Richa Gupta

• Post Graduate Institute of Medical Education and Research

Introduction: Baseline expression of p16INK4a characterises cellular senescence. Similarly, the measurement of γ-GammaH2AX (γ-H2AX) foci levels in cells provides a reliable method for quantification of Deoxyribonucleic Acid (DNA) damage. Aim: To explore the role of p16INK4a and γ-H2AX as biomarkers of senescence in skin tissue. Materials and Method...

Background: The auditory tube (AT), an osteocartilaginous channel, connects the nasopharynx to the middle ear cavity. At the nasopharyngeal opening of the AT, there are dense collections of submucosal glands. In a recent article, Valstar et al. proposed these nasopharyngeal tubal glands conglomerate as salivary glands, which starkly contrasts with...

The purpose of this article is to form a basic guide for beginning the cadaver dissection training programs focused on oculoplastic surgical procedures. Ours was a collaborative study between the departments of Ophthalmology and Anatomy in a tertiary care teaching institute. We formed a step‑wise approach to begin the cadaver dissection focused on...

Better understanding of the surgical anatomy of the triangle of doom and the triangle of pain with fixed bony landmarks like the anterior superior iliac spine (ASIS) and the pubic symphysis (PS) can help in defining a safe location for trocar placement during laparoscopic surgeries and minimize neurovascular complications. Ten cadavers were dissect...

The selection study is the study of the basic mechanism by which nature ensures better adaptation, survival, and selective reproduction of some animals as compared to other animals

A three dimensional triangular space 'the Kambin's triangle (KT)' present on the dorsolateral aspect of the intervertebral disc, is considered to be a safe area for transforaminal approaches. It allows access to the exiting and traversing nerve roots, the thecal sac and to the intervertebral disc spaces. Our aim was to calculate the area of the tri...

Background: At the time of pandemics like COVID-19, dental professionals being one of the frontline workers must face a lot of challenges in workplace bringing about a lot of anxiety and stress. The purpose of this survey was to assess the physiological well-being of the dental professionals, the majority of challenges faced by them, , how they are...

This article is a pilot study and a cross sectional survey about the challenges faced by dental professionals during the initial months of shutdown due to COVID-19.

Abstract: The novel corona virus which was detected for the first time in Wuhan city, Hubei province, China in December, 2019, rapidly spread all over the world to be recognized as pandemic by March, 2020. Although, initially, the major symptoms were related to the respiratory system but gradually several manifestations have surfaced, thus making o...

Background: Malarial drug resistance is becoming a serious concern. Drug designing is a cumbersome and time taking process. The need of hour is to repurpose the existing drugs. The invasion inhibitory potential of Azithromycin has long been known through in-vitro and in-vivo studies. Here we intended to study the invasion inhibitory potential of dr...

Background:Increased resistance to anti-malarial drugs has caused a havoc, tolling many lives It has become an imminent need of hour is to find therapeutics drugs with novel mechanism of action. In the present study,we intended to study the invasion inhibitory potential of drugs belonging to the class of Glycomimetics. Methodology: Molecular dockin...

Oxidative stress is a common factor in all the chronic degenerative diseases. Whereas medicines combat the disease itself, another therapeutic modality like antioxidants prevents and aims to restrict the culprit ‘Oxidative stress’ itself. Lately, antioxidants have been more in demand due to increased prevalence of chronic debilitating diseases like...

Objective Hassall's corpuscles are unique component of the thymic medulla, which participate in the physiological activities of the thymus. Although, they have role in maturation and differentiation of thymocytes, their function still remains an enigma. Present study proposes immunohistochemical criteria for assessing structural and functional char...

Introduction: The medial arm region can be a potential donor site for the flap surgeries because of its excellent color and ideal thickness. It is an excellent choice for coverage of elbow, axilla, distant microvascular transfer, as the free posterior brachial fascial flap or the superficial circumflex iliac artery perforator flap, to head and neck...

Introduction There is increasing evidence implicating the active role of melatonin beyond regulation of the human biological clock and reproduction. Its therapeutic use has been extended to neurodegenerative disorders, psychiatric disturbances, memory as well as a host of other neurological manifestations. This study was thus designed to identify r...

