
Robert P BatzingerPayap University · Department of Information Technology
Robert P Batzinger
PhD Pathobiology, Johns Hopkins; MS Applied Mathematics and Computer Science, IUSB
About
38
Publications
1,290
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
1,207
Citations
Introduction
Robert P Batzinger currently teaches Computer Science at Payap University. Recent research interest include adapting of Applied Mathematics and Artificial Intelligence techniques to develop applications to that solve issues in Big Data, Software Engineering and Program Development. The most recent publications is 'Successful implementation of an active learning laboratory in computer science', .
Additional affiliations
November 2011 - present
January 2011 - February 2016
April 1984 - October 2004
United Bible Societies
Position
- Manager
Publications
Publications (38)
MIT App Inventor is a tool used to create applications that run on the Android Operating System. MIT App Inventor uses component-based software development approach enabling users to develop applications so easily without coding in Java that many people have mentioned that MIT App Inventor cannot actually be used to develop real-world applications....
The combined emergence of Large Language Models (LLMs) and Generative Pre-Trained Transformer has resulted in applications like ChatGPT which have revolutionized higher education, offering unprecedented access to information and facilitating rapid document generation and summarization. Because the output is written in a tone that appears objective...
This paper describes an attempt to improve the management and the success of student capstone projects through the development and use of an online project management framework compliant with ISO29110. Within this framework, students develop their ideas which are captured incrementally as updates to a GitLab repository. Thus, the process of develop...
There is ample evidence of positive impact of active learning on student learning, attitudes, critical thinking, and retention. The traditional lecture-style classrooms are not suitable for group interaction or activities. Having an appropriate classroom with proper technology to support active learning is essential. In order to foster easier group...
Understanding the parameters that affect student retention and developing remedies to improve overall student success is challenging. For several years, the authors have been engaged in the development of an intelligent and user-friendly early-warning and student retention system known as IU-RETAIN. The planning and design was initiated in 2005. Th...
As computer science continues to move toward a more pragmatic market driven discipline, some of the traditional core topics in computing have become less popular. At-risk topics include compilers, file organizations, and operating systems. Viewed collectively, it appears that courses that either deal with the internal working of computers or course...
Inspection is one of the most common sorts of review practices in software projects. However, there are some controversial reports about the efficiencies of software inspections. In this paper, we perform an empirical study to analyze the efficiencies of code inspections in both software development and software maintenance. The study is performed...
Recent in vitro studies indicate that intestinal bacteria convert amoscanate (4-nitro-4'-isothiocyanodiphenylamine), an antischistosomal drug, to a potent mutagen. The present study indicates that the implantation of germfree mice with Streptococcus equinus, isolated from the small intestine of conventional mice, restores the mutagenic activation o...
The methodologies and status of the Host-Mediated Assay were reviewed using the published literature available up to June 1980. The Working Group reviewed 274 documents, including abstracts, research articles, review articles, and publicly available contracts and grant final reports. From this group, abstracts and reviews were rejected from critica...
The methodologies and status of the Host-Mediated Assay were reviewed using the published literature available up to June 1980. The Working Group reviewed 274 documents, including abstracts, research articles, review articles, and publicly available contracts and grant final reports. From this group, abstracts and reviews were rejected from critica...
The methodologies and status of Body Fluid Analysis were reviewed using the published literature available up to June 1980. 98 documents were reviewed by the Working Group. These included abstracts, research articles, and review articles. From this selection, abstracts and reviews were rejected from critical evaluation by the Working Group, who acc...
Without external activation, cis- and trans-dichlorodiammineplatinum(II) (DDP) and the cis, trans(-), and trans(+) forms of dichloro-1,2-diaminocyclohexaneplatinum(II) (DDCP) and sulfato-1,2-diaminocyclohexaneplatinum(II) (SHP) showed a 400-fold range of mutagenicity for Salmonella typhimurium TA100 and TA98; they were 2 to 10 times more mutagenic...
Oral administration to mice of high doses of 4-isothiocyano-4'nitrodiphenylamine (amoscanate), a potent antischistosomal drug, produced focal necrotizing lesions of the large intrahepatic and extrahepatic bile ducts and the gallbladder. Coadministration of erythromycin and, to a somewhat lesser degree, of paromomycin, markedly reduced the effects o...
Previous studies have shown that a new antischistosomal drug, 4-isothiocyano-4'-nitro diphenylamine (CGP 4540, amoscanate), is not mutagenic in vitro, but the urines of animals treated with this drug have mutagenic activity. Mutagenicity can be eliminated by coadministration of some antibacterial agents and is not demonstrable in germ-free animals....
Most, if not all, clinically used antischistosomal drugs are mutagenic. Several approaches to reduce or eliminate this liability will be discussed. 1. Structural modifications of the hycanthone molecule have resulted in the synthesis of analogs whose mutagenic and carcinogenic potentials and whose acute toxicity were markedly reduced, while antisch...
Experiments were designed to determine whether hycanthone methanesulfonate (1-([2-(diethylamino)ethyl]amino)-4-(hydroxymethyl)thioxanthen-9-one monomethanesulfonate), an antischistosomal drug, and its analog, IA-4-N-oxide (8-chloro-2-[2-(diethylamino)ethyl]-2H-[1]benzothiopyrano[4,3,2-cd]indazole 5-methanol monomethanesulfonate), will induce neopla...
