Robert Astur

University of Connecticut | UConn · Department of Psychology

This study examined whether a conditioned place preference (CPP) could be established for a virtual reality (VR) room that previously contained virtual alcohol stimuli. 298 undergraduates with varying levels of alcohol use completed six, three-minute conditioning sessions in which they were confined to one of two visually-distinct VR rooms: one of...

Nicotine has been shown to facilitate hippocampal-dependent context fear conditioning (FC), but not hippocampal-independent delay cued fear conditioning. Studies examining the effects of nicotine on learned fear have been exclusively limited to nonhumans. The present study aimed to translate nonhuman findings by investigating the effects of nicotin...

Individuals with addictions often exhibit approach bias, or the relatively automatic action tendency to approach rather than avoid addiction-related stimuli. The current study used a cannabis-Approach-Avoidance Task (AAT) to assess approach-avoidance tendencies toward cannabis stimuli among 211 undergraduate college students with varying levels of...

To examine the role of estradiol in hippocampal-dependent spatial memory in women, 86 female undergraduates were tested in a virtual Morris water task (VMWT), a virtual radial arm maze (VRAM), and a mental rotation task (MRT) within a single daily session. The VMWT and RAM were also administered 24hours later to examine the effects of estradiol on...

Mass shooting events threaten people's safety with growing frequency and casualties. However, occupants may have difficulties behaving properly for survival because of a lack of information. Although gunfire locations and emergency guidance can be provided to occupants by technological advances, the effects of providing such information and guidanc...

Background Nicotine has recently been shown to enhance the motivational value of non-nicotine stimuli in nonhumans. To investigate whether nicotine also enhances reward in humans, we used a virtual translation of the conditioned place preference (CPP) paradigm to examine nicotine’s reward-enhancing effects using a low-dose 2 mg nicotine lozenge tar...

In view of the growing interest regarding binge-watching (i.e., watching multiple episodes of television (TV) series in a single sitting) research, two measures were developed and validated to assess binge-watching involvement (“Binge-Watching Engagement and Symptoms Questionnaire”, BWESQ) and related motivations (“Watching TV Series Motives Questi...

Repeated engagement in addictive behaviors may lead to relatively automatic action tendencies whereby individuals approach rather than avoid addictive stimuli. This study assessed whether an approach bias for erotic stimuli exists among heterosexual college-aged females who report using pornography. We tested 121 female undergraduates using an appr...

Oral contraception (OC) has been a common method of birth control for decades, yet the effects of this hormone manipulation on cognition are largely unknown. Although some studies have addressed this subject, efforts to make definitive conclusions are hampered by methodological issues including variations in OC type and hormone constituents, incons...

Background and aims: Addicted individuals often demonstrate relatively automatic action tendencies in response to addiction-related stimuli, whereby they approach rather than avoid addictive stimuli. This study assessed whether an approach bias for erotic stimuli exists among heterosexual college-aged males who report using pornography. Methods:...

In view of the emerging psychological research on binge-watching (i.e., watching TV series episodes back-to-back), two assessment measures were developed and validated in a French-speaking population to evaluate TV series watching motives (Watching TV Series Motives Questionnaire) and binge-watching engagement and symptoms (Binge-Watching Engagemen...

Background Physical exercise (PE) is a safe, non-stigmatizing, and side-effect free intervention that has the potential to mitigate neurocognitive dysfunction in psychosis, as well as reduce anxiety and paranoia. Developing and promoting PE programs for people with SMI in the community where participants cannot be paid to participate requires an in...

Computerized tasks based on conditioned place preference (CPP) methodology offer the opportunity to study learning mechanisms involved in conditioned reward in humans. In this study, we examined acquisition and extinction of a CPP for virtual environments associated with monetary reward ($). Healthy men and women (N = 57) completed a computerized C...

The current study examined sex differences in initial and subsequent strategies in solving a navigational problem within a virtual reality environment. We tested 163 undergraduates on a virtual T-maze task that included probe trials designed to assess whether participants were responding using either a place or response strategy. Participants were...

Anxiety impairs evacuees' ability to select appropriate routes during building fire and smoke evacuations. Understanding anxiety is thus essential to provide proper guidance to evacuees. However, it is challenging to model how anxiety affects evacuees' decision-making process, and how to validate the resulting approach with very limited available d...

