Richard Yomi Akele

Richard Yomi Akele
University of Brighton · Biomedical Science (School of Applied Science)

Doctor of Philosophy

About

79
Publications
55,355
Reads
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487
Citations
Additional affiliations
December 2006 - January 2007
National Veterinary Research Institute, Vom
Position
  • Intern
October 2013 - March 2022
Afe Babalola University
Position
  • Lecturer/ Researcher

Publications

Publications (79)
Article
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Mpox, declared a Public Health Emergency of International Concern by the World Health Organization (WHO), poses a growing global threat. The resurgence, driven by the highly transmissible and severe clade Ib strain from the Democratic Republic of the Congo, raises concerns about a potential pandemic. This narrative review aims to identify actionabl...
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Background: Dengue fever remains a global health threat, particularly in tropical regions, with no effective vaccines or antiviral treatments available. This review explores plant-based therapies as a promising approach to manage dengue by focusing on bioactive compounds, immunotargets, and mechanisms of action. Aim: The review aims to explore the...
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BACKGROUND: Vaccine hesitancy is a major challenge in the fight against the coronavirus disease 2019 (COVID-19) pandemic. Identifying the sociodemographic factors associated with vaccine acceptance among Nigerians is crucial for improving vaccine uptake. AIM: To assess the acceptance rate of COVID-19 vaccine and its related determinants among Niger...
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Background and study aim: In Nigeria, there is paucity of information on the epidemiology of infections due to Chikungunya virus (CHIKV) especially among patients with febrile illness. Cases of febrile illness are usually associated with malaria and typhoid fever without considering the possibility of viral aetiology. The aim of the study was to de...
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Yellow fever (YF) remains a significant public health concern in Nigeria, with sporadic outbreaks causing considerable morbidity and mortality. This zoonotic viral disease is transmitted primarily by Aedes mosquitoes, posing a constant threat to human populations. Although vaccination efforts have been ongoing for years, outbreaks still occur, unde...
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Microbial biotechnology Pharmacology, pharmaceutical microbiology and nanotechnology in recent years gave birth to an exciting new field called Microbial Nanotechnology. Engineered microbial nanoparticles take on the role of carriers, with biocompatibility and tunable properties for precise drug delivery. By introducing surface modification or liga...
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In an increasingly interconnected world shaped by globalization, international travel plays a significant role in facilitating the spread of infectious diseases. Travel medicine plays a vital role in preventing and controlling the spread of infectious diseases. This specialized field focuses on providing pre-travel advice, administering necessary v...
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The essential role of medical microbiologists in the field of travel medicine becomes apparent amidst the escalating challenges faced by our world. This article highlights their indispensable contributions to safeguarding global health during travel. Medical microbiologists play a pivotal part in defending against infectious threats encountered d...
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Psoriasis vulgaris is a significant health problem and up to 30% of the patients are most likely to develop psoriatic arthritis. Secukinumab, an interleukin-17A (IL-17A) inhibitor, is used to treat patients with moderate-to-severe plaques associated with psoriatic arthritis. The aim of this case report was to highlight the efficacy of secukinumab t...
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Yellow fever still represents a major public health threat in Africa largely due to inadequate vaccine supply, insufficient vaccine coverage, increase in people without of vaccination living in endemic areas and occupation of individuals. The aim of this study was to assess the acceptability to yellow fever vaccination among skilled and unskilled w...
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Background: Human Cytomegalovirus (HCMV) infection in pregnancy, especially in the first trimester often lead to congenital abnormalities and is associated with serious complications, such as microcephaly, mental retardation, spastic paralysis, hepatosplenomegaly, anaemia, thrombocytopenia, deafness, and optic nerve atrophy leading to blindness in...
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Ocular infections have been associated with bacterial contamination of eyeglasses. This study assessed bacterial contaminants associated with the eyeglasses of the staff and students of Babcock University, Ilishan-Remo, Ogun State, Nigeria. A total of 100 participants comprising 33 males and 67 females (aged 16-76 years) were recruited for the stud...
