Robert H Sagerman

Robert H Sagerman
State University of New York Upstate Medical University | SUNY Upstate Medical · Department of Radiation Oncology

MD

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125
Publications
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2,950
Citations
Citations since 2017
0 Research Items
181 Citations
20172018201920202021202220230102030
20172018201920202021202220230102030
20172018201920202021202220230102030
20172018201920202021202220230102030
Introduction
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Publications

Publications (125)
Article
To determine the important clinical/pathologic prognostic factors and optimal treatment of malignant parotid tumors. This study was a retrospective chart review of 163 patients treated for malignant parotid tumors at two institutions. Of the 163 patients, 91 were treated with surgical resection and radiotherapy (RT), 56 were treated with surgery al...
Article
Glioblastoma multiforme is a highly malignant glioma with a well-known tendency for intracranial spread but rarely for extracranial spread. We report a case of an adult woman who presented with symptoms of leptomeningeal metastasis from an intracranial glioblastoma multiforme located adjacent to the lateral ventricle. There have been very few cases...
Chapter
Age-related macular degeneration (ARMD) is the leading cause of blindness in people older than 65 and the second most common cause for patients aged 45–64 years (Ganley and Roberts 1983; Leibowitz et al. 1980a, Leibowitz et al. 1980b; Klein et al. 1992), There are approximately 200,000 new cases of ARMD each year, with over 100,000 people considere...
Article
Members of the Society of Chairmen of Academic Radiation Oncology Programs (SCAROP) were surveyed in November 1997 to evaluate the current status of radiation oncology training in the United States and to help determine how it should be carried out in the coming decade. A detailed questionnaire was sent to all members of SCAROP; 68 of 82 questionna...
Article
With the progress of modern multimodality cancer treatment, retreatment of late recurrences or second tumors became more commonly encountered in management of patients with cancer. Spinal cord retreatment with radiation is a common problem in this regard. Because radiation myelopathy may result in functional deficits, many oncologists are concerned...
Article
Malignancy spread throughout a hemithorax without distant metastasis poses a difficult therapeutic challenge. Irradiation is often not considered because of the risk of pulmonary and cardiac toxicity. We report on a patient with thymoma recurrent throughout the left pleural cavity. Disease progressed despite chemotherapy, and subsequently a radical...
Article
Malignancy spread throughout a hemithorax without distant metastasis poses a difficult therapeutic challenge. Irradiation is often not considered because of the risk of pulmonary and cardiac toxicity. We report on a patient with thymoma recurrent throughout the left pleural cavity. Disease progressed despite chemotherapy, and subsequently a radical...
Article
This study was undertaken to assess the toxicity and possible benefits from the administration of low-dose external-beam irradiation for Age-Related Macular Degeneration (ARMD). The premise of the treatment is that radiation induces regression and/or promotes inactivation of the subretinal neo-vasculature, resulting in reabsorption of fluid and blo...
Article
To determine survival, long-term tumor control, and the effects of irradiation for stage II seminoma. Forty-five patients with stage II testicular seminoma were treated between 1966 and 1989. There were 31 patients with stage IIA disease and 14 with stage IIB disease. All patients underwent orchiectomy followed by iliac and paraaortic irradiation (...
Article
Second malignancies have been reported among patients who were treated by radiation therapy or chemotherapy alone or in combination. Studies have implied an increased risk of breast cancer in women who received radiotherapy as part of their treatment for Hodgkin's disease. This review was performed to determine if there is an association between sp...
Article
In 1972, the Intergroup Rhabdomyosarcoma Study standardized the classification and treatment of orbital rhabdomyosarcoma. It established chemotherapy with external beam radiotherapy as the standard of treatment, yet there was no comparison to treatment with external beam radiotherapy alone. We retrospectively examined the charts of patients with or...
Article
A clinically useful classification system is suggested that can be used in prospective trials to evaluate the effects of radiation on the visual system. We review radiation-induced pathophysiological and clinical changes of the various ocular structures as well as dose-response data and management of ocular complications. The rationale for the clas...
Article
The rare occurrence of malignant fibrous histiocytoma of the orbit followed combined modality therapy in an adolescent is reported.
Article
To determine the late clinical effects of irradiation in stage I seminoma. From 1966 to 1991, 104 patients with stage I seminoma were treated and followed up. After inguinal orchiectomy, all underwent megavoltage infradiaphragmatic irradiation through a "hockey stick" field encompassing the periaortic and ipsilateral iliac lymph nodes (30 Gy in 1.5...
