Ricardo Marcos Pautassi

Ricardo Marcos Pautassi
Instituto de Investigación Médica Mercedes y Martín Ferreyra | IMMF · Psychophysiology

Biological Sciences PhD

About

227
Publications
51,806
Reads
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2,299
Citations
Introduction
I analyze the rewarding effects of alcohol during adolescence, as assessed through animal and human experimental models, and epidemiological approaches. The research aims at identifying subpopulations of subjects with differential susceptibility to exhibit problematic alcohol consumption. The aim is to determine predictors of vulnerability to excessive alcohol consumption in adolescents. Follow my Twitter @rpautassi
Additional affiliations
March 2009 - present
December 2008 - present
National Scientific and Technical Research Council
Position
  • Adjunct Researcher
Description
  • The main interest of my research is the analysis of the rewarding effects of alcohol during the adolescent stage of development, as assessed through animal models.
July 2007 - November 2008
State University of New York at Binghamton
Position
  • Research Assistant
Education
February 2006 - July 2007
Binghamton University
Field of study
  • Psychobiology
May 2001 - April 2005
Faculty of Exacts, Physics and Natural Sciences, National University of Cordoba
Field of study
  • Biological Sciences
February 1995 - December 1999

Publications

Publications (227)
Article
Full-text available
El consumo de alcohol, tabaco y marihuana presenta una alta prevalencia entre adultos emergentes universitarios. Una variable que incide en el consumo de estas tres sustancias psicoactivas es la percepción de riesgo asociada a dicha conducta. Este estudio examinó -en adultos emergentes universitarios argentinos- la relación bi o multivariada, entre...
Article
Full-text available
RationaleSerotonin (5-HT) is a monoamine neuromodulator that plays a key role in the organization of the central nervous system. 5-HT alterations may be associated to the emergence of social deficits and psychiatric disorders, including anxiety, depression, and substance abuse disorders. Notably, disruption of the 5-HT system during sensitive perio...
Article
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Past research has examined the association of cultural orientation with drinking motives, alcohol use, and alcohol-related problems, mainly, at the country level or in participants from a single region. This study examined the indirect associations of features of cultural orientation (i.e., vertical individualism, vertical collectivism, horizontal...
Chapter
Alcohol use disorder is a condition in which the individual keeps drinking alcohol despite repeated attempts to stop or control such behavior, which in turn generates negative social, occupational, and health consequences. Animal models have been developed to reproduce the deleterious effects of excessive ethanol intake, including ethanol-induced c...
Poster
Full-text available
Asociación de estados emocionales negativos con síntomas de adicción a los alimentos mediante conductas alimentarias y motivos de consumo Fernández, Macarena*a; Dal Bianco, Nicólasb; Dato, Rocío, Positerib, Luciana; Pautassi, Ricardo b,c & Pilatti, Angelina a,b a Instituto de Investigaciones Psicológicas (CONICET-UNC), Córdoba, Argentina b Facult...
Article
Background: The identification of factors promoting simultaneous alcohol and marijuana (SAM) use is important to promote early intervention efforts. The associations between impulsivity facets and SAM (or concurrent alcohol and marijuana, CAM) use have been analyzed in North American samples. These topics, however, remain unexplored in South Americ...
Article
Background: Chronic alcohol misuse is associated with alcoholic myopathy, characterized by skeletal muscle weakness and atrophy. Moreover, there is evidence that sports-related people seem to exhibit a greater prevalence of problematic alcohol consumption, especially binge drinking (BD), which might not cause alcoholic myopathy but can negatively...
Article
There is a high level of comorbidity between depression and alcohol use disorder. Subanesthetic doses of ketamine induce short-acting and enduring antidepressant effects after a single or a few administrations. Considering such comorbidity, we assessed, in Swiss male mice, if ketamine-induced antidepressant-like effects would alter ethanol’s reward...
Article
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Animal models of alcohol (ethanol) self-administration are crucial to dissect the neurobiological mechanisms underlying alcohol dependence, yet only a few of these induce pharmacologically relevant levels of alcohol consumption and rarely the alcohol self-administration co-occurs with other addictive behaviours. The present study aims to validate a...
Article
Ethanol-induced conditioned taste aversion (CTA) is greater in late adolescence or young adulthood than in early adolescence. The role of the sigma receptor system in this age-related difference has not been extensively explored, particularly in female rats. This study assessed the effects of the activation of sigma-1 receptors (S1-R), via the sele...
