Richard BensonCambridge University Hospitals NHS Foundation Trust · Department of Oncology (Addenbrooke)
Richard Benson
MB BS, FRCR, FRCP
About
59
Publications
5,544
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
1,423
Citations
Introduction
Additional affiliations
May 1994 - present
Publications
Publications (59)
Objectives
To quantify the impact of neuroradiologist presence on head and neck cancer (HNC) radiotherapy peer review (PR) changes.
Methods
Prospective data was collected from HNC radiotherapy PR meetings; major, minor, and organ at risk (OAR) changes recorded. Differences in changes made with a neuroradiologist present were determined. Chi-square...
Background and purpose:
The impact of weight loss and anatomical change during head and neck (H&N) radiotherapy on spinal cord dosimetry is poorly understood, limiting evidence-based adaptive management strategies.
Materials and methods:
133 H&N patients treated with daily mega-voltage CT image-guidance (MVCT-IG) on TomoTherapy, were selected. E...
Background:
L'Hermitte's sign (LS) after chemoradiotherapy for head and neck cancer appears related to higher spinal cord doses. IMRT plans limit spinal cord dose, but the incidence of LS remains high.
Methods:
One hundred seventeen patients treated with TomoTherapy™ between 2008 and 2015 prospectively completed a side-effect questionnaire (VoxT...
BACKGROUND L’Hermitte’s sign (LS) after chemoradiotherapy for head and neck cancer appears related to higher spinal cord doses. IMRT plans limit spinal cord dose, but the incidence of LS remains high. METHODS 117 patients treated with TomoTherapy™ between 2008 and 2015 prospectively completed a side-effect questionnaire (VoxTox Trial Registration:...
To determine delivered dose to the spinal cord, a technique has been developed to propagate manual contours from kilovoltage computed-tomography (kVCT) scans for treatment planning to megavoltage computed-tomography (MVCT) guidance scans. The technique uses the Elastix software to perform intensity-based deformable image registration of each kVCT s...
JES was supported by Cancer Research UK through the Cambridge Cancer Centre. NGB, ASP and MG are supported by the National Institute of Health Research Cambridge Biomedical Research Centre. KH, MR AMB, EW and SJB were supported by the VoxTox Research Programme, funded by Cancer Research UK. DJN is supported by Addenbrooke’s Charitable Trust and Can...
The VoxTox research programme has applied expertise from the physical sciences to the problem of radiotherapy toxicity, bringing together expertise from engineering, mathematics, high energy physics (including the Large Hadron Collider), medical physics and radiation oncology. In our initial cohort of 109 men treated with curative radiotherapy for...
Background:
More than 400,000 cases of oropharyngeal squamous cell carcinoma (OPSCC) are diagnosed each year worldwide and the incidence is rising, partly as a result of human papillomavirus. Human papillomavirus-associated OPSCC affects younger patients and often presents at a higher stage; however, it is associated with a better prognosis.Until...
Pelvic nodal irradiation (PNRT) in prostate cancer; Cambridge experience
Objective:
To investigate whether planning target volume (PTV) margins may be safely reduced in radiotherapy of localized prostate cancer incorporating daily online tube potential-cone beam CT (CBCT) image guidance and the anticipated benefit in predicted rectal toxicity.
Methods:
The prostate-only clinical target volume (CTV2) and rectum were d...
Background:
Human papillomavirus-associated oropharyngeal squamous cell carcinomas are a distinct subgroup of tumours that may have a better prognosis than traditional tobacco/alcohol-related disease. Iatrogenic complications, associated with conventional practice, are estimated to cause mortality of approximately 2% and high morbidity. As a resul...
To assess the efficacy of transoral robotic surgery or transoral laser microsurgery for early-stage (T1-2, N0-2) oropharyngeal carcinomain comparison to radiotherapy / chemoradiotherapy.
