Richard Edgar Hodgett

University of Leeds · Centre for Decision Research (CDR)

In recent years, the chemical and pharmaceutical industries have observed a noticeable decline in economic activity. This has resulted in many companies focusing on innovative research and development as they consider this key to business success. In particular, a number of leading industrial organisations have adopted the principles of Whole Proce...

Equipment selection is a complex task that requires the consideration of multiple criteria with different measurement units. A number of decision-making methods have been proposed for analysing equipment selection problems, each having their own distinctive advantages and limitations. Despite the number of decision-making techniques available, few...

Reaching a decision when multiple, possibly conflicting, criteria are taken into account is often a difficult task. This normally requires the intervention of an analyst to aid the decision maker in following a clear methodology with respect to the steps that need to be taken, as well as the use of different algorithms and software tools. Most of t...

Managerial decision-making often involves the consideration of multiple criteria with high levels of uncertainty. Multi-attribute utility theory, a primary method proposed for decision-making under uncertainty, has been repeatedly shown to be difficult to use in practice. This paper presents a novel approach termed Simulated Uncertainty Range Evalu...

In recent years, the chemical and pharmaceutical industries have faced increased development times and costs with fewer novel chemicals being discovered. This has resulted in many companies focusing on innovative research and development as they consider this key to business success. In particular, a number of leading industrial organisations have...

Unlabelled: Biomarkers for the classification of rheumatoid arthritis (RA), and particularly for anti-citrullinated peptide antibody (ACPA)-negative patients, remain an important hurdle for the early initiation of treatment. Taking advantage of DNA-methylation patterns specific to early RA, quantitative methylation-specific qPCR (qMSP) offers a ro...

This paper provides an overview of multi-criteria decision analysis (MCDA) applications in managing water-related disasters (WRD). Although MCDA has been widely used in managing natural disasters, it appears that no literature review has been conducted on the applications of MCDA in the disaster management phases of mitigation, preparedness, respon...

Background/Aims Diagnosing rheumatoid arthritis (RA) early is difficult despite the use of anti-citrullinated protein antibodies in the new EULAR-2010 classification criteria, particularly for antibody-negative patients. Alterations in epigenetic patterns have been associated with RA CD4+T-cells at the TNF gene locus (1). The second aim of my PhD...

Background: The genetic risk associated with rheumatoid arthritis (RA) includes genes regulating DNA methylation, one of the hallmarks of epigenetic re-programing, as well as many T-cell genes, with a strong MHC association, pointing to immunogenetic mechanisms as disease triggers leading to chronicity. The aim of our study was to explore DNA meth...

Measuring real-world impact is vital for demonstrating the success of a project and one of the most direct ways to justify taxpayers’ contributions towards public funding. Impact reporting should identify and examine the potential positive and negative consequences of the continuing operations of a proposed project and suggest strategies to expand,...

Career situation of first and presenting author Student for a master or a PhD. Introduction Alterations in DNA methylation patterns (epimutations) have been related to several diseases, including Rheumatoid Arthritis (RA). We hypothesise that such epimutations occur early in the RA disease process. T-cells are important cells in early pathogenesis...

Introduction Alterations in DNA methylation patterns have been related to several diseases, including Rheumatoid Arthritis (RA). Objectives To identify changes in DNA methylation pattern of naïve and memory CD4 +T cells and monocytes in early, drug naïve RA patients to help understand early event in disease pathology. Methods The methylation patt...

Objectives: Despite the well-established value of currently used classification criteria for the early diagnosis of rheumatoid arthritis (RA) there is a constant demand for novel biomarkers notably in autoantibody-negative patients. Interleukin 7 (IL-7) has been reported as a candidate diagnostic biomarker based on ACR-1987 criteria. However, clin...

Background Alteration in epigenetic patterns have been related to several diseases including RA. Early detection of RA will enable more effective treatment. The aim of our project is to identify the early changes in DNA methylation patterns of naïve and memory CD4⁺T-cells, and monocytes in Early RA patient to help understanding early disease pathol...

Background Recently, epigenetics has become an important field of research, with several diseases related to alteration in methylation patterns. Whether these epimutations are early events due to a local perturbation causing the initial epigenetic event and then leading to pathogenesis, or a later consequence of the pathology itself remains open fo...