Robert F Leeman

Northeastern University | NEU · Department of Health Sciences

Background Mobile health (mHealth) technology use may reduce alcohol use and related negative consequences; however, little is known about its efficacy without prompting from researchers or pay‐per‐use. This exploratory analysis assessed relationships between mHealth technology use frequency and alcohol‐use outcomes. Methods Young adults who drink...

Impaired control (i.e., difficulty adhering to limits on alcohol use) prospectively predicts self-reported alcohol-related problems in undergraduates yet remains understudied. In particular, there is little evidence regarding whether brief interventions can reduce impaired control. An efficacious, very brief, web-based intervention focused on prote...

Introduction: The self-medication hypothesis (SMH) suggests that individuals consume alcohol to alleviate stressful emotions. Still, the underlying mechanisms between stress and heavy episodic drinking remain to be explored. Impaired control over drinking (IC) reflects a failure of self-regulation specific to the drinking context, with individuals...

Long-acting injectable (LAI) cabotegravir/rilpivirine (CAB/RPV) for antiretroviral therapy (ART) could benefit many people with HIV (PWH). However, its impact will largely be determined by providers' willingness to prescribe it and PWH's willingness to take it. This study explores the perceived barriers and facilitators of LAI CAB/RPV implementatio...

Purpose of Review Alcohol use and associated consequences are among the top preventable causes of death in the USA. Research links high impulsivity and adverse and traumatic experiences (ATEs) to increased alcohol use/misuse, as all three similarly affect brain functioning and development. Yet, studies measuring different specific domains yield dif...

Pre-exposure prophylaxis (PrEP) use may be associated with condom use decisions. The current investigation examined sexual decision-making in the context of PrEP among young adult men who have sex with men (MSM) between 18 and 30 years old, using an explanatory sequential mixed methods design. For the quantitative aim, 99 MSM currently taking PrEP...

Preexposure prophylaxis (PrEP) prevents human immunodeficiency virus (HIV) but not other sexually transmitted infections (STIs). Men who have sex with men (MSM) who take PrEP tend to report reduced condom use, but little is known about the underlying mechanisms. For this study, MSM who take PrEP (i.e., PrEP experienced; n = 88) and MSM who do not (...

Background and aim: Impaired control over alcohol is a hallmark of addiction relevant to young adults but additional prospective findings are needed, particularly in samples reporting heavy drinking. Further, we lack understanding of how attempts and failed efforts to control drinking relate to each other in predicting outcomes. We hypothesized at...

Aims To test differential outcomes between three 6‐month text‐messaging interventions to reduce at‐risk drinking in help‐seeking adults. Design A three‐arm single‐blind randomized controlled trial with 1‐, 3‐, 6‐ and 12‐month follow‐ups. Setting United States. A fully remote trial without human contact, with participants recruited primarily via s...

Introduction Impulsivity is a known risk factor for the development of substance use disorders and other psychiatric conditions that is influenced by both genetics and environment. Although research has linked parental mental health to children’s impulsivity, potential mediators of this relationship remain understudied. The current investigation le...

Alcohol consumption is associated with negative sexual outcomes among heavy drinking young adults. Smartphone interventions are a promising approach to reducing alcohol consumption. This study aimed to test whether a smartphone app designed to reduce heavy drinking (via feedback on the cued go/no-go task) would reduce reports of negative sexual out...

Introduction: The legal landscape surrounding purchasing cannabis without a medical cannabis card (i.e., without MCC) is changing rapidly, affecting consumer access and purchasing behaviors. Cannabis purchasing behaviors are related to subsequent use and experiencing greater cannabis-related negative consequences. However, purchasing behaviors of...

Human laboratory methods are valuable approaches to studying the etiology of alcohol misuse and interventions to ameliorate misuse because they offer advantages such as enhanced experimental control and relative efficiency compared to other methods. Yet, published reports from laboratory alcohol administration experiments typically do not provide a...

Aims: Alcohol biosensors, including the BACtrack Skyn, provide an objective and passive method of continuously assessing alcohol consumption in the natural environment. Despite the many strengths of the Skyn, six key challenges in the collection and processing of data include (1) identifying consumed alcohol; (2) identifying environmental alcohol;...

The Appraisal-Disruption Model (ADM) suggests that individuals use alcohol as a means of dampening negative self-talk. Relationship-contingent self-esteem (RCSE) emerges from validating one’s self-esteem depending on one’s romantic relationship(s) and is known to predict alcohol-related problems. We hypothesized that RCSE indirectly predicts drinki...

