Robert Corns

• Consultant at Leeds Teaching Hospitals NHS Trust

We assessed prognostic factors in relation to OS from progression in recurrent glioblastomas. Retrospective multicentric study enrolling 407 (training set) and 370 (external validation set) adult patients with a recurrent supratentorial glioblastoma treated by surgical resection and standard combined chemoradiotherapy as first-line treatment. Four...

Introduction: Surgical resection of supratentorial cavernous angiomas located in eloquent areas poses a significant risk to the patient of postoperative neurological impairment and justifies intraoperative functional monitoring. Methods: Multicentre retrospective series of adult patients with cavernous angiomas located within eloquent areas and...

Introduction: Intraoperative application of electrical current to the brain is a standard technique during brain surgery for inferring the function of the underlying brain. The purpose of intraoperative functional mapping is to reliably identify cortical areas and subcortical pathways involved in eloquent functions, especially motor, sensory, lang...

Objective: Incidentally discovered diffuse low-grade gliomas progress in a fashion similar to their symptomatic counterparts. Their early detection allows more effective pre-emptive and individualized oncological treatment. We assessed the safety and efficacy of maximal safe resection according to functional boundaries for incidental diffuse low-g...

Introduction: The aim of brain glioma surgery is to maximize the quality of resection, while minimizing the risk of sequelae. Due to the frequent location of gliomas near or within eloquent areas, owing to their infiltrative feature, and because of major interindividual variability, the anatomofunctional organization and connectivity must be studi...

OBJECTIVE There are no guidelines for the management of postoperative lateral sinus thrombosis following posterior fossa surgery. Introducing treatment-dose anticoagulant therapy during the immediate postoperative period increases the risk of intracranial bleeding. This study assessed the incidence of and risk factors associated with postoperative...

Background: The standard of care for newly diagnosed glioblastoma is maximal safe surgical resection, followed by chemoradiation therapy. We assessed carmustine wafer implantation efficacy and safety when used in combination with standard care. Methods: Included were adult patients with (n = 354, implantation group) and without (n = 433, standar...

Overall survival for patients with glioblastoma multiforme (GBM) has been consistently shown to improve when the surgeon achieves a gross total resection of the tumour. It has also been demonstrated that surgical adjuncts such as 5-aminolevulinic acid (5-ALA) fluorescence-which delineates malignant tumour tissue- normal brain tissue margin seen usi...

High complication rates have been cited following olfactory groove meningioma (OGM) resection but data are lacking on attendant risk factors. We aimed to review the complications following OGM resection and identify prognostic factors. A retrospective review was performed on 34 consecutive patients who underwent primary OGM resection at a single Lo...

On 30 June 1559, Henry II, King of France, was mortally wounded in the head by a lance during a jousting match. Despite the best efforts of his physicians, Ambroise Paré and Andreas Vesalius, King Henry died 11 days later. This article, based on previously unpublished evidence, aims at examining the historical account of his death against modern me...

Dear Editor,Cranial trepanation is among the oldest surgical procedures performed. Remains of human skulls with evidence of successful trepanation have been found in many countries such as Peru [1], Syria [2] and China [3], dating from the Neolithic Age to modern times [4]. In 1876 [5], Paul Broca described three putative goals for such trepanation...

Objectives. The popularity of cycling, both as a sport and for transportation has increased dramatically in the UK over the past decade. Cycling is known to have positive effects on body fitness and cardiovascular health, but the effects on the musculoskeletal system and joint structure/function are unknown. We aim to study the effects of high inte...

A 54-year-old man presented with symptoms of cauda equina syndrome, which spontaneously resolved. Initial MRI did not show any compression of the cauda equine; however, an unusual pattern of epidural fat lead to further investigation and ultimately the diagnosis.

A previously well 13-year-old girl presented with a 4-month history of progressively worsening headache and visual disturbance. At fourth presentation, examination showed bilateral papilloedema and a left homonymous hemianopia. CT and MRI scans revealed a tumour obstructing the third ventricle with consequent hydrocephalus. Following uncomplicated...

Object: Endovascular coiling is a common treatment for ruptured intracranial aneurysms. However, concerns have been raised over the durability of this treatment. The aim of this study was to establish the rate of recurrence and retreatment of coiled aneurysms treated in our unit. Methods: We performed a retrospective analysis of 264 surviving pa...

Hydrocephalus is a common condition in both adult and paediatric neurosurgery. We outline how an understanding of its cause in an individual patient helps to guide treatment. The clinical features, investigation and treatment of hydrocephalus are described.

Since 2006, National Institute for Health and Clinical Excellence (NICE) guidelines advise referral of any suspected brain tumour to a dedicated neuro-oncology multidisciplinary team (MDT). We investigated two aspects of MDT safety: whether time to operation was delayed and whether brain abscesses were inappropriately referred to the MDT. MATERIAL(...

A gentleman, aged 54, with shunted hydrocephalus presented with recurrent chest infections. He had a ventriculoperitoneal (VP) shunt inserted when he was 38 years old for obstructive hydrocephalus due to a cerebellar tumour, with no subsequent shunt revisions since. Over a 2-year period, he presented with three episodes of pneumonia, which, on each...

Chondromyxoid fibroma (CMF) is a rare bone tumor representing less than 1% of total bone neoplasms. It is a slow-growing, locally destructive tumor that usually affects the metaphyseal region of long bones. The occurrence of this tumor in the skull base or cervical spine is exceptionally rare. We present the first case of CMF originating in the cli...

Low-grade primary T-cell lymphoma of the central nervous system is extremely rare. We present a case developing in a previously fit young woman presenting with symptoms of raised intracranial pressure and found on CT to have a cerebellar mass. Biopsy of this lesion revealed features of non-Hodgkin's lymphoma with histochemical analysis confirming T...

In this paper the authors' goal was to report on and examine (in the context of a large hospital with good endovascular intervention provisions) the activities of a neurosurgeon with a dedicated vascular interest in the era after the International Subarachnoid Aneurysm Trial in the United Kingdom. They also aimed to establish therapeutic trends and...

Boerhaave's syndrome is the postemetic rupture of a normal oesophagus, the diagnosis of which is not always immediately apparent. We present here a case report which illustrates the value of computed tomography (CT) scanning in making this often difficult diagnosis.

The distribution of the calcium binding protein neurocalcin a has been examined in the enteric nervous system of young adult (3 months) and aged (24+ months) male rats by immunofluorescence. Neurocalcin-immunoreactive (NC-ir) neurons were observed in the submucous and myenteric plexuses throughout the gastrointestinal tract from the oesophagus to t...

In the rat the majority of sympathetic and parasympathetic postganglionic neurons that innervate the pelvic viscera are located together in the major pelvic ganglia. We have ascertained that it is only the sympathetic population of this ganglion that exhibits age-associated attrition. Recent immunohistochemical investigations of the distribution of...

The rat major pelvic ganglion contains the majority of sympathetic and parasympathetic postganglionic neurons that innervate the pelvic viscera. Previous studies have indicated that it is only the sympathetic population of this ganglion that is susceptible to age-associated changes. We have examined the distribution of the neuronal calcium binding...