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Introduction
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Publications
Publications (502)
Intestinal colonization of the oral bacterium Haemophilus parainfluenzae has been associated with Crohn’s disease (CD) severity and progression. This study examines the role of periodontal disease (PD) as a modifier for colonization of H. parainfluenzae in patients with CD and explores the mechanisms behind H. parainfluenzae-mediated intestinal inf...
Several serum inflammatory biomarkers have been associated with blood pressure and hypertension prevalence in cross-sectional studies. Few of these associations have been evaluated prospectively. We examined associations for 10 serum inflammatory biomarkers with incident hypertension among 471 postmenopausal women (mean age = 65) in the Buffalo Ost...
Diabetes affects one in 10 adults and periodontal disease affects four in 10 adults in the USA, and they are linked. Individuals with diabetes are more likely to suffer from periodontal disease and periodontal disease affects glycemic control and complications of diabetes. The role of diabetes as a risk factor for periodontal disease and other oral...
Severe periodontitis is defined by extensive loss of the tooth attachment apparatus. It is the sixth most common human disease and is estimated to affect 11.2% of the global adult population, hence representing a significant healthcare, social, and economic burden. Since the 1990s, multiple epidemiologic, experimental, and interventional studies ha...
Atherosclerosis is central to the pathology of cardiovascular diseases, a group of diseases in which arteries become occluded with atheromas that may rupture, leading to different cardiovascular events, such as myocardial infarction or ischemic stroke. There is a large body of epidemiologic and animal model evidence associating periodontitis with a...
Epidemiologic and cancer control studies on the association of periodontal disease and cancer risk mostly suggest a positive association with overall cancer risk and certain specific types of cancer. These findings are generally consistent among cross‐sectional and longitudinal studies. In this paper, we review epidemiologic studies and current kno...
Diabetes mellitus is a group of metabolic disorders with high mortality and morbidity associated with complications such as cardiovascular disease, kidney disease, and stroke. The prevalence of diabetes is 9.4% in US adults, and prevalence increases markedly with age, with 1 in 4 adults aged ≥65 years affected by diabetes. The estimated number of a...
Purpose of Review
Periodontal disease is a common bacteria-initiated inflammatory disease generating alveolar bone destruction around the dentition. Chronic periodontitis leads to the formation of a nutrient-rich periodontal microenvironment where opportunistic pathogens can thrive and flourish. The dissemination of these microbes from the oral cav...
The most important development in the epidemiology of periodontitis in the USA during the last decade is the result of improvements in survey methodologies and statistical modeling of periodontitis in adults. Most of these advancements have occurred as the direct outcome of work by the joint initiative known as the Periodontal Disease Surveillance...
Background and objective:
Use of self-reported questionnaires in Dentistry may be useful to estimate the prevalence of periodontitis in epidemiological studies. This study aims to assess the accuracy of self-reporting for predicting the prevalence of periodontitis in a Spanish population participating in a diabetes incidence study.
Materials and...
Background:
The extent to which the composition and diversity of the oral microbiome varies with age is not clearly understood.
Methods:
The 16S rRNA gene of subgingival plaque in 1219 women, aged 53-81 years, was sequenced and its taxonomy annotated against the Human Oral Microbiome Database (v.14.5). Composition of the subgingival microbiome w...
Introduction
A possible role of the oral microbiome, specifically oral nitrate reducing flora, in blood pressure (BP) homeostasis, if proven etiologic in nature, could lead to novel mechanism-based therapy to improve hypertension prevention and control.
Aim
This cross-sectional study characterized and compared the oral microbiome between four stud...
Background:
Periodontitis is more common and severe in people with diabetes than the general population. We have reported in the Joslin Medalist Study that people with type 1 diabetes of ≥50 years (Medalists) may have endogenous protective factors against diabetic nephropathy and retinopathy.
Methods:
In this cross-sectional study, the prevalenc...
Background:
Multiple cross-sectional epidemiologic studies have suggested an association between periodontal disease and tooth loss and hypertension, but the temporality of these associations remains unclear. The objective of our study was to evaluate the association of baseline self-reported periodontal disease and edentulism with incident hypert...
