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Richard Izrael currently works at the Institute of Enzymology in the Research Centre for Natural Sciences, Budapest. Richard does research in Parasitology, Molecular Biology and Cell Biology, most notably he characterizes the genomic integrity and nucleotide metabolism of the malaria parasite, Plasmodium falciparum.
June 2016 - April 2023
Research Centre of Natural Sciences
- Research Associate
Understanding and characterizing the molecular background of the maintenance of genomic integrity might be a major factor in comprehending the exceptional ability of the malaria parasite, Plasmodium falciparum to adapt at a fast pace to antimalarials. A balanced nucleotide pool is an essential factor for high-fidelity replication. The lack of detai...
The phospholipid biosynthesis of the malaria parasite, Plasmodium falciparum is a key process for its survival and its inhibition is a validated antimalarial therapeutic approach. The second and rate-limiting step of the de novo phosphatidylcholine biosynthesis is catalysed by CTP: phosphocholine cytidylyltransferase (PfCCT), which has a key regula...
Emergence of resistant Plasmodium species makes drug efficacy testing a crucial part of malaria control. Here we describe a novel assay for sensitive, fast and simple drug screening via the magneto-optical detection of hemozoin, a natural biomarker formed during the hemoglobin metabolism of Plasmodium species. By quantifying hemozoin production ove...
The development of the malaria parasite, Plasmodium falciparum, in the human erythrocyte, relies on phospholipid metabolism to fulfil the massive need for membrane biogenesis. Phosphatidylcholine (PC) is the most abundant phospholipid in Plasmodium membranes. PC biosynthesis is mainly ensured by the de novo Kennedy pathway that is considered as an...
Plasmodium falciparum parasites undergo multiple genome duplication events during their development. Within the intraerythrocytic stages, parasites encounter an oxidative environment and DNA synthesis necessarily proceeds under these circumstances. In addition to these conditions, the extreme AT bias of the Plasmodium falciparum genome poses furthe...
In spite of the extended and active research, malaria is still a major threat amongst vector-borne diseases. The prevalence of multidrug-resistant Plasmodium strains urges the identification of new potential drug targets. The parasite depends crucially on membrangenesis during the intraerythrocytic stage. Phosphatidyl-choline (PC), the major compon...