factors of actinic keratoses (AK). Within the Rotterdam Study, full body skin examinations were performed among participants aged 45 years or older to estimate the age- and sex standardized prevalence of AK and its associated risk factors. Odds ratios (OR) with 95% confidence intervals (95%CI) we...

The aim of this study is to assess time trends of the risk of melanoma as a second primary cancer (MSPC) among cancer patients in the Netherlands during 1989-2008. Data from the population-based Netherlands Cancer Registry (NCR) were used for an analysis of time trends in the risk of MSPC in a fixed inception cohorts design (1989-1990, 1996-1997, a...

Euromelanoma is a dermatologist-led skin cancer prevention programme conducting an annual screening and public education campaign in over 20 European countries. Within its 10-year history, Euromelanoma has screened over 260,000 individuals across Europe, detecting a significant number of cutaneous melanomas and nonmelanoma skin cancers, identifying...

Background Patients with melanoma are at increased risk of developing a subsequent melanoma. Objectives To estimate the risks of developing a second primary in situ or invasive cutaneous melanoma after a first melanoma, between 1989 and 2008. Methods Patients were followed until diagnosis of a second melanoma, date of death or end of study. Cumulat...

Euromelanoma is a skin cancer education and prevention campaign that started in 1999 in Belgium as 'Melanoma day'. Since 2000, it is active in a large and growing number of European countries under the name Euromelanoma. To evaluate results of Euromelanoma in 2009 and 2010 in 20 countries, describing characteristics of screenees, rates of clinicall...

Background Study on risk of subsequent melanoma among melanoma patients is scarce. Objective To investigate melanoma risk in melanoma patients. Material and Methods Netherlands Cancer Registry incidence data (1989–2008) were employed. Patients (N=57 817) diagnosed melanoma in this period were followed. Follow-up censored at second melanoma, death...

A 22 year old male presented with a red, itchy rash of the right upper arm. Examination revealed a group of vesicles with ascending lymphangitis. A PCR test reveals herpes simplex type-1. Although mucosal surfaces are the predilection site for herpes simplex type-1 virus, any cutaneous location can be infected. In this case, symptoms and signs were...

Neoplasms of the skin are found most often on the face. Malignant tumors of the facial skin pose a challenge in treatment, prohibiting compromises between oncologically responsible surgery and functional plus cosmetic outcome. The incidence of melanoma and nonmelanoma skin cancers is rising. Not all malignancies of the skin need to be treated by su...