Purpose
The Buffalo Osteoporosis and Periodontal Disease (OsteoPerio) study is a prospective cohort study focused on the relationship between the microbiome and oral and systemic health outcomes in postmenopausal women. The cohort was established to examine how the oral microbiome is affected by (and how it affects) periodontal disease presence, se...
Motivation:
Sequence analysis is arguably a foundation of modern biology. Classic approaches to sequence analysis are based on sequence alignment, which is limited when dealing with large-scale sequence data. A dozen of alignment-free approaches have been developed to provide computationally efficient alternatives to alignment-based approaches. Ho...
Aging invokes physiological changes, such as immunosenescence and inflammation, that could increase host susceptibility to oral microbiome shifts that enable periodontitis progression in later life. At present, there is a dearth of studies specifically evaluating the oral microbiome and periodontitis in older adults. We used high-throughput untarge...
Motivation
The rapid development of sequencing technology has led to an explosive accumulation of genomic data. Clustering is often the first step to be performed in sequence analysis. However, existing methods scale poorly with respect to the unprecedented growth of input data size. As high-performance computing systems are becoming widely accessib...
Background:
This report presents weighted average estimates of the prevalence of periodontitis in the adult US population during the 6 years 2009-2014 and highlights key findings of a national periodontitis surveillance project.
Methods:
Estimates were derived for dentate adults 30 years or older from the civilian noninstitutionalized population...
Periodontal health is defined by absence of clinically detectable inflammation. There is a biological level of immune surveillance that is consistent with clinical gingival health and homeostasis. Clinical gingival health may be found in a periodontium that is intact, i.e. without clinical attachment loss or bone loss, and on a reduced periodontium...
Background
: Hypertension and periodontal disease are common conditions among postmenopausal women. Periodontal disease has been found associated with hypertension in previous studies, but data in postmenopausal women is limited.
Methods
: We assessed the cross‐sectional associations of clinically measured periodontal disease with prevalent hypert...
Periodontal disease (PD) is more common and severe in people with diabetes than the general population. The presence of severe PD is correlated with decreased survival, since it can potentially affect glycemic control and severity of complications in people with diabetes. We have reported that Medalists (people with T1DM of 50 years or longer durat...
The periodontal pathogen Tannerella forsythia has the unique ability to produce methylglyoxal (MGO) an electrophilic compound, which can covalently modify amino acid side chains and generate inflammatory adducts known as advanced glycation endproducts (AGEs). In periodontitis, the concentrations of gingival‐crevicular fluid MGO increase, and correl...
Background:
A number of studies have associated obesity with altered gut microbiota, although results are discordant regarding compositional changes in the gut microbiota of obese animals. Herein we aimed to obtain an unbiased evaluation of structural and functional changes of the gut microbiota in diet-induced obese rodents using a meta-analysis....
Objective
Bile acids are regulators of lipid and glucose metabolism, and modulate inflammation in the liver and other tissues. Primary bile acids such as cholic acid and chenodeoxycholic acid (CDCA) are produced in the liver, and converted into secondary bile acids such as deoxycholic acid (DCA) and lithocholic acid by gut microbiota. Here we inves...
Background: Periodontal pathogens have been isolated from precancerous and cancerous lesions and also shown to promote a procarcinogenic microenvironment. Few studies have examined periodontal disease as a risk factor for total cancer, and none have focused on older women. We examined whether periodontal disease is associated with incident cancer a...
Background—Few studies have reported associations between periodontitis and cardiovascular disease (CVD) risk in older women, which is the objective of the present investigation.
Methods and Results—Participants were 57 001 postmenopausal women ages 55 to 89 years (mean 68 years; >85% 60 and older) who were enrolled (1993–1998) in the Women’s Heal...
The older adult population is growing rapidly in the USA and it is expected that by 2040 the number of adults ≥ 65 years of age will have increased by about 50%. With the growth of this subpopulation, oral health status, and periodontal status in particular, becomes important in the quest to maintain an adequate quality of life. Poor oral health ca...
Objective:
To determine population-average risk profiles for severe and non-severe periodontitis in US adults (30 years and older) using optimal surveillance measures and standard case definitions.
Methods:
We used data from the 2009-2012 National Health and Nutrition Examination Survey (NHANES), which for the first time used the "gold standard"...
