Rima Dada

All India Institute of Medical Sciences | AIIMS · LAB FOR MOLECULAR REPRODUCTION &GENETICS, Department of Anatomy

Telomeres are vital for cellular function. Oxidative stress is detrimental to telomere function as it causes telomere attrition. Increase in oxidative stress has a negative impact on sperm telomere and chromatin integrity and therefore, on sperm function and male fertility. TERRA, a long non-coding RNA is a fundamental component required for telome...

Background Mild cognitive impairment (MCI) and Alzheimer's disease (AD) are progressive neurodegenerative disorders, and probiotics may offer therapeutic benefits by modulating gut microbiota and reducing inflammation. Objective This study systematically evaluated the impact of probiotics on cognitive function in MCI and AD through a meta-analysis...

Rheumatoid arthritis (RA) is linked to various signs of advanced aging, such as premature immunosenescence which occurs due to decline in regenerative ability of T cells. RA T cells develop a unique aggressive inflammatory senescent phenotype with an imbalance of Th17/T regulatory (Treg) cell homeostasis and presence of CD28− T cells. The phenotypi...

Citation: Borthakur D, Dada R, Kumar R, Jacob TG. Scrotoliths in the testicular tunica vaginalis in an elderly male cadaver: clinical implications. Folia Med (Plovdiv) 2024;66(4):574-577. Abstract Scrotoliths, or "scrotal pearls, " are calcified fibrous loose bodies found within the tunica vaginalis, often seen during radiological evaluation or aut...

Yoga is a popular Indian origin mind-body medicine for physical development, mental growth, and spiritual elevation. It enhances physical efficacy, emotional resilience, awareness and helps us to understand at deeper realms the purpose of life and aims to achieve the union of individual and universal consciousness. Various therapeutic advantages of...

Achieving successful pregnancy outcomes is a delicate interplay between the maternal and the fetal counterparts. Paternal factors play a critical role in health and disease of offspring. Early pregnancy loss (EPL) is a psychologically devastating condition affecting the quality of life (QOL). Thus, it needs to be managed by a mind body integrated a...

The gut microbiome (GM) has been identified as a crucial factor in the development and progression of various diseases, including cancer. In the case of prostate cancer, commensal bacteria and other microbes are found to be associated with its development. Recent studies have demonstrated that the human GM, including Bacteroides , Streptococcus , B...

Infertility, a widespread medical condition affecting numerous couples globally, persists as a challenge despite advances in assisted reproductive technologies (ARTs), often burdened by financial, physical, and emotional strains. Complementary and alternative approaches, notably yoga, have garnered attention for potentially enhancing fertility outc...

Oxidative stress has gained more attention as a significant factor in the development of idiopathic male infertility. Infertile men have higher than normal levels of reactive oxygen species in their seminal plasma, and lower levels of antioxidants, which work to neutralize them. Sperm DNA damage is often caused by oxidative stress and is considered...

Nutcracker phenomenon (NCP) typically refers to the entrapment of the left renal vein (LRV) between the aorta and the superior mesenteric artery. Similar to the classic NCP, the renal vein can also get entrapped between the segmental branches of the renal artery at the renal hilum, which has been referred to as ‘renal hilar nutcracker phenomenon (R...

The optic nerve comprises approximately 1.2 million axons of retinal ganglion cells and is vulnerable to degeneration due to a myriad of causes. While traditional treatments have been the cornerstone of ocular care, emerging evidence highlights the benefits of integrative approaches, which can be used as an adjunct in the management of optic neurop...

Complex and chronic lifestyle disorders have become the leading cause of death and disability worldwide. They involve multiple morbidities necessitating the attention of numerous healthcare facilities as well as community-based care too. Stress and anxiety brought on by the fast-paced life, unhealthy eating habits, sedentary lifestyle, poor quality...

Polycystic Ovary Syndrome (PCOS) is a multifactorial condition that affects a significant number of women, involving a complex interplay of reproductive, metabolic, and psychological factors that have extensive impacts on a woman's life. The causes of PCOS are intricate, resulting from a combination of genetic and epigenetic factors, disruptions in...

