Rik Oldenkamp

Rik Oldenkamp
Vrije Universiteit Amsterdam | VU · Amsterdam Institute for Life and Environment ALIFE

PhD

About

40
Publications
10,019
Reads
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667
Citations
Additional affiliations
January 2019 - August 2019
Amsterdam Institute for Global Health and Development
Position
  • PostDoc Position
Description
  • Domain Expert AMR
January 2018 - August 2018
The University of York
Position
  • PostDoc Position
January 2016 - December 2018
Radboud University
Position
  • PostDoc Position

Publications

Publications (40)
Article
Species in the aquatic environment differ in their toxicological sensitivity to the various chemicals they encounter. In aquatic risk assessment, this interspecies variation is often quantified via species sensitivity distributions. Because the information available for the characterization of these distributions is typically limited, optimal use o...
Article
Full-text available
Environmental risk assessment of pharmaceuticals requires the determination of their environmental exposure concentrations. Existing exposure modelling approaches are often computationally demanding, require extensive data collection and processing efforts, have a limited spatial resolution, and have undergone limited evaluation against monitoring...
Article
Full-text available
Surveillance is critical in containing globally increasing antimicrobial resistance (AMR). Affordable methodologies to prioritize AMR surveillance efforts are urgently needed, especially in low- and middle-income countries (LMICs), where resources are limited. While socioeconomic characteristics correlate with clinical AMR prevalence, this correlat...
Article
Full-text available
Despite the worldwide presence of pharmaceuticals in the aquatic environment, a comprehensive picture of their aquatic risk (AR) at the global scale has not yet been produced. Here, we present a procedure to estimate ARs of human pharmaceuticals at a freshwater ecoregion level. First, we predicted country- and year-specific per capita consumption w...
Article
Full-text available
Chemical pollution of surface waters is considered an important driver for recent declines in biodiversity. Species sensitivity distributions (SSDs) are commonly used to evaluate ecological risks of chemical exposure, accounting for variation in interspecies sensitivity. SSDs, however, do not reflect effects of chemical exposure on species abundanc...
Article
Full-text available
Environmental exposure to active pharmaceutical ingredients (APIs) can have negative effects on the health of ecosystems and humans. While numerous studies have monitored APIs in rivers, these employ different analytical methods, measure different APIs, and have ignored many of the countries of the world. This makes it difficult to quantify the sca...
Article
Full-text available
Environmental exposure to active pharmaceutical ingredients (APIs) can have negative effects on the health of ecosystems and humans. While numerous studies have monitored APIs in rivers, these employ different analytical methods, measure different APIs, and have ignored many of the countries of the world. This makes it difficult to quantify the sca...
Preprint
Full-text available
Escherichia coli is an opportunistic pathogen that can colonize or infect various host species. There is a significant gap in our understanding to what extent genetic lineages of E. coli are adapted or restricted to specific hosts. In addition, genomic determinants underlying such host specificity are unknown.By analyzing a randomly sampled collect...
Article
Active pharmaceutical ingredients (APIs) can reach surface waters used for drinking water extraction and recreational activities, such as swimming and fishing. The aim of the present study was to systematically assess the lifetime human health risks posed by 15 individual APIs and their mixtures occurring in the German‐Dutch transboundary Vecht Riv...
Article
Full-text available
Millions of people rely on active pharmaceutical ingredients (APIs) to prevent and cure a wide variety of illnesses in humans and animals, which has led to a steadily increasing consumption of APIs across the globe and concurrent releases of APIs into the environment. APIs in the environment can have a detrimental impact on wildlife, particularly a...
Article
When assessing the environmental exposure of active pharmaceutical ingredients (APIs), the mass contributed from over the counter (OTC) sales are often not included due to difficulty obtaining this data and topical formats are overlooked completely. This study presents a comprehensive approach, investigating the significance of OTC and topical appl...
Article
Full-text available
Xenobiotics from anthropogenic and natural origin enter animal feed and human food as regulated compounds, environmental contaminants or as part of components of the diet. After dietary exposure, a chemical is absorbed and distributed systematically to a range of organs and tissues, metabolised, and excreted. Physiologically based kinetic (PBK) mod...
Article
Full-text available
A reliable quantification of the potential effects of chemicals on freshwater ecosystems requires ecotoxicological response data for a large set of species which is typically not available in practice. In this study, we propose a method to estimate hazardous concentrations (HCs) of chemicals on freshwater ecosystems by combining two in silico appro...
Article
Full-text available
The development of three generic multi-compartment physiologically based kinetic (PBK) models is described for farm animal species, i.e. cattle, sheep, and swine. The PBK models allow one to quantitatively link external dose and internal dose for risk assessment of chemicals relevant to food and feed safety. Model performance is illustrated by pred...
Article
Full-text available
Physiologically based kinetic (PBK) models for farm animals are of growing interest in food and feed safety with key applications for regulated compounds including quantification of tissue concentrations, kinetic parameters and the setting of safe exposure levels on an internal dose basis. The development and application of these models requires da...
Article
Full-text available