Individuals with mental illness often cannot perform day to day activities due to a psychiatric or emotional disorder. Schizophrenia is one such psychiatric disorder characterized by worsening self-care ability with progressing mental illness. This disease may potentially deteriorate oral health by affecting the subject's ability to perform oral hy...

Aim: There are few complications associated with harvesting of full thickness coastal cartilage grafts i.e., pneumothorax (0.9%), contour deformities and prolonged post-operative pain. To address these issues, authors devised special scalpel to harvest split-thickness costal cartilage grafts. Materials and methods: Standard inframammary incision...

Introduction: The aim of the current study was to observe the expression of cytokeratins in human fetal thymuses. Specific cytokeratin markers in adult humans and mice have been well described but there has been little similar work on human fetuses. We also aimed to see whether progenitor stem cells that could be harvested to treat various immunod...

Any kind of anatomical variation whether encountered during cadaveric dissections or routine clinical or surgical procedures needs to be reported and taken into account. This can be quite helpful in planning surgeries accordingly and avoid disastrous complications. During routine cadaveric dissection, authors found a superficial course of arteries...

This chapter discusses the branches of the abdominal aorta, including ventral branches, lateral branches, dorsal branches, and terminal branches. The superior mesenteric artery (SMA) are unpaired branch, classically arises from the anterior aspect of the abdominal aorta. The middle suprarenal arteries (MSRA) are paired branches, classically arise f...

Abstract: The past decade has witnessed breakthrough advancements in the field of Regenerative medicine. With advancements in the knowledge and fabrication of tissue engineered constructs, complete regeneration of soft and hard tissues remains a farfetched goal. Stem cell therapy has emerged as one of the predictable; powerful tool to generate biol...

Background: We studied the bifurcation of sciatic nerve into two components which change their position throughout the early period of life. We proposed dimensions that would help reducing failure rates of anesthesia in popliteal fossa region and screening of malignancy related to sciatic nerve. Methods:The back of thigh and popliteal fossa of both...

Background: Pterion is a very crucial landmark. Thus, the present study was conducted to study pterion from

Background: Advances in neonatology have improved the survival of preterm and term infants with life threatening conditions. Over past two decades there has been renewed interest in regional anesthesia (RA) for pediatric procedures and has been suggested as good alternative to general anaesthesia (GA). Classical posterior approach of Labat modified...

Intramuscular drug injection in the gluteal region is often the most frequent cause of sciatic nerve injury in preterm newborns. Local anatomic variation is one of the predisposing causes of iatrogenic sciatic nerve injury. The aim of this morphological study was to assess the relationship of sciatic nerve with the piriformis muscle and to elucidat...

There is a plethora of evidence suggesting the role of barrier membranes in bone augmentation at sites of inadequate bone volume and height. Amongst the resorbable membranes, native collagen membranes are the standard treatment for guided regeneration procedures. However, native collagen resorbs rapidly whereas cross linking delays it. Pericardium...

Abstract : The loss of teeth has serious functional, esthetic disabilities, in addition to compromising the patients' quality of life. Currently, in the private sector, the status of prosthetic rehabilitation is only limited to anterior teeth due to esthetic reasons and rarely the posteriors. This could be called as inefficiency or lack of knowledg...

The aim of this study was to measure the lumbar pedicle dimensions and its angulations for the development of techniques and devices for spinal instrumentation on computed tomography (CT) scan. Fifty CT scans of lumbar vertebral column of patients belonging to North West Indian population was randomly selected. Various morphometric parameters were...

During routine dissection of 82-year-old female cadaver with no known unfavorable medical history, we observed bilateral bifid ureter and variation in arterial supply of left kidney only. Careful examination revealed that there were bifid ureters on both sides enclosed in single facial sheath. It was also observed that both the ureter have differen...

Background: Transpedicular stabilization of subaxial cervical spine is a very delicate procedure that requires thorough understanding of the pedicle anatomy to minimize the rate of neurovascular complications. The current study was conducted to investigate the morphometric details including dimensions and axis of typical cervical vertebrae (C3-C6)...

Regional anesthesia plays a key role in elective as well as emergency orthopedic and other surgeries in children. However, peripheral nerve blocks are quite challenging in children due to lack of precise anatomical knowledge of the course and distribution of these nerves. The purpose of this study was to explore the terminal branches of the superfi...