Minimally invasive surgery has become one of the most accepted surgical options across the globe. In most laparoscopic surgeries, medial umbilical fold (MUF) containing the umbilical artery (UA) serves as an important landmark for creation of peritoneal flap. 50% of gynaecological laparoscopic injuries occur at the time of entry into the anterior a...

Effect of medical yoga therapy on pain physiology and musculoskeletal physiology of fibromyalgia patients.

The pathogenesis of rheumatoid arthritis (RA) is characterized by a Th17/Treg cell imbalance. A pro-inflammatory cytokine milieu that promotes the continued proliferation of Th17 cells is related to the development of autoinflammation. In RA, T cells have several hallmarks of cellular aging, and they accumulate DNA damage, predisposing to the occur...

Background: Schwannoma and neurofibroma constitute the benign peripheral nerve sheath tumours (BPNSTs) which may present as single or multiple lesions. Multiple schwannomas are rare in the peripheral nerves of the upper extremity. Solitary small schwannoma is usually asymptomatic, while larger and multiple ones may have variable symptoms due to pre...

Introduction: anatomical variation of inferior gluteal nerve (IGN) has not received much attention from clinicians. Mechanical injuries of IGN such as entrapment, compression by adjacent structures in the gluteal region are not infrequent. The present case reports unusual bilateral IGN anatomical variation formed by variable contributions of dorsal...

Background: Men with idiopathic obstructive azoospermia (OA) are candidates for surgical reconstruction with a vasoepididymal anastomosis (VEA) performed on one or both testis. There are no randomised trials comparing the success of unilateral versus bilateral VEA. Objective: We conducted a randomised trial to compare the two surgical options....

Quick Response Code: Glaucoma is a series of linked optic diseases resulting in progressive vision loss and total blindness due to the acquired loss of retinal ganglion cells. This harm to the optic nerve results in visual impairment and, ultimately, total blindness if left untreated. Primary open-angle glaucoma (POAG) is the most frequent variety...

Objective: The introduction of competency-based medical education curriculum and a shifted focus towards self-directed learning (SDL) in medical schools across the world has necessitated a reduction of didactic teaching hours. Museum specimens are an indispensable tool in anatomy teaching and can play a pivotal role in fostering and reinforcing SD...

In humans, the gut microbiota (GM) are known to play a significant role in the metabolism of nutrients and drugs, immunomodulation, and pathogen defense by inhabiting the gastrointestinal tract (GIT). The role of the GM in the gut–brain axis (GBA) has been documented for different regulatory mechanisms and associated pathways and it shows different...

Introduction: MTHFR being a key regulatory enzyme of 1-carbon metabolism pathway serves critical function of generation of SAM, replenishment of glutathione and nucleotide synthesis and finally methylation of the bio molecules. MTHFR gene mutation is a rare au-tosomal recessive inborn error of metabolism and presents with severe hyperhomocysteinem...

Myocardial Bridge (MB) on the coronary artery and myocardial coat (MC) on the cardiac veins are usually detected in angiography and cadaveric dissection. Left anterior descending branch (LAD) of the left coronary artery is the most frequent site of MB. Rarely MB is also seen over the right coronary arterial branches. MB has proven association with...

Yoga and meditation address mind and body, affecting many molecular processes like metabolism, epigenetic, oxidative processes, and subjective well-being. In this review, we have compiled the results of various clinical trials that have looked into the effect of yoga-based intervention programs on gene expression changes in peripheral blood mononuc...

Polycystic Ovary Syndrome (PCOS) is a multifactorial condition that affects a significant number of women, involving a complex interplay of reproductive, metabolic, and psychological factors that have extensive impacts on a woman's life. The causes of PCOS are intricate, resulting from a combination of genetic and epigenetic factors, disruptions in...

Abstract Central insulin resistance, the diminished cellular sensitivity to insulin in the brain, has been implicated in diabetes mellitus, Alzheimer's disease and other neurolagical disorders. However, whether and how central insulin resistance plays a role in the eye remains unclear. Here, we performed intracerebroventricular injection of S961, a...