Article
Tumors of the lacrimal sac are rare and have traditionally been treated surgically. We investigated the use of irradiation for treatment. Three consecutive patients with primary epithelial cancer of the nasolacrimal apparatus were treated with irradiation. A tumor dose of 52-66 Gy was delivered with conventional fractionation to fields limited to t...
Article
Cateracts, a loss of transparency of the lens, are a feared reaction to irradiation of the eye and orbit, and of nearby structures such as the paranasal sinuses and the pituitary gland. Their development has followed external irradiation, with beams of different linear energy transfer, as well as brachytherapy and total body irradiation. The epithe...
Article
Induction and repair of DNA double-strand breaks (DSBs) was measured using a pulsed-field gel electrophoresis system. A cell line of methotrexate-resistant EMT-6 cells that contain numerous double-minutes (DMs) 3 million base pairs in size was employed. The electrophoretic mobility of these DMs depends on whether they have zero, one, or more than o...
Chapter
Although retinoblastoma accounts for only 1% of all childhood malignancies, it has been studied intensively because of its genetic features, the association with chromosomal deletions, and the known predisposition of children with retinoblastoma to develop other nonocular malignant tumors.
Book
Radiotherapy of Intraocular and Orbital Tumors presents a new approach to the role of radiation therapy in the management of ophthalmic cancer. The indications for ultrasonography, computed tomography, and magnetic resonance imaging studies are analyzed, and treatment techniques, together with their results, are described for each tumor. Particle b...
Article
Of 34 evaluated patients with primary spinal cord tumors, 32 were irradiated at our institutions between 1969 and 1983. The results are reported of 32 patients, 16 with ependymoma and 16 with astrocytoma, who were treated with postoperative external beam radiotherapy following biopsy or subtotal resection. Twenty-nine patients received 45–55 Gy meg...
Article
One hundred forty patients with testicular seminoma were treated at the State University of New York Health Science Center at Syracuse between 1966 and 1985. Disease was classified as stage II in 32 patients (23%): stage IIA in 21 patients and stage IIB in 11 patients. All patients underwent irradiation below the diaphragm after a radical orchiecto...
Article
Five hundred nineteen patients with prostate cancer were seen in the Radiation Oncology Division of the State University of New York (SUNY) Health Science Center, Syracuse, New York, between 1969 and 1981. The results for the 239 patients treated with radical intent are reported here. All patients received 60 to 70 Gy to the prostate with megavolta...
Article
A chronic shortage of radiation therapy technologists exists in the United States. This report presents the data obtained in a 1987 survey of all radiation oncology facilities identified by the Patterns of Care master list. Of the 1,142 questionnaires mailed, 52% were returned. The survey identified 2,328 credentialed (ARRT) and 554 non-credentiale...
Article
Full-text available
The results of postoperative radiation therapy in 12 patients with stage III thymoma treated during 1966-1986 were reviewed. Surgical therapy consisted of total resection in one, subtotal resection in seven, and biopsy only in four. Megavoltage irradiation in the dose range of 3,000-5,600 cGy was employed, with nine patients receiving a dose of at...
Article
Bilateral peripheral pulmonary infiltrates caused by Pneumocystis carinii developed in a patient undergoing mediastinal irradiation after chemotherapy for Hodgkin disease. The paramediastinal part of the lung included within the treatment port remained clear during the 2 1/2 weeks of radiation therapy. The distribution of the pneumocystis infiltrat...
Article
The records of 16 patients with optic nerve glioma treated between 1961 and 1984 were reviewed. All patients except two had extension of tumor beyond the chiasm to the hypothalamus, adjacent brain and/or along the posterior optic tract. Eleven of 16 cases were biopsy-proven, two patients had craniotomy and visual inspection but no biopsy was perfor...
Article
Plasma cell granuloma is a rare, benign tumor that affects people at all ages and most frequently involves the lung, gastrointestinal tract, and salivary gland. They are the most common, isolated, primary lesion of the lung in children less than 16 years of age, and usually present as circumscribed, peripheral, parenchymal tumors, which may be stat...
Article
Four hundred twenty-one patients with bladder carcinoma were treated with radical intent between 1968 and 1981: 356 were treated with irradiation alone with megavoltage tumor doses of 60-66 Gy delivered over a period of 6 to 7 weeks. Actuarial 5- and 10-year survival was 66% and 58% for Stage A (58 patients), 42% and 35% for Stage B1 (62 patients),...
