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Richard Y Zhang

Richard Y Zhang
Pfizer · Pfizer Pharmaceuticals Group

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5
Publications
189
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118
Citations

Publications

Publications (5)
Article
Background: The increasing prevalence of Alzheimer disease (AD) and lack of effective agents to attenuate progression have accelerated research and development of disease modifying (DM) therapies. The traditional parallel group design and single time point analysis used in the support of past AD drug approvals address symptomatic benefit over rela...
Article
Background: Defining treatment success in progressive diseases, such as Alzheimer’s disease (AD), can be challenging. Objective: To explore the impact of employing different criteria to define a treatment ‘responder’ using analyses of patient-level data from randomized, placebo-controlled studies of donepezil in AD. Methods: Trials were included...
Article
Defining treatment success in progressive diseases, such as Alzheimer's disease (AD), can be challenging. To explore the impact of employing different criteria to define a treatment 'responder' using analyses of patient-level data from randomized, placebo-controlled studies of donepezil in AD. Trials were included in the analysis if they met severa...
Article
A deformation twinning model which simulates the characteristic twin shear and corresponding grain reorientation has been developed using the finite element method. This model has been used to study how twinning affects the stress state in both the parent grain and twin. The results show that the local shear stress is the driving force for the twin...

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