Article
Full-text available
Abstract Impulsivity and risk taking: prospective effect on alcohol consumption in Argentine adolescents. Impulsivity and risk taking are personality traits associated to alcohol use. However, there is a scarcity of longitudinal studies evaluating how these factors affect alcohol use in Latin-American adolescents. The present study aimed at identif...
Article
Full-text available
Aunque el consumo de marihuana es altamente prevalente entre universitarios de Argentina, poco se sabe respecto a los factores que permiten distinguir a los consumidores frecuentes de marihuana de quienes consumen esporádicamente. Por esta razón, en el presente trabajo se indagó sobre las posibles variaciones en los contextos de consumo, motivos de...
Article
Full-text available
El consumo de sustancias es altamente prevalente en estudiantes universitarios de Argentina y el mundo. Diferenciar consumidores con diversos patrones de consumo de sustancias es importante para identificar aquellos más vulnerables a avanzar hacia un consumo patológico. Por ello, el objetivo fue identificar, mediante Análisis de Clases Latentes (AC...
Article
Introduction: Previous work suggests that college students who perceive themselves as less able to tolerate negative affect are more motivated to use alcohol to alleviate psychological distress. Recent findings also indicate that distress tolerance influences alcohol outcomes via a positive reinforcement pathway. However, results concerning the as...
Article
Full-text available
This study examined the association of social norms (i.e., descriptive and injunctive norms) and perceived risk with alcohol, tobacco, and marijuana use in a sample of 378 Argentinean adolescents (60.3% girls, mean age 15.26 [SD = 1.26]). We conducted descriptive, correlation, and multivariate (i.e., hierarchical regression) analyses to describe su...
Article
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Introduction Use of Social networking sites (SNSs) is a highly prevalent behavior worldwide and, for some individuals, its use can turn maladaptive. There has been growing interest to identify which variables are associated with problematic use of SNSs. Aim The present study cross-sectionally examined whether the associations between different feat...
Article
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Health measures instantiated to reduce the spread of COVID-19 have imposed significant constraints for the population and impacted on drinking habits and mental health. This study longitudinally compared changes in alcohol consumption before and after the COVID-19 outbreak and the impact of sociodemographic and mental health variables on such chang...
Article
Background: We have reported induction of ∆FosB in adolescent rats that drank less ethanol than adults yet exhibited a progressive increase in ethanol intake.Objective: To test the hypothesis that an escalating pattern of ethanol exposure is more effective to induce ∆FosB expression [at prelimbic cortex (PrL), nucleus accumbens core and shell, stri...
Article
Objective: Normative perceptions have been shown to mediate the effect of personality traits on cannabis outcomes. We examined descriptive norms, injunctive norms, and the role of cannabis in college life as possible mediators of the association between impulsivity-related traits (i.e., negative urgency, positive urgency, sensation seeking, persev...
Article
Full-text available
Objectives: This study aimed to analyse how the health crisis associated with the COVID-19 pandemic affected psychoactive substance consumption in Uruguay. Methods: An online survey was answered by 1,916 Uruguayan citizens between March and April 2020 regarding psychoactive substance use before and after the instauration of a recommended quarant...
Article
Novelty seems to reduce the persistence of aversive memories and to modulate frustration responses, yet much less is known on how this treatment affects memories lacking hedonic or emotional content. The present study analyzed how a 5-min exposure to a novel open field modulated the expression of a spatial recognition memory. Experiment 1 indicated...
Article
Full-text available
Se analizó la correspondencia entre estimaciones de consumo de alcohol obtenidas mediante mediciones retrospectivas (Cuestionario de Consumo de Alcohol —CCA—) y un Diario de Consumo. Participaron 134 jóvenes de la ciudad de Córdoba, Argentina (M edad = 23,31, DE = 3,18) que reportaron diariamente y por 60 días su consumo de alcohol. Al final del pr...
Article
Recent frameworks in cognitive neuroscience and behavioral neurology underscore interoceptive priors as core modulators of negative emotions. However, the field lacks experimental designs manipulating the priming of emotions via interoception and exploring their multimodal signatures in neurodegenerative models. Here, we designed a novel task that...
Article
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Objetivos. Se analizó el desarrollo de tolerancia aguda a los efectos del alcohol (dosis = 0.08%) sobre la capacidad de conducción de automotor – medida con un simulador -- y los efectos de esta dosis de alcohol sobre inhibición de respuesta en curso y procesos atencionales. Metodología. Los participantes (n = 56, edad= 22± 2.92 años) fueron distri...