Article
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Introduction: The coronavirus disease 2019 (COVID-19) is a vaccine-preventable disease amongst all ages; however, parental attitudes, perceptions and concerns towards children’s vaccination can hamper immunization efforts and leave this vulnerable group of the society unprotected. The aim of this study is to assess the attitude, perception and conc...
Article
Ocular infections have been associated with bacterial contamination of eyeglasses. This study assessed bacterial contaminants associated with the eyeglasses of staffs and students of Babcock University, Ilishan–Remo, Ogun State, Nigeria.
Article
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Introduction: Vaccine hesitancy is a global phenomenon and vaccination efforts against the Coronavirus Disease 2019 (COVID-19) pandemic may be hampered by it. This study assessed the acceptance rate of COVID-19 vaccination at different hypothetical efficacy and safety levels in Nigeria. Methods: This web-based study was conducted among a selected N...
Article
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Infectious threats to humans are continuously emerging. The 2022 worldwide monkeypox outbreak is the latest of these threats with the virus rapidly spreading to 106 countries by the end of September 2022. The burden of the ongoing monkeypox outbreak is manifested by 68,000 cumulative confirmed cases and 26 deaths. Although monkeypox is usually a se...
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Background: A few studies have demonstrated the medicinal benefits of Bio-Clean II herbal remedy. The aim of this study is to determine the phytochemical screening, proximate analysis and microbiological quality of Bio-Clean II. Materials and Methods: Samples of the herbal remedy were procured from the manufacturer and were analyzed using standard...
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Chlamydia trachomatis (CT) infection in the genitourinary tract is the most prevalent bacterial sexually transmitted disease (STD) worldwide. Genital chlamydial infection has a huge impact on sexual and reproductive health, and it is very common in developed and developing countries. The aim of this study is to determine the prevalence of Chlamydia...
Preprint
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Background: Vaccination efforts against the Coronavirus Disease 2019 (COVID-19) pandemic may be hampered by vaccine hesitancy. This study assessed the acceptance rate of COVID-19 vaccination at different hypothetical efficacy and safety levels in Nigeria. Methods: This web-based study was conducted among a selected Nigerian population between the m...
Preprint
Full-text available
The aim of this study was to determine the microbiological quality, phytochemicals, trace elements and proximate analysis of Bio-Clean II. Samples of the herbal remedy were procured from the manufacturer and were analyzed using standard procedure of analysis including sterility test, Spectrophotometry, Atomic Absorption spectroscopy, and gravimetri...
Preprint
Full-text available
BACKGROUND: Human Cytomegalovirus (HCMV) infection in pregnancy, especially in the first trimester often lead to congenital abnormalities and is associated with serious complications, such as microcephaly, mental retardation, spastic paralysis, hepatosplenomegaly, anaemia, thrombocytopenia, deafness, and optic nerve atrophy leading to blindness in...
Article
Full-text available
Background: Risk perceptions of coronavirus disease 2019 (COVID-19) are considered important as they impact community health behaviors. The aim of this study was to determine the perceived risk of infection and death due to COVID-19 and to assess the factors associated with such risk perceptions among community members in low- and middle-income cou...
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Bacterial inflammatory diseases have continued to be a major threat to public health. The aim of this study is to determine the effects of Bio-Clean II on serum levels of some selected cytokines in rats exposed to purified bacterial lipopolysaccharide (LPS). A total of 36 male Wistar rats weighing 150g±50g (mean±SD) were purchased and randomly assi...
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Background: Bio-Clean II has been previously shown to fight viral infection, boost immunity, and possesses anti-inflammatory properties by regulating the serum level of inflammatory cytokines, as well as T-Helper 4 and Cytotoxic T-Lymphocytes in rats exposed to purified bacterial lipopolysaccharide (LPS). Aim: The aim of this study is to assess the...
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Amidst global relaxation of the Coronavirus Disease 2019 (COVID-19) intervention measures and celebration of the unprecedented grounds conquered in the fight against the pandemic, the monkeypox virus (MPXV) has emerged and remerged in many countries taking over major headlines around the globe at the present. Since 1 January and as of 22 June 2022,...