Background:
Vitamin D is hypothesized to reduce risk for tooth loss via its influence on bone health, inflammation, and the immune response. We examined the association between plasma 25-hydroxyvitamin D (25[OH]D) concentrations and the prevalence and 5-year incidence of tooth loss in a cohort of postmenopausal women.
Methods:
Participants under...
Purpose:
Few prospective studies have reported on relationships between objective periodontal disease (PD) measures and cancer risk. This association was examined in 1,337 postmenopausal women participating in the Buffalo OsteoPerio Study.
Methods:
Oral alveolar crestal height (ACH) was measured using oral radiographs. Incident cancers were adju...
Background:
Periodontal disease has been consistently associated with chronic disease; there are no large studies of breast cancer, although oral-associated microbes are present in breast tumors.
Methods:
In the Women's Health Initiative Observational Study, a prospective cohort of postmenopausal women, 73,737 women without previous breast cance...
Background:
Extra-oral translocation of oral bacteria may contribute to associations between periodontal disease and cancer. We investigated the associations among the presence of three orange-complex periodontal pathogens (Fusobacterium nucleatum, Prevotella intermedia, and Campylobacter rectus), two red-complex periodontal pathogens (Porphyromon...
Background:
Currently, taxonomic interrogation of microbiota is based on amplification of 16S rRNA gene sequences in clinical and scientific settings. Accurate evaluation of the microbiota depends heavily on the primers used, and genus/species resolution bias can arise with amplification of non-representative genomic regions. The latest Illumina M...
Background: Periodontal disease (PD) has been found to be associated with increased cancer risk, including among participants in the Women's Health Initiative (WHI). Microbial colonization of the subgingival area is a necessary causal factor for the development of PD. Previous findings of positive relationships between PD and cancer risk may be par...
Oral infections are the most common diseases of mankind. Numerous reports have implicated oral infections, particularly periodontitis, as a risk factor for atherosclerotic cardiovascular disease (CVD). In this review we examine the epidemiology and biologic plausibility of this association with an emphasis on oral bacteria and inflammation. Longitu...
Background:
This report describes prevalence, severity, and extent of periodontitis in the US adult population using combined data from the 2009 to 2010 and 2011 to 2012 cycles of the National Health and Nutrition Examination Survey (NHANES).
Methods:
Estimates were derived for dentate adults, aged ≥30 years, from the US civilian non-institution...
Background:
Declines in endogenous estrogen levels after menopause can lead to systemic bone loss, including loss of oral bone and alveolar crest height (ACH). However, few studies have assessed both serum 17β-estradiol (E2) and exogenous hormone therapy (HT) use in relation to oral bone loss.
Methods:
This study examines the associations among...
Purpose
Few prospective studies have reported on relationships between objective periodontal disease (PD) measures and cancer risk. This association was examined in 1,337 postmenopausal women participating in the Buffalo OsteoPerio Study.
Methods
Oral alveolar crestal height (ACH) was measured using oral radiographs. Incident cancers were adjudicat...
The effect of nonsurgical periodontal therapy on hemoglobin A1c levels in persons with type 2 diabetes and chronic periodontitis: a randomized clinical trial. Engebretson SP, Hyman LG, Michalowicz BS, Schoenfeld ER, Gelato MC, Hou W, et al (16 authors). JAMA 2013;310(23):2523-32.
Purpose:
While some evidence suggests that periodontal disease (PD) might be positively associated with lung cancer, prospective studies in women are limited. Previous findings may reflect residual confounding by smoking. The study aims to determine whether history of PD diagnosis is associated with incident lung cancer in a large cohort of postme...
Declarative Title
There is a role for dentistry in the interprofessional management of chronic diseases by addressing common risk factors
Background
A critical scientific foundation has developed for management of risk factors common to major diseases including periodontal disease, caries, diabetes, heart disease, and cancer.
Purpose
The purpose...
Background:
The objective of this study is to characterize the association between metabolic syndrome (MetS) and periodontitis in women, for which there is limited evidence.
Methods:
Cross-sectional associations between MetS and periodontitis were examined in 657 postmenopausal women aged 50 to 79 years enrolled in a periodontal disease study an...