Differentiating obstructive (OA) from non‐obstructive (NOA) azoospermia is clinically important in managing infertile men. Classically, the differentiation has been based on clinical, hormonal and histological analysis. Histological tests are invasive and may miss spermatogenic areas. Seminal fluid can serve as a medium to assess the status of sper...

Current evidence suggests obesity alters the expression of various genes related to oxidative stress, inflammation, and aging. The complementary therapy like yoga-based lifestyle intervention (YBLI) is used as an adjunct therapy to modern medicine. This study examines the efficacy of 12-weeks of YBLI with standard care (SC) on the expression of gen...

Background: Retinoblastoma (RB) is initiated by mutation in both alleles of RB1 gene. However, few cases may occur even in the absence of RB1 mutation suggesting the role of genes other than RB1. Methodology: The current study was planned to utilize targeted exome sequencing in Indian RB patients affected with unilateral non-familial RB. 75 unil...

Background & objectives: Human leucocyte antigen (HLA)-G plays a vital role in immunomodulation in rheumatoid arthritis (RA). The mounting evidence suggests a link between HLA-G gene polymorphisms, disease susceptibility and methotrexate treatment response. Various environmental factors influence the onset and progression of RA and its treatment ou...

Introduction: Premature ovarian insufficiency (POI) being a heterogeneous genetic disease involves the interaction of multiple genes and environmental factors and has been associated with several chromosomal abnormalities, single gene mutations, and genetic polymorphisms. BMP-15 (bone morphogenic protien-15) is a member of the transforming growth f...

Study question Can a yoga intervention bring about alterations in immune aging, fertility potential and quality of life in men with Rheumatoid arthritis? Summary answer Yoga not only reduces disease severity, minimizes usage of drugs but also reduces the rate of immune aging and cellular aging. What is known already The complex mechanism of Rheum...

AIM: Aim of the study is to investigate the effect of 4-week medical yoga therapy on pain sensitivity, flexibility and range of motion in fibromyalgia patients.

Pain is an unpleasant and upsetting experience. Persistent pain has an impact on an individual’s quality of life which causes stress and mood disorders. There are currently no pain-relieving techniques available that can eliminate pain and offer relief without causing any adverse effects. These factors draw attention to traditional treatments like...

Background & objectives: Primary or idiopathic osteonecrosis of femur head (ONFH) is the second most commonly observed cause among Indian patients suffering from ischemic ONFH. Although a number of genetic polymorphisms have been associated with idiopathic ONFH pathogenesis in Korean and Chinese populations, there are no studies in the Indian popu...

American Center for Reproductive Medicine Reasearch Collaborators-2018

Background: Telomeres and telomerase are considered cardinal biomarkers of cellular aging. Shorter telomeres and low telomerase activity have been associated with obesity and accelerated aging. Objective: To compare the effects of a yoga-based lifestyle intervention (YBLI) with the standard of care (SOC) on cellular aging by estimating telomere le...

Aim To evaluate mitochondrial genome alterations, cytochrome c oxidase (COX) activity, and oxidative stress in primary open-angle glaucoma (POAG). Methodology Whole mitochondrial genome was screened in 75 POAG cases and 105 controls by polymerase chain reaction (PCR) sequencing. COX activity was measured from peripheral blood mononuclear cells (PB...

Genetics

Major depressive disorder (MDD) is a mind-body disorder. Cellular aging has been implicated in the pathogenesis of MDD with the altered mind-body communication markers like stress response, immune response, nutrition sensing, and a range of other regulatory feedback systems. In this age of super specializations, one specific target and intervention...

A broad range of degenerative disorders present with an underlying mitochondrial dysfunction. Various environmental triggers such as air pollutants, smoking, and poor lifestyle induce oxidative stress, which may compromise mitochondrial integrity. An adoption of yoga-based lifestyle may hold the key to increase mitochondrial copy number, optimize o...

