Richard S Rivlin

Richard S Rivlin
Cornell University | CU · Weill Cornell Medical College (New York City)

About

24
Publications
1,724
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517
Citations
Citations since 2016
0 Research Items
143 Citations
20162017201820192020202120220510152025
20162017201820192020202120220510152025
20162017201820192020202120220510152025
20162017201820192020202120220510152025

Publications

Publications (24)
Chapter
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IntroductionSummaryAcknowledgmentsReferences
Article
Healthy older individuals can take several measures to preserve and improve their health. Even if past nutritional and lifestyle practices were not optimal, much can be done to reduce the risk of chronic disease and disability in future years. The first challenge is to recognize and address the profound changes in body composition that occur with a...
Article
Garlic has been used medicinally since antiquity. In virtually every early civilization known, such as ancient India, Egypt, Rome, China, and Japan, garlic was part of the therapeutic regimen for a variety of maladies. Therefore, the ancient medicinal tradition of garlic use would qualify it as a folk medicine or as an alternative or complementary...
Article
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As early as 1550 B.C., Egyptians realized the benefits of garlic as a remedy for a variety of diseases. Many epidemiological studies support the protective role of garlic and related allium foods against the development of certain human cancers. Natural garlic and garlic cultivated with selenium fertilization have been shown in laboratory animals t...
Article
The goal of this review is to evaluate the current status of knowledge concerning cardiovascular effects of allium derivatives from garlic and to identify potential areas of future research. To date, the cardiovascular actions most studied include lipoprotein metabolism, hypertension, thrombosis, and antioxidant capacity. There are also some prelim...
Article
Full-text available
Epidemiological studies link increased garlic (Allium sativum) con- sumption with a reduced incidence of colon cancer in various human populations. Experimental carcinogenesis studies in animal models and in cell culture systems indicate that several allium-derived compounds ex- hibit inhibitory effects and that the underlying mechanisms may involv...
Conference Paper
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Epidemiologic and laboratory investigations document the relation between garlic consumption and decreased risk of developing cancer at various organ sites but the precise mechanisms are not known. This study examined the antiproliferative and cell cycle effects of two water-soluble constituents of garlic, SAMC and S-allylcysteine (SAC), on the hum...
Article
Full-text available
Epidemiological studies link increased garlic (Allium sativum) consumption with a reduced incidence of colon cancer in various human populations. Experimental carcinogenesis studies in animal models and in cell culture systems indicate that several allium-derived compounds exhibit inhibitory effects and that the underlying mechanisms may involve bo...
Article
A number of new developments have emerged in our understanding of the metabolic role of riboflavin in health and disease and of the impact of the deficiency state. This article reviews some of the nutritional aspects of the vitamin and briefly discusses two recent highlights: a) findings supporting antimalarial effects of riboflavin deficiency, and...
Article
Taste preferences for saccharin in concentrations ranging from 0.16 mM to 50 mM were determined in rats made hypothyroid with radioactive iodine and in their littermate controls. Hypothyroid rats demonstrated taste preferences for saccharin which were similar to those of controls only at very low (0.016 mM) or very high (49.0 mM) saccharin concentr...
Article
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The anticancer drug Adriamycin® has photosensitizing properties which potentially may be detrimental to lens tissue. Since reduced glutathione (GSH) serves to protect lens from photo-oxidative stress and dietary riboflavin is required by glutathione reductase to regenerate GSH, we investigated whether Adriamycin® intensifies the depletion of GSH le...
Article
Dietary riboflavin deficiency is known to diminish malarial parasitemia. In this study, we determined whether imipramine and amitriptyline, drugs which inhibit riboflavin metabolism, have antimalarial efficacy. In addition, we evaluated whether these drugs, like other antimalarial agents, increase the hemolytic response to ferriprotoporphyrin IX (F...
Article
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The effects of riboflavin deficiency on the activity in vitro of prostaglandin synthetase were determined in rat kidney homogenates. For a period of two to five months, weaning rats were fed either a diet deficient in riboflavin or equal amounts of a diet identical in composition except for the addition of riboflavin at four times the RDA for this...
Article
Full-text available
In livers of adult rats that have been treated with thyroxine, the rate of incorporation of radiolabeled riboflavin into both flavin adenine clinucleotide (FAD) and FAD covalently attached to specific apoflavoenzymes was enhanced markedly. By contrast, thyroxine diminished riboflavin incorporation into FAD in cerebrum and cerebellum but continued t...
Article
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The present study was undertaken to determine whether treatment with chlorpromazine accelerates the depletion of tissue stores of flavin adenine dinucleotide during dietary riboflavin deficiency. These investigations derived their impetus from earlier findings that low doses of chlorpromazine in rats fed abundant riboflavin increase urinary ribofla...
Article
Full-text available
Chlorpromazine, imipramine and amitriptyline, drugs structurally related to riboflavin, each inhibited the formation in vivo of flavin adenine dinucleotide (FAD) from riboflavin in rat heart at 2–5 mg/kg body weight, doses comparable on a weight basis to those used clinically. All three drugs inhibited FAD formation in heart within 5 hr after a sin...
Article
Full-text available
Chlorpromazine inhibits the incorporation of riboflavin into flavin adenine dinucleotide and flavins bound covalently to proteins in vivo in rat liver. In addition, this drug markedly blunts thyroxine enhancement of riboflavin incorporation into flavins, both observations being made at concentrations of chlorpromazine commonly used clinically. Thes...
Article
A competitive protein binding assay is described for the determination of riboflavin in human urine. The method uses chicken egg white as the source of specific riboflavin-binding protein and 2-14C-riboflavin as tracer. The average 24-hr urinary output of RF was 1.23 mg in men and 0.79 in women. The method is simple, specific, sensitive, and reprod...
Article
The plasma concentrations of glutamic acid and tyrosine were measured in euthyroid, hyperthyroid, and hypothyroid patients. In the group of normal individuals, plasma concentrations of glutamic acid were more variable than were those of tyrosine. Levels of glutamic acid in plasma were elevated proportionately more than were those of tyrosine in hyp...
Article
The plasma concentration of tyrosine has been measured at intervals during two successive 24-hr periods in eight hyperthyroid, six hypothyroid and eight normal individuals hospitalized on a metabolic ward. The time of food intake and the concentration of protein in the diet have been controlled in each subject. The fasting level of tyrosine in hype...

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