Riccardo Faccini

Riccardo Faccini
Sapienza University of Rome | la sapienza · Department of Physics

PhD Physics

About

2,052
Publications
338,416
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34,298
Citations
Additional affiliations
January 2002 - December 2010
Università degli Studi di Roma "La Sapienza"
April 1998 - February 2002
University of California, San Diego
Position
  • Research Assistant

Publications

Publications (2,052)
Article
Full-text available
Background: Recently, a flexible DROP-IN gamma-probe was introduced for robot-assisted radioguided surgery, using traditional low-energy SPECT-isotopes. In parallel, a novel approach to achieve sensitive radioguidance using beta-emitting PET isotopes has been proposed. Integration of these two concepts would allow to exploit the use of PET tracers...
Article
Radioguided surgery (RGS) is a medical practice which thanks to a radiopharmaceutical tracer and a probe allows the surgeon to identify tumor residuals up to a millimetric resolution in real-time. The employment of β− emitters, instead of γ or β+, reduces background from healthy tissues, administered activity to the patient, and medical exposure. I...
Preprint
Full-text available
Background: Recently, a flexible DROP-IN gamma-probe was introduced for robot-assisted radioguided surgery, using traditional low-energy SPECT-isotopes. In parallel, a novel approach to achieve sensitive radioguidance using beta-emitting PET-isotopes has been proposed. Integration of these two concepts would allow to exploit the use of PET-tracers...
Preprint
Full-text available
Background: Recently, a flexible DROP-IN gamma-probe was introduced for robot-assisted radioguided surgery, using traditional low-energy SPECT-isotopes. In parallel, a novel approach to achieve sensitive radioguidance using beta-emitting PET-isotopes has been proposed. Integration of these two concepts would allow to exploit the use of PET-tracers...
Article
Full-text available
The main goal of the FOOT (FragmentatiOn Of Target) experiment is the measurement of the differential cross sections as a function of energy and direction of the produced fragments in the nuclear interaction between a ion beam (proton, helium, carbon, ...) and different targets (proton, carbon, oxygen, ...).Depending on the beam energy, the purpose...
Article
Full-text available
The FOOT (FragmentatiOn Of Target) experiment aims to determine the fragmentation cross-sections of nuclei of interest for particle therapy and radioprotection in space. The apparatus is composed of several detectors that allow fragment identification in terms of charge, mass, energy and direction. The fragment time of flight (ToF) along a lever ar...
Article
Purpose A reliable model to simulate nuclear interactions is fundamental for Ion-therapy. We already showed how BLOB (“Boltzmann-Langevin One Body”), a model developed to simulate heavy ion interactions up to few hundreds of MeV/u, could simulate also ¹²C reactions in the same energy domain. However, its computation time is too long for any medical...
Preprint
Purpose: A reliable model to simulate nuclear interactions is fundamental for Ion-therapy. We already showed how BLOB ("Boltzmann-Langevin One Body"), a model developed to simulate heavy ion interactions up to few hundreds of MeV/u, could simulate also $^{12}$C reactions in the same energy domain. However, its computation time is too long for any m...
Article
This paper provides a first insight of the potential of the β- Radio Guided Surgery (β--RGS) in a complex surgical environment like the abdomen, where multiple sources of background concur to the signal at the tumor site. This case is well reproduced by ex-vivo samples of 90Y-marked Gastro-Entero-Pancreatic Neuroendocrine Tumors (GEP NET) in the bo...
Preprint
Full-text available
Background: Recently, a flexible DROP-IN gamma-probe was introduced for robot-assisted radioguided surgery, using traditional low-energy SPECT-isotopes. This study explores the use of a novel DROP-IN beta-particle (DROP-IN b ) detection probe to support the implementation of the large number of PET-tracers available during robot-assisted tumor-rece...
Article
Full-text available
The possibility to use β⁻ decaying isotopes for radioguided surgery (RGS) has been recently proposed, and first promising tests on ex-vivo samples of Meningioma and intestinal Neuroendocrine Tumor (NET) have been published. This paper reports a study of the uptake of ⁶⁸Ga-DOTATOC in pancreatic NETs (pNETs) in order to assess the feasibility of a ne...
Article
Full-text available
In a carbon ion treatment the nuclear fragmentation of both target and beam projectiles impacts on the dose released on the tumour and on the surrounding healthy tissues. Carbon ion fragmentation occurring inside the patient body has to be studied in order to take into account this contribution. These data are also important for the development of...
Article
In a carbon ion treatment the nuclear fragmentation of both target and beam projectiles impacts on the dose released on the tumour and on the surrounding healthy tissues. Carbon ion fragmentation occurring inside the patient body has to be studied in order to take into account this contribution. These data are also important for the development of...