The aim of this experiment was to examine the extent to which eating disorder risk affects the strength of food-reward conditioning. Eighty food-restricted undergraduates were placed into a VR environment consisting of 2 visually distinct rooms. Participants underwent multiple pairing sessions in which they were confined into one of the two rooms a...

To extend a standard paradigm of conditioning in nonhumans to humans, we created a virtual reality (VR) conditioned place preference task, with real-life food rewards. Undergraduates were placed into a VR environment consisting of 2 visually distinct rooms. On Day 1, participants underwent 6 pairing sessions in which they were confined into one of...

Tamoxifen (TMX) is a selective estrogen receptor modulator that is used as an estrogen receptor antagonist for the treatment and prevention of breast cancer. Whether TMX has antagonist activities in the human brain is less clear and its effects on cognitive function have not been experimentally explored. This study examined how TMX affected cogniti...

Abnormal hippocampal function likely contributes to relational learning deficits observed in schizophrenia. It is unknown whether these deficits can be attenuated with a training intervention. The purpose of this project was to determine if training could facilitate relational learning of the transverse patterning task in schizophrenia. Healthy and...

Background / Purpose: To study reward in humans, we created a virtual reality conditioned place preference task using real-life food rewards. This conditioned place preference paradigm is common in rodent research, whereby a specific environment is paired with a reinforcer such as drugs or food, and a preference emerges for this environment in th...

Learning and memory impairments are present in schizophrenia (SZ) throughout the illness course and predict psychosocial function. Abnormalities in prefrontal and hippocampal function are thought to contribute to SZ deficits. The radial arm maze (RAM) is a test of spatial learning and memory in rodents that relies on intact prefrontal and hippocamp...

Patients with epilepsy are at risk of traffic accidents when they have seizures while driving. However, driving is an essential part of normal daily life in many communities, and depriving patients of driving privileges can have profound consequences for their economic and social well-being. In the current study, we collected ictal performance data...

Driving while under the influence of alcohol is a major public health problem whose neural basis is not well understood. In a recently published functional magnetic resonance imaging (fMRI) study (Meda et al., 2009), our group identified 5, independent critical driving-associated brain circuits whose inter-regional connectivity was disrupted by alc...

Previous studies have reported learning and navigation impairments in schizophrenia patients during virtual reality allocentric learning tasks. The neural bases of these deficits have not been explored using functional MRI despite well-explored anatomic characterization of these paradigms in non-human animals. Our objective was to characterize the...

The objective is to assess performance on virtual reality spatial memory tasks as well as classical neuropsychological tests in patients with fibromyalgia (FM). Fifteen FM patients and fifteen healthy age- and education-matched controls performed the virtual versions of the Morris water maze and the hole board (a virtual version called Boxes room)....

Sex differences are pervasive in schizophrenia, ranging from differences in the age of onset and symptoms of the illness to structural brain differences. Yet, there has been very little research on the interaction of these differences with established cognitive sex differences that exist in healthy populations. We tested 25 patients with schizophre...

Driving while intoxicated remains a major public health hazard. Driving is a complex task involving simultaneous recruitment of multiple cognitive functions. The investigators studied the neural substrates of driving and their response to different blood alcohol concentrations (BACs), using functional magnetic resonance imaging (fMRI) and a virtual...

Prior studies report that accidents involving intoxicated drivers are more likely to occur during performance of secondary tasks. We studied this phenomenon, using a dual-task paradigm, involving performance of a visual oddball (VO) task while driving in an alcohol challenge paradigm. Previous functional MRI (fMRI) studies of the VO task have shown...

Identifying intermediate phenotypes of genetically complex psychiatric illnesses such as schizophrenia is important. First-degree relatives of persons with schizophrenia have increased genetic risk for the disorder and tend to show deficits on working memory (WM) tasks. An open question is the relationship between such behavioral endophenotypes and...

The hippocampus has long been implicated in spatial memory, from work in rodents to imaging and brain lesion studies in humans. However, recent evidence has pointed to the recruitment of areas outside the hippocampus proper on spatial memory tasks, including the parahippocampal gyrus and precuneus, possibly suggesting a more focused role for the hi...