Article
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Background: Human Papillomavirus (HPV) is an oncogenic sexually transmitted virus. It is the leading cause of cervical cancer, penile, vulva, vaginal and anal high-grade dysplasia. Infections are usually asymptomatic only to manifest after several years, implying that most adults with symptoms must have been infected at their young ages. The risky...
Article
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Introduction: Bio-Clean II has been previously shown to boost immunity, fight viral infection, and possesses anti-inflammatory properties by regulating the serum level of inflammatory cytokines in rats exposed to purified bacterial lipopolysaccharide (LPS). In this study, we investigated the immunomodulatory effect of Bio-Clean II on T-Helper 4 and...
Article
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Vaccine hesitancy is considered as one of the greatest challenges to control the ongoing coronavirus disease 2019 (COVID-19) pandemic. Arelatedchallenge is theunwillingness of the general publicto pay for vaccination. The objective of this study was to determine willingness-to-pay (WTP) for COVID-19 vaccine among individuals from ten low-middle-inc...
Article
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Background: Risk perceptions of coronavirus disease 2019 (COVID-19) are considered important as they impact community health behaviors. The aim of this study was to determine the perceived risk of infection and death due to COVID-19 and to assess the factors associated with such risk perceptions among community members in low- and middle-income cou...
Article
Full-text available
Vaccine hesitancy, defined as the reluctance or rejection in receiving a vaccine despite its availability, represents a major challenge to global health efforts aiming to control the ongoing COVID-19 pandemic. Understanding the possible factors correlated with COVID-19 vaccine hesitancy using a refined well-informed approach can be helpful to addre...
Article
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Background: We earlier reported that datumetine possesses binding affinity with NMDAR and that 14-day exposure to datumetine altered NMDAR signalling by mimicking glutamate toxicity. Here, we investigated the potential neuroprotective effect of a single shot of a low dose of datumetine administration in BALB/c mice. Results: Relative to Veh, datume...
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Background: Syphilis is still one of the major causes of death in some developing countries where HIV infection is also prevalent. The aim of this study was to determine the prevalence of syphilis among HIV positive and negative women in Ogun state. Methods: The serum samples of 240 (120 HIV Positive and 120 HIV Negative) consenting female particip...
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COVID-19 has been ravaging the world since late December, 2019 and it is not slowing down as the global cumulative counts of confirmed cases and fatalities continue to rise every day. Currently, there is no established cure. Monoclonal antibodies (mAbs) are the major therapeutic agents for passive immunotherapy in the fight against viral infection....
Article
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Vaccine hesitancy is considered one of the greatest threats to the ongoing coronavirus disease 2019 (COVID-19) vaccination programs. Lack of trust in vaccine benefits, along with concerns about side effects of the newly developed COVID-19 vaccine, might significantly contribute to COVID-19 vaccine hesitancy. The objective of this study was to deter...
Article
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Background: Human Parvovirus B19 (B19V) is a DNA virus, transmitted through respiratory secretions, hand-to-mouth-contact, blood transfusion and trans-placental transfer. It causes high mortality and morbidity in pregnant women, thus contributing to poor maternal and child health. B19V has been neglected due to dearth of epidemiological data. The...
Article
Objetive: Manufacturers of toothpastes claim that their products are active against oral microbiome capable of causing tooth decay. The objective of this study was to investigate the manufacturers’ claim using some of the toothpaste products sold in Ado-Ekiti, Nigeria. Material and methods: The antibacterial potentials of five commercialized toothp...
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Amidst the second wave of the pandemic across the globe, three (3) new variants of SARS-CoV-2 have been detected in recent weeks in the United Kingdom (SARS-CoV-2 VOC 202012/01), South Africa (SARS-CoV-2 501.V2) and Nigeria (SARS-CoV-2 P681H). The SARS-CoV-2 VOC 202012/01 variant in particular, has been implicated in more than 1,000 cases especiall...
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The Coronavirus Disease-2019 (COVID-19) outbreak which started about a year ago (late December, 2019) in Wuhan-China has escalated to 220 countries and territories of the world, resulting in the current pandemic with more than 70 million confirmed cases and over 1.5 million fatalities recorded so far as of December 11, 2020. The disease as we now k...
