Robert Pistey

Boston University | BU · Department of Pathology and Laboratory Medicine

Objectives/hypothesis: To evaluate the usefulness of elastic scattering spectroscopy (ESS) as a diagnostic adjunct to frozen section analysis in patients with diagnosed squamous cell carcinoma of the oral cavity. Study design: Prospective analytic study. Methods: Subjects for this single institution, institutional review board-approved study w...

Purpose: The distinction between prostate cancer and co-existent chronic prostatitis poses a clinical dilemma. This is in part due to overlap in biochemical markers of chronic prostatitis and prostate cancer which may both present with elevated PSAs and the fact that chronic prostatitis is a common finding in prostatectomy specimens. Additionally,...

Objective We used reflectance and fluorescence spectroscopy to noninvasively and quantitatively distinguish benign from dysplastic/malignant oral lesions. We designed diagnostic algorithms to account for differences in the spectral properties among anatomic sites (gingiva, buccal mucosa, etc). Methods In vivo reflectance and fluorescence spectra w...

We used reflectance and fluorescence spectroscopy to noninvasively and quantitatively distinguish benign from dysplastic/malignant oral lesions. We designed diagnostic algorithms to account for differences in the spectral properties among anatomic sites (gingiva, buccal mucosa, etc). In vivo reflectance and fluorescence spectra were collected from...

In order to evaluate the impact of anatomy on the spectral properties of oral tissue, we used reflectance and fluorescence spectroscopy to characterize nine different anatomic sites. All spectra were collected in vivo from healthy oral mucosa. We analyzed 710 spectra collected from the oral cavity of 79 healthy volunteers. From the spectra, we extr...

We have collected 800 in vivo reflectance and fluorescence spectra from the oral cavity of 82 healthy volunteers. We show that spectroscopy can characterize normal anatomical variation by providing parameters that reflect tissue physical properties.

CDKN1C (also known as p57KIP2) is a cyclin-dependent kinase inhibitor previously implicated in several types of human cancer. Its family members (CDKN1A/p21CIP1 and B/p27KIP1) have been implicated in breast cancer, but information about CDKN1C's role is limited. We hypothesized that decreased CDKN1C may be involved in human breast carcinogenesis in...

Abstract Background CDKN1C (also known as p57^KIP2) is a cyclin-dependent kinase inhibitor previously implicated in several types of human cancer. Its family members (CDKN1A/p21^CIP1and B/p27^KIP1) have been implicated in breast cancer, but information about CDKN1C's role is limited. We hypothesized that decreased C...

Mandibular lesions develop from both odontogenic and nonodontogenic origins and have varying degrees of destructive potential. Common benign cystic lesions include periapical (radicular) cysts, follicular (dentigerous) cysts, and odontogenic keratocysts. Benign solid tumors represent a broad spectrum of lesions such as ameloblastomas, odontomas, os...

We hypothesized that the method of breast cancer margin assessment may be associated with different rates of positive margins and residual carcinoma. A total of 178 breast cancer specimens were divided into 2 groups (A and B) based on the margin assessment method used. Rates of positive margins, re-excision, and residual carcinoma at re-excision we...

Solitary fibrous tumors are submesothelial mesenchymal fibroblastic tumors that typically occur in relation to parietal or visceral pleura. However, the tumor also occurs in extrapleural sites, including the peritoneum, mediastinum, orbit, and oral cavity. With the advent of immunohistochemical testing, certain tumors may be more readily identifiab...

A 37-year-old woman presented with a slowly growing mass in the posterior aspect of her right external auditory canal. The mass was occasionally tender and caused subjective mild hearing loss. She denied fevers, otorrhea, facial weakness, or previous surgery. On physical examination, a posterior canal mass was seen obstructing 60% of the external a...

Until recently, digital imaging in pathology has been used by only a minority of practicing pathologists, primarily technology enthusiasts. Now, many pathology departments are considering the installation of networked digital imaging as part of their pathology information systems. As digital technology becomes ubiquitous, established vendors and in...