Richard Thomas

Richard Thomas
Lahey Hospital and Medical Center

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38
Publications
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Publications

Publications (38)
Article
Li-Fraumeni syndrome (LFS) is a rare autosomal dominant familial cancer syndrome caused by germline mutations of the tumor protein p53 gene (TP53), which encodes the p53 transcription factor, also known as the "guardian of the genome." The most common types of cancer found in families with LFS include sarcomas, leukemia, breast malignancies, brain...
Article
Objective: The aim of the study is to analyze the imaging findings and injury patterns seen on head computed tomography (CT) examinations performed on survivors of intimate partner violence (IPV). Methods: An institutional review board-approved retrospective analysis of 668 patients reporting IPV to our institution's violence intervention and pr...
Article
PurposeTo recognize the imaging patterns of thoracic injuries in survivors of intimate partner violence (IPV).Materials and methodsA retrospective radiological review of 688 patients self-reporting IPV to our institution’s violence intervention and prevention program between January 2013 and June 2018 identified 30 patients with 89 thoracic injurie...
Article
Full-text available
The past decade has witnessed a change in landscape of cancer management with the advent of precision oncology. Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment and have played an important role in improving patient survival. While the patients are living longer, treatment with ICIs are sometimes associated with adverse effe...
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Full-text available
Cancer therapy has evolved from being broadly directed towards tumor types, to highly specific treatment protocols that target individual molecular subtypes of tumors. With the ever-increasing data on imaging characteristics of tumor subtypes and advancements in imaging techniques, it is now often possible for radiologists to differentiate tumor su...
Article
Purpose: To evaluate the imaging findings of facial injuries in patients reporting intimate partner violence (IPV). Methods: A retrospective review of radiology studies performed for 668 patients reporting IPV to our institution's violence prevention support program identified 96 patients with 152 facial injuries. Demographics, imaging findings,...
Article
Full-text available
Novel anticancer agents have replaced conventional chemotherapy as first line agents for many cancers, with continued new and expanding indications. Small molecule inhibitors act on cell surface or intracellular targets and prevent the downstream signaling that would otherwise permit tumor growth and spread. Anticancer antibodies can be directed ag...
Article
Objectives To describe the imaging findings of intimate partner violence (IPV)–related injury and to evaluate the role of longitudinal imaging review in detecting IPV.Methods Radiology studies were reviewed in chronological order and IPV-related injuries were recorded among 400 victims of any type of abuse (group 1) and 288 of physical abuse (group...
Article
Full-text available
The original version of the article unfortunately contained an error in the Table 2. In the column ‘Motilityimmune-related adverse event’ of Table 2, the term ‘Intestinal pseudo-obstruction’ was inadvertently removed in the final version. Corrected Table 2 is given below.
Article
Full-text available
Background Immune checkpoint inhibitors (ICI) have improved outcomes in patients with various malignancies; however, they can cause immune-related hepatitis and enterocolitis. Patients on ICI may also develop upper gastrointestinal symptoms and undergo measurement of gastric emptying.AimsOur aim was to review records of patients with gastroparesis...
Article
PurposeTo describe the pattern and distribution of lower extremity injuries in victims of intimate partner violence (IPV).Materials and methodsA retrospective radiological review of 688 patients reporting IPV to our institution’s violence intervention and prevention program between January 2013 and June 2018 identified 88 patients with 154 lower ex...
Article
Objectives To recognize most common patterns of upper extremity (UE) injuries in victims of Intimate Partner Violence (IPV).Methods Radiological review of 308 patients who reported physical IPV at our institution from January 2013 to June 2018, identified 55 patients with 88 unique UE injuries. Demographic data and injury patterns and associations...
Article
Intimate partner violence (IPV) is an urgent, prevalent, and under-detected public health issue. We present machine learning models to assess patients for IPV and injury. We train the predictive algorithms on radiology reports with 1) IPV labels based on entry to a violence prevention program and 2) injury labels provided by emergency radiology fel...
Article
Purpose: To describe the incidence and patterns of the spinal injuries in the victims of physical IPV. Materials and methods: With institutional review board (IRB) approval, we retrospectively reviewed patients referred to our institution's domestic violence intervention and prevention program with a diagnosis directly related to physical abuse...
Preprint
Full-text available
Intimate partner violence (IPV) is an urgent, prevalent, and under-detected public health issue. We present machine learning models to assess patients for IPV and injury. We train the predictive algorithms on radiology reports with 1) IPV labels based on entry to a violence prevention program and 2) injury labels provided by emergency radiology fel...
Article
OBJECTIVE. The purpose of this article is to review the spectrum of imaging manifestations of epithelioid hemangioendothelioma across different organ systems and briefly describe its current treatment strategies. CONCLUSION. Epithelioid hemangioendothelioma is a rare, locally invasive neoplasm with metastatic potential. Although most commonly occur...