Article
Purpose: Radio Guided Surgery (RGS) is a technique that helps the surgeon to achieve an as complete as possible tumor resection, thanks to the intraoperative detection of particles emitted by a radio tracer that bounds to tumoral cells. In the last years, a novel approach to this technique has been proposed that, exploiting β- emitting radio trace...
Article
Full-text available
Purpose: Monte Carlo (MC) simulations are widely used for medical applications and nuclear reaction models are fundamental for the simulation of the particle interactions with patients in ion therapy. Therefore, it is of utmost importance to have reliable models in MC simulations for such interactions. Geant4 is one of the most used toolkits for M...
Article
Full-text available
In the last decade, many innovative nanodrugs have been developed, as well as many nanoradiocompounds that show amazing features in nuclear imaging and/or radiometabolic therapy. Their potential uses offer a wide range of possibilities. It can be possible to develop nondimensional systems of existing radiopharmaceuticals or build engineered systems...
Article
Full-text available
Charged particle therapy exploits proton or ¹²C beams to treat deep-seated solid tumors. Due to the advantageous characteristics of charged particles energy deposition in matter, the maximum of the dose is released to the tumor at the end of the beam range, in the Bragg peak region. However, the beam nuclear interactions with the patient tissues in...
Article
Purpose: To develop and validate an Artificial Intelligence (AI) model based on texture analysis of high-resolution T2 weighted MR images able 1) to predict pathologic Complete Response (CR) and 2) to identify non-responders (NR) among patients with locally-advanced rectal cancer (LARC) after receiving neoadjuvant chemoradiotherapy (CRT). Method:...
Article
Full-text available
In hadron therapy, the accelerated ions, interacting with the body of the patient, cause the fragmentation of both projectile and target nuclei. The fragments interact with the human tissues depositing energy both in the entrance channel and in the volume surrounding the tumor. The knowledge of the fragments features is crucial to determine the ene...
Chapter
Full-text available
Reliable nuclear fragmentation models are of utmost importance in hadron therapy, where Monte Carlo (MC) simulations are used to compute the input parameters of the treatment planning software, to validate the deposited dose calculation, to evaluate the biological effectiveness of the radiation, to correlate the \( \beta + \) emitters production in...
Article
Full-text available
Charged Particle Therapy (CPT) is a powerful radiotherapy technique for the treatment of deep-seated tumours characterized by a large dose released in the Bragg peak area (corresponding to the tumour region) and a small dose delivered to the surrounding healthy tissues. The precise measurement of the fragments produced in the nuclear interactions o...
Article
Full-text available
Purpose Radio-guided surgery with β- decays is a novel technique under investigation. One of the main advantages is its capability to detect small (⩽0.1 ml) samples after injecting the patient with low activity of radiopharmaceutical. This paper presents an experimental method to quantify this feature based on ex-vivo tests on specimens from mening...
Article
Full-text available
We present first evidence that the cosine of the CP-violating weak phase 2β is positive, and hence exclude trigonometric multifold solutions of the Cabibbo-Kobayashi-Maskawa (CKM) Unitarity Triangle using a time-dependent Dalitz plot analysis of B0→D(*)h0 with D→KS0π+π− decays, where h0∈{π0,η,ω} denotes a light unflavored and neutral hadron. The me...
Article
Full-text available
We report measurements of sin2β and cos2β using a time-dependent Dalitz plot analysis of B0→D(*)h0 with D→KS0π+π− decays, where the light unflavored and neutral hadron h0 is a π0, η, or ω meson. The analysis uses a combination of the final data sets of the BaBar and Belle experiments containing 471×106 and 772×106 BB¯ pairs collected at the ϒ(4S) r...
Article
Full-text available
Radio Guided Surgery is a technique helping the surgeon in the resection of tumors: a radiolabeled tracer is administered to the patient before surgery and then the surgeon evaluates the completeness of the resection with a handheld detector sensitive to emitted radiation. Established methods rely on γ emitting tracers coupled with γ detecting prob...
Poster
Full-text available
The FOOT experiment is a �xed target experiment aiming for high precision (better than 5%) measurement of fragmentation cross section for hadron-therapy and space radioprotection purposes. Both target and projectile fragmentation are studied by using mainly proton, Carbon and Oxygen ion beams in both direct and inverse kinematic regime, alternative...
Research Proposal
Full-text available
The FOOT (FragmentatiOn Of Target) experiment has therefore been conceived in order to perform a set of measurements of nuclear fragmentation cross sections which will be used to develop a new generation of biologically oriented Treatment Planning Systems for proton and ion therapy.