Gonadal steroid effects during puberty are often hypothesized to account for the male advantage seen in certain spatial tasks. One spatial task where males consistently show better performance than females is the Morris Water Task in which subjects must navigate to a goal location in a pool. We examined whether sex differences exist in pre-pubertal...

Performance on a novel, virtual reality (VR) assessment of medication management skills, the Virtual Reality Apartment Medication Management Assessment (VRAMMA), was investigated in 25 patients with schizophrenia and 18 matched healthy controls. The VRAMMA is a virtual 4-room apartment consisting of a living room with an interactive clock and TV, a...

Voluntary and relatively involuntary subsystems of attention often compete. On one hand, people can intentionally "tune" attention for features that then receive visual priority; on the other hand, more reflexive attentional shifts can "short-circuit" top-down control in the face of urgent, behaviourally relevant stimuli. Thus, it is questionable w...

Background: An early observable sign of mild Dementia of the Alzheimer’s Type (mDAT) is difficulty finding and navigating around familiar/unfamiliar environments (wayfinding). Decline in the ability to process visuospatial (VS) information is thought to contribute to wayfinding difficulties, increased disorientation and loss of functional independe...

Previous neuroimaging studies of working memory (WM) in schizophrenia, typically focusing on dorsolateral prefrontal cortex, yield conflicting results, possibly because of varied choice of tasks and analysis techniques. We examined neural function changes at several WM loads to derive a more complete picture of WM dysfunction in schizophrenia. We u...

It is becoming common to collect data from multiple functional magnetic resonance imaging (fMRI) paradigms on a single individual. The data from these experiments are typically analyzed separately and sometimes directly subtracted from one another on a voxel-by-voxel basis. These comparative approaches, although useful, do not directly attempt to e...

Medication compliance is essential to treating the symptoms of schizophrenia effectively. This study utilized a virtual reality (VR) apartment paradigm to assess medication compliance behaviors in 25 patients with schizophrenia and in 16 healthy control subjects. Participants were assigned a prescription consisting of three medications and were ask...

Post-traumatic stress disorder (PTSD) is often accompanied by memory problems and abnormal brain structure, particularly within the hippocampus. We implemented a cross-species, hippocampal-dependent task--the virtual Morris Water task--to assess hippocampal function in people with PTSD and age-matched controls during functional magnetic resonance i...

Virtual reality in the form of simulated driving is a useful tool for studying the brain. Various clinical questions can be addressed, including both the role of alcohol as a modulator of brain function and regional brain activation related to elements of driving. We reviewed a study of the neural correlates of alcohol intoxication through the use...

Exposure to drug cues has been shown to induce cravings and precede relapse in substance abusers. This extends from the specific implements of drug administration to the context and environment in which the drug is used. These learned associations are problematic for the treatment for drug addiction, as it is exceedingly difficult to avoid all plac...

The use of virtual reality in the form of simulated tasks can provide a realistic environment in which to study complex naturalistic behaviors. Many of the behavioral effects of alcohol intoxication are well known, but there is relatively little imaging evidence examining how alcohol exposure might transiently modulate brain function, especially in...

Numerous studies have shown that the hippocampus is critical for spatial memory. Within nonhuman research, a task often used to assess spatial memory is the radial arm maze. Because of the spatial nature of this task, this maze is often used to assess the function of the hippocampus. Our goal was to extrapolate this task to humans and examine wheth...

The present study examined sex differences in object memory by using 2-dimensional object arrays and in spatial memory by using a computerized virtual 12-arm radial maze. Virtual T-maze and water maze tasks were also used to examine sex differences in the use of spatial and nonspatial strategies during navigation. Women significantly outperformed m...

VR technology provides unique assets for assessing, training and rehabilitating spatial abilities. Its capacity for creating, presenting, and manipulating dynamic three-dimensional (3D) objects and environments in a consistent manner enables the precise measurement of human interactive performance with these stimuli. VE spatial ability testing and...

Hypofunction of the N-methyl-D-aspartate receptor (NMDAR) may be involved in the pathophysiology of schizophrenia. NMDAR antagonists like ketamine induce schizophrenia-like features in humans. In rodent studies, NMDAR antagonism impairs learning by disrupting long-term potentiation (LTP) in the hippocampus. This study investigated the effects of ke...

