Richard Price

University of South Wales

St Augustine has been the most influential single voice in the history of western Christianity. Those in quest of a new theology often find it necessary to begin by criticizing him. This is fair enough; but a Christianity conscious of its past cannot discard him. This is clear in ecumenical dialogue with the Churches of the Reformation: their theol...

Background The Polycomb Repressor Complex (PRC) is an epigenetic regulator of transcription whose action is mediated by 2 protein complexes, PRC1 and PRC2. PRC is oncogenic in glioblastoma, where it is involved in cancer stem cell maintenance and radioresistance.Methods We used a set of glioblastoma patient samples, glioma stem cells, and neural st...

The role of the immune response to oncolytic Herpes simplex viral (oHSV) therapy for glioblastoma is controversial because it might enhance or inhibit efficacy. We found that within hours of oHSV infection of glioblastomas in mice, activated natural killer (NK) cells are recruited to the site of infection. This response substantially diminished the...

Tumor virotherapy has been and continues to be used in clinical trials. One barrier to effective viral oncolysis, consisting of the interferon (IFN) response induced by viral infection, is inhibited by valproic acid (VPA) and other histone deacetylase inhibitors (HDACi). Innate immune cell recruitment and activation have been shown to be deleteriou...

Nodes within existing P2P networks typically exchange periodic keep-alive messages in order to maintain network connections between neighbours. Keep-alive messages serve a dual purpose, they're used to detect node failures and to prevent idle connections from being expired by NAT devices. However despite being widely used, the interval between mess...

Nodes within existing P2P networks typically exchange periodic keep-alive messages in order to maintain network connections between neighbours. This paper investigates a number of algorithms which allow each individual connections to extend the interval between successive keep-alive messages based upon the likelihood that a corresponding node will...

The E2f3 locus encodes two Rb-binding gene products, E2F3a and E2F3b, which are differentially regulated during the cell cycle and are thought to be critical for cell cycle progression. We targeted the individual inactivation of E2f3a or E2f3b in mice and examined their contributions to cell proliferation and development. Chromatin immunoprecipitat...

Distributed hash tables (DHTs) often maintain additional routing information regarding each node's surrounding neighbors within a network overlay. Sequential neighbors play a critical role in network recovery, providing alternative routes thus allowing more flexible and robust routing around a overlay. This paper details our analysis of a existing...

Adaptive multiagent algorithms based upon the behaviour of social insects are powerful decentralised systems capable of solving complex problems. The intelligence of such a system lies not within a single agent but is a product of a network of simple interactions. Under the context of a mail collection environment difierent techniques are im- pleme...