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The anterior cruciate ligament (ACL) has been considered to not heal spontaneously after complete injury due to its unique intra-articular environment. However, several clinical and animal studies have reported that ruptured ACL could heal spontaneously by controlling abnormal joint movement. On the other hand, heled ACL has lower collagen maturity...
Objective
The ACL-deficient model helps to clarify the mechanism of knee OA; however, the conventional ACL injury model could have included concurrent onset factors such as direct compression stress to cartilage and subchondral bone. In this study, we established a novel Non-invasive ACL-Ruptured mouse model without concurrent injuries and elucidat...