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The World Health Organization (WHO) officially declared the novel Coronavirus outbreak a pandemic on the 11 th of March, 2020. International flights from the epicenter of the outbreak (Wuhan, China) were identified as a key driver of the current pandemic. About 231 international flights were reported to have left China to other parts of the world i...
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The Coronavirus Disease-2019 (COVID-19) is an emerging zoonotic disease with global impact. Different intervention measures have been rolled out to flatten the curve, however the unhygienic conditions of abattoirs in Nigeria may be a perfect breeding ground for the novel coronavirus, hence could pose a threat to public health. The severe acute resp...
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The quest for a safe and effective HIV vaccine holds life-saving potential for people globally. Interestingly, the HIV/COVID-19 overlapping pandemic have impacted each other in diverse ways, some being advantageous, while others detrimental. On one hand, the HIV platforms for development of rapid test kits, neutralizing antibodies, vaccine developm...
Article
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Nigeria has continued to record a dramatic rise in the number of confirmed cases and fatalities of Coronavirus Diseas-2019 (COVID-19) since the first incidence was reported on the 27th of February, 2020. As of 25 August, 2020; Nigeria has the largest COVID-19 outbreak in the West-Africa sub-region (52,800), second to South-Africa (613,017) in the c...
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Background: Developing an effective and safe COVID-19 vaccine is a global public health necessity in containing the pandemic, however, recruiting volunteers can be challenging in a clinical trial phase because of poor knowledge, negative perception, ethical issues and safety concerns. Aim: The survey was conducted to assess the knowledge, perceptio...
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Aim: Though Rubella is vaccine-preventable and enlisted on the expanded program on immunization (EPI) list, vaccination and testing are not routinely practiced in Ido-Ekiti. There is also paucity of epidemiological data on the prevalence of rubella infection at Ido-Ekiti, hence the study aimed at carrying out a serosurvey to generate epidemiologica...
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The Coronavirus Disease-2019 (COVID-19) virus has infected more than one million people, leaving more than 50,000 people dead across the globe. The health system of many countries has been overwhelmed by the pandemic, with many losing a significant number of their health professionals in the fight against the virus. While doctors and nurses are so...
Article
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The Coronavirus Disease – 2019 (COVID-19) is officially now a pandemic and not just a public health emergency of international concern as previously labelled. Worldwide, the new coronavirus has infected more than 4.9 million people and leaving more than 300,000 people dead in 188 countries. As countries of the world get locked down in an effort to...
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Background: Oral and dental problem is common among many Nigerian populace. The human oral cavity is one of the most dynamic habitats for numerous bacterial species where they undergo intense interspecies competition to form multispecies biofilm structure. Aim: The present study was designed to assess the oral bacterial profile and antibiogram of A...
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This study explores the effects of chronic alcohol and cannabinol exposure on the testosterone levels and the histomorphological integrity/cytoarchitecture of the rats’ testes. Adults male Wistar rats were randomly divided into control (distilled water), methanol (2mg/kg bw), alcohol (3g/kg bw), cannabinol (10mg/kg bw) and alcohol (3g/kg bw) plus c...
Article
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Background; Products of conception, abbreviated poc, is medical term used for tissue derived from the union of an egg and a sperm. It encompasses an embryonic gestation (blight ovum) which does not have a viable embryo. The prognostic indicators based on currently available clinical and histopathological variables such as villous size, outlines, st...
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The present study assessed the microbiological quality and efficacy of two common disinfectants (Jik and Lysol) used in a hospital laboratory. Sterility test using Nutrient Agar and Sabour Dextrose Agar plates incubated at 37°C and 25°C, respectively, were employed to detect the present of potential bacterial and fungal contaminants in 3 new batche...
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This present study investigated the antimicrobial potential of the leaf and stem extracts of Gongronema latifolium against some selected wound-associated pathogens: Pseudomonas aeruginosa, Escherichia coli, Proteus mirabilis, Klebsiella pneumonae and Candida albican using the punch-hole agar diffusion method. The outcome of the study show that neit...