To the Editor The report by Dr Engebretson and colleagues1 explored the effect of nonsurgical periodontal therapy (scaling and root planing) on glycemic control in persons with type 2 diabetes and chronic periodontitis. Given the high global prevalence of both diseases, the adverse effect of periodontal infection on blood glucose levels and diabete...
Background:
Vitamin D is hypothesized to prevent periodontal disease progression through its immune-modulating properties and its role in maintaining systemic calcium concentrations. The authors investigated associations between plasma 25-hydroxyvitamin D [25(OH)D] (collected 1997 to 2000) and the 5-year change in periodontal disease measures from...
This tribute to Marty Taubman is written on the occasion of his retirement from full-time faculty status at The Forsyth Institute and Harvard Dental School, and his stepping down as editor of the "Discovery!" section of the Journal of Dental Research. It recognizes his seminal contributions to oral immunology, his mentoring of a generation of new s...
/st> In this field trial, the authors assess the feasibility of screening for diabetes and prediabetes in dental practices and in a community health center.
/st> Dental patients 45 years and older who were not aware of their diabetic status underwent evaluation for diabetes risk with an American Diabetes Association Diabetes Risk Test and with hemo...
http://www.quintpub.com/display_detail.php3?psku=B6508#.Uvnoe0JdX6Q
In today's health care environment, the emphasis on disease prevention means that, more than ever before, dentists are expected to promote the general as well as oral health of their patients. Over the past several decades, an impressive body of knowledge has accumulated about the...
Declarative Title
The randomized controlled trial (RCT) published by the Journal of the American Medical Association (JAMA) on the impact of periodontal therapy on glycated hemoglobin (HbA1c) has fundamental flaws.
Article Title and Bibliographic Information
The effect of nonsurgical periodontal therapy on hemoglobin A1c levels in persons with typ...
Background:
This study examines the accuracy of self-reported periodontal disease in a cohort of older females.
Methods:
The study comprised 972 postmenopausal females aged 53 to 83 years who completed baseline (1997 to 2001) and follow-up (2002 to 2006) whole-mouth oral examinations. Examinations included: 1) probing depth, 2) clinical attachme...
Background:
Previous findings of an association between 25-hydroxyvitamin D [25(OH)D] concentrations and periodontal disease may be partially explained by the antimicrobial properties of vitamin D. To the best of the authors' knowledge, no study has investigated the association between 25(OH)D and pathogenic oral bacteria, a putative cause of peri...
The purpose of this study was to evaluate the performance of self-reported measures in predicting periodontitis in a representative US adult population, based on 2009-2010 National Health and Nutrition Examination Survey (NHANES) data. Self-reported gum health and treatment history, loose teeth, bone loss around teeth, tooth not looking right, and...
Importance
Dental caries is the demineralization of tooth structures by lactic acid from fermentation of carbohydrates by commensal gram-positive bacteria. Cariogenic bacteria have been shown to elicit a potent Th1 cytokine polarization and a cell-mediated immune response.Objective
To test the association between dental caries and head and neck s...
Risk factors play an important role in an individual's response to periodontal infection. Identification of these risk factors helps to target patients for prevention and treatment, with modification of risk factors critical to the control of periodontal disease. Shifts in our understanding of periodontal disease prevalence, and advances in scienti...
Multiplexing arrays increase the throughput and decrease sample requirements for studies employing multiple biomarkers. The goal of this project was to examine the performance of Multiplex arrays for measuring multiple protein biomarkers in saliva and serum. Specimens from the OsteoPerio ancillary study of the Women's Health Initiative Observationa...
Current clinical therapies for critical-sized bone defects (CSBDs) remain far from ideal. Previous studies have demonstrated that engineering bone tissue using mesenchymal stem cells (MSCs) is feasible. However, this approach is not effective for CSBDs due to inadequate vascularization. In our previous study, we have developed an injectable and por...
Higher magnification image of immunostaining. (A-E) Immunostaining of endothelial cell marker - vWF. (A’-E’) Immunostaining of VEGF. (A, A’): nCS/A; (B, B’): nCS/A+M; (C, C’): nCS/A+M+E; (D, D’): nCS/A+B2/M; (E, E’): nCS/A+B2/(M+E). Bars: 0.25 mm.