Objective:
To illustrate the wider potential scope of image-guided intensity-modulated radiotherapy (IG-IMRT), outside of the "standard" indications for IMRT.
Methods:
Nine challenging clinical cases were selected. All were treated with radical intent, although it was accepted that in several of the cases the probability of cure was low. IMRT al...
This Cochrane Review is at the protocol stage and there is no abstract or plain language summary. The objectives for the review are as follows:
Primary objective
To determine which treatment regimen (that must include one or more of chemotherapy, radiotherapy or biotherapy) given with the intention to cure HPV-positive local advanced oropharyngea...
A study of interobserver variation in the segmentation of the post-operative clinical target volume (CTV) and organs at risk (OARs) for parotid tumours was undertaken. The segmentation exercise was performed as a baseline, and repeated after 3 months using a segmentation protocol to assess whether CTV conformity improved.
Four head and neck oncolog...
To quantify the changes in contours of the target and organs at risk and the differences between planned and delivered doses to the target and organs at risk during the course of radiotherapy in head and neck cancer patients treated with intensity-modulated radiotherapy on the TomoTherapy HiArt™ system.
Five patients with squamous cell carcinoma of...
A substantial proportion of patients who have undergone a radical prostatectomy for localised prostate cancer will have either persistently detectable prostate-specific antigen (PSA) levels or a delayed rise in PSA. The optimum treatment for these situations is not known. The key question is whether the PSA is reflective of local or distant progres...
To assess the effectiveness of different on-treatment correction strategies on set-up accuracy in patients with head and neck cancer (HNC) treated on a TomoTherapy HiArt system. To assess the adequacy of clinical target volume (CTV) to planning target volume (PTV) treatment planning margins when treating with intensity-modulated radiotherapy withou...
The purpose of this study was to assess the referral system, clinical notes and radiographs of patients presenting with metastatic disease of long bones. The study demonstrated that 93% of oncologists did not use a reliable scoring system to assess risk of pathological fracture, and 60% felt an improvement in communication was required. Notes and r...
To study the feasibility of using implanted gold seeds in combination with a commercial software system for daily localisation of the prostate gland during conformal radiotherapy, and to assess the effect this may have on departmental workload.
Six patients had three gold radio-opaque seeds implanted into the prostate gland before starting a course...
Recently, cancer mortality has been compared to research spending by the National Cancer Research Institute (NCRI), whose research budget is approximately pound sterling 250 million. The analysis shows a mis-match between mortality and research spending. As well as crude mortality rates, other measures of cancer burden should be considered because...
In high precision radiotherapy, the more accurately the patient can be relocated, the smaller the clinical to planning target volume margin can be, with reduction in the volume of normal tissue irradiated. The Gill-Thomas-Cosman (GTC) relocatable stereotactic head frame provides immobilization of the patient which is highly reproducible. A depth he...
To assess the outcome following local excision and postoperative radiotherapy (RT) for distal rectal carcinoma.
Seventy-three patients received postoperative radiotherapy following local surgery for primary rectal carcinoma at Princess Margaret Hospital from 1983 to 1998. Selection factors for postoperative RT were patient preference, poor operativ...
A departmental audit was conducted to assess the frequency, extent and causes of late completion of oncology clinics. Data were collected prospectively from clinical, medical, haematological and multidisciplinary oncology clinics. The data recorded included: clinic start and finish times, number of patients seen, type of consultation, number of doc...
We report the occurrence of a malignant melanoma of the uterine cervix in a patient previously irradiated for a squamous cell carcinoma of the cervix. The management of malignant melanoma of the cervix is reviewed. The risk of second cancers in general, malignant melanoma in particular, after radiotherapy for cervical cancer is also discussed.
The British government has recently stated its aim of reducing deaths from cancer by a fifth over the next decade, with contributions from prevention, early diagnosis, and better treatments. British cancer cure rates are poorer than those of continental Europe and North America,1 and under—resourcing of radiotherapy services contributes to this.2 T...