Article
Purpose A very promising technique for radio-guided surgery (RGS) based on β-radiation is being developed. The lower background, with respect to the established approach with high penetrant γ radiation, can allow for a large diffusion of such a technique and extending the RGS to cases with a large uptake of surrounding healthy organs, such as abdom...
Article
Radio-Guided Surgery enables the surgeon to identify tumor residuals in real time, with millimetric resolution. This technique takes advantage of a radiopharmaceutical as tracer and a probe as detector. The employment of β⁻ emitters as tracers, instead of γ or β⁺, reduces the background from the healthy tissues and the medical exposition risk. The...
Article
P-terphenyl crystals are high light yield organic scintillators characterised by a relatively short intrinsic light attenuation length. The effective value of this physical quantity depends on the actual design of the detector and can be tuned for a specific application with the appropriate combination of crystal size and shape, its bulk and superf...
Article
We report measurements of sin2β and cos2β using a time-dependent Dalitz plot analysis of B⁰ → D(*)h⁰ with D→K⁰[subscript S]π⁺π⁻ decays, where the light unflavored and neutral hadron h⁰ is a π⁰, η, or ω meson. The analysis uses a combination of the final data sets of the BaBar and Belle experiments containing 471×10⁶ and 772×10⁶ BB[over ¯] pairs col...
Article
Full-text available
The CUORE experiment, a ton-scale cryogenic bolometer array, recently began operation at the Laboratori Nazionali del Gran Sasso in Italy. The array represents a significant advancement in this technology, and in this work we apply it for the first time to a high-sensitivity search for a lepton-number-violating process: Te130 neutrinoless double-be...
Article
Full-text available
We study the process e+e−→π+π−ηγ, where the photon is radiated from the initial state. About 8000 fully reconstructed events of this process are selected from the BABAR data sample with an integrated luminosity of 469 fb−1. Using the π+π−η invariant mass spectrum, we measure the e+e−→π+π−η cross section in the e+e− center-of-mass energy range from...
Article
Full-text available
Proton and carbon ion beams are used in the clinical practice for external radiotherapy treatments achieving, for selected indications, promising and superior clinical results with respect to x-ray based radiotherapy. Other ions, like 4He have recently been considered as projectiles in particle therapy centres and might represent a good compromise...
Article
Full-text available
The aim of the present work has been the mass spectrometry characterization of the Nimotuzumab (NIM) antibody chemically modified with the bifunctional chelating agent para-S-2-(4-isothiocyanatobenzyl)-1,4,7,10-tetraaza cyclododecanetetraacetic acid (p-SCN-Bn-DOTA). The conjugate, upon labeling with the pure β⁻-emitter ⁹⁰Y³⁺, could represent a prom...
Article
We study the process e[superscript +]e[superscript -] →π[superscript +]π[superscript -]ηγ, where the photon is radiated from the initial state. About 8000 fully reconstructed events of this process are selected from the BABAR data sample with an integrated luminosity of 469 fb[superscript -1]. Using the π[superscript +]π[superscrit -]η invariant ma...
Article
Full-text available
The process e+e−→π+π−2π0γ is investigated by means of the initial-state radiation technique, where a photon is emitted from the incoming electron or positron. Using 454.3 fb−1 of data collected around a center-of-mass energy of s=10.58 GeV by the BABAR experiment at SLAC, approximately 150000 signal events are obtained. The corresponding nonradiati...
Article
Full-text available
We measure the mass difference, Δm+, between the D*(2010)+ and the D+ using the decay chain D*(2010)+→D+π0 with D+→K−π+π+. The data were recorded with the BABAR detector at center-of-mass energies at and near the ϒ(4S) resonance, and correspond to an integrated luminosity of approximately 468 fb−1. We measure Δm+=(140 601.0±6.8[stat]±12.9[syst]) ke...
Article
Purpose Beta-particle radioguided tumor resection may potentially overcome the limitations of conventional gamma-ray guided surgery by eliminating, or at least minimizing, the confounding effect of counts contributed by activity in adjacent normal tissues. The current study evaluates the clinical feasibility of this approach for a variety of radion...
Article
Full-text available
The CUORE experiment, a ton-scale cryogenic bolometer array, recently began operation at the Laboratori Nazionali del Gran Sasso in Italy. The array represents a significant advancement in this technology, and in this work we apply it for the first time to a high-sensitivity search for a lepton-number--violating process: $^{130}$Te neutrinoless dou...
Article
Full-text available
We report a Dalitz plot analysis of charmless hadronic decays of charged B mesons to the final state KS0π+π0 using the full BABAR data set of 470.9±2.8 million BB¯ events collected at the Υ(4S) resonance. We measure the overall branching fraction and CP asymmetry to be B(B+→K0π+π0)=(31.8±1.8±2.1−0.0+6.0)×10−6 and ACP(B+→K0π+π0)=0.07±0.05±0.03−0.03+...