The hippocampus (HPC) has an essential role in relational memory. One task used to test relational memory is the transverse patterning (TP) problem (A+ B-, B+ C-, and C+ A-), which is sensitive to HPC damage across species. Using functional magnetic resonance imaging in humans, the authors observed activation maps and time course data indicating th...

Different tasks are often used to assess spatial memory in humans compared to nonhumans. In order to bridge this paradigmatic gap, we used a within-subject design to test 61 undergraduates on three spatial memory tasks. One of these tasks, the Vanderberg 3D mental rotation task, is classically used to assess spatial memory in humans. The other two...

A chasm divides the huge corpus of maze studies found in the literature, with animals tested in mazes on the one side and humans tested with mazes on the other. Advances in technology and software have made possible the production and use of virtual mazes, which allow humans to navigate computerized environments and thus for humans and nonhuman ani...

To examine how olfactory and visual factors affect object discriminations in rats with and without hippocampus damage, the authors trained Long-Evans rats on simple object discriminations. They then examined how these discriminations were affected by rotations of the objects, by coating the objects in a transparent acrylic coating, or by both rotat...

For nonhumans, it has been shown that the hippocampus (HPC) is critical for spatial memory. We tested patients with unilateral HPC resections on a virtual analogue of a classic spatial task to assess HPC functioning in nonhumans: the Morris water task. We found that when humans are required to use spatial cues to navigate to a hidden escape platfor...

We review evidence from experiments conducted in our laboratory on retrograde amnesia in rats with damage to the hippocampal formation. In a new experiment reported here, we show that N-methyl-D-aspartate (NMDA)-induced hippocampal damage produced retrograde amnesia for both hidden platform and two-choice visible platform discriminations in the Mor...

Using a within-subjects design, rats were trained on two place-memory problems and five object-discrimination problems at different intervals prior to receiving either ibotenate lesions of the hippocampal formation or sham surgery. Places # 1 and 2 were fixed-platform water-maze tasks that were run in different rooms and they were learned during th...

Accurate knowledge of cortical functional organization is important in the surgical treatment of brain disorders, because the relevant pathology is often within, or adjacent to, cortical regions that are critical for essential sensory, motor, or cognitive functioning. Avoidance of sensorimotor cortex is especially important because damage to this a...

Most learning theorists concur that some sort of configural representation system is required for animals to solve certain compound discriminations. Transverse patterning (A+ vs. B-, B+ vs. C-, CS vs. A-) is one example of a problem that requires a configural solution. It has been reported in the past that adult humans are unable to solve this prob...

In many mammalian species, it is known that males and females differ in place learning ability. The performance by men and women is commonly reported to also differ, despite a large amount of variability and ambiguity in measuring spatial abilities. In the non-human literature, the gold standard for measuring place learning ability in mammals is th...

Investigations of working memory tend to focus on the retention of verbal information. The present experiments were designed to characterize the active maintenance rehearsal process used in the retention of visuospatial information. Rhesus monkeys (Macaca mulatta; N = 6) were tested as well as humans (total N = 90) because these nonhuman primates h...

Neurodevelopmental evidence of the cerebellum's protracted course of postnatal development suggests that it is particularly sensitive to early toxic insult from cancer therapy. If this is the case, one would expect that there is a relationship between the pattern of neuropsychological and magnetic resonance imaging deficits and that both may indica...

A serial probe recognition task was used to examine the interhemispheric exchange of visual data in macaques. Each block of trials began with the memorization of one to six visual target images. The monkeys then had to determine, in tests that followed immediately, whether probe images were or were not members of the learned target set. Previous wo...

To assess anomalous cortical organization of somatosensory function in a 23-year-old man who had had a neonatal infarct involving the left middle cerebral artery. The infarct destroyed the primary and secondary somatosensory areas of the subject's left hemisphere but caused only mild perturbation of somatosensation on the right side of his body. Wi...

th century, the traditional tools available to researchers have typically involved studying behavioral changes following a brain injury or lesion, as well as a number of physiology measures such as recording and stimulating brain areas (either inter-operatively or chronically during medical telemetry, often implemented to localize epileptic foci)....

Exposure to drug cues has been shown to induce cravings and precede relapse in substance abusers. This extends from the specific implements of drug administration to the context and environment in which the drug is used. These learned associations are problematic for the treatment for drug addiction, as it is exceedingly difficult to avoid all plac...