Article
Four hundred twenty-one patients with bladder carcinoma were treated with radical intent between 1968 and 1981: 356 were treated with irradiation alone with megavoltage tumor doses of 60-66 Gy delivered over a period of 6 to 7 weeks. Actuarial 5- and 10-year survival was 66% and 58% for Stage A (58 patients), 42% and 35% for Stage B1 (62 patients),...
Article
A group of 18 patients with squamous cell carcinoma of the mid one-third of the tongue was treated by local resection and planned postoperative radiotherapy between 1976 and 1980. Tumors 0.5 cm or greater in thickness were included; no patients had cervical adenopathy. Six were categorized as T1, 10 as T2 and two as T3. In eight patients, histologi...
Article
Twenty-four patients with biopsy-proved squamous-cell carcinoma of the penis underwent external-beam radiation therapy between 1966 and 1980. Fifteen were treated for the primary tumor and 9 for metastatic inguinal lymphadenopathy; no patient received prophylactic nodal irradiation. Doses ranged from 4,500 rad (45 Gy)/15 fractions/3 wk. to 6,400 ra...
Article
This study investigated dose to bone tissue in electron beam therapy. Measurements were made using films and thermoluminescent dosimeters in a polystyrene phantom containing bone inhomogeneity for 15-MeV, 12-MeV, and 9-MeV electron beams. An increase in dose of approximately 18%, 12%, and 11%, for the three electron energies respectively, relative...
Article
Microglioma (reticulum-cell sarcoma) of the central nervous system is uncommon. The authors reviewed 12 biopsy-proved cases with clinical and radiographic evidence of involvement limited to the central nervous system which were seen between 1966 and 1980. The age range was 15-81 and there were 8 females and 4 males. No patient had clinical evidence...
Article
Full-text available
The effect of elevated temperature (44 degrees) on the intracellular uptake of the 2-nitroimidazole hypoxic cell radiosensitizer, misonidazole (MIS), and analogues more hydrophilic than MIS was studied in Chinese hamster ovary cells. It was found that the intracellular uptake of these compounds which enter cells by restricted passive diffusion can...
Article
Postoperative irradiation reduces the local recurrence rate for malignant salivary gland tumors. Less extensive surgery followed by immediate radiotherapy is possible without decreasing local control; moreover, cosmetic appearance and physiological function are preserved. Local tumor control was achieved in 16 out of 17 patients without gross tumor...
Article
Fifty-eight patients receiving planned high-dose preoperative radiotherapy followed by en bloc oro-mandibular-cervical resection for oropharyngeal cancer were reviewed. These patients received continued close observation and care from both the Otolaryngology and Radiotherapy services. In light of the ongoing controversy of preoperative vs. postoper...
Article
A multiplanar display of pelvic anatomy and intracavitary radioactive source positions was achieved with a plastic after-loading applicator. Using these CT images, dosimetric evaluation within the tumor volume, uterus, and adjacent organs was feasible. This type of analysis many allow direct dose adjustment to cover the tumor volume adequately and...
Article
We have reviewed 126 patients with squamous cell carcinoma of the anterior tongue. Our experience suggests that carcinoma of the anterior tongue is a highly aggressive disease. It is no less aggressive and dangerous than carcinoma of the posterior tongue. The clinically negative neck is a problem. Many clinical stage I and II cancers are, in fact,...
Article
Effects of irradiation on vascular tissue include endothelial cell degeneration, vasoconstriction, and thrombus formation. The effect of irradiation on the in-vitro production of prostacyclin (PGI2) was evaluated, since it is a potent antithrombotic metabolite and vasodilator. After a single dose of 200 rad, umbilical artery PGI2 levels were much d...
Article
Computed tomography is indispensable in determining the deeper extensions of tumors and proper treatment planning as well as in documentation of tumor resolution for lesions arising in the nasal cavity, paranasal sinuses, orbit, and salivary glands. In the hypopharynx and larynx, computed tomography provides information of differing degrees of valu...
Article
• Twenty-five patients with primary epithelial carcinoma of the nasal cavity without nodal or distant metastases were treated by irradiation between 1967 and 1978. Small field, beam-directed techniques delivered 6,000 to 7,000 rads with conventional fractionation. Control of the primary tumor was achieved in 21 (84%) patients after irradiation. All...