(TIF)
Negative and positive controls for the immunostaining. The negative control staining was performed on the same bone slides under the same conditions except using the goat serum to replace the primary antibodies of anti- vWF (A) and anti-VEGF (A’). The positive control staining was performed on the kidney slides with the same primary and secondary a...
Periodontal disease and diabetes mellitus are common, chronic diseases worldwide. Epidemiologic and biologic evidence suggest periodontal disease may affect diabetes.
To systematically review non-experimental, epidemiologic evidence for effects of periodontal disease on diabetes control, complications and incidence.
Electronic bibliographic databas...
Abstract Background: Periodontal disease and diabetes mellitus are common, chronic diseases worldwide. Epidemiologic and biologic evidence suggest periodontal disease may affect diabetes. Objective: To systematically review non-experimental, epidemiologic evidence for effects of periodontal disease on diabetes control, complications and incidence....
Abstract Background: Diabetes and periodontitis are complex chronic diseases with an established bidirectional relationship. There is long-established evidence that hyperglycaemia in diabetes is associated with adverse periodontal outcomes. However, given the ubiquity of periodontal diseases and the emerging global diabetes epidemic, the complicati...
Diabetes and periodontitis are complex chronic diseases with an established bidirectional relationship. There is long-established evidence that hyperglycaemia in diabetes is associated with adverse periodontal outcomes. However, given the ubiquity of periodontal diseases and the emerging global diabetes epidemic, the complications of which contribu...
Objectives: To test and quantify the association between periodontal treatment and medical utilization among patients with periodontal disease. Methods: This study was a retrospective case-control study that matched patients with periodontal disease over a three-year period (n=5,317 each for the Study and Control groups, from a total population of...
Objective: Dental caries and periodontitis are two plaque-related but distinct diseases in terms of etiology and pathogenesis. Periodontitis, associated with gram-negative anaerobic bacteria, is characterized by Th2- and Th17-polarized immune responses, which are associated with increased risk of cancer. Dental caries, associated with gram-positive...
/st> Smoking is associated with tooth loss. However, smoking's relationship to the specific reason for tooth loss in postmenopausal women is unknown.
/st> Postmenopausal women (n = 1,106) who joined a Women's Health Initiative ancillary study (The Buffalo OsteoPerio Study) underwent oral examinations for assessment of the number of missing teeth, a...
Background:
Vitamin D has anti-inflammatory and antimicrobial properties that, together with its influence on bone health, may confer periodontal benefit.
Methods:
Cross-sectional associations (years 1997-2000) between plasma 25-hydroxyvitamin D concentration [25(OH)D] and periodontal measure were investigated among 920 postmenopausal women. Mea...
Background: Smoking has been associated with poor oral health and tooth loss. Our study aim was to evaluate the association between smoking history and tooth loss, and determine if this association differed by loss due to caries or periodontal disease (PD). Methods: Smoking and potential confounding variables were obtained via self-administered que...
Background: Vitamin D is hypothesized to prevent alveolar bone loss due to its anti-inflammatory properties and its role in maintaining adequate systemic calcium concentrations. To our knowledge, no study has prospectively investigated associations between vitamin D status, assessed with 25(OH)D concentrations, and change in ACH.
Purpose: We inve...
Background: Studies have found an association between 25(OH)D concentrations and periodontal disease (PD), which may be explained in part by vitamin D's antimicrobial properties. To our knowledge, no study has investigated the relationship between 25(OH)D and the prevalence of pathogenic oral bacteria, a putative cause of PD. Purpose: We examined t...
Background: Vitamin D (VitD) and calcium (Ca) are hypothesized to play important roles in reducing bone destruction in periodontal disease (PD). To our knowledge, we conducted the first large epidemiologic study investigating associations between PD, assessed by alveolar crestal height (ACH), and intake of these nutrients in women. Purpose: We inve...
The guest editor of this special supplement to JADA provides an overview of salivary diagnostic testing and introduces the articles presented in this supplement to The Journal of the American Dental Association.
The repair of craniofacial bone defects is surgically challenging due to the complex anatomical structure of the craniofacial skeleton. Current strategies for bone tissue engineering using a preformed scaffold have not resulted in the expected clinical regeneration due to difficulty in seeding cells into the deep internal space of scaffold, and ina...