Alcohol use can be measured in many ways, including objectively through transdermal alcohol biosensors (e.g., transdermal alcohol concentration; TAC) or blood biomarkers (e.g., phosphatidylethanol; PEth), or subjectively through self-report (e.g., with the timeline followback; TLFB). However, it is unclear which measures best indicate changes in al...

Background Transdermal alcohol biosensors measure alcohol use continuously, passively, and non‐invasively. There is little field research on the Skyn biosensor, a new‐generation, wrist‐worn transdermal alcohol biosensor, and little evaluation of its sensitivity and specificity and the day‐level correspondence between transdermal alcohol concentrati...

Optimal adherence to pre-exposure prophylaxis (PrEP) is critical, but challenging. Men who have sex with men and transgender women have high rates of HIV incidence and substance use. Substance use is associated with reduced adherence to other medications, but associations between substance use and adherence to PrEP are less clear. Thus, the current...

The International Society for Biomedical Research on Alcoholism BULLETIN Volume 4 Issue 4

The Sexual Delay Discounting Task (SDDT; Johnson & Bruner, 2012) is a behavioral economic task that assesses sexual risk-taking by measuring likelihood of immediate and delayed condom use. The SDDT is ecologically valid and has been used to test effects of various substances on sexual risk-taking. However, considerable variety in implementation, an...

BACKGROUND Alcohol misuse is highly prevalent in the U.S. and results in a great financial and public health burden. Current alcohol reduction treatments are underutilized and there is a critical need for innovation in the field. Transdermal alcohol biosensors measure alcohol use passively and continuously and may be helpful tools in alcohol interv...

Background: Alcohol misuse is highly prevalent in the United States and results in a huge financial and public health burden. Current alcohol reduction treatments are underused, and there is a critical need for innovation in the field. Transdermal alcohol biosensors measure alcohol use passively and continuously and may be helpful tools in alcohol...

Alcohol use is associated with poor outcomes among people living with HIV (PLWH), but it remains unclear which alcohol use measures best predict future HIV viral non-suppression over time. This study aimed to compare the ability of five alcohol use measures to predict risk of suboptimal HIV viral load trajectories over 36 months. We analyzed data f...

Men who have sex with men (MSM) account for two-thirds of new HIV diagnoses. Pre-exposure prophylaxis (PrEP), a highly efficacious HIV preventive medication, is underutilized. Identifying correlates of PrEP awareness and attitudes may help increase PrEP use. Thus, we evaluated (1) PrEP awareness; (2) differences in awareness related to substance us...

Objective Naltrexone is an effective treatment for heavy drinking among young adults. Laboratory‐based studies have shown that naltrexone dampens the subjective response to alcohol and craving. However, few studies have tested naltrexone's dynamic, within‐person effects on subjective response and craving among young adults in natural drinking envir...

Alcohol-using Black MSM (Men who have sex with men) are disproportionately impacted by HIV in the U.S.—particularly in the southern U.S.—despite the availability of antiretroviral therapy (ART). The purpose of this study was to summarize the current evidence on alcohol use and ART adherence among Black MSM in the U.S. and in the South and to identi...

Objective: Innovative strategies are needed to reduce young adult drinking. Real-time feedback via mobile health (mHealth) technology (e.g., smartphone devices/apps) may facilitate moderate drinking, yet requires evidence of feasibility, acceptability, and usability. Method: Young adults reporting frequent heavy drinking (N = 99, Mage = 23, 51%...

Recent studies have extended the acquired preparedness model to experimental data, finding that impulsivity predicts subjective alcohol response, a related yet distinct construct from expectancies. However, studies have not tested whether specific facets of impulsivity predict subjective response, or whether impulsivity indirectly predicts alcohol...

Background Transdermal alcohol biosensors can objectively monitor alcohol use by measuring transdermal alcohol concentration (TAC). However, it is unclear how sociodemographic and clinical factors that influence alcohol metabolism are associated with TAC. The main aim of this study was to examine how sociodemographic factors (sex, age, race/ethnici...

Contributing to the advancement of alcohol research globally.

Introduction: Among people living with HIV (PLWH), alcohol use can have negative impacts beyond HIV-related outcomes. The objectives of this study are to identify the most common alcohol-related consequences among PLWH in Florida and describe factors associated with experiencing more alcohol-related consequences. Methods: Data were collected from P...