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p> Background: Immunosuppressive Acidic protein (IAP) is a marker of the extent of immune defects occurring in most cancers. Its correlation with CD4 cell count used as an indicator of immune function and disease progression in Human Immuno-deficiency Virus (HIV) infection is not well documented. Aims and Objectives: To determine if IAP levels cor...
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Honey has been used for various purposes including treatment of some diseases locally especially in wounds and upper respiratory tract infections (URTIs). There is paucity of information on the scientific basis for the use of honey in the treatment of upper respiratory tract infections caused by bacteria. This study was carried out to determine ant...
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The use of natural products as anti-infective agents, have given rise to new chemical diversity and are preferred in modern world. Among all these natural sources, plants and its products is more reliable because of its renewability. Urinary tract infections (UTIs) are among the most common infectious diseases occurring in either the community or h...
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Aims The aim of this study was to determine the incidence of thrombocytopenia in pregnancy and determine possible immune thrombocytopenia correlates with blood dyscrasia involving other cellular components of blood. Settings and design: The study was an institution-based cross sectional study. Participants and methods The full blood count of 200 wo...
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In different communities across the globe, we see more of divergence from normal and/or expected behaviour; some psychotic in nature while others are neurodegenerative diseases of unknown origin. However, the use or exposure to some psycho stimulants at any stage of an individual's development may not be unconnected with these developments. The aim...
Article
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Highly active antiretroviral viral therapy (HAART), a combination of three antiretrovirals from at least two drug classes for optimization of hindrance to HIV replication has greatly increased life expectance. There however, exist numerous of these combinations and thus the questions of which is the best HAART combination with respect to the indivi...
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Aim: To assess the effect of highly active antiretroviral therapy (HAART) on CD 4 + cell count and liver enzymes in HIV-infected patients six months post-therapy based on age and sex distribution. Methods: A cohort of 200 (66 males, 134 females) consenting HAART naïve patients, aged between 16 and 65 years with confirmed cases of HIV infection (by...
Article
Full-text available
Aim: To assess the effect of highly active antiretroviral therapy (HAART) on CD 4 + cell count and liver enzymes in HIV-infected patients six months post-therapy based on age and sex distribution. Methods: A cohort of 200 (66 males, 134 females) consenting HAART naïve patients, aged between 16 and 65 years with confirmed cases of HIV infection (by...
Article
Full-text available
Aim: To assess the effect of highly active antiretroviral therapy (HAART) on CD 4 + cell count and liver enzymes in HIV-infected patients six months post-therapy based on age and sex distribution. Methods: A cohort of 200 (66 males, 134 females) consenting HAART naïve patients, aged between 16 and 65 years with confirmed cases of HIV infection (by...
Article
Full-text available
Aim: To assess the effect of highly active antiretroviral therapy (HAART) on CD 4 + cell count and liver enzymes in HIV-infected patients six months post-therapy based on age and sex distribution. Methods: A cohort of 200 (66 males, 134 females) consenting HAART naïve patients, aged between 16 and 65 years with confirmed cases of HIV infection (by...
Article
Full-text available
Aim: To assess the effect of highly active antiretroviral therapy (HAART) on CD 4 + cell count and liver enzymes in HIV-infected patients six months post-therapy based on age and sex distribution. Methods: A cohort of 200 (66 males, 134 females) consenting HAART naïve patients, aged between 16 and 65 years with confirmed cases of HIV infection (by...
Article
Full-text available
Aim: To assess the effect of highly active antiretroviral therapy (HAART) on CD 4 + cell count and liver enzymes in HIV-infected patients six months post-therapy based on age and sex distribution. Methods: A cohort of 200 (66 males, 134 females) consenting HAART naïve patients, aged between 16 and 65 years with confirmed cases of HIV infection (by...
Article
Full-text available
Aim: To assess the effect of highly active antiretroviral therapy (HAART) on CD 4 + cell count and liver enzymes in HIV-infected patients six months post-therapy based on age and sex distribution. Methods: A cohort of 200 (66 males, 134 females) consenting HAART naïve patients, aged between 16 and 65 years with confirmed cases of HIV infection (by...