Selecting good-quality sperm for use in in-vitro fertilization is a key step in assisted reproduction. For many years purely morphological attributes have been used to assess suitability, but increasingly biochemical and molecular biological techniques are now identifying sperm with the best chances of producing viable and healthy embryos. Focusing...

Background Oxidative stress (OS) and mitochondrial alterations have been implicated in the pathogenesis of rheumatoid arthritis (RA). Various environmental triggers like air pollutants, smoking, unhealthy social habits and sedentary lifestyle induce OS, which may compromise mitochondrial integrity. This trial was designed to explore the effect of 8...

Sperm, one of the complex cells of biological inheritance, are not only considered as mere vectors of transmission of paternal genome at the time of fertilization but also to events post-fertilization. The contribution of sperm molecular factors as a critical determinant of optimal embryonic development and pregnancy outcomes has been brought to su...

Rheumatoid arthritis (RA) is one of the most common chronic inflammatory autoimmune diseases, which adversely affects the quality of life. RA is a disease of unknown etiology, however, both genetic and environmental factors appear to contribute to the susceptibility to this disease. The severity and progression of the disease are attributable to th...

Males contribute to about half of the infertility cases. Research on male infertility has come a long way. Y-deletion analysis is close to becoming a routine investigation in the assisted reproduction laboratories. However, still more than 80% of infertility cases remain idiopathic, and normozoospermic infertile individuals are of particular intere...

Males contribute to about half of the infertility cases. Research on male infertility has come a long way. Y-deletion analysis is close to becoming a routine investigation in the assisted reproduction laboratories. However, still more than 80% of infertility cases remain idiopathic, and normozoospermic infertile individuals are of particular intere...

The coronavirus disease (COVID-19) pandemic has undoubtedly created an unbearable psychological pressure on our minds ranging from anxiety, fear, worry, changing sleep patterns, changing eating patterns, worsening of existing chronic or mental health conditions. There is an urgent need for the adoption of an effective coping strategy. We propose th...

Background: . Although the outcomes of assisted reproductive technologies (ART) and corrective surgery for male infertility are reported in the literature, these are based on studies specifically designed to assess the outcomes of individual interventions and do not reflect the real-life (intent-to-treat) outcomes of managing infertility. There ar...

Purpose To evaluate the effect of mindfulness meditation (MM) on intraocular pressure (IOP) and trabecular meshwork (TM) gene expression in patients with medically uncontrolled primary open angle glaucoma (POAG). Design Parallel arm, single masked, randomized controlled trial. Methods Sixty patients of POAG with IOP ≥ 21 mmHg on maximal topical m...

The pandemic outbreak of coronavirus disease (COVID-19) has emerged as the most threatening public health challenge. The clinical presentation range from asymptomatic and mild clinical symptoms to acute respiratory-distress syndrome (ARDS) and death. Apart from the respiratory system, other organ systems like cardiovascular, renal, and gastrointest...

Various external stressors and environmental challenges lead to the provocation of the immune system in autoimmune diseases like Rheumatoid arthritis (RA). The inappropriate immune response further triggers the cascade of inflammatory changes resulting in precipitation of symptoms and hampers quality of life (QOL). The underlying psycho-somatic com...

Complex chronic lifestyle disorders are the leading causes of death and disability worldwide. Stress and anxiety associated with today’s hectic life schedule and polluted environment have contributed a lot in triggering and causing many chronic diseases and decreased quality of life, even with pharmacologic treatment. Most of the chronic complex di...

A majority of the cases of primary male infertility are idiopathic with the underlying molecular mechanisms contributing to the pathophysiology as yet unknown. Effects of the environment can alter the sperm epigenome thereby impacting male reproductive health. Epigenetic mechanisms are crucial to understanding health and disease, and methylome alte...

Male reproductive fitness has faced significant challenges in the current scenario. Derangement in the fertility spectrum has been associated with a host of modifiable and non-modifiable lifestyle factors and affected by equally contributing holistic, complementary and alternative therapies for their management. Infertility has stepped up the ladde...