Article
Research suggests that addictive traits are indeed heritable, but very few preclinical studies have explored transgenerational effects of paternal alcohol exposure. The present study addressed this gap in knowledge. We explored if offspring of ethanol exposed sires would be more likely to accept ethanol than descendants of water-exposed and control...
Article
Full-text available
Los cuadros depresivos en humanos cursan con significativas alteraciones en la memoria espacial. Este trabajo estudió esta función en un modelo animal de depresión. Ratas Wistar (n=28), machos y hembras, fueron administradas con reserpina (0.0 o 1.0 mg/kg/cada 2 días por cuatro días). Luego del tratamiento se evaluó la función motora a través de la...
Article
Full-text available
Rationale Serotonin (5-HT) plays an important role in the organization of the central nervous system and in the development of social interaction deficits and psychiatric disorders, including anxiety, depression, and addiction disorders. Notably, disruption of the 5-HT system during sensitive periods of development exerts long-term consequences, in...
Article
Full-text available
Validation of the Spanish version of the brief UPPS-P Impulsivity Scale for children and adolescents (BUPPS-P NA)Abstract: The Scale of Impulsivity for Children and Adolescents (UPPS-P NA) is a self-report instrument that assesses the impulsivity trait in children and adolescents. However, the UPPS-P NA does not have a short version in Spanish. The...
Article
Aims The present study examined which types of alcohol protective behavioral strategies ([PBSs], Manner of Drinking [MOD] strategies, Serious Harm Reduction [SHR] or Limiting/Stopping Drinking strategies [LSD]) mediate the effects of a comprehensive number of distal antecedents on alcohol drinking quantity and alcohol-related negative consequences....
Article
Full-text available
Objective: Neurological nosology, based on categorical systems, has largely ignored dimensional aspects of neurocognitive impairments. Transdiagnostic dimensional approaches of interoception (the sensing of visceral signals) may improve the descriptions of cross-pathological symptoms at behavioral, electrophysiological, and anatomical levels. Alte...
Article
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La previa (i.e., el consumo de alcohol antes de asistir al evento de la salida en el que puede, o no, consumirse más alcohol) incrementa marcadamente el riesgo de experimentar consecuencias negativas asociadas al consumo de alcohol. Aunque el consumo de alcohol es muy prevalente entre los adolescentes argentinos, son escasos los trabajos centrados...
Article
Full-text available
La previa (i.e., el consumo de alcohol antes de asistir al evento de la salida en el que puede, o no, consumirse más alcohol) incrementa marcadamente el riesgo de experimentar consecuencias negativas asociadas al consumo de alcohol. Aunque el consumo de alcohol es muy prevalente entre los adolescentes argentinos, son escasos los trabajos centrados...
Article
Full-text available
Background Discriminating between adolescents who will eventually have ethanol use problems from those who do not is important. Environmental enrichment is a promising approach to reduce drug-related problems, but its impact on ethanol’s effects and intake is being scrutinized. Objective: We tested the effects of environmental enrichment on ethanol...
Article
Background Ethanol use during adolescence is a significant health problem, yet the pharmacological treatments to reduce adolescent binge drinking are scarce. The present study assessed, in male and female adolescent Wistar rats, if the sigma-1 receptor (S1-R) antagonists S1RA or BD-1063 disrupted ethanol drinking. Methods Three times a week, for t...
Article
Alcohol (ethanol) use is almost normative by late adolescence, in most western countries. It is important to identify factors that distinguish those who progress from alcohol initiation to sustained use of the drug, from those that keep a controlled pattern of drinking. The factors precipitating this transition may change across development. This s...
Poster
Full-text available
Underage alcohol use is an important health concern. Drinking behaviors are prevalent among Argentinean children/adolescents, with about 60% of drinkers exhibiting first contact with alcohol by the age of 15 or before. The present study aimed at identifying the prospective role of risk taking and trait-like impulsivity on drinking patterns in Argen...
Article
Full-text available
Heavy episodic drinking (HED) is highly prevalent in college students. In Argentina, there is a notable lack of longitudinal studies examining drinking trajectories. The present study identified HED trajectories in Argentinean college students during the first 3 years of college (seven waves) and examined the association between risk factors for al...
Article
Full-text available
Esta revisión, narrativa y no sistemática, repasa datos y tendencias sobre la prevalencia del consumo de alcohol en niños y adolescentes, con foco en trabajos de la región sur de América Latina; asimismo, describimos algunos factores, y la investigación asociada que los sustenta, que regulan el consumo de alcohol, particularmente en niños y adolesc...