Wrist-worn alcohol biosensor technology has developed rapidly in recent years. These devices are light, easy to wear, relatively inexpensive, and resemble commercial fitness trackers. As a result, they may be more suitable for a wide range of clinical and research applications. In this paper, we describe three pilot projects examining the associati...

Aims Theory‐driven, exploratory study to: (1) identify a reward drinking phenotype in young adults, (2) evaluate this phenotype as a predictor of naltrexone response, and (3) examine mechanisms of naltrexone in reward drinkers. Design Secondary analysis of a randomized controlled trial. Setting USA. Participants 128 young adult (ages 18‐25) heav...

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Neurobiological and clinical data indicate that maladaptive engagement in certain behaviors warrants consideration as “behavioral” or non-substance addictions. This chapter reviews existing neurobiological and genetic/family history evidence for behavioral addictions involving gambling, internet use, video-gaming, sex, eating, and shopping. At a ne...

BACKGROUND Impulsivity is a hallmark feature of self-regulation failures that lead to poor health decisions and outcomes, making understanding and treating impulsivity one of the most important constructs to tackle in building a culture of health. Despite a large literature base, impulsivity measurement remains difficult due to the multi-dimensiona...

Background The classic Marshmallow Test, where children were offered a choice between one small but immediate reward (eg, one marshmallow) or a larger reward (eg, two marshmallows) if they waited for a period of time, instigated a wealth of research on the relationships among impulsive responding, self-regulation, and clinical and life outcomes. Im...

Self-Discrepancy Theory (Higgins, 1987) predicts that the difference between the ideal and the actual self will be associated with impaired-control-over-drinking (IC; dysregulated drinking beyond one's own limits) as well as alcohol-related-problems. According to Slaney et al. (2001) perfectionism is a multi-faceted personality trait which represen...

OBJECTIVES/GOALS: Guided by the health belief model and social identity theory, we aim to identify socio-cultural and psychological factors that influence rural tobacco users a) participation in research and b) quitting tobacco use. We also explore how citizen scientists are perceived as disseminators of messages. METHODS/STUDY POPULATION: In Phase...

Background Alcohol consistently impairs response inhibition in the laboratory, and alcohol impairment of response inhibition may lead to excess consumption or increases in intoxicated risk behavior, both of which contribute to risk for alcohol‐related problems. To our knowledge, no prior studies have examined relations between alcohol impairment of...

Objective Two thirds of adults experience at least one lifetime traumatic incident. Specifically, childhood traumas (physical neglect, emotional neglect, physical abuse, emotional abuse, and sexual abuse) are associated with increased alcohol use. According to the self-medication hypothesis, alcohol is used to alleviate upsetting thoughts and memor...

Background Little is known about designing research recruitment campaigns that connect with underserved, geographically isolated rural populations. A theoretically informed process is needed to assist research teams and practitioners in their evaluation of Facebook’s feasibility as a recruitment tool and development of online materials for recruiti...

Genetically modified foods (GMFs) have met with strong opposition for most of their existence. According to one account—the consequence-based perspective (CP)—lay people oppose GMFs because they deem them unsafe as well as of dubious value. The CP is backed by the data and offers a clear solution for easing GMF opposition. However, several scholars...

Objective: Marijuana and nonprescription opioids remain the two most commonly used illicit substances in the United States. They have commonalities, yet the use of both at the same time may have a greater impact on psychological and health outcomes. Research is needed to determine whether dual-use is associated with more negative outcomes than ind...

Impulsivity and subjective response (SR) to alcohol (i.e., individual differences in sensitivity to pharmacologic alcohol effects) are both empirically supported risk factors for alcohol use disorder; however, these constructs have been infrequently studied as related risk factors. The present investigation examined a self-report measure of impulsi...

Background: Morbidity and mortality attributed to prescription opioids are a crisis in the US and spreading globally. Sex differences related to these conditions have not been adequately assessed. Methods: Through our community engagement program, data on demographics, health status, and substance use, including prescription opioids (e.g., Vicod...

Study Aim: Examine the effect of alcohol self-administration on APT demand indices in a human laboratory paradigm.

Devaluing or diminishing the worth of others is how many individuals destroy their relationships, such as by drinking beyond limits at inappropriate times and letting others down. Impaired control over drinking (IC) reflects consuming alcohol beyond predetermined limits. This investigation sought to determine whether facets of vulnerable narcissism...