Article
The need for Radiation Therapy Technologists trained at the Baccalaureate Level was explored using a survey, sent to 99 Radiotherapists located in the North Eastern United States. The conclusion drawn was that a limited number of technologists with such degrees are needed in the areas of education, administration, and dosimetry.
Article
Thirty-eight patients with residual or recurrent primary thyroid cancers which did not take up 1-131 were treated with external beam irradiation. Excluding 5 patients with malignant lymphoma, there were 23 patients with local disease and 10 with distant metastases. Doses ranged from 3,500 to 7,000 rads (35-70 Gy) among the 23 with local disease; lo...
Article
• Treatment of subclinical cervical metastases from advanced squamous carcinomas of the nasopharynx, oropharynx, oral cavity, hypopharynx, and larynx remains contentious. Watchful waiting, elective neck surgery, and, more recently, neck irradiation all have their advocates. The possibility of "sterilization" of the neck showing no clinical signs of...
Article
Thirty patients with stage B/sub 2/-C-D/sub 1/ and/or grade III-IV transitional cell carcinoma of the bladder were entered into a pilot study of integrated surgery and radiotherapy. Staging laparotomy with formation of an ileal loop preceded the delivery of 4000 to 5000 rad in 4 to 5 weeks to the pelvis; cystectomy was accomplished in 26 patients 4...
Article
Of 40 patients treated for brain-stem tumors, 20 had lesions of the thalamus and midbrain (group A) and 20 had lesions of the pons and medulla (group B). Performance status measured 1 month after irradiation improved in 16 of 20 group A and 11 of 20 group B patients and was a valuable prognostic factor. The survival rate at 5 years was 40% (8/20) i...
Article
Three hundred seventy-nine consecutive patients with adenocarcinoma of the corpus uteri, in whom irradiation was part of the treatment, were reviewed. The minimum follow-up was 3 years and none were lost. An increased incidence of corpus cancer in Central New York was demonstrated but could not be attributed to estrogen usage. There were 310 patien...
Article
Full-text available
Preoperative irradiation of 5,000 rad in 5 weeks before total laryngectomy with radical neck dissection was compared for two groups of patients: (1) those treated to a smaller volume through lateral opposed fields (37 patients) and (2) those treated to a larger volume by adding a third field directed to the lower neck and supraclavicular fossae (46...
Article
Preoperative irradiation of 5,000 rad in 5 weeks before total laryngectomy with radical neck dissection was compared for two groups of patients: (1) those treated to a smaller volume through lateral opposed fields (37 patients) and (2) those treated to a larger volume by adding a third field directed to the lower neck and supraclavicular fossae (46...
Article
For most renal lesions, the abnormalities demonstrated with Tc-99m skeletal agents resemble those with Tc-99m renal agents. In contrast, an instance of obviously increased renal uptake of Tc-99m MDP due to radiation therapy is reported. There were only minimal imaging abnormalities with Tc-99m glucoheptonate. The radiotherapy was given to a child a...
Article
In an attempt to improve the radiotherapeutic management of patients with bladder carcinoma, we have added computed tomography (CT) scanning of the pelvis and abdomen to conventional evalution, including cystoscopy with bimanual examination under anesthesia. Sixty consecutive new patients were studied from July 1976 to November 1977. Operative find...
Article
For most renal lesions, the abnormalities demonstrated with Tc-99m skeletal agents resemble those with Tc-99m renal agents. In contrast, an instance of obviously increased renal uptake of Tc-99m MDP due to radiation therapy is reported. There were only minimal imaging abnormalities with Tc-99m glucoheptonate. The radiotherapy was given to a child a...
Article
Occasionally, during the course of combined (radiation plus surgery) treatment of head and neck malignancies, the patient experiences a profound response to radiotherapy alone and elects to decline the second phase of treatment, namely, surgery. After a variable interval, radiotherapy is reinstituted to a “curative” level. A series of 14 laryngeal...
Article
Combined therapy, consisting of 5000 rads delivered in five weeks followed by total laryngectomy ± radical neck dissection, was compared with treatment by irradiation (6000–7000 rads) with surgical salvage when clinically possible for radiation failure. Patients were categorized according to site of primary cancer (glottic, supraglottic and pyrifor...