By using a bacterial test system, it has been shown that hydroperoxy derivatives of thymine and thymidine produced by ionizing radiation, near-UV radiation, and certain oxidation reactions are highly mutagenic. Considering that hydroperoxy derivatives of biomolecules have been implicated widely as likely candidates causing mutagenesis, carcinogenes...
Administration of 4 nitro-4' isothiocyano-diphenylamine (CGP 4540, amoscanate) to two nonhuman primates, Macaca mulatta and Cebus apella, resulted in the appearance of mutagenic material in the urines of these animals. Mutagenic metabolites of this drug could also be detected in the urines when the drug was administered to primates infected with Sc...
Administration of the antioxidants 2(3)-tert-butyl-4-hydroxyanisole (BHA) and ethoxyquin (1,2-dihydro-6-ethoxy-2,2,4-trimethylquinoline) with the diet resulted in a marked decrease in the levels of mutagens present in mice treated with benzo(a)pyrene. This was reflected in the results of the host-mediated assay and determinations of the mutagenic a...
Addition of either 2(3)-tert-butyl-4-hydroxyanisole (BHA) or 1,2-dihydro-6-ethoxy-2,2,4-trimethylquinoline (ethoxyquin) to the diet greatly decreases the levels of mutagenic metabolites of benzo(a)pyrene in CD-1 mice. The mutagenic activity of the urinary metabolites of benzo(a)pyrene is markedly reduced in the presence of glutathione together with...
A new broad-spectrum antiparasitic agent, 4-isothiocyano-4'-nitrodiphenylamine, is devoid of mutagenic activity in vitro, either alone or in the presence of activating enzymes of rat liver. However, six species of mammals receiving this drug excrete as as yet unidentified mutagenic metabolite. Several observations suggested that one or several cons...
The protection afforded by antioxidants against the induction of a variety of experimental tumors in rodents in a phenomenon on great theoretical interest and potentially of practical importance. The possibility that the antioxidants exert their effects by interacting directly with the electrophilic species of ultimate carcinogens cannot be exclude...
Saccharin preparations commonly distributed as artificial sweeteners exhibited mutagenic activity in bacterial tests. When administered orally to mice, mutagenic activity was demonstrable in the urines of these animals as well as in a host-mediated assay. Highly purified saccharin was not mutagenic in the direct assay, but the urines of mice to whi...
Mandelonitrile beta-glucuronide, the compound patented as Laetrile, has been synthesized from rabbit liver uridine diphosphate-glucuronosyl
transferase immobilized on beaded sepharose, has been analyzed by thin-layer chromatography, nuclear magnetic resonance, and
gas chromatography-mass spectrometry, and has been tested for cytotoxicity and mutage...
While 4-isothiocyano-4'-nitrodiphenylamine has high schistosomicidal activity in vivo and is devoid of mutagenic properties in vitro, the reverse is true for the isocyano analogue of this compound; i.e., replacement of the sulfur by oxygen results in a compound that has no demonstrable antischistosomal effects and exhibits significant mutagenic act...
Five antischistosomal compounds--hycanthone, two of its chloroindazole analogs (IA-4 and IA-4 N-oxide), oxamniquine, and metrifonate--were tested for mutagenic activity, using Salmonella typhimurium strains TA 98 and TA 100 under in vitro and in vivo (host-mediated) conditions. In all assay systems hycanthone exhibited by far the highest mutagenic...
The genetic activity of furapromidium (F30066), an antischistosomal drug, was studied in Salmonella typhimurium, Saccharomyces cerevisiae, Neurospora crassa and cultured Chinese hamster cells. The results show that F30066 induces gene mutations in S. typhimurium, N. crassa and Chinese hamster cells. This compound also causes gene conversions in S....
A procedure to enhance the schistosomicidal effectiveness in vivo of an isothiocyanate derivative and some of its antischistosomal properties are reported. Determinations of the effects of this compound on tissue thiol levels and on highly sensitivity bacterial tester strains have indicated that its mutagenic potential is of a low order and that th...
Administration of the antloxidants2(3)-tert-butyl-4-hy droxyanisole (BHA)andethoxyquln (1,2-dihydro-6-ethoxy 2,2,4-trimethylqulnoline) wfththedietresultedina marked decrease in the levels of mutagens present in mice treated wfth benzo(a)pyrene.This was reflected in the results of the host-mediatedassay and determinationsof the mutagenicactivitiesof...
Addition of either 2(3)-tert-butyl-4-hydroxyanlsole (BHA) or I ,2-dlhydro-6-ethoxy-2 ,2,4-trlmethylquinollne(eth oxyquin) to the diet greatly decreases the bevels of muta genicmetabobites of benzo(a)pyrene in CD-I mice.(R. P. Batzinger, S-V. L. Ou, and E. Bueding, Cancer Res., 38: 000,1978).The mutagenicactivity of the urinary metabo litesof benzo(...
As computer science continues to move toward a more pragmatic market driven discipline, some of the traditional core topics in computing have become less popular. At-risk topics include compilers, file organizations, and operating systems. Viewed collectively, it appears that courses that either deal with the internal working of computers or course...