Book
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Este libro tiene, como objetivo principal, ayudar a todo aquel que quiera implementar un programa de prevención de consumo de alcohol basado en preceptos de normas sociales y/o behavioral insights. Como veremos en los capítulos subsiguientes, este tipo de abordaje preventivo es marcadamente diferentes de los abordajes más tradicionales, basados en...
Article
Full-text available
The present study assessed the effects of ethanol exposure during adolescence or adulthood. We exposed Wistar rats, males or females, to self-administered 8–10% (v/v) ethanol (BINGE group) during the first 2 h of the dark cycle, three times a week (Monday, Wednesday, and Friday) during postnatal days (PDs) 32–54 or 72–94 (adolescent and adults, res...
Article
Historically, the roots of alcoholism have been linked to either environment or heredity. However, the interaction between these factors is still largely unexplored. The evidence supports a link between alcohol consumption and the endogenous opioid system. We here studied the opioid genes expression in male and female Wistar rats derived from a sho...
Article
Full-text available
La impulsividad y la toma de riesgos se asocian positivamente al consumo de alcohol. Asimismo, la impulsividad y la toma de riesgos aumentan luego de la ingesta aguda de alcohol. Objetivo. Examinar el efecto de una dosis de alcohol (0.6/0.7 g/kg mujeres y varones) sobre el desempeño en pruebas de control inhibitorio, sensibilidad a las recompensas...
Article
Ethanol use is widespread in adolescents, yet only some transition to problematic drinking. It is important to understand why the risk for problematic drinking varies across sub-groups of adolescents. This study reports a short-term selection program to generate Wistar rat lines (high and low adolescent ethanol drinking, ADHI and ADLO lines, respec...
Article
It has been shown that exposure to familiar odors facilitate the acceptance of bitter flavors in preweanling rats, yet it unknown how long this phenomenon persists. This study assessed, in 9‐ or 15‐day‐old Wistar rats, the influence of a familiar scent (i.e., lemon) on the intake of and behavioral responsiveness (i.e., mouthing, paw lick, chin rub,...
Article
Background Alcohol use, and the association between alcohol-related variables and drinking outcomes, seem to be context dependent. We employed Latent Class Analysis, a person-centered approach, to identify distinct subpopulations based on contexts of alcohol use. We also examined if the resulting classes differ in a set of alcohol-related variables...
Article
Full-text available
Interoception (the sensing of inner-body signals) is a multi-faceted construct with major relevance for basic and clinical neuroscience research. However, the neurocognitive signatures of this domain (cutting across behavioral, electrophysiological, and fMRI connectivity levels) are rarely reported in convergent or systematic fashion. Additionally,...
Article
Full-text available
Se examinaron variaciones estacionales en el uso de estrategias conductuales de protección (ECP) y en indicadores de consumo de alcohol en dos épocas del calendario universitario: cursado en primavera y receso estival. Participaron 223 universitarios que reportaron consumo de alcohol, consecuencias negativas de dicho consumo y uso de ECP. Se encont...
Article
Full-text available
Prenatal ethanol exposure (PEE) promotes ethanol consumption in the adolescent offspring accompanied by the transcriptional regulation of kappa opioid receptor (KOR) system genes. This study analysed if environmental enrichment (EE, from gestational day 20 to postnatal day 26) exerts protective effects upon PEE-modulation of gene expression, ethano...
Article
Psychological distress can promote alcohol consumption during emerging adulthood. Still unknown is, however, how predisposition to emotional contagion alters psychological distress, and how these phenomena are affected by level of education. The present study analyzed the effect of psychological distress, age of first contact with alcohol (early, l...
Article
Full-text available
Repeated exposure to alcohol increases retrieval of fear‐conditioned memories, which facilitates, among other factors, the emergence of post‐traumatic stress disorder (PTSD). Individuals with PTSD are more likely to develop alcohol and substance abuse related disorders. We assessed if prenatal and early postnatal alcohol exposure (PAE) increased th...
Article
Full-text available
El policonsumo de sustancias psicoactivas está asociado a consecuencias negativas para la salud. Asimismo, diferentes contextos recreativos se asocian al consumo de determinadas sustancias. En Argentina, sin embargo, son escasas las investigaciones que examinen el policonsumo de sustancias y, además, su asociación con contextos recreativos particul...