OBJECTIVES/SPECIFIC AIMS: Our overarching theoretical framework is the health belief model (HBM). Guided by HBM, we aim to identify rural adults’ perceived barriers and motivations to participating in research. Specifically, our research questions are listed below. RQ1: What socio-cultural factors influence rural tobacco users’ intentions to a) par...

Objectives: Cocaine use is increasing and many cocaine users engage in polysubstance use. Within polysubstance use, relationships among use of individual substances are necessarily complex. To address this complexity, we used latent class analysis (LCA) to identify patterns of polysubstance use among lifetime cocaine users and examine associations...

Aims: Subjective response to alcohol and impulsivity are both independent predictors of alcohol use and may be related risk factors for alcohol use disorders (AUDs). Recent findings suggest that more impulsive individuals may experience higher risk subjective response patterns at moderate-to-high doses of alcohol. However, whether these relationshi...

Impulsivity's relationships to addictive and sexual behaviours raise questions regarding the extent impulsivity may constitute a vulnerability factor for subsequent addictive and sexual behaviours and/or results from each of these. Here, we systematically reviewed empirical support for impulsivity as a precipitating factor or a consequence of addic...

Background: Positive alcohol expectancy (AE) contributes to excessive drinking. Many imaging studies have examined cerebral responses to alcohol cues and how these regional processes related to problem drinking. However, it remains unclear how AE relates to cue response and whether AE mediates the relationship between cue response and problem drin...

Background: Social Learning Theory suggests how one conceptualizes time will be passed from parent to child (Bandura & Walters, 1963). Through the lens of Behavioral Economics Theory (Vuchinich & Simpson, 1998), impaired control may be characterized as consuming alcohol as a form of immediate gratification as a choice over more distal rewards. Bec...

Scott, Inbar and Rozin (2016) presented evidence that trait disgust predicts opposition to genetically modified food (GMF). Royzman, Cusimano, and Leeman (2017) argued that these authors did not appropriately measure trait disgust (disgust qua oral inhibition or OI) and that, once appropriately measured, the hypothesized association between disgust...

Objective: Drinking goals set at treatment onset predict treatment outcome in patients with alcohol use disorders. Yet the cognitive constructs of goal setting and goal attainment are understudied in young adult drinkers. This study sought to examine how the interplay of goal setting and goal attainment during treatment impacts treatment outcome i...

Wearable alcohol biosensors have emerged as a valuable tool for noninvasive, objective and continuous monitoring of alcohol consumption. However, to date their research and clinical applications have been limited by several factors including large size, high cost, and social stigma. In contrast, recently developed wrist-worn alcohol biosensors are...

Introduction Addressing nicotine dependence is key to effective smoking cessation. While self-report measures of nicotine dependence are often challenged for their reliability and validity, there is a lack of non-invasive and inexpensive objective measures of nicotine dependence. In this study, we aimed to explore the potential of using video-assis...

Mild traumatic brain injury, commonly known as a concussion, has gained widespread public attention. Approximately 1.1 to 1.9 million children ≤18 years old suffer sport/recreation-related concussions in the U.S. annually. The purpose of this review was to assess research articles examining concussion knowledge of youth sport athletes, coaches and...

Background: Anxiety sensitivity (AS) reflects an individual's belief that experiencing anxiety will cause illness or embarrassment, and may be a reason individuals self-medicate with alcohol. Harsh or indulgent parenting could contribute to the development of AS. We examined the direct and indirect associations between parenting styles and alcohol...

Background: Young adult heavy drinking is an important public health concern. Current interventions have efficacy but with only modest effects, thus novel interventions are needed. In prior studies, heavy drinkers, including young adults, have demonstrated stronger automatically triggered approach tendencies to alcohol-related stimuli than lighter...

Tension Reduction Theory (Kushner, Sher, Wood, & Wood, 1994) suggests alcohol is used as a means to alleviate negative affect (NA) such as shame and guilt. Shame is an internalized response in which blame is placed on the self, while guilt is not internalized and the blame is placed on the situation (Dearing, Stuewig, & Tangney, 2005). This study a...

Objective: Impulsivity and subjective response to alcohol are predictors of alcohol use disorder. The purpose of this study was to replicate and extend prior research examining relationships between impulsivity and subjective response patterns. In addition, impulsivity and initial subjective response patterns were examined in relation to current h...