Article
Background Intimate partner violence (IPV) is a global social and public health problem but published literature regarding the exacerbation of physical IPV during the COVID-19 pandemic is lacking. Purpose To assess the incidence, patterns, and severity of injuries in victims of intimate partner violence (IPV) during the COVID-19 pandemic in 2020, c...
Article
OBJECTIVE. The purpose of this review is to elucidate the mechanisms, types, and clinical significance of molecular targeted therapy (MTT) and immune checkpoint inhibitors (ICIs) and their related toxicity, emphasizing the radiologic manifestations. CONCLUSION. The related toxicities of MTT and ICIs can have acute, recurrent, chronic, and delayed p...
Article
The past decade has witnessed a paradigm shift in cancer therapy owing to the introduction of immune checkpoint inhibitors (ICIs) and it is now commonplace for radiologists to image patients on therapy with these agents. The purpose of this review is to detail the mechanism, radiological manifestations and clinical significance of ICI related toxic...
Article
Objective Investigate the spectrum of radiographic patterns of radiation pneumonitis (RP) in lung cancer patients and identify imaging markers for high-grade RP and RP-related death. Methods Eighty-two patients with lung cancer treated with conventional chest radiotherapy who had symptomatic RP were identified from the radiation oncology database....
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Full-text available
Background Although pleural effusions are common among patients with acute heart failure, the relevance of pleural effusion size assessed on thoracic ultrasound has not been investigated systematically. Methods In this prospective observational study, we included patients hospitalised for acute heart failure and performed a thoracic ultrasound ear...
Article
Computed tomography of the chest may be occasionally performed with the arm in mid extended position, in patients unable to fully raise their arms overhead. In such patients, a combination of beam hardening, incomplete projection and subtle motion artifacts may result in an appearance of diffuse cortical thickening and irregularity of the humerus....
Article
OBJECTIVE. This review describes the influence of histology and metastatic sites on prognosis in male patients with metastatic germ cell tumors (GCTs) and explains the role imaging in assessing therapeutic response, residual disease, recurrence, sand treatment-related toxicities. CONCLUSION. Seminomatous and nonseminomatous GCTs differ in imaging a...
Article
OBJECTIVE. We describe the range of organ systems involved and the spectrum of imaging findings seen in Waldenström macroglobulinemia (WM). CONCLUSION. Although imaging is not mandatory in the initial workup of a patient with WM, a multimodality imaging approach can lead toward the diagnosis of a lymphoproliferative disorder, establish the tumor bu...
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Full-text available
Advances in the management of genitourinary neoplasms have resulted in a trend towards providing patients with personalized care. Texture analysis of medical images, is one of the tools that is being explored to provide information such as detection and characterization of tumors, determining their aggressiveness including grade and metastatic pote...
Article
OBJECTIVE. The purpose of this study is to assess the most common causes of the reverse halo sign (RHS) in immunocompromised patients and to identify clinicoradiologic features that help in achieving a specific diagnosis. MATERIALS AND METHODS. This retrospective study included 70 patients with hematologic malignancy, neutropenia, or history of sol...
Article
Objective: The purpose of this study is to assess the frequency of atypical response patterns in oncology patients treated with the programmed cell death protein-1 inhibitor nivolumab. Materials and methods: This retrospective study included 254 patients treated with nivolumab alone or in combination, from January 2013 through August 2017. A bli...
Article
Congenital anomalies of the aortic arch include diverse subgroups of malformations that may be clinically silent or may present with severe respiratory or esophageal symptoms especially when associated with complete vascular rings. These anomalies may be isolated or may be associated with other congenital heart diseases. Volume rendered computed to...
Article
We describe an infundibulum of a common origin of the fourth lumbar arteries and the median sacral artery. To the best of our knowledge there has been no such published case thus far and its natural course is unknown, in view of its novelty. Infundibular dilatations in intracranial arteries have been described to progress in size and potentially ru...
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Full-text available
The authors attempted to use metal artifact reduction software in 2 computed tomographic angiogram studies to decrease beam hardening. Although the beam hardening artifacts were reduced in the postprocessed images, there was an artifactual appearance of thrombosis in the adjacent arteries in the first case and in the inflow cannula of a left ventri...
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Full-text available
While gastrointestinal stromal tumors frequently metastasize, the scrotum is an extremely rare site of involvement. This case is of a 48-year-old male who, having undergone debulking surgery for metastatic gastrointestinal stromal tumor (GIST) of the small intestine 2 years ago, presented with bilateral scrotal swelling. Ultrasound showed hypoechoi...

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