Article
A one-third octave spectral analysis was performed on two sentences spoken by 5 patients with laryngeal cancer, 5 with head/neck cancer not involving the vocal cords, and 12 normal subjects. Recordings were made prior to and at weekly intervals during radiotherapy as well as at periodic intervals post-treatment. Patients with laryngeal cancer exhib...
Article
A one-third octave spectral analysis was performed on two sentences spoken by 5 patients with laryngeal cancer, 5 with head/neck cancer not involving the vocal cords, and 12 normal subjects. Recordings were made prior to and at weekly intervals during radiotherapy as well as at periodic intervals post-treatment. Patients with laryngeal cancer exhib...
Article
Three hundred seventy-nine consecutive patients with adenocarcinoma of the corpus uteri, in whom irradiation was part of the treatment, were reviewed. The minimum follow-up was 3 years and none were lost. An increased incidence of corpus cancer in Central New York was demonstrated but could not be attributed to estrogen useage. There were 310 patie...
Article
One hundred sixty-nine patients with carcinoma involving the larynx treated with surgery, combined preoperative radiotherapy plus surgery, or failed curative radiotherapy with surgical salvage have been evaluated with respect to complications. Major complications occurred at approximately the same rate with all three modes of therapy. Major complic...
Article
Combined therapy, consisting of 5000 rads delivered in five weeks by total laryngectomy +/- radical neck dissection, was compared with treatment by irradiation (6000-7000 rads) with surgical salvage when clinically possible for radiation failure. Patients were categorized according to site of primary cancer (glottic, supraglottic and pyriform sinus...
Article
Malignant change in tissues exposed to ionizing radiation has been reported for more than 75 yr. Benign and malignant bone tumors have occurred even when the bone was not involved in the process being treated, but was only incidentally included in the field. Osteosarcomas and fibrosarcomas make up the vast majority of the more than 200 such cases i...
Article
Soft tissue sarcomas are the fourth most frequent solid tumors in children. They arise at many sites, most frequently in the orbit, head and neck, and pelvis. Diagnostic radiologic studies play an integral role in patient evaluation, allowing direct visualization of the primary lesion, its vascular supply, its direct and regional extensions; of dis...
Article
Soft tissue sarcomas are the fourth most frequent solid tumors in children. They arise at many sites, most frequently in the orbit, head and neck, and pelvis. Diagnostic radiologic studies play an integral role in patient evaluation, allowing direct visualization of the primary lesion, its vascular supply, its direct and regional extensions; of dis...
Article
Full-text available
The authors present 3 cases of recurrence of medulloblastoma at 6 years, 6 years 7 months, and 7 years 4 months disease-free intervals from the time of diagnosis. Two of these cases have violated Collins' rule of survivorship; i.e., an interval longer than the patient's age plus 9 months being equivalent to cure. Two of the cases were biopsy proven...
Article
Following mantle field irradiation for Hodgkin's disease, patients experience a transient acute pulmonary reaction resulting in a decreased vital capacity and forced expiratory volume. This reaction begins 2-3 mth after the start of therapy, reaching a maximum intensity at 4-6 mth and subsiding by about 8 mth. In patients with intrathoracic disease...
Article
Recent reports have suggested that carcinoma of the tonsil and adjacent structures (tonsillar pillars, adjacent soft palate and lateral pharyngeal wall) can be treated with improved survival rates by combining definitive surgery with planned preoperative radiotherapy. Experience to date does not clearly demonstrate the ideal dose of preoperative ra...
Article
Full-text available
Rhabdomyosarcoma (RMS) accounts for 4–8% of malignancies in children under 15 years old (CRIST et al. 1990). RMS is the most common orbital malignancy in children and was the primary site in 65 of 686 (9.47%) patients reported in the Intergroup RMS studies I and II (Crist et al. 1990). Knowles et al. (1978) gathered data from four major reviews (As...
Article
A case is reported of mesonephric adenocarcinoma of the vagina in a 7-month-old girl. Clinical and radiographic features simulated embryonal rhabdomyosarcoma. Radiotherapy alone was successfully utilized and the patient is free of evident disease 2 years following diagnosis.
Article
Full-text available
Forty-four children with Wilms' tumor were seen in the combined Pediatric Tumor Clinic of the Babies Hospital, Columbia-Presbyterian Medical Center, from 1952 through 1965. This period of time was chosen for evaluation because the philosophy of the pediatric, surgical and radiotherapeutic members of the Tumor Clinic remained stable throughout this...

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