Article
The CUORE experiment, a ton-scale cryogenic bolometer array, recently began operation at the Laboratori Nazionali del Gran Sasso in Italy. The array represents a significant advancement in this technology, and in this work we apply it for the first time to a high-sensitivity search for a lepton-number-violating process: [superscript 130]Te neutrino...
Article
We measure the mass difference, Δm₊, between the D*(2010)⁺ and the D⁺ using the decay chain D*(2010)⁺→D⁺π⁰ with D⁺→K⁻π⁺π⁺. The data were recorded with the BABAR detector at center-of-mass energies at and near the ϒ(4S) resonance, and correspond to an integrated luminosity of approximately 468 fb⁻¹. We measure Δm₊=(140 601.0±6.8[stat]±12.9[syst]) ke...
Article
Full-text available
We search for single-photon events in 53 fb−1 of e+e− collision data collected with the BABAR detector at the PEP-II B-Factory. We look for events with a single high-energy photon and a large missing momentum and energy, consistent with production of a spin-1 particle A′ through the process e+e−→γA′; A′→invisible. Such particles, referred to as “da...
Article
Full-text available
The process e [superscript +] e [superscript -] →π [superscript +] π [superscript -] 2π [superscript 0] γ is investigated by means of the initial-state radiation technique, where a photon is emitted from the incoming electron or positron. Using 454.3 fb [superscript -1] of data collected around a center-of-mass energy of √s =10.58 GeV by the BABAR...
Article
Full-text available
Purpose: The real-time monitoring of the spread-out Bragg peak would allow the planned dose delivered during treatment to be directly verified, but this poses a major challenge in modern ion beam therapy. A possible method to achieve this goal is to exploit the production of secondary particles by the nuclear reactions of the beam with the patient...
Article
The processes e+e−→KS0K±π∓π0 and e+e−→KS0K±π∓η are studied over a continuum of energies from threshold to 4 GeV with the initial-state photon radiation method. Using 454 fb−1 of data collected with the BABAR detector at the SLAC PEP-II storage ring, the first measurements of the cross sections for these processes are obtained. The intermediate reso...
Article
Radiolabeled nanoparticles are promising tools in cancer diagnosis and therapy. Moreover, yttrium-90 (⁹⁰Y) is a good candidate as suitable β⁻ emitting radioisotope for a new approach to radio-guided surgery (RGS) proposed by some researchers of our group. In this work, we developed new composite nanoparticles, based on polymethylmethacrylate (PMMA)...
Article
Based on the full BABAR data sample of 466.5 million BB¯ pairs, we present measurements of the electron spectrum from semileptonic B meson decays. We fit the inclusive electron spectrum to distinguish Cabibbo-Kobayashi-Maskawa (CKM) suppressed B→Xueν decays from the CKM-favored B→Xceν decays, and from various other backgrounds, and determine the to...
Article
Full-text available
The processes e[superscript +]e[superscript -] →K[superscript 0][subscript S]K[superscript ±]π[superscript ∓]π[superscript 0] and e[superscript +]e[superscript -] →K[superscript 0][subscript S]K[supercript ±]π[superscript ∓]η are studied over a continuum of energies from threshold to 4 GeV with the initial-state photon radiation method. Using 454 f...
Article
We study the processes e+e−→KS0KL0π0γ, KS0KL0ηγ, and KS0KL0π0π0γ, where the photon is radiated from the initial state, providing cross section measurements for the hadronic final states over a continuum of center-of-mass energies. The results are based on 469 fb−1 of data collected at or near the Υ(4S) resonance with the BABAR detector at SLAC. We...
Article
We search for the rare flavor-changing neutral current process B^+ → K^+τ^+τ^− using data from the BABAR experiment. The data sample, collected at the center-of-mass energy of the Υ(4S) resonance, corresponds to a total integrated luminosity of 424 fb^(−1) and to 471×10^6 BB pairs. We reconstruct one B meson, produced in the Υ(4S) → B^+B^− decay, i...
Article
Charged particle therapy is a technique for cancer treatment that exploits hadron beams, mostly protons and carbon ions. A critical issue is the monitoring of the beam range so to check the correct dose deposition to the tumor and surrounding tissues. The design of a new tracking device for beam range real-time monitoring in pencil beam carbon ion...
Conference Paper
Full-text available
Particle therapy uses protons or 12 C beams for the treatment of deep-seated solid tumors. Due to the features of the energy deposition of charged particles in matter, a limited amount of dose is released to the healthy tissue in the beam entrance region, while the maximum of the dose is released to the tumor at the end of the beam range, in the Br...