Ecological risk assessments are hampered by limited availability of ecotoxicity data. The present study aimed to explore the possibility of deriving SSD (species sensitivity distribution) parameters for non‐tested compounds, based on simple physicochemical characteristics, known SSDs for data‐rich compounds and a QSAR‐type approach. The median toxi...
Article
Over the past decade, the health care sector has become increasingly aware of the impact of pharmaceutical emissions to the environment. Yet, it remains unclear which compounds are the most relevant to address and at what point emission control is most effective. This study presents a modelling framework to prioritize pharmaceuticals based on their...
Article
Full-text available
An environmental risk assessment (ERA) is presented for Mycophenolic acid (MPA), an immunosuppressive pharmaceutical used for prevention of organ rejection, and its prodrug Mycophenolate mofetil (MPM). MPA will not significantly adsorb to activated sludge. 14C‐MPA attained >80% degradation in activated sludge, supporting an older environmental fate...
Article
Full-text available
Nowadays, many pharmaceuticals are detected in surface waters around the world. Because of the extent of theissue, monitoring alone cannot provide a complete overview of the situation. To guide smart monitoring effortsand optimal mitigation measures, spatially explicit models can be used. We show that geographical variabilityleads to substantial di...
Article
Full-text available
Physiologically based kinetic (PBK) models in the 10 most common species of farm animals were identified through an extensive literature search. This resulted in 39 PBK models, mostly for pharmaceuticals. The models were critically assessed using the WHO criteria for model evaluation, i.e. 1) purpose, 2) structure and mathematical representation, 3...
Article
Full-text available
The use of down-the-drain products and the resultant release of chemicals may lead to pressures on the freshwater environment. Ecotoxicological impact assessment is a commonly used approach to assess chemical products but is still influenced by several uncertainty and variability sources. As a result, the robustness and reliability of such assessme...
Article
The successful treatment of infectious diseases heavily relies on the therapeutic usage of antibiotics. However, the high use of antibiotics in humans and animals leads to increasing pressure on bacterial populations in favour of resistant phenotypes. Antibiotics reach the environment from a variety of emission sources and are being detected at rel...
Article
Full-text available
Low amounts of human pharmaceuticals in the aquatic environment can affect bacteria, animals and ultimately humans. Here, the environmental consequences of a shift in prescription behavior from prednisolone to berberine was modeled using an environmental decision support system based on four consecutive steps: emission, fate, exposure and effect. T...
Article
Full-text available
Deriving reliable estimates of chemical emissions to the environment is a key challenge for impact and risk assessment methods and typically the associated uncertainty is not characterised. We have developed an approach to spatially quantify annual chemical emission loads to the aquatic environment together with their associated uncertainty using c...
Chapter
Full-text available
This chapter outlines models to quantify fate, exposure, and effects of chemicals on humans and the environment. These models can be applied in risk assessment of chemicals and life cycle assessment of products. These models are able to handle multiple chemicals based on specific properties of chemicals and species. In other words, models will be a...
Article
Human exposure limits (HELs) for chemicals with a toxicological threshold are traditionally derived using default assessment factors that account for variations in exposure duration, species sensitivity and individual sensitivity. The present paper elaborates a probabilistic approach for human hazard characterization and the derivation of HELs. It...
Article
This study used a geographic based water quality model to predict the environmental concentrations of three pharmaceuticals 17-ethinylestradiol (EE2), 17-estradiol (E2) and diclofenac throughout the rivers of Europe. The work was prompted by the proposal of the European Community (COM(2011)876) to consider these chemicals as candidates for future...
Article
The present study evaluated the potential environmental concentrations of 4 cytostatic (also known as cytotoxic) drugs in rivers. The antimetabolite 5-fluorouracil (5FU) and its pro-drug capecitabine were examined based on their very high use rates, cyclophosphamide (CP) for its persistence, and carboplatin for its association with the metal elemen...
Article
This paper presents a screening tool for the location-specific prioritization of human pharmaceutical emissions in Europe, based on risk quotients for the aquatic environment and human health. The tool provides direction towards either monitoring activities or additional research. Its application is illustrated for a set of 11 human antibiotics and...
Article
Parameter uncertainty and interindividual variability in the predictions of a generic human physiologically based pharmacokinetic (PBPK) model were separated by means of nested Monte Carlo simulations. Separate information on uncertainty and variability can help decision makers to identify whether they should focus on identification of sensitive in...
Article
We performed a cumulative risk assessment for people living in a hypothetical urban environment, called Urbania. The main aims of the study were to demonstrate how a cumulative risk assessment for a middle-sized European city can be performed and to identify the bottlenecks in terms of data availability and knowledge gaps. The assessment focused on...

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Projects

Projects (4)
Project
The overall aim of the IPiE project is to develop predictive frameworks that utilise information from existing datasets on environmental fate and effects of APIs, toxicological studies, pharmacological mode of action and in silico models to support more intelligent environmental testing of pharmaceuticals in development and to prioritise legacy pharmaceuticals for full environmental risk assessment and/